LIVIVO - Search results -

Search results

Result 1 - 10 of total 65

Search options

Article: [Spatial autocorrelation and its application in public health field].

Shi, J M / Zhao, J Q / Li, J G

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

2020 Volume 38, Issue 5, Page(s) 395–400

Abstract: The prevalence and distribution of infectious diseases and occupational diseases in specific time and space is the result of the interaction between natural environment, social economy and other factors, its distribution pattern has spatial properties. ... ...

Abstract	The prevalence and distribution of infectious diseases and occupational diseases in specific time and space is the result of the interaction between natural environment, social economy and other factors, its distribution pattern has spatial properties. Based on the assumption of independence, the traditional statistical methods ignore the spatial attributes of diseases and cannot analyze the spatial characteristics of diseases. On the basis of geographic information system, the spatial autocorrelation analysis can simultaneously analyze the spatial relationship and attribute value of diseases, explore the spatial dependence of disease data in different spatial units, and provide decision-making basis for the prediction and early warning of diseases such as occupational and infectious diseases, and the formulation and evaluation of prevention and control measures.
MeSH term(s)	China ; Geographic Information Systems ; Humans ; Prevalence ; Public Health ; Spatial Analysis
Language	Chinese
Publishing date	2020-06-13
Publishing country	China
Document type	Journal Article
ISSN	1001-9391
ISSN	1001-9391
DOI	10.3760/cma.j.cn121094-20190507-00183
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Zoledronic acid and fracture risk: a meta-analysis of 12 randomized controlled trials.

He, B / Zhao, J-Q / Zhang, M-Z / Quan, Z-X

European review for medical and pharmacological sciences

2021 Volume 25, Issue 3, Page(s) 1564–1573

Abstract: Objective: Zoledronic acid is widely used in patients with osteoporosis, and this meta-analysis aims to explore the influence of zoledronic acid on fracture risk and mortality in patients with osteoporosis or osteopenia.: Materials and methods: We ... ...

Abstract	Objective: Zoledronic acid is widely used in patients with osteoporosis, and this meta-analysis aims to explore the influence of zoledronic acid on fracture risk and mortality in patients with osteoporosis or osteopenia. Materials and methods: We searched PubMed, Google Scholar, and Cochrane Library for randomized clinical trials comparing zoledronic acid with control intervention (i.e., placebo or nothing) for osteoporosis or osteopenia. The fracture and mortality were estimated using the random-effect model. Results: 12 randomized trials were included in this meta-analysis. Compared to control intervention, zoledronic acid was associated with significantly reduced incidence of fracture at the follow-up of 12 months, 24 months, 36 months and 72 months. In addition, zoledronic acid could remarkably reduce mortality at 12 months and 24 months than control intervention but revealed no influence on mortality at 36 months or 72 months. In terms of adverse events, zoledronic acid might result in the increase in serious atrial fibrillation and death from stroke than control intervention. Conclusions: Zoledronic acid is beneficial to reduce the incidence of fracture, while its benefits to reduce the mortality are only observed at the follow-up time of 24 months.
MeSH term(s)	Atrial Fibrillation/drug therapy ; Bone Density/drug effects ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Fractures, Bone/drug therapy ; Humans ; Randomized Controlled Trials as Topic ; Zoledronic Acid/adverse effects ; Zoledronic Acid/therapeutic use
Chemical Substances	Bone Density Conservation Agents ; Zoledronic Acid (6XC1PAD3KF)
Language	English
Publishing date	2021-02-24
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202102_24865
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1887: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: MiR-212-5p regulates the proliferation and apoptosis of AML cells through targeting FZD5.

Lin, J-F / Zeng, H / Zhao, J-Q

European review for medical and pharmacological sciences

2019 Volume 22, Issue 23, Page(s) 8415–8422

Abstract: Objective: To explore the effects of microRNA-212-5p (miR-212-5p) on biological functions of acute myeloid leukemia (AML) and to find the potential molecular mechanism.: Patients and methods: We measured the expression level of miR-212-5p in 35 AML ... ...

Abstract	Objective: To explore the effects of microRNA-212-5p (miR-212-5p) on biological functions of acute myeloid leukemia (AML) and to find the potential molecular mechanism. Patients and methods: We measured the expression level of miR-212-5p in 35 AML patients and 20 patients with idiopathic thrombocytopenic purpura (ITP) as control cases. Besides, the miR-212-5p expression at cellular level was checked as well. In order to screen the functional targets of miR-212-5p, online prediction software was used and gene frizzled class receptor 5 (FZD5) attracted our attention. The effects of miR-212-5p on biological functions of AML cell line (Kasumi-1) were analyzed by subsequent experiments. The mRNA and protein expressions of FZD5 were detected by quantitative Real-time polymerase chain reaction (qRT-PCR) and Western blotting (WB) analysis, respectively. Cell proliferation was tested by cell counting kit-8 (CCK-8) assay. Cell cycle and apoptosis were measured by ﬂow cytometry. Finally, protein expression of β-catenin was analyzed by WB assay. Results: In AML cases and cells, miR-212-5p was found to be lowly expressed. The potential target of miR-212-5p was predicated in three public databases. Through a series of experiments including qRT-PCR, WB and luciferase assay, we identified FZD5 as a functional target of miR-212-5p. In further cellular functional experiments on Kasumi-1, we found overexpression of miR-212-5p in Kasumi-1 cells greatly inhibited the cell viability and proliferation. The ratio of cells in G0/G1 phase and the proportion of apoptotic cells increased after miR-212-5p overexpression. Furthermore, Wnt/β-catenin signal pathway was the most apparent pathway that was regulated by miR-212-5p according to WB results. However, the effects of miR-212-5p were suppressed after restoring the expression of FZD5. Conclusions: Expression of miR-212-5p was significantly lower in AML patients and cell lines, indicating that miR-212-5p served as a tumor-suppressor gene in AML. According to our in vitro experiments, miR-212-5p/FZD5 was likely to become a new therapeutic target for AML.
MeSH term(s)	Apoptosis/genetics ; Case-Control Studies ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Survival/genetics ; Frizzled Receptors/metabolism ; Humans ; Leukemia, Myeloid, Acute/genetics ; MicroRNAs/genetics ; RNA, Messenger/genetics ; Up-Regulation ; beta Catenin/metabolism
Chemical Substances	CTNNB1 protein, human ; FZD5 protein, human ; Frizzled Receptors ; MIRN212 microRNA, human ; MicroRNAs ; RNA, Messenger ; beta Catenin
Language	English
Publishing date	2019-11-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201812_16540
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1887: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [The effect of occupational stress on anxiety of nursing staff in a third-grade general hospital and mediating effect of job burnout].

Gao, Y / Zhao, J Q / Zhao, Y Y / Zhao, C X / Shi, J M / Li, J G

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

2022 Volume 40, Issue 2, Page(s) 127–131

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Anxiety/epidemiology ; Burnout, Professional/epidemiology ; Cross-Sectional Studies ; Hospitals, General ; Humans ; Job Satisfaction ; Nursing Staff ; Occupational Stress/epidemiology ; Surveys and Questionnaires
Language	Chinese
Publishing date	2022-03-10
Publishing country	China
Document type	Journal Article
ZDB-ID	1050900-8
ISSN	1001-9391
ISSN	1001-9391
DOI	10.3760/cma.j.cn121094-20210224-00106
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7219: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Current views of depressive disorders in children - a review.

Zhang, D-L / Liu, X-M / Zhao, J-Q

European review for medical and pharmacological sciences

2017 Volume 21, Issue 4 Suppl, Page(s) 54–57

Abstract: Objective: Depression is one of the most debilitating worldwide mental illnesses, which is included in the Diagnostic and Statistical Manual of Mental Disorders. The main risk factors for the development of depression are female gender, early life ... ...

Abstract	Objective: Depression is one of the most debilitating worldwide mental illnesses, which is included in the Diagnostic and Statistical Manual of Mental Disorders. The main risk factors for the development of depression are female gender, early life stress family history of mood disorders, former anxiety disorders, substance abuse and life events. The present review article is focused on the various causative factors like childhood early life stress, cortisol or cortisol awakening response. The review would update readers with regards to the current view of factors responsible for pediatric depression, which in turn helps to plan better therapeutic approaches in the near future.
MeSH term(s)	Alcohol Drinking ; Antidepressive Agents/therapeutic use ; Anxiety Disorders/complications ; Anxiety Disorders/diagnosis ; Depressive Disorder/diagnosis ; Depressive Disorder/drug therapy ; Depressive Disorder/etiology ; Humans ; Hydrocortisone/therapeutic use ; Life Style ; Mood Disorders/complications ; Mood Disorders/diagnosis ; Risk Factors ; Stress, Psychological
Chemical Substances	Antidepressive Agents ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2017-11-30
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1887: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Metformin reduces pancreatic cancer cell proliferation and increases apoptosis through MTOR signaling pathway and its dose-effect relationship.

Zhao, H-W / Zhou, N / Jin, F / Wang, R / Zhao, J-Q

European review for medical and pharmacological sciences

2020 Volume 24, Issue 10, Page(s) 5336–5344

Abstract: Objective: To study the influences of metformin on the proliferation and apoptosis of pancreatic cancer cells and its dose-effect relationship and crucial molecular mechanism.: Materials and methods: With human pancreatic cancer cell line PANC-1 as ... ...

Abstract	Objective: To study the influences of metformin on the proliferation and apoptosis of pancreatic cancer cells and its dose-effect relationship and crucial molecular mechanism. Materials and methods: With human pancreatic cancer cell line PANC-1 as the study object, different concentrations of metformin were added for intervention. Then, the proliferation of PANC-1 cells was detected via methyl thiazolyl tetrazolium (MTT) assay to determine the dose-effect relationship of metformin in PANC-1 cell proliferation. PANC-1 cells were treated with metformin at three appropriate concentrations as Metformin treatment groups, and an equal amount of dimethyl sulfoxide (DMSO) was added in Control group. Flow cytometry was performed to detect PANC-1 cell cycle and apoptosis, and the apoptosis of PANC-1 cells was also evaluated via terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Caspase-3 protein localization and expression in PANC-1 cells were detected using immunofluorescence assay. Besides, the expressions of the apoptosis-associated proteins Caspase-3, B-cell lymphoma 2 (Bcl-2), and Bcl-2 associated X protein (Bax) and phosphatidylinositol 3-hydroxy kinase (PI3K), phosphorylated protein kinase B (p-Akt), and p-mammalian target of rapamycin (mTOR) proteins related to the mTOR pathway were detected using Western blotting. Results: Metformin repressed the proliferation of human pancreatic cancer PANC-1 cells in a concentration-dependent and time-dependent manner. Compared with Control group, Metformin treatment groups (0, 20 and 40 mM) exhibited a higher proportion of PANC-1 cells in G0/G1 phases, and a lower proportion of PANC-1 cells in S phase (p<0.05), and the change in the proportion of cells in G2/M phase was not statistically significant (p>0.05). Moreover, Metformin treatment groups (0, 20, and 40 mM) had more apoptotic PANC-1 cells, higher expression levels of pro-apoptosis proteins Caspase-3 and Bax and lower expression levels of anti-apoptosis protein Bcl-2 and the mTOR pathway-related proteins PI3K, p-Akt, and p-mTOR in cells than Control group (p<0.05). Conclusions: Metformin modulates the mTOR signaling pathway to reduce the proliferation of pancreatic cancer cell, but increase their apoptosis.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Metformin/pharmacology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/metabolism ; Tumor Cells, Cultured
Chemical Substances	Antineoplastic Agents ; Metformin (9100L32L2N) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
Language	English
Publishing date	2020-06-03
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202005_21316
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1887: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19.

Zhao, J-Q / Li, X-N / Fu, L-P / Zhang, N / Cai, J-H

European review for medical and pharmacological sciences

2020 Volume 24, Issue 22, Page(s) 11602–11609

Abstract: Objective: To explore the role and potential mechanism of isochorismatase domain-containing 1 (ISOC1) in gastric cancer.: Patients and methods: The expression levels of ISOC1 in gastric cancer (GC) tissues, as well as corresponding cell lines, was ... ...

Abstract	Objective: To explore the role and potential mechanism of isochorismatase domain-containing 1 (ISOC1) in gastric cancer. Patients and methods: The expression levels of ISOC1 in gastric cancer (GC) tissues, as well as corresponding cell lines, was evaluated by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). A cell line stably expressing ISOC1 was constructed by vector construction and cell transfection, and the proliferation ability of the stably transfected cells was examined. Subsequently, the ISOC1 target database was screened, which suggested that CDK19 may be the potential target. The correlation between ISOC1 and CDK19 mRNA and protein expressions in clinical tissue specimens and cell lines was evaluated by qRT-PCR and Western blot, and the Luciferase reporter gene experiment was applied to verify the regulatory effect of ISOC1 on CDK19. Results: ISOC1 was shown to be markedly increased in GC tissues compared to adjacent cancer tissues by qRT-PCR. In addition, compared with patients with low ISOC1 expression, the pathological stage and tumor size of gastric cancer patients with high ISOC1 expression were remarkably larger. Then, the ISOC1 knockdown cell line was established, and it was found through cell proliferation function experiments that the proliferation rate of gastric cancer cells was remarkably slower than the control group after knocking down ISOC1. Subsequently, bioinformatics and Luciferase reporter gene experiments suggested that ISOC1 had a direct regulatory effect on CDK19. In addition, recovery experiments also demonstrated that CDK19 overexpression could reverse the effect of ISOC1 silencing on cell proliferation. Conclusions: ISOC1 was markedly upregulated in GC tissues. It could positively regulate its downstream target CDK19, which in turn promoted the proliferation of GC cells. Therefore, our study may provide new ideas for understanding the progression of GC.
MeSH term(s)	Cell Proliferation ; Cells, Cultured ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Female ; Humans ; Hydrolases/genetics ; Hydrolases/metabolism ; Male ; Middle Aged ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology
Chemical Substances	CDK19 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; Hydrolases (EC 3.-) ; isochorismatase (EC 3.3.2.1)
Language	English
Publishing date	2020-12-03
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202011_23803
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1887: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: High-capacity full lithium-ion cells based on nanoarchitectured ternary manganese–nickel–cobalt carbonate and its lithiated derivative

Zhao, J. Q / Wang, Y

Journal of materials chemistry A. 2014 Aug. 19, v. 2, no. 36

2014

Abstract: A full lithium-ion battery cell has been assembled based on nanoarchitectured ternary manganese–nickel–cobalt compounds, in which multi-shell spherical Mn0.54Ni0.13Co0.13(CO3)0.8 serves as the anode and the subsequently lithiated Li-excess Li[Li0.2Mn0 ... ...

Abstract	A full lithium-ion battery cell has been assembled based on nanoarchitectured ternary manganese–nickel–cobalt compounds, in which multi-shell spherical Mn0.54Ni0.13Co0.13(CO3)0.8 serves as the anode and the subsequently lithiated Li-excess Li[Li0.2Mn0.54Ni0.13Co0.13]O2 with a yolk–shell structure acts as the cathode. The performance of a lithium-ion full battery significantly relies on the electrochemical properties of both anode and cathode materials. A multi-shell carbonate anode is first tested in a half battery cell with metallic lithium as the counter electrode, revealing an unexpectedly high initial charge capacity of 1173.1 mA h g−1 at a specific current of 25 mA g−1, which is two times higher than its theoretical capacity. Moreover, when cycled at 250 mA g−1 for 100 electrochemical cycles, this carbonate anode retains a final specific capacity of 434.6 mA h g−1. Accordingly, a yolk–shell-structured Li-excess layered cathode material has been facilely obtained through lithiation of carbonate compounds, showing an initial discharge capacity of 250.7 mA h g−1 when cycled at 0.1 C (1 C = 250 mA g−1) in a half battery cell. Furthermore, this cathode retains a final capacity of 156.3 mA h g−1 at 1 C after 100 cycles and exhibits an outstanding capacity retention of 90.3%. Such remarkable electrochemical properties of carbonate anode and Li-excess oxide cathode materials are attributed to their nanoarchitectures resulting from the water-based solvothermal process, i.e., multi-shell and yolk–shell structures composed of numerous primary nanoparticles, in comparison with mediocre performances from monodispersive carbonate microspheres and Li-excess oxide nanoparticles synthesized via an ethylene-glycol-based solvothermal method. Combination of the nanostructured ternary transition metal carbonate anode and the Li-excess layered cathode into a full lithium-ion battery results in a remarkable specific capacity above 250 mA h g−1 at 0.1 C in the voltage range of 0.1–4.0 V, which demonstrates the application as a very promising electrochemical device for future energy conversion and storage.
Keywords	anodes ; carbonates ; cathodes ; electric potential difference ; electrochemistry ; energy conversion ; lithium ; lithium batteries ; microparticles ; nanoparticles
Language	English
Dates of publication	2014-0819
Size	p. 14947-14956.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702232-8
ISSN	2050-7496 ; 2050-7488
ISSN (online)	2050-7496
ISSN	2050-7488
DOI	10.1039/c4ta02574a
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: [Increased risk of cardiovascular disease in elderly population with carotid plaque and low ankle brachial index].

Li, W / Chen, S H / Zhao, J Q / Shen, T Z / Li, X Q / Jiang, Y M / Wu, S L

Zhonghua xin xue guan bing za zhi

2021 Volume 49, Issue 3, Page(s) 263–268

Abstract: Objective: ...

Abstract	Objective:
Language	Chinese
Publishing date	2021-03-24
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20200401-00272
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2276: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [A review on the RET proto-oncogene mutation in medullary thyroid carcinoma].

Zhao, J Z / Guo, L / Zhao, J Q / Lou, J L / Tan, X R

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2019 Volume 32, Issue 22, Page(s) 1754–1758

Abstract: Medullary thyroid carcinoma（MTC） is a special type of neuroendocrine tumor originated from C-cells of the thyroid gland, MTC can be divided into sporadic(70%-80%)and hereditary(20%-30%), about 98% of the hereditary MTC patients have RET proto-oncogene ... ...

Abstract	Medullary thyroid carcinoma（MTC） is a special type of neuroendocrine tumor originated from C-cells of the thyroid gland, MTC can be divided into sporadic(70%-80%)and hereditary(20%-30%), about 98% of the hereditary MTC patients have RET proto-oncogene germline mutation in exon 10, 11, 13, 14, 15, 16. The mutation of RET proto oncogene is closely related to the pathogenesis of MTC, and different mutation of RET proto oncogene exon may lead to different MTC phenotypes.More than 100 kinds of mutations in the RET gene were reported. This paper reviews the research progress of RET proto-oncogene mutation in MTC.
Language	Chinese
Publishing date	2019-01-30
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ISSN	1001-1781
ISSN	1001-1781
DOI	10.13201/j.issn.1001-1781.2018.22.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED