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Article ; Online: Study effect and mechanism of ofloxacin and levofloxacin on development of Rana nigromaculata tadpoles based on the hypothalamus-pituitary-thyroid axis.

Zhang, Wenjun / Teng, Miaomiao / Zhao, Lihui / Chen, Li

2023 Volume 259, Page(s) 114985

Abstract: Excessive antibiotics transferred into the aquatic environment may affect the development of amphibians. Previous studies on the aquatic ecological risk of ofloxacin generally ignored its enantiomers. The purpose of this study was to compare the effects ... ...

Abstract	Excessive antibiotics transferred into the aquatic environment may affect the development of amphibians. Previous studies on the aquatic ecological risk of ofloxacin generally ignored its enantiomers. The purpose of this study was to compare the effects and mechanisms of ofloxacin (OFL) and levofloxacin (LEV) on the early development of Rana nigromaculata. After 28-day exposure at environmental levels, we found that LEV exerted more severe inhibitory effects on the development of tadpoles than OFL. According to the enrichment results of differentially expressed genes in the LEV and OFL treatments, LEV and OFL had different effects on the thyroid development of tadpoles. dio2 and trh were affected by the regulation of dexofloxacin instead of LEV. At the protein level, LEV was the main component that affected thyroid development-related protein, while dexofloxacin in OFL had little effect on thyroid development. Furthermore, molecular docking results further confirmed that LEV was a major component affecting thyroid development-related proteins, including DIO and TSH. In summary, OFL and LEV regulated the thyroid axis by differential binding to DIO and TSH proteins, thereby exerting differential effects on the thyroid development of tadpoles. Our research is of great significance for comprehensive assessment of chiral antibiotics aquatic ecological risk.
MeSH term(s)	Animals ; Ofloxacin/toxicity ; Ofloxacin/metabolism ; Levofloxacin/pharmacology ; Levofloxacin/metabolism ; Larva ; Thyroid Gland ; Molecular Docking Simulation ; Anti-Bacterial Agents/toxicity ; Anti-Bacterial Agents/metabolism ; Ranidae/metabolism ; Hypothalamus ; Thyrotropin/metabolism
Chemical Substances	Ofloxacin (A4P49JAZ9H) ; Levofloxacin (6GNT3Y5LMF) ; Anti-Bacterial Agents ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2023-05-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.114985
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Zs.A 1418: Show issues

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Article ; Online: Copper in cancer: From pathogenesis to therapy.

Guan, Defeng / Zhao, Lihui / Shi, Xin / Ma, Xiaoling / Chen, Zhou

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114791

Abstract: One of the basic trace elements for the structure and metabolism of human tissue is copper. However, as a heavy metal, excessive intake or abnormal accumulation of copper in the body can cause inevitable damage to the organism because copper can result ... ...

Abstract	One of the basic trace elements for the structure and metabolism of human tissue is copper. However, as a heavy metal, excessive intake or abnormal accumulation of copper in the body can cause inevitable damage to the organism because copper can result in direct injury to various cell components or disruption of the redox balance, eventually leading to cell death. Interestingly, a growing body of research reports that diverse cancers have raised serum and tumor copper levels. Tumor cells depend on more copper for their metabolism than normal cells, and a decrease in copper or copper overload can have a detrimental effect on tumor cells. New modalities for identifying and characterizing copper-dependent signals offer translational opportunities for tumor therapy, but their mechanisms remain unclear. Therefore, this article summarizes what we currently know about the correlation between copper and cancer and describes the characteristics of copper metabolism in tumor cells and the prospective application of copper-derived therapeutics.
MeSH term(s)	Humans ; Copper/metabolism ; Trace Elements/metabolism ; Oxidation-Reduction ; Neoplasms/drug therapy
Chemical Substances	Copper (789U1901C5) ; Trace Elements
Language	English
Publishing date	2023-04-25
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114791
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Article: Oral rifampicin interferes with urine dipstick tests for patients with pulmonary tuberculosis.

Wang, Fei / Zhao, Lihui / Du, Wei / Hu, Yan / Ren, Yi

Journal of thoracic disease

2023 Volume 15, Issue 5, Page(s) 2636–2643

Abstract: Background: Rifampicin (RMP) and its major metabolite, desacetyl rifampicin (dRMP), can interfere with urine dipstick tests (UDTs) in patients with tuberculosis (TB) who receive oral RMP. This study sought to examine the effects of RMP and dRMP on UDTs ... ...

Abstract	Background: Rifampicin (RMP) and its major metabolite, desacetyl rifampicin (dRMP), can interfere with urine dipstick tests (UDTs) in patients with tuberculosis (TB) who receive oral RMP. This study sought to examine the effects of RMP and dRMP on UDTs using 2 different urine dipsticks (i.e., Arkray's Aution Sticks 10EA and GIMA's Combi-Screen 11SYS Plus sticks). Methods: Urine colorimetry was applied to measure RMP concentrations and determine the range of total RMP concentration in the urine within 2-6 and 12-24 h of oral administration of RMP. In vitro interference assays and confirmatory tests were performed to evaluate the effects of RMP and dRMP on the analytes. Results: The total RMP concentration in the urine of the 40 TB patients analyzed as urine sample was 88-376 µg/mL within 2-6 h and 22-112 µg/mL within 12-24 h of oral administration of RMP. Interference was observed for different analytes at consistent or varied RMP concentrations between the Conclusions: RMP and dRMP interfered with the analytes of the UDTs using the 2 urine dipsticks in different levels. The
Language	English
Publishing date	2023-05-08
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-310
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Article ; Online: Inhibitory Effect of Fingolimod on Head and Neck Squamous Cell Carcinoma and Its Mechanism: Gene Set Enrichment Analysis.

Chang, Lemeng / Xie, Chunhua / Chou, Kaiping / Meng, Qingnan / Zhao, Lihui

Cellular and molecular biology (Noisy-le-Grand, France)

2023 Volume 69, Issue 7, Page(s) 150–157

Abstract: This study aimed to clarify the therapeutic effect of Fingolimod on head and neck squamous cell carcinoma (HNSC) and initially explore its mechanism through data mining, clinical sample analysis and basic experiments. The normalized Enrichment Score (NES) ...

Abstract	This study aimed to clarify the therapeutic effect of Fingolimod on head and neck squamous cell carcinoma (HNSC) and initially explore its mechanism through data mining, clinical sample analysis and basic experiments. The normalized Enrichment Score (NES) of Fingolimod in tumor tissues was obtained by SwissTargetPrediction and The Cancer Genome Atlas (TCGA) database. IC50 (50% inhibitory concentration) of Fingolimod for HNSC was verified based on the Genomics of Drug Sensitivity in Cancer (GDSC) database. SCC9 cells were cultured in vitro for the application of Fingolimod. Cell proliferation was determined by the Cell Counting Kit-8 (CCK-8). The expression levels of genes were determined by reverse transcription-polymerase chain reaction (RT-PCR). The molecular regulatory mechanism of Fingolimod acting on HNSC was analyzed with WebGestalt. Cyclin expression was determined by Western blot assay. The key targeted genes for Fingolimod against HNSC were screened with the TCGA database and verified in clinical samples. Gene Set Enrichment Analysis (GSEA) showed the highest NES score in HNSC (NES=1.53, P<0.05). GDSC showed the lowest IC50 in Fingolimod SSC9 cells. IC50 calculated by the cell activity detected by CCK8 was 4.34 μmol/L, and RT-PCR showed significantly suppressed expression of proliferation-related gene Ki-67 after adding Fingolimod (P<0.05). Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that the targeted genes for Fingolimod were mainly enriched in cell cycle-related pathways. Western blot showed significantly decreased cyclin expression in SSC9 cells after the treatment with Fingolimod (P<0.05). TCGA analysis revealed that PLK1 is a key targeted gene for Fingolimod in the treatment of HNSC. RT-PCR showed the significantly increased activity of SCC9 after over-expressing PLK1, and the increased proliferation and anti-apoptosis abilities (P<0.05), as well as the significantly inhibited expression of Ki-67 and Bcl-2 after adding Fingolimod. Fingolimod can promote the arrest in G0/G1 of SCC9 cells, and PLK1 is a key targeted gene for the treatment of HNSC. Fingolimod can inhibit cell proliferation caused by PLK1 over-expression.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Fingolimod Hydrochloride/pharmacology ; Fingolimod Hydrochloride/therapeutic use ; Ki-67 Antigen ; Cyclins ; Head and Neck Neoplasms
Chemical Substances	Fingolimod Hydrochloride (G926EC510T) ; Ki-67 Antigen ; Cyclins
Language	English
Publishing date	2023-07-31
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2023.69.7.24
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Zs.A 3812: Show issues

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Article ; Online: The Role of miRNA in Ovarian Cancer: an Overview.

Zhao, Lihui / Liang, Xiaolei / Wang, Liyan / Zhang, Xuehong

Reproductive sciences (Thousand Oaks, Calif.)

2022 Volume 29, Issue 10, Page(s) 2760–2767

Abstract: Ovarian cancer (OC) is a highly malignant disease that seriously threatens women's health and poses challenges for clinicians. MicroRNAs (miRNAs) have recently been intensively studied in the field of oncology due to their regulatory roles in gene ... ...

Abstract	Ovarian cancer (OC) is a highly malignant disease that seriously threatens women's health and poses challenges for clinicians. MicroRNAs (miRNAs) have recently been intensively studied in the field of oncology due to their regulatory roles in gene expressions through RNA degradation and/or translation inhibition. This review summarizes the current studies on miRNAs in OC and introduces the latest updates of miRNAs in the early screening, treatment, and prognostic prediction of OC, thereby demonstrating the clinical significance of miRNAs in OC. Further exploration on potential targets of miRNAs in OC may provide new insights on optimizing the diagnosis and treatment of OC. MiRNAs are important driving factors for the progression of OC and the dysregulation of miRNAs can serve as biomarkers in the diagnosis, treatment and prognosis of OC. Therefore, miRNAs are potential biological targets for early screening, targeted therapy, drug resistance monitoring, and prognosis improvement in malignancies such as OC.
MeSH term(s)	Carcinoma, Ovarian Epithelial/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/metabolism ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Prognosis
Chemical Substances	MicroRNAs
Language	English
Publishing date	2022-01-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-021-00717-w
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Zs.A 4113: Show issues

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Article: Artificial neural network model of co-gasification of petroleum coke with coal or biomass in bubbling fluidized bed

Kang, Jun / Zhao, Lihui / Li, Weiwei / Song, Yuncai

Renewable energy. 2022 May 16,

2022

Abstract: Co-gasification of petroleum coke (petcoke) with coal or biomass in fluidized bed is a promising way to avoid environmentally problems caused by its discharge. To give more accurately prediction in this process, feed-forward back propagation neural ... ...

Abstract	Co-gasification of petroleum coke (petcoke) with coal or biomass in fluidized bed is a promising way to avoid environmentally problems caused by its discharge. To give more accurately prediction in this process, feed-forward back propagation neural network (FFBPNN) with three optimization algorithms were conduct, including Levenberge Marquardt (LM), genetic algorithm (GA) and particle swarm optimization (PSO). The input parameters in the ANN model were petcoke ratio (W), equivalence ratio (ER), steam flow rate (S), particle diameter (Dp), volatiles (V), and fixed carbon (FC). And the output data were carbon conversion (X), ratio of H₂/CO, LHV of syngas and gas yield (Q). The predicted data showed a good agreement with the experimental results. The PSO showed much better performances than those of LM and GA. With ER increased, the predicted X increased and the ratio of H₂/CO decreased. But they were almost no changed with Dp increased. The contributive ratio of W was the largest (0.37) at petcoke ratio of 20%. The contributive ratio of ER increased not the same ratio as ER increased. The contributive ratio of particle size (Dp) almost not changed with Dp increased.
Keywords	algorithms ; biomass ; carbon ; coal ; fluidized beds ; gasification ; neural networks ; particle size ; petroleum ; prediction ; renewable energy sources ; steam ; synthesis gas
Language	English
Dates of publication	2022-0516
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2022.05.096
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification and functional characterization of a novel heterozygous splice‑site mutation in the calpain 3 gene causes rare autosomal dominant limb‑girdle muscular dystrophy.

Mao, Bin / Yang, Jie / Zhao, Xiaodong / Jia, Xueling / Shi, Xin / Zhao, Lihui / Banerjee, Santasree / Zhang, Lili / Ma, Xiaoling

Experimental and therapeutic medicine

2024 Volume 27, Issue 3, Page(s) 97

Abstract: Limb-girdle muscular dystrophies are a group of extremely heterogenous neuromuscular disorders that manifest with gradual and progressive weakness of both proximal and distal muscles. Autosomal dominant limb-girdle muscular dystrophy (LGMDD4) or ... ...

Abstract	Limb-girdle muscular dystrophies are a group of extremely heterogenous neuromuscular disorders that manifest with gradual and progressive weakness of both proximal and distal muscles. Autosomal dominant limb-girdle muscular dystrophy (LGMDD4) or calpainopathy is a very rare form of myopathy characterized by weakness and atrophy of both proximal and distal muscles with a variable age of onset. LGMDD4 is caused by germline heterozygous mutations of the calpain 3 (
Language	English
Publishing date	2024-01-11
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2024.12385
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Article ; Online: Molecular Stratification and Treatment Monitoring of Lung Cancer Using a Small Extracellular Vesicle-Activated Nanocavity Architecture.

Li, Junrong / Li, Meiqin / Wuethrich, Alain / Guan, Rui / Zhao, Lihui / Hu, Cong / Trau, Matt / Sun, Yao

Analytical chemistry

2024

Abstract: Development of molecular diagnostics for lung cancer stratification and monitoring is crucial for the rational planning and timely adjustment of treatments to improve clinical outcomes. In this regard, we propose a nanocavity architecture to sensitively ... ...

Abstract	Development of molecular diagnostics for lung cancer stratification and monitoring is crucial for the rational planning and timely adjustment of treatments to improve clinical outcomes. In this regard, we propose a nanocavity architecture to sensitively profile the protein signature on small extracellular vesicles (sEVs) to enable accurate, noninvasive staging and treatment monitoring of lung cancer. The nanocavity architecture is formed by molecular recognition through the binding of sEVs with the nanobox-based core-shell surface-enhanced Raman scattering (SERS) barcodes and mirrorlike, asymmetric gold microelectrodes. By imposing an alternating current on the gold microelectrodes, a nanofluidic shear force was stimulated that supported the binding of sEVs and the efficient assembly of the nanoboxes. The binding of sEVs further induced a nanocavity between the nanobox and the gold microelectrode that significantly amplified the electromagnetic field to enable the simultaneous enhancement of Raman signals from four SERS barcodes and generate patient-specific molecular sEV signatures. Importantly, evaluated on a cohort of clinical samples (
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.4c00558
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Zs.A 4033: Show issues

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Article: Diagnostic Value of Multi-Mode Ultrasonic Flow Imaging Examination in Solid Renal Tumors of Different Sizes.

Zhang, Dai / Wang, Ying / Yang, Fan / Mao, Yiran / Mu, Jie / Zhao, Lihui / Xu, Wengui

Journal of clinical medicine

2023 Volume 12, Issue 2

Abstract: Purposes: To explore the value of Microflow Imaging (MFI) in renal solid tumors. Methods: A total of 195 patients with 199 lesions pathologically confirmed masses were retrospectively analyzed. The 199 masses were divided into the tumor ≤ 4 cm group (n = ...

Abstract	Purposes: To explore the value of Microflow Imaging (MFI) in renal solid tumors. Methods: A total of 195 patients with 199 lesions pathologically confirmed masses were retrospectively analyzed. The 199 masses were divided into the tumor ≤ 4 cm group (n = 104) and tumor > 4 cm group (n = 95). The diagnostic efficacy of Color Doppler Flow Imaging (CDFI), Power Doppler Imaging (PDI) and MFI in renal tumors sizes were compared by determining the Adler grade, vascular morphology and peripheral blood flow. Results: Among 199 tumors, 161 lesions were malignant and 38 lesions were benign. MFI in malignant tumor ≤ 4 cm demonstrated statistically significant differences in Adler grade and vascular morphology as compared to CDFI and PDI (p < 0.05). In malignant tumor > 4 cm group, MFI showed significant difference in vascular morphology compared with CDFI (p < 0.05). MFI showed a significant difference in the peripheral annular blood flow of malignant tumors when compared to CDFI and PDI (p < 0.05). In addition, the malignant tumors of the two sizes by MFI in peripheral annular blood flow detection showed significant difference (p < 0.05). The area under the curve of ROC by MFI in the tumor ≤ 4 cm was 0.771, which was higher than CDFI and PDI (p < 0.05), but no obvious difference among the tumor > 4 cm (p > 0.05). Conclusion: MFI provides a new method for the differential diagnosis of small renal carcinoma. Based on the convenience and non-radiation of MFI, we can choose MFI as an imaging diagnostic tool for patients who need long-term active surveillance (AS) follow-up.
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12020566
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Article ; Online: The comparative study of color doppler flow imaging, superb microvascular imaging, contrast-enhanced ultrasound micro flow imaging in blood flow analysis of solid renal mass.

Mao, Yiran / Mu, Jie / Zhao, Jing / Yang, Fan / Zhao, Lihui

Cancer imaging : the official publication of the International Cancer Imaging Society

2022 Volume 22, Issue 1, Page(s) 21

Abstract: Purposes: To evaluate the value of Color Doppler Flow Imaging (CDFI), Superb Microvascular Imaging (SMI) and Contrast-enhanced Ultrasound Microflow Imaging (MFI) in display the microvascular blood flow signals in renal solid lesions.: Methods: 142 ... ...

Abstract	Purposes: To evaluate the value of Color Doppler Flow Imaging (CDFI), Superb Microvascular Imaging (SMI) and Contrast-enhanced Ultrasound Microflow Imaging (MFI) in display the microvascular blood flow signals in renal solid lesions. Methods: 142 patients with 144 renal masses were examined by CDFI, SMI and MFI simultaneously. We compared the difference of blood flow grading and vascular architecture based on CDFI, SMI and MFI. Results: The blood flow signals detection rates of CDFI, SMI and MFI were 78.5% (113/144), 88.9% (128/144) and 93.8% (135/144), respectively. Concentrated on blood flow grading, The coincidence rates of CDFI and SMI were 64.58% (93/144) and 81.25% (117/144) referring to MFI, respectively. Blood flow grade 2-3 in CDFI is significantly lower than SMI(x Conclusion: SMI and MFI are superior to CDFI in showing blood flow signals in renal solid masses, and it can perform blood flow and vascular architecture more accurately. Advances in knowledge: SMI is similar to MFI in its ability to display fine vessels and diagnostic efficiency, and has application value in the diagnosis and differential diagnosis of renal solid masses.
MeSH term(s)	Humans ; Microvessels/diagnostic imaging ; ROC Curve ; Sensitivity and Specificity ; Ultrasonography/methods ; Ultrasonography, Doppler, Color/methods
Language	English
Publishing date	2022-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2104862-9
ISSN	1470-7330 ; 1470-7330
ISSN (online)	1470-7330
ISSN	1470-7330
DOI	10.1186/s40644-022-00458-2
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