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  1. Article: [Morphological study of extraocular muscles in dissociated vertical deviation by magnetic resonance imaging].

    Hao, R / Liu, Y / Zhang, W / Zhao, K X

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2023  Volume 59, Issue 3, Page(s) 202–206

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Female ; Male ; Humans ; Oculomotor Muscles ; Cross-Sectional Studies ; Strabismus ; Eye ; Magnetic Resonance Imaging
    Language Chinese
    Publishing date 2023-02-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20220801-00377
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  2. Article ; Online: MiR-298 suppresses the malignant progression of osteosarcoma by targeting JMJD6.

    Zhang, R / Li, Y-Z / Zhao, K-X

    European review for medical and pharmacological sciences

    2022  Volume 26, Issue 7, Page(s) 2250–2258

    Abstract: Objective: To explore the role of microRNA-298 (miR-298) in affecting biological characteristics of osteosarcoma cells, and the possible molecular mechanism.: Patients and methods: Fifty clinical cases of osteosarcoma were collected for detecting ... ...

    Abstract Objective: To explore the role of microRNA-298 (miR-298) in affecting biological characteristics of osteosarcoma cells, and the possible molecular mechanism.
    Patients and methods: Fifty clinical cases of osteosarcoma were collected for detecting differential expressions of miR-298 using quantitative Real Time-Polymerase Chain Reaction (qRT-PCR), and its level in osteosarcoma cell lines was determined as well. Proliferative and migratory changes in MG63 and U2OS cells overexpressing miR-298 were assessed by Cell Counting Kit-8 (CCK-8), transwell and wound healing assay. Candidate targets of miR-298 were predicted using online databases, and JMJD6, the most optimal target, was specifically analyzed by Dual-Luciferase reporter assay and rescue experiments.
    Results: MiR-298 was both expressed in osteosarcoma and healthy bone tissues, which was lowly expressed in the former tissues. It was downregulated in osteosarcoma cell lines as well. Low level of miR-298 predicted higher incidences of lymphatic metastasis, distant metastasis, and lower overall survival and progression-free survival in osteosarcoma. Overexpression of miR-298 weakened proliferative and migratory changes in MG63 and U2OS cells. JMJD6 was confirmed as the target gene binding miR-298, and negatively correlated to miR-298 level in osteosarcoma tissues. Overexpression of JMJD6 reversed the effect of overexpressed miR-298 on alleviating the malignant progression of osteosarcoma.
    Conclusions: MiR-298 is less abundant in osteosarcoma samples, which is correlated to metastasis and prognosis of osteosarcoma. MiR-298, serving as a tumor suppressor, weakens proliferative and migratory abilities of osteosarcoma cells.
    MeSH term(s) Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteosarcoma/pathology
    Chemical Substances MIRN298 microRNA, human ; MicroRNAs ; JMJD6 protein, human (EC 1.14.11.-) ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-)
    Language English
    Publishing date 2022-04-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202204_28455
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  3. Article: [Graded vertical rectus tenotomy for small angle vertical deviation].

    Hao, R / Chen, L P / Zhang, W / Zhao, K X

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2022  Volume 58, Issue 3, Page(s) 182–186

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Diplopia/surgery ; Female ; Humans ; Male ; Middle Aged ; Oculomotor Muscles/surgery ; Retrospective Studies ; Strabismus/surgery ; Tenotomy/methods
    Language Chinese
    Publishing date 2022-03-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20210409-00170
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  4. Article ; Online: Meterscale Strong Coupling between Magnons and Photons.

    Rao, Jinwei / Wang, C Y / Yao, Bimu / Chen, Z J / Zhao, K X / Lu, Wei

    Physical review letters

    2023  Volume 131, Issue 10, Page(s) 106702

    Abstract: We experimentally realize a meterscale strong coupling effect between magnons and photons at room temperature, with a coherent coupling of ∼20  m and a dissipative coupling of ∼7.6  m. To this end, we integrate a saturable gain into a microwave cavity ... ...

    Abstract We experimentally realize a meterscale strong coupling effect between magnons and photons at room temperature, with a coherent coupling of ∼20  m and a dissipative coupling of ∼7.6  m. To this end, we integrate a saturable gain into a microwave cavity and then couple this active cavity to a magnon mode via a long coaxial cable. The gain compensates for the cavity dissipation, but preserves the cavity radiation that mediates the indirect photon-magnon coupling. It thus enables the long-range strong photon-magnon coupling. With full access to traveling waves, we demonstrate a remote control of photon-magnon coupling by modulating the phase and amplitude of traveling waves, rather than reconfiguring subsystems themselves. Our method for realizing long-range strong coupling in cavity magnonics provides a general idea for other physical systems. Our experimental achievements may promote the construction of information networks based on cavity magnonics.
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.106702
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  5. Article: [MRI study of rectus extraocular muscles in concomitant exotropia with small angle vertical deviation].

    Hao, R / Zhang, W / Zhao, K X

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2021  Volume 57, Issue 3, Page(s) 223–227

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Cross-Sectional Studies ; Exotropia/diagnostic imaging ; Eye Movements ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Oculomotor Muscles/diagnostic imaging ; Young Adult
    Language Chinese
    Publishing date 2021-03-16
    Publishing country China
    Document type Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20200317-00195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Clinical analysis and surgical treatment of atypical acute acquired concomitant esotropia].

    Hao, R / Zhang, W / Zhao, K X

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2021  Volume 57, Issue 5, Page(s) 348–352

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Case-Control Studies ; Esotropia/surgery ; Exotropia/surgery ; Female ; Humans ; Male ; Oculomotor Muscles/surgery ; Ophthalmologic Surgical Procedures ; Retrospective Studies ; Treatment Outcome
    Language Chinese
    Publishing date 2021-04-29
    Publishing country China
    Document type Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20200802-00521
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  7. Article: [Characteristics of Guyton's exaggerated forced duction test (FDT) and torsional FDT in congenital superior oblique palsy].

    Li, Y P / Chen, H R / Gu, S Y / Ding, J / Zhang, W / Zhao, K X

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2023  Volume 59, Issue 7, Page(s) 535–541

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Cross-Sectional Studies ; Exotropia ; Oculomotor Muscles/surgery ; Ophthalmoplegia ; Retrospective Studies ; Strabismus/surgery ; Male ; Female
    Language Chinese
    Publishing date 2023-07-05
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20230417-00153
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  8. Article: [Could binocular treatment be a substitute for patching].

    Shi, X F / Zhao, K X

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2018  Volume 53, Issue 12, Page(s) 885–889

    Abstract: Amblyopia is a common eye disease with a high prevalence in clinical practice of pediatric ophthalmology and strabismus. The primary treatment strategy for amblyopia is precise correction of refractive errors and patching of the dominant eye. The ... ...

    Abstract Amblyopia is a common eye disease with a high prevalence in clinical practice of pediatric ophthalmology and strabismus. The primary treatment strategy for amblyopia is precise correction of refractive errors and patching of the dominant eye. The application of patching has a history of more than 200 years, and now is still the most effective method for treatment of amblyopia. Similar to the principle of traditional patching, atropine penalization has been testified that it can be used as an initial treatment for amblyopia with similar therapeutic effects as patching. In the past decade, binocular treatment has been proposed as a strategy for the treatment of amblyopia. Successively, different kinds of binocular treatment methods were reported by the researchers. This article systematically reviews all these methods reported in the recent years and their therapeutic effects. Most results about the therapeutic effect of binocular treatment are from the designers of the studies themselves, but in recent 2 years the results from monocenter or multicenter randomized controlled clinical trials to compare the therapeutic effects of binocular treatment and patching were reported. We hope to help colleagues have a comprehensive and objective understanding of the research progress on binocular treatment for amblyopia and thus keep a cool head on the question of whether binocular treatment could be a substitute for patching.
    MeSH term(s) Amblyopia/therapy ; Child ; Follow-Up Studies ; Humans ; Sensory Deprivation ; Treatment Outcome ; Vision, Binocular ; Visual Acuity
    Language Chinese
    Publishing date 2018-01-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.issn.0412-4081.2017.12.002
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  9. Article: [Advances in research on Crouzon syndrome and related ophthalmic complications].

    Xie, F / Zhao, K X / Zhang, W

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2020  Volume 56, Issue 7, Page(s) 544–548

    Abstract: Crouzon syndrome is an autosomal dominant disorder characterized by acrocephaly, exophthalmos, hypertelorism, strabismus, parrot-beaked nose, and hypoplastic maxilla. It is usually caused by a pathogenic mutation in the fibroblast growth factor receptor ... ...

    Abstract Crouzon syndrome is an autosomal dominant disorder characterized by acrocephaly, exophthalmos, hypertelorism, strabismus, parrot-beaked nose, and hypoplastic maxilla. It is usually caused by a pathogenic mutation in the fibroblast growth factor receptor 2 gene and premature fusion of the sutures of the cranium and the base of the skull. This article documents the ophthalmic complications in patients with Crouzon syndrome before and after the influence of craniofacial surgery with particular emphasis on the different mechanisms and treatments involved. It is important to perform timely decompressive surgery before the presence of optic atrophy and corneal defects, and make early detection and adequate management of amblyopia, ptosis and strabismus.
    MeSH term(s) Amblyopia ; Craniofacial Dysostosis/genetics ; Craniofacial Dysostosis/surgery ; Craniosynostoses ; Humans ; Optic Atrophy ; Strabismus
    Language Chinese
    Publishing date 2020-08-12
    Publishing country China
    Document type Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20191128-00606
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  10. Article: [The development history of CAPOS and the diagnosis and treatment of pediatric eye diseases in China since 1949].

    Zhang, W / Zhao, K X / Li, Y P

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2020  Volume 56, Issue 3, Page(s) 161–165

    Abstract: On the occasion of the 70(th) anniversary of the founding of Chinese Journal of Ophthalmology, we review the establishment and development of Chinese Association for Pediatric Ophthalmology and Strabismus (CAPOS) and the major advances in the diagnosis ... ...

    Abstract On the occasion of the 70(th) anniversary of the founding of Chinese Journal of Ophthalmology, we review the establishment and development of Chinese Association for Pediatric Ophthalmology and Strabismus (CAPOS) and the major advances in the diagnosis and treatment of pediatric eye diseases in China since 1949, so as to remember our predecessors and inspire young generations, and to provide important reference for the future clinical and scientific research.
    MeSH term(s) Asian Continental Ancestry Group ; Child ; China ; Eye Diseases/diagnosis ; Eye Diseases/therapy ; History, 20th Century ; History, 21st Century ; Humans ; Ophthalmology/history ; Pediatrics
    Language Chinese
    Publishing date 2020-03-18
    Publishing country China
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.issn.0412-4081.2020.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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