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  1. Article: [Medicinal evolution and modern research progress on Mume Fructus].

    Zhang, Ying / Qu, Qiong / Zhao, Xiao-Mei / Zhao, Pei-Yuan / Zhang, Xin-Bo / Qiu, Jin-Qing / Duan, Xi / Song, Xiao

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2023  Volume 48, Issue 14, Page(s) 3753–3764

    Abstract: Prunus mume is an edible and medicinal material, and Mume Fructus is its processed product, which was first recorded in Shennong's Classic of Materia Medica(Shen Nong Ben Cao Jing). It is an effective drug for stopping diarrhea with astringents and ... ...

    Abstract Prunus mume is an edible and medicinal material, and Mume Fructus is its processed product, which was first recorded in Shennong's Classic of Materia Medica(Shen Nong Ben Cao Jing). It is an effective drug for stopping diarrhea with astringents and promoting fluid production to quiet ascaris. By consulting the ancient herbal works of the past dynasties, modern codes, and other rela-ted literature, this paper sorted out the medicinal evolution of Mume Fructus, examined the ancient efficacy of Mume Fructus and the main indications, and summarized the inclusion of Mume Fructus in national and provincial standards. It is recorded in the ancient herbal works of the past dynasties that Mume Fructus can be processed by various methods such as roasting, stir-frying or micro-frying, stir-frying with charcoal, single steaming, steaming with wine, and steaming after soaking in wine or vinegar, and prepared into pills, powders, and ointments, which are used in the treatment of fatigue, diabetes, malaria, dysentery, ascariasis, and other diseases. Mume Fructus has been included in nine editions of Chinese Pharmacopoeia and 19 provincial and municipal preparation specifications. The processing method of Mume Fructus is determined, namely, clean P. mume should be softened by moistening in water or steaming and pitted. By reviewing the effects of processing on its chemical composition, pharmacological effects, and its modern clinical application, this paper identified the following issues. The ancient application methods of Mume Fructus are diverse but less commonly used in modern times, there is a lack of standardized research on the processing, and the research on the changes caused by the difference in Mume Fructus before and after processing is not deep. Therefore, it is necessary to further investigate the change pattern of its chemical composition before and after processing and its correlation between its medicinal activity to standardize the processing technology and provide a solid basis for the use of Mume Fructus in parts and its quality control.
    MeSH term(s) Drugs, Chinese Herbal/pharmacology ; Materia Medica/analysis ; Fruit/chemistry ; Quality Control ; Prunus/chemistry ; Medicine, Chinese Traditional
    Chemical Substances Drugs, Chinese Herbal ; Materia Medica
    Language Chinese
    Publishing date 2023-07-21
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230331.302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 Epidemic: Possibility of Artificial Intelligence in Infection Control and Prevention.

    Qi, Zhao-Yao / Zhao, Pei-Yuan / Geng, Shao-Hui / Yi, Huai-Min / Yang, Li-Ping

    Journal of epidemiology

    2020  Volume 30, Issue 8, Page(s) 371

    MeSH term(s) Artificial Intelligence ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Epidemics/prevention & control ; Global Health ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control
    Keywords covid19
    Language English
    Publishing date 2020-06-06
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1442118-5
    ISSN 1349-9092 ; 0917-5040
    ISSN (online) 1349-9092
    ISSN 0917-5040
    DOI 10.2188/jea.JE20200203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Corrigendum to "Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/ NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis" [J. Ethnopharmacol. 217 (2018) 36-48].

    Zhao, Pei-Yuan / Wang, Yong-Qiang / Liu, Xi-Hong / Zhu, Ying-Jun / Zhao, Hui / Zhang, Qiu-Xia / Qi, Fang / Li, Jun-Ling / Zhang, Nan / Fan, Yong-Ping / Li, Kang-Ning / Zhao, Yuan-Yuan / Lei, Jian-Feng / Wang, Lei

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt A, Page(s) 116853

    Language English
    Publishing date 2023-06-29
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: COVID-19 Epidemic: Possibility of Artificial Intelligence in Infection Control and Prevention

    Qi, Zhao-Yao / Zhao, Pei-Yuan / Geng, Shao-Hui / Yi, Huai-Min / Yang, Li-Ping

    J Epidemiol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #548456
    Database COVID19

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  5. Article: Prenatal Stress Impairs Postnatal Learning and Memory Development via Disturbance of the cGMP-PKG Pathway and Oxidative Phosphorylation in the Hippocampus of Rats.

    Li, Yu-Jie / Yang, Li-Ping / Hou, Jun-Lin / Li, Xin-Min / Chen, Lei / Zhu, Jiang-Hui / Wang, Qi-Yang / Li, Gai / Zhao, Pei-Yuan / Liu, Xi-Hong / Shi, Zhan-Jiang

    Frontiers in molecular neuroscience

    2020  Volume 13, Page(s) 158

    Abstract: Clinical and animal studies have found that prenatal stress can lead to pathological changes in embryos and fetuses. However, the mechanisms through which this occurs have not been made clear. In the present study, pregnant rats were subjected to chronic ...

    Abstract Clinical and animal studies have found that prenatal stress can lead to pathological changes in embryos and fetuses. However, the mechanisms through which this occurs have not been made clear. In the present study, pregnant rats were subjected to chronic psychological stress during gestational days using an improved communication box system, and the changes in behavioral performance and proteins in the hippocampus of offspring were analyzed. It was found that prenatal stress caused postnatal growth retardation and impairment in spatial learning and memory. Furthermore, in isobaric tags for relative and absolute quantitation-based proteomics analyses, 158 significantly differentially expressed proteins (DEPs) were found between the two groups. Further analyses showed that these DEPs are involved in different molecular function categories and participate in several biological processes, such as energy metabolism, learning or memory, and synaptic plasticity. Moreover, the enrichment of pathways showed that the learning and memory impairment was primarily connected with the cyclic guanosine monophosphate-protein kinase G (cGMP-PKG) pathway and oxidative phosphorylation. At the same time, the cGMP level and the expression of PKG protein were significantly decreased, and the neuronal mitochondria appeared to have a swollen and irregular shape in the hippocampus of offspring of stressed rats. These results suggest that the chronic psychological stress that pregnant rats were subjected to during gestational days may have impaired the spatial learning and memory of offspring. This affected the hippocampal oxidative phosphorylation and inhibited the cGMP-PKG pathway.
    Language English
    Publishing date 2020-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2020.00158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bu-Shen-Yi-Sui Capsule, an Herbal Medicine Formula, Promotes Remyelination by Modulating the Molecular Signals via Exosomes in Mice with Experimental Autoimmune Encephalomyelitis.

    Zhao, Pei-Yuan / Ji, Jing / Liu, Xi-Hong / Zhao, Hui / Xue, Bin / Jin, Liang-Yun / Fan, Yong-Ping / Zhao, Wen-Jing / Wang, Lei

    Oxidative medicine and cellular longevity

    2020  Volume 2020, Page(s) 7895293

    Abstract: Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central nervous system. Bu-shen-yi-sui capsule (BSYSC) could significantly reduce the relapse rate, prevent the progression of MS, and enhance remyelination following ... ...

    Abstract Multiple sclerosis (MS) is a common inflammatory demyelinating disorder of the central nervous system. Bu-shen-yi-sui capsule (BSYSC) could significantly reduce the relapse rate, prevent the progression of MS, and enhance remyelination following neurological injury in experimental autoimmune encephalomyelitis (EAE), an established model of MS; however, the mechanism underlying the effect of BSYSC on remyelination has not been well elucidated. This study showed that exosomes carrying biological information are involved in the pathological process of MS and that modified exosomes can promote remyelination by modulating related proteins and microRNAs (miRs). Here, the mechanism by which BSYSC promoted remyelination via exosome-mediated molecular signals was investigated in EAE mice and oligodendrocyte progenitor cells (OPCs) in vitro. The results showed that BSYSC treatment significantly improved the body weight and clinical scores of EAE mice, alleviated inflammatory infiltration and nerve fiber injury, protected the ultrastructural integrity of the myelin sheath, and significantly increased the expression of myelin basic protein (MBP) in EAE mice. In an in vitro OPC study, BSYSC-containing serum, especially 20% BSYSC, promoted the proliferation and migration of OPCs and induced OPCs to differentiate into mature oligodendrocytes that expressed MBP. Furthermore, BSYSC treatment regulated the expression of neuropilin- (NRP-) 1 and GTX, downregulated the expression of miR-16, let-7, miR-15, miR-98, miR-486, and miR-182, and upregulated the level of miR-146 in serum exosomes of EAE mice. In conclusion, these results suggested that BSYSC has a neuroprotective effect and facilitates remyelination and that the mechanism underlying the effect of BSYSC on remyelination probably involves regulation of the NRP-1 and GTX proteins and miRs in serum exosomes, which drive promyelination.
    MeSH term(s) Animals ; Cell Differentiation ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Exosomes/metabolism ; Female ; Herbal Medicine/methods ; Humans ; Mice ; Multiple Sclerosis/complications ; Multiple Sclerosis/drug therapy ; Remyelination/drug effects ; Signal Transduction
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2020/7895293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis

    Zhao, Pei-Yuan / Fang Qi / Hui Zhao / Jian-Feng Lei / Jun-Ling Li / Kang-Ning Li / Lei Wang / Nan Zhang / Qiu-Xia Zhang / Xi-Hong Liu / Ying-Jun Zhu / Yong-Ping Fan / Yong-Qiang Wang / Yuan-Yuan Zhao

    Journal of ethnopharmacology. 2018 May 10, v. 217

    2018  

    Abstract: Bu Shen Yi Sui capsule (BSYSC), based on traditional Chinese formula Liu Wei Di Huang pill, is effective for the treatment of multiple sclerosis (MS) in clinical experience and trials. Our previous studies confirmed that BSYSC had the neuroprotective ... ...

    Abstract Bu Shen Yi Sui capsule (BSYSC), based on traditional Chinese formula Liu Wei Di Huang pill, is effective for the treatment of multiple sclerosis (MS) in clinical experience and trials. Our previous studies confirmed that BSYSC had the neuroprotective effect in MS and its animal model, experimental autoimmune encephalomyelitis (EAE); however, its mechanism of action was not clear. Thus, the effect of BSYSC on remyelination and the underlying mechanisms were investigated in the EAE mice.The EAE model was established by injecting subcutaneously myelin oligodendrocyte protein (MOG) 35–55 in mice. Mice were treated with BSYSC (3.02 g/kg) or vehicle daily by oral gavage for 40 days. The body weight and clinical score of mice were evaluated. Brain was observed by magnetic resonance imaging. The inflammation infiltrate of brain and spinal cord was determined by hematoxylin-eosin staining, while the structure of myelin sheath was visualized by transmission electron microscopy on days 23 and 40 post immunization (dpi), respectively. The protein and mRNA levels of platelets-derived growth factor receptor (PDGFR) α and 2′, 3′-cyclic nucleotide-3′-phosphodiesterase (CNPase) were measured by immunohistochemistry, western blot and quantitative real-time polymerase chain reaction. The protein expressions of semaphorins (Sema) 3A, Neuropilin (NRP) − 1, leukemia inhibitory factor (LIF), LIF receptor (LIFR) and Nkx6.2 were further investigated by western blot.BSYSC treatment improved the body weight and clinical score of EAE mice, alleviated inflammatory infiltration and nerve fiber injuries. It also protected the ultrastructural integrity of myelin sheath. BSYSC significantly increased expressions of PDGFRα and CNPase in mice with EAE on 40 dpi. Furthermore, BSYSC treatment increased the expressions of LIF, LIFR and Nkx6.2 and reduced Sema3A and NRP-1 in EAE mice on 40 dpi.The data demonstrated that BSYSC exhibited the neuroprotective effect against EAE by promoting oligodendrocyte progenitor cells (OPCs) proliferation and differentiation, thus facilitating remyelination. Sema3A/NRP-1, LIF/LIFR and Nkx6.2 are likely contributed to the effects of BSYSC on OPCs.
    Keywords animal models ; autoimmune diseases ; body weight ; brain ; encephalitis ; immunization ; immunohistochemistry ; inflammation ; leukemia inhibitory factor ; magnetic resonance imaging ; mechanism of action ; messenger RNA ; mice ; myelin sheath ; nerve fibers ; neuroprotective effect ; oligodendroglia ; Oriental traditional medicine ; platelet-derived growth factor receptor alpha ; quantitative polymerase chain reaction ; sclerosis ; spinal cord ; staining ; stem cells ; transmission electron microscopy ; Western blotting
    Language English
    Dates of publication 2018-0510
    Size p. 36-48.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2018.02.014
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis.

    Zhao, Pei-Yuan / Wang, Yong-Qiang / Liu, Xi-Hong / Zhu, Ying-Jun / Zhao, Hui / Zhang, Qiu-Xia / Qi, Fang / Li, Jun-Ling / Zhang, Nan / Fan, Yong-Ping / Li, Kang-Ning / Zhao, Yuan-Yuan / Lei, Jian-Feng / Wang, Lei

    Journal of ethnopharmacology

    2018  Volume 217, Page(s) 36–48

    Abstract: Ethnopharmacological relevance: Bu Shen Yi Sui capsule (BSYSC), based on traditional Chinese formula Liu Wei Di Huang pill, is effective for the treatment of multiple sclerosis (MS) in clinical experience and trials. Our previous studies confirmed that ... ...

    Abstract Ethnopharmacological relevance: Bu Shen Yi Sui capsule (BSYSC), based on traditional Chinese formula Liu Wei Di Huang pill, is effective for the treatment of multiple sclerosis (MS) in clinical experience and trials. Our previous studies confirmed that BSYSC had the neuroprotective effect in MS and its animal model, experimental autoimmune encephalomyelitis (EAE); however, its mechanism of action was not clear. Thus, the effect of BSYSC on remyelination and the underlying mechanisms were investigated in the EAE mice.
    Materials and methods: The EAE model was established by injecting subcutaneously myelin oligodendrocyte protein (MOG)
    Results: BSYSC treatment improved the body weight and clinical score of EAE mice, alleviated inflammatory infiltration and nerve fiber injuries. It also protected the ultrastructural integrity of myelin sheath. BSYSC significantly increased expressions of PDGFRα and CNPase in mice with EAE on 40 dpi. Furthermore, BSYSC treatment increased the expressions of LIF, LIFR and Nkx6.2 and reduced Sema3A and NRP-1 in EAE mice on 40 dpi.
    Conclusions: The data demonstrated that BSYSC exhibited the neuroprotective effect against EAE by promoting oligodendrocyte progenitor cells (OPCs) proliferation and differentiation, thus facilitating remyelination. Sema3A/NRP-1, LIF/LIFR and Nkx6.2 are likely contributed to the effects of BSYSC on OPCs.
    MeSH term(s) 2',3'-Cyclic-Nucleotide Phosphodiesterases/metabolism ; Administration, Oral ; Animals ; Brain/drug effects ; Brain/metabolism ; Brain/ultrastructure ; Capsules ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Homeodomain Proteins/metabolism ; Leukemia Inhibitory Factor/metabolism ; Leukemia Inhibitory Factor Receptor alpha Subunit/metabolism ; Mice, Inbred C57BL ; Myelin Sheath/drug effects ; Myelin Sheath/metabolism ; Myelin Sheath/ultrastructure ; Myelin-Oligodendrocyte Glycoprotein ; Neuropilin-1/metabolism ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/pharmacology ; Oligodendrocyte Precursor Cells/drug effects ; Oligodendrocyte Precursor Cells/metabolism ; Oligodendrocyte Precursor Cells/pathology ; Peptide Fragments ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Semaphorin-3A/metabolism ; Signal Transduction/drug effects ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Spinal Cord/ultrastructure ; Time Factors ; Transcription Factors/metabolism
    Chemical Substances Capsules ; Drugs, Chinese Herbal ; Homeodomain Proteins ; Leukemia Inhibitory Factor ; Leukemia Inhibitory Factor Receptor alpha Subunit ; Lif protein, mouse ; Lifr protein, mouse ; Myelin-Oligodendrocyte Glycoprotein ; Neuroprotective Agents ; Nkx6-2 protein, mouse ; Peptide Fragments ; Sema3a protein, mouse ; Semaphorin-3A ; Transcription Factors ; bushen yisui ; myelin oligodendrocyte glycoprotein (35-55) ; Neuropilin-1 (144713-63-3) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; 2',3'-Cyclic-Nucleotide Phosphodiesterases (EC 3.1.4.-)
    Language English
    Publishing date 2018-02-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2018.02.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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