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  1. Article ; Online: Shape transformations of red blood cells in the capillary and their possible connections to oxygen transportation.

    Wang, Caiqun / Li, Jianfeng / Zhao, Liutao / Qian, Ping

    Journal of biological physics

    2021  Volume 48, Issue 1, Page(s) 79–92

    Abstract: In this work, a series of numerical simulations have been performed to obtain the steady shapes of red blood cells under a shear force field in the capillary. Two possible classes of steady shapes, the axisymmetric parachute and the non-axisymmetric ... ...

    Abstract In this work, a series of numerical simulations have been performed to obtain the steady shapes of red blood cells under a shear force field in the capillary. Two possible classes of steady shapes, the axisymmetric parachute and the non-axisymmetric parachute, are found. If we assume that oxygen diffusion across the red cell membrane is mediated by membrane curvature, it is found that the non-axisymmetric parachute will be more favorable due to its special shape which enables it to have a larger portion of membrane patch capable of releasing oxygen to tissues.
    MeSH term(s) Capillaries ; Erythrocyte Membrane ; Erythrocytes ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-11-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016734-9
    ISSN 1573-0689 ; 0092-0606
    ISSN (online) 1573-0689
    ISSN 0092-0606
    DOI 10.1007/s10867-021-09594-5
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  2. Article ; Online: Triple receiver public key encryption cryptosystem

    ZHAO Liutao, WANG Caiqun / ZHONG Lin, LIU Jidong / WU Dan

    网络与信息安全学报, Vol 6, Iss 6, Pp 128-

    2020  Volume 136

    Abstract: A triple receiver public key cryptosystem was proposed. In the cryptosystem, a sender encrypted a message and sent to three receivers, while the three receivers were able to decrypt the message with their own private keys. Based on bilinear map, two ... ...

    Abstract A triple receiver public key cryptosystem was proposed. In the cryptosystem, a sender encrypted a message and sent to three receivers, while the three receivers were able to decrypt the message with their own private keys. Based on bilinear map, two triple receiver public key encryption schemes with different security were constructed. If the gap bilinear Diffie-Hellman (GBDH) problem and the computational Diffie-Hellman (CDH) problem were proved formally to be intractable, then the two schemes proposed were semantically secure against chosen-plaintext attacks and against adaptive chosen ciphertext attacks respectively. The proposed scheme only added an exponential operation and a hash operation, and constructed three independent receivers which had a high efficiency. Analyses show that proposed scheme can improve the security of TLS protocol and apply to hierarchical public key cryptosystems.
    Keywords triple receiver ; public key encryption ; bilinear map ; gap bilinear diffie-hellman problem ; computational diffie-hellman problem ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 005
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher POSTS&TELECOM PRESS Co., LTD
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Acute toxicity and safety profile evolution of aqueous extracts of Sanren decoction using in vivo models

    Wang, Qing / Zhao, Liutao / Zhang, Hui / Zhang, Shuo / Yang, Pu / Wang, Huanhuan / Yuan, Qingyan / Wu, Guanlian / Wu, Chunli

    Journal of ethnopharmacology. 2022 Apr. 06, v. 287

    2022  

    Abstract: Sanren decoction (SRD) is a well-known traditional Chinese medicine prescription containing eight kinds of materials. SRD has been used mainly in China for more than 200 years for the treatment of respiratory disorders that co-occur with a bad fever ... ...

    Abstract Sanren decoction (SRD) is a well-known traditional Chinese medicine prescription containing eight kinds of materials. SRD has been used mainly in China for more than 200 years for the treatment of respiratory disorders that co-occur with a bad fever after midday.To evaluate the acute and 28-day subacute toxicity of an aqueous extract of SRD using in vivo methods.To determine acute toxicity, SRD was administered by gavage at a dosage of 58.5 g/kg/day to male and female mice for 7 days. To determine subacute toxicity, SRD was administered at 3.3, 6.5, or 13 g/kg/day to male and female rats for 28 days. The general behavior, body weight, biochemical and hematological parameters, organ coefficients and pathological morphology of the treated animals were analyzed.Neither acute nor subacute concentrations of SRD caused significant changes in the body weights, general behavior, hematology and biochemical parameters, organ weights, or histopathological appearances of the liver, kidney, spleen, brain, lung or heart in mice or rats.The administration of SRD can be considered safe within the conditions of this study.
    Keywords Oriental traditional medicine ; acute toxicity ; body weight ; brain ; females ; fever ; heart ; hematology ; histopathology ; kidneys ; liver ; lungs ; males ; spleen ; subacute toxicity ; China
    Language English
    Dates of publication 2022-0406
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2021.114940
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  4. Article: Toxicological evaluation of aqueous extract of the traditional Chinese formula Qing Hao Gan Cao.

    Li, Yongchun / Zhang, Hui / Chen, Shanshan / Zhao, Liutao / Wu, Jie / Li, Pan / Wu, Guanlian / Wang, Qing / Wu, Chunli / Xu, Hongde

    Toxicology research

    2021  Volume 10, Issue 2, Page(s) 183–191

    Abstract: Qing Hao Gan ... ...

    Abstract Qing Hao Gan Cao
    Language English
    Publishing date 2021-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2684701-2
    ISSN 2045-4538 ; 2045-452X
    ISSN (online) 2045-4538
    ISSN 2045-452X
    DOI 10.1093/toxres/tfaa103
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  5. Article ; Online: Acute toxicity and safety profile evolution of aqueous extracts of Sanren decoction using in vivo models.

    Wang, Qing / Zhao, Liutao / Zhang, Hui / Zhang, Shuo / Yang, Pu / Wang, Huanhuan / Yuan, Qingyan / Wu, Guanlian / Wu, Chunli

    Journal of ethnopharmacology

    2021  Volume 287, Page(s) 114940

    Abstract: Ethnopharmacological relevance: Sanren decoction (SRD) is a well-known traditional Chinese medicine prescription containing eight kinds of materials. SRD has been used mainly in China for more than 200 years for the treatment of respiratory disorders ... ...

    Abstract Ethnopharmacological relevance: Sanren decoction (SRD) is a well-known traditional Chinese medicine prescription containing eight kinds of materials. SRD has been used mainly in China for more than 200 years for the treatment of respiratory disorders that co-occur with a bad fever after midday.
    Aim of the study: To evaluate the acute and 28-day subacute toxicity of an aqueous extract of SRD using in vivo methods.
    Materials and methods: To determine acute toxicity, SRD was administered by gavage at a dosage of 58.5 g/kg/day to male and female mice for 7 days. To determine subacute toxicity, SRD was administered at 3.3, 6.5, or 13 g/kg/day to male and female rats for 28 days. The general behavior, body weight, biochemical and hematological parameters, organ coefficients and pathological morphology of the treated animals were analyzed.
    Results: Neither acute nor subacute concentrations of SRD caused significant changes in the body weights, general behavior, hematology and biochemical parameters, organ weights, or histopathological appearances of the liver, kidney, spleen, brain, lung or heart in mice or rats.
    Conclusions: The administration of SRD can be considered safe within the conditions of this study.
    MeSH term(s) Animals ; Animals, Outbred Strains ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/toxicity ; Female ; Male ; Mice ; Organ Size/drug effects ; Rats ; Rats, Sprague-Dawley ; Toxicity Tests, Acute ; Toxicity Tests, Subacute
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2021-12-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2021.114940
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Toxicological safety evaluation in acute and 28-day studies of aqueous extract from Bei-Qi-Wu-Jia formula

    Zhao, Liutao / Chen, Jingjing / Gao, Ziqing / Han, Bingqian / Li, Jianglong / Li, Pan / Li, Xianbin / Wu, Chunli / Xu, Hongde

    Journal of ethnopharmacology. 2020 Feb. 10, v. 248

    2020  

    Abstract: Bei Qi Wu Jia (BQWJ), a modern preparation of a traditional Chinese medicinal formula, is a combination of Radix Astragali and Acanthopanacis Senticosi. Although BQWJ has been used to treat insomnia, fatigue, and loss of appetite, toxicological safety ... ...

    Abstract Bei Qi Wu Jia (BQWJ), a modern preparation of a traditional Chinese medicinal formula, is a combination of Radix Astragali and Acanthopanacis Senticosi. Although BQWJ has been used to treat insomnia, fatigue, and loss of appetite, toxicological safety studies are rare in the literature.Aim of the study: To evaluate the acute and subacute toxicity of BQWJ extract after oral administration in mice and rats, respectively.In the acute toxicity study, mice underwent oral administration of 67.5 g extract/kg/day. In the subacute toxicity study, rats underwent a single oral administration of 1.25, 2.5, 5.0, or 10.0 g/kg/day of BQWJ extract for 28 days. The animals’ general behavior, body weight, food intake, biochemical and hematologic parameters, organ coefficients, and pathological morphology were analyzed.No evidence of toxicity was observed in the mice after acute exposure to BQWJ extract. The subacute results included no deaths and no changes in general behavior. Although BQWJ extract resulted in some significant changes in other parameters, these alterations cannot be considered treatment-related because they remained within normal ranges throughout the 28 days.In conclusion, the oral administration of BQWJ extract at doses of less than 67.5 g/kg/day for 1 day or 10.0 g/kg/day for 28 consecutive days can be considered safe and showed no distinct toxicity or side effects in this study.
    Keywords acute exposure ; acute toxicity ; adverse effects ; body weight ; food intake ; hematologic tests ; mice ; oral administration ; rats ; subacute toxicity ; toxicology ; traditional medicine
    Language English
    Dates of publication 2020-0210
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.112324
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  7. Article ; Online: Toxicological safety evaluation in acute and 28-day studies of aqueous extract from Bei-Qi-Wu-Jia formula.

    Zhao, Liutao / Li, Pan / Xu, Hongde / Han, Bingqian / Chen, Jingjing / Gao, Ziqing / Li, Jianglong / Li, Xianbin / Wu, Chunli

    Journal of ethnopharmacology

    2019  Volume 248, Page(s) 112324

    Abstract: Ethnopharmacological relevance: Bei Qi Wu Jia (BQWJ), a modern preparation of a traditional Chinese medicinal formula, is a combination of Radix Astragali and Acanthopanacis Senticosi. Although BQWJ has been used to treat insomnia, fatigue, and loss of ... ...

    Abstract Ethnopharmacological relevance: Bei Qi Wu Jia (BQWJ), a modern preparation of a traditional Chinese medicinal formula, is a combination of Radix Astragali and Acanthopanacis Senticosi. Although BQWJ has been used to treat insomnia, fatigue, and loss of appetite, toxicological safety studies are rare in the literature.
    Aim of the study: To evaluate the acute and subacute toxicity of BQWJ extract after oral administration in mice and rats, respectively.
    Materials and methods: In the acute toxicity study, mice underwent oral administration of 67.5 g extract/kg/day. In the subacute toxicity study, rats underwent a single oral administration of 1.25, 2.5, 5.0, or 10.0 g/kg/day of BQWJ extract for 28 days. The animals' general behavior, body weight, food intake, biochemical and hematologic parameters, organ coefficients, and pathological morphology were analyzed.
    Results: No evidence of toxicity was observed in the mice after acute exposure to BQWJ extract. The subacute results included no deaths and no changes in general behavior. Although BQWJ extract resulted in some significant changes in other parameters, these alterations cannot be considered treatment-related because they remained within normal ranges throughout the 28 days.
    Conclusions: In conclusion, the oral administration of BQWJ extract at doses of less than 67.5 g/kg/day for 1 day or 10.0 g/kg/day for 28 consecutive days can be considered safe and showed no distinct toxicity or side effects in this study.
    MeSH term(s) Administration, Oral ; Animals ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/toxicity ; Female ; Male ; Mice ; No-Observed-Adverse-Effect Level ; Rats, Sprague-Dawley ; Risk Assessment ; Time Factors ; Toxicity Tests, Acute ; Toxicity Tests, Subacute
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2019-10-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.112324
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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Dual-doping to suppress cracking in spinel LiMn2O4: a joint theoretical and experimental study.

    Zhang, Zhifeng / Chen, Zhenlian / Wang, Guangjin / Ren, Heng / Pan, Mu / Xiao, Lingli / Wu, Kuicheng / Zhao, Liutao / Yang, Jianqing / Wu, Qingguo / Shu, Jie / Wang, Dongjie / Zhang, Hongli / Huo, Ni / Li, Jun

    Physical chemistry chemical physics : PCCP

    2016  Volume 18, Issue 9, Page(s) 6893–6900

    Abstract: Electrochemical cycling stabilities were compared for undoped and Al/Co dual-doped spinel LiMn2O4 synthesized by solid state reactions. We observed the suppression of particle fracture in Al/Co dual-doped LiMn2O4 during charge/discharge cycling and its ... ...

    Abstract Electrochemical cycling stabilities were compared for undoped and Al/Co dual-doped spinel LiMn2O4 synthesized by solid state reactions. We observed the suppression of particle fracture in Al/Co dual-doped LiMn2O4 during charge/discharge cycling and its distinguishable particle morphology with respect to the undoped material. Systematic first-principles calculations were performed on undoped, Al or Co single-doped, and Al/Co dual-doped LiMn2O4 to investigate their structural differences at the atomistic level. We reveal that while Jahn-Teller distortion associated with the Mn(3+)O6 octahedron is the origin of the lattice strain, the networking -i.e. the distribution of mixed valence Mn ions - is much more important to release the lattice strain, and thus to alleviating particle cracking. The calculations showed that the lattice mismatching between Li(+) intercalation and deintercalation of LiMn2O4 can be significantly reduced by dual-doping, and therefore also the volumetric shrinkage during delithiation. This may account for the near disappearance of cracks on the surface of Al/Co-LiMn2O4 after 350 cycles, while some obvious cracks have developed in undoped LiMn2O4 at similar particle size even after 50 cycles. Correspondingly, Al/Co dual-doped LiMn2O4 showed a good cycling stability with a capacity retention of 84.1% after 350 cycles at a rate of 1C, 8% higher than the undoped phase.
    Language English
    Publishing date 2016-03-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/c5cp07182h
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