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Article ; Online: Comment on:

Zhao, Jiashen / Laksmi, Narasimhan Kannan / Gogna, Apoorva

2022 Volume 37, Issue 10, Page(s) 1162–1163

Language	English
Publishing date	2022-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2022.0498
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Article ; Online: Effect of blood type on mortality among patients with brain metastases.

Zheng, Yilong / Zhang, Zheting / Zhao, Jiashen / Teo, Kejia / Nga, Vincent Diong Weng / Yeo, Tseng Tsai / Lim, Mervyn Jun Rui

Clinical neurology and neurosurgery

2023 Volume 233, Page(s) 107963

Abstract: Objective: ABO blood type has been associated with mortality among patients with cancer, but this association has thus far not been investigated among patients with brain metastases. Hence, we aimed to investigate the association between ABO blood type ... ...

Abstract	Objective: ABO blood type has been associated with mortality among patients with cancer, but this association has thus far not been investigated among patients with brain metastases. Hence, we aimed to investigate the association between ABO blood type and mortality among patients who underwent surgical resection of brain metastases. Methods: A single-center retrospective study of patients who underwent surgical resection of brain metastases between 2011 and 2019 was conducted. Cox proportional hazards models were constructed, adjusting for potential confounders, to evaluate whether blood type was independently associated with overall mortality. Results: A total of 158 patients were included in the analysis. The mean (SD) age of the cohort was 59.3 (12.0) years, and 67.7% of patients were female. The median overall survival of patients with blood type AB was 11.2 months, while the median overall survival of patients with blood types O, B, and A were 11.7, 13.5, and 14.4 months respectively. On univariate analysis, patients with blood type AB had a higher risk of overall mortality (p = 0.017). On multivariate analysis adjusting for potential confounders, blood type AB was again associated with a higher risk of overall mortality (HR: 2.29, 95% CI: 1.11-4.72, p = 0.025). Conclusion: Blood type AB was independently associated with a higher risk of overall mortality among patients who underwent surgical resection of brain metastases, indicating the potential prognostic value of ABO blood type in brain metastases.
Language	English
Publishing date	2023-09-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2023.107963
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Article ; Online: Elective Delivery versus Expectant Management for Gastroschisis: A Systematic Review and Meta-Analysis.

Chen, Yong / Zhao, Jiashen / Alganabi, Mashriq / Mesas-Burgos, Carmen / Eaton, Simon / Wester, Tomas / Pierro, Agostino

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie

2022

Abstract: Introduction: The optimal timing of delivery for pregnancies complicated by prenatally diagnosed gastroschisis remains controversial. Therefore, the aim of this study was to find whether elective or expectant delivery is associated with improved ... ...

Abstract	Introduction: The optimal timing of delivery for pregnancies complicated by prenatally diagnosed gastroschisis remains controversial. Therefore, the aim of this study was to find whether elective or expectant delivery is associated with improved neonatal outcome. Materials and methods: MEDLINE and Embase databases were searched for studies up to 2021 that reported timing of delivery for prenatally diagnosed gastroschisis. A systematic review and meta-analysis were then performed in group 1: moderately preterm (gestational age [GA]: 34-35 weeks) elective delivery versus expectant management after GA 34-35 weeks; and group 2: near-term (GA: 36-37 weeks) elective delivery versus expectant management after GA 36-37 weeks. The following clinical outcomes were evaluated: length of stay (LOS), total parenteral nutrition (TPN) days, bowel morbidity (atresia, perforation, and volvulus), sepsis, time of first feeding, short gut syndrome and respirator days, and mortality. Results: Two randomized controlled trials (RCT)s and eight retrospective cohort studies were included, comprising 629 participants. Moderately preterm elective delivery failed to improve clinical outcomes. However, near-term elective delivery significantly reduced bowel morbidity (7.4 vs. 15.4%, relative risk = 0.37; 95% confidence interval [CI]: 0.18, 0.74; Conclusion: Based on the data analyzed, near-term elective delivery (GA 36-37 weeks) appears to be the optimal timing for delivery of pregnancies complicated by gastroschisis as it is associated with less bowel morbidity and shorter TPN days. However, more RCTs are necessary to better validate these findings.
Language	English
Publishing date	2022-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1065043-x
ISSN	1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
ISSN (online)	1439-359X
ISSN	0939-7248 ; 0939-6764 ; 0930-7249
DOI	10.1055/a-1896-5345
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Article ; Online: Multi-disciplinary diabetic limb salvage programme in octogenarians with diabetic foot ulcers is not futile: An observational study with historical controls.

Ge, Lixia / Zhao, Jiashen / Tan, Matthew / Tan, Elaine / Liew, Huiling / Yong, Enming / Hoe, Jeremy / Shi, Claris / Chan, Dexter Yak Seng / Ang, Gary Yee / Molina, Joseph Antonio / Sun, Yan / Hoi, Wai Han / Chandraskear, Sadhana / Lo, Zhiwen Joseph

International wound journal

2024 Volume 21, Issue 3, Page(s) e14801

Abstract: This study evaluated the effectiveness of a multi-disciplinary diabetic limb salvage programme in improving clinical outcomes and optimising healthcare utilisation in 406 patients aged ≥80 years with diabetic foot ulcers (DFUs), compared to 2392 younger ... ...

Abstract	This study evaluated the effectiveness of a multi-disciplinary diabetic limb salvage programme in improving clinical outcomes and optimising healthcare utilisation in 406 patients aged ≥80 years with diabetic foot ulcers (DFUs), compared to 2392 younger patients enrolled from June 2020 to June 2021 and against 1716 historical controls using one-to-one propensity score matching. Results showed that elderly programme patients had lower odds of amputation-free survival (odds ratio: 0.64, 95% CI: 0.47, 0.88) and shorter cumulative length of stay (LOS) compared to younger programme patients (incidence rate ratio: 0.45, 95% CI: 0.29, 0.69). Compared to the matched controls, participating in the programme was associated with 5% higher probability of minor lower extremity amputation, reduced inpatient admissions and emergency visits, shorter LOS but increased specialist and primary care visits (all p-values <0.05). The findings suggest that the programme yielded favourable impacts on the clinical outcomes of patients aged≥80 years with DFUs. Further research is needed to develop specific interventions tailoring to the needs of the elderly population and to determine their effectiveness on patient outcomes while accounting for potential confounding factors.
MeSH term(s)	Aged, 80 and over ; Humans ; Amputation, Surgical ; Diabetes Mellitus ; Diabetic Foot/surgery ; Limb Salvage/methods ; Octogenarians ; Retrospective Studies
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14801
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Article ; Online: Impact of RNA degradation on influenza diagnosis in the surveillance system.

Bai, Hongyan / Zhao, Jiashen / Ma, Chunyan / Wei, Hejiang / Li, Xiyan / Fang, Qiongqiong / Yang, Peng / Wang, Quanyi / Wang, Dayan / Xin, Li

Diagnostic microbiology and infectious disease

2021 Volume 100, Issue 4, Page(s) 115388

Abstract: Background: The continuous evolution of influenza viruses is monitored by the World Health Organization Global Influenza Surveillance and Response System. Sample quality is essential for surveillance quality.: Methods: To evaluate the RNA degradation ...

Abstract	Background: The continuous evolution of influenza viruses is monitored by the World Health Organization Global Influenza Surveillance and Response System. Sample quality is essential for surveillance quality. Methods: To evaluate the RNA degradation of clinical samples, influenza-like illness samples were collected from four sentinel hospitals, and seasonal influenza was tested by real-time reverse transcription polymerase chain reaction and quantified by digital reverse transcription polymerase chain reaction at different time points. Results: RNA degradation was observed in the majority of samples eight days after sample collection. A significant and faster rate of RNA content reduction was observed in low viral load samples (<10 copies/µl) than in high viral load samples (>10 copies/μl), stored at 2 to 8°C for up to eight days. RNase P (RNP) RNA, which is a key indicator to evaluate sample collection quality, was detected. Sample collection quality was uneven in different hospitals. Conclusion: Low viral load samples increase the risk of false negatives due to RNA degradation to undetectable levels.
MeSH term(s)	Hospitals/statistics & numerical data ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza, Human/diagnosis ; Influenza, Human/virology ; RNA Stability ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Sentinel Surveillance ; Specimen Handling/standards ; Viral Load/statistics & numerical data
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2021.115388
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Article: Elective Delivery versus Expectant Management for Gastroschisis: A Systematic Review and Meta-Analysis

Chen, Yong / Zhao, Jiashen / Alganabi, Mashriq / Mesas-Burgos, Carmen / Eaton, Simon / Wester, Tomas / Pierro, Agostino

European Journal of Pediatric Surgery

2022 Volume 33, Issue 01, Page(s) 2–10

Abstract	Introduction: The optimal timing of delivery for pregnancies complicated by prenatally diagnosed gastroschisis remains controversial. Therefore, the aim of this study was to find whether elective or expectant delivery is associated with improved neonatal outcome. Materials and Methods: MEDLINE and Embase databases were searched for studies up to 2021 that reported timing of delivery for prenatally diagnosed gastroschisis. A systematic review and meta-analysis were then performed in group 1: moderately preterm (gestational age [GA]: 34–35 weeks) elective delivery versus expectant management after GA 34–35 weeks; and group 2: near-term (GA: 36–37 weeks) elective delivery versus expectant management after GA 36–37 weeks. The following clinical outcomes were evaluated: length of stay (LOS), total parenteral nutrition (TPN) days, bowel morbidity (atresia, perforation, and volvulus), sepsis, time of first feeding, short gut syndrome and respirator days, and mortality. Results: Two randomized controlled trials (RCT)s and eight retrospective cohort studies were included, comprising 629 participants. Moderately preterm elective delivery failed to improve clinical outcomes. However, near-term elective delivery significantly reduced bowel morbidity (7.4 vs. 15.4%, relative risk = 0.37; 95% confidence interval [CI]: 0.18, 0.74; p = 0.005; I2 = 0%) and TPN days (mean difference =−13.44 days; 95% CI: −26.68, −0.20; p = 0.05; I2 = 45%) compared to expectant delivery. The mean LOS was 39.2 days after near-term delivery and 48.7 days in the expectant group ( p = 0.06). Conclusion: Based on the data analyzed, near-term elective delivery (GA 36–37 weeks) appears to be the optimal timing for delivery of pregnancies complicated by gastroschisis as it is associated with less bowel morbidity and shorter TPN days. However, more RCTs are necessary to better validate these findings.
Keywords	gastroschisis ; elective delivery ; expectant management ; meta-analysis
Language	English
Publishing date	2022-07-11
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1065043-x
ISSN	1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
ISSN (online)	1439-359X
ISSN	0939-7248 ; 0939-6764 ; 0930-7249
DOI	10.1055/a-1896-5345
Database	Thieme publisher's database

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Article ; Online: Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation.

Song, Lige / Zhao, Jiashen / Zhang, Xiuzhen / Li, Hong / Zhou, Yun

European journal of pharmacology

2013 Volume 714, Issue 1-3, Page(s) 15–22

Abstract: Icariin, the main active flavonoid glucoside isolated from Herba epimedii (HEF), is an anabolic agent in bone that has been reported to prevent bone loss in ovariectomized rats and postmenopausal women. However, the molecular mechanism for this anabolic ... ...

Abstract	Icariin, the main active flavonoid glucoside isolated from Herba epimedii (HEF), is an anabolic agent in bone that has been reported to prevent bone loss in ovariectomized rats and postmenopausal women. However, the molecular mechanism for this anabolic action of Icariin remain largely unknown. Here, we found that Icariin could promote MC3T3-E1 osteoblastic cell proliferation and reduce cell apoptosis, associated with increased mRNA levels of positive regulators of cell cycle gene Cyclin E and proliferating cell nuclear antigen (PCNA), decreaed mRNA level of negative regulator gene, Cyclin-dependent kinase 4 inhibitor B (Cdkn2B), and reduced caspase-3 activity. Icariin also enhanced MC3T3-E1 cell differentiation and mineralization demonstrated by increased the expression of differentiation markers, alkaline phosphatase (ALP) and collagen type I (Col I), and bone nodule formation via Alizarin red S staining. To characterize the underlying mechanisms, we examined the effect of Icariin on mitogen-activated protein kinase (MAPK) signaling. Icariin treatment rapidly induced extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) activation but showed no effect on activation of p38 kinase. Furthermore, Icariin-mediated effects on osteoblasts were dramatically attenuated by treatment with specific inhibitors of MAPKs, U0126 (ERK inhibitor) and SP600125 (JNK inhibitor). Interestingly, treatment of osteoblasts with estrogen receptor antagonist ICI182780 attenuated Icariin-mediated effect of proliferation and mineralization, associated with suppression of ERK and JNK phosphorylation. These observations provide a potential mechanism of anabolic actions of Icariin involving ERK and JNK pathway by estrogen receptor.
MeSH term(s)	Anabolic Agents/pharmacology ; Animals ; Apoptosis/drug effects ; Calcification, Physiologic/drug effects ; Cell Differentiation/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Flavonoids/pharmacology ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Signaling System/drug effects ; Mice ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Rats ; Receptors, Estrogen/metabolism
Chemical Substances	Anabolic Agents ; Flavonoids ; Receptors, Estrogen ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; icariin (VNM47R2QSQ)
Language	English
Publishing date	2013-08-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2013.05.039
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Article: Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation

Song, Lige / Zhao, Jiashen / Zhang, Xiuzhen / Li, Hong / Zhou, Yun

European journal of pharmacology. 2013 Aug. 15, v. 714, no. 1-3

2013

Abstract	Icariin, the main active flavonoid glucoside isolated from Herba epimedii (HEF), is an anabolic agent in bone that has been reported to prevent bone loss in ovariectomized rats and postmenopausal women. However, the molecular mechanism for this anabolic action of Icariin remain largely unknown. Here, we found that Icariin could promote MC3T3-E1 osteoblastic cell proliferation and reduce cell apoptosis, associated with increased mRNA levels of positive regulators of cell cycle gene Cyclin E and proliferating cell nuclear antigen (PCNA), decreaed mRNA level of negative regulator gene, Cyclin-dependent kinase 4 inhibitor B (Cdkn2B), and reduced caspase-3 activity. Icariin also enhanced MC3T3-E1 cell differentiation and mineralization demonstrated by increased the expression of differentiation markers, alkaline phosphatase (ALP) and collagen type I (Col I), and bone nodule formation via Alizarin red S staining. To characterize the underlying mechanisms, we examined the effect of Icariin on mitogen-activated protein kinase (MAPK) signaling. Icariin treatment rapidly induced extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) activation but showed no effect on activation of p38 kinase. Furthermore, Icariin-mediated effects on osteoblasts were dramatically attenuated by treatment with specific inhibitors of MAPKs, U0126 (ERK inhibitor) and SP600125 (JNK inhibitor). Interestingly, treatment of osteoblasts with estrogen receptor antagonist ICI182780 attenuated Icariin-mediated effect of proliferation and mineralization, associated with suppression of ERK and JNK phosphorylation. These observations provide a potential mechanism of anabolic actions of Icariin involving ERK and JNK pathway by estrogen receptor.
Keywords	alizarin ; alkaline phosphatase ; antagonists ; apoptosis ; bone resorption ; caspase-3 ; cell cycle ; cell differentiation ; cell proliferation ; collagen ; cyclin-dependent kinase ; estrogen receptors ; flavonoids ; gene expression ; messenger RNA ; mineralization ; mitogen-activated protein kinase ; osteoblasts ; ovariectomy ; pharmacology ; phosphorylation ; postmenopause ; proliferating cell nuclear antigen ; rats ; regulator genes ; women
Language	English
Dates of publication	2013-0815
Size	p. 15-22.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2013.05.039
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Article: Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation

Song, Lige / Zhao, Jiashen / Zhang, Xiuzhen / Li, Hong / Zhou, Yun

European journal of pharmacology

Volume v. 714,, Issue no. 1

Abstract	Icariin, the main active flavonoid glucoside isolated from Herba epimedii (HEF), is an anabolic agent in bone that has been reported to prevent bone loss in ovariectomized rats and postmenopausal women. However, the molecular mechanism for this anabolic action of Icariin remain largely unknown. Here, we found that Icariin could promote MC3T3-E1 osteoblastic cell proliferation and reduce cell apoptosis, associated with increased mRNA levels of positive regulators of cell cycle gene Cyclin E and proliferating cell nuclear antigen (PCNA), decreaed mRNA level of negative regulator gene, Cyclin-dependent kinase 4 inhibitor B (Cdkn2B), and reduced caspase-3 activity. Icariin also enhanced MC3T3-E1 cell differentiation and mineralization demonstrated by increased the expression of differentiation markers, alkaline phosphatase (ALP) and collagen type I (Col I), and bone nodule formation via Alizarin red S staining. To characterize the underlying mechanisms, we examined the effect of Icariin on mitogen-activated protein kinase (MAPK) signaling. Icariin treatment rapidly induced extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) activation but showed no effect on activation of p38 kinase. Furthermore, Icariin-mediated effects on osteoblasts were dramatically attenuated by treatment with specific inhibitors of MAPKs, U0126 (ERK inhibitor) and SP600125 (JNK inhibitor). Interestingly, treatment of osteoblasts with estrogen receptor antagonist ICI182780 attenuated Icariin-mediated effect of proliferation and mineralization, associated with suppression of ERK and JNK phosphorylation. These observations provide a potential mechanism of anabolic actions of Icariin involving ERK and JNK pathway by estrogen receptor.
Keywords	estrogen receptors ; regulator genes ; ovariectomy ; apoptosis ; alkaline phosphatase ; antagonists ; caspase-3 ; pharmacology ; proliferating cell nuclear antigen ; mineralization ; osteoblasts ; cyclin-dependent kinase ; cell differentiation ; rats ; bone resorption ; messenger RNA ; postmenopause ; mitogen-activated protein kinase ; cell cycle ; women ; flavonoids ; cell proliferation ; collagen ; alizarin ; gene expression ; phosphorylation
Language	English
Document type	Article
ISSN	0014-2999
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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