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  1. Article: The implications and prospect of cuproptosis-related genes and copper transporters in cancer progression.

    Zhao, Qianwen / Qi, Tonggang

    Frontiers in oncology

    2023  Volume 13, Page(s) 1117164

    Abstract: Currently, cancer has become one of the major public health problems worldwide. Apoptosis is an important anti-cancer defense mechanism, which is used in the development of targeted drugs. Because cancer cells have endogenous resistance to apoptosis,the ... ...

    Abstract Currently, cancer has become one of the major public health problems worldwide. Apoptosis is an important anti-cancer defense mechanism, which is used in the development of targeted drugs. Because cancer cells have endogenous resistance to apoptosis,the clinical efficacy of related drugs is not ideal. Therefore, non-apoptotic regulatory cell death may bring new therapeutic strategies for cancer treatment. Cuproptosis is a novel form of regulatory cell death which is copper-dependent, regulated and distinct from other known cell death regulatory mechanisms. FDX1,LIAS,and DLAT named cuproptosis-related genes play an essential role in regulating cuproptosis. Meanwhile, abnormal accumulation of copper can be observed in various malignant tumors. The correlation has been established between elevated copper levels in serum and tissues and the progression of several cancers. Copper transporters, CTR1 and Copper-transporting ATPases(ATP7A and ATP7B), are mainly involved in regulating the dynamic balance of copper concentration to maintain copper homeostasis. Thus,cuproptosis-related genes and copper transporters will be the focus of cancer research in future. This review elaborated the basic functions of cuproptosis-related genes and copper transporters by retrievalling PubMed. And then we analyzed their potential relationship with cancer aiming to provide theoretical support and reference in cancer progression, diagnosis and treatment for future study.
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1117164
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  2. Article ; Online: Letter: metabolic dysfunction-associated fatty liver disease increases risk of all-cause mortality in patients with chronic hepatitis C.

    Zhao, Qianwen / Deng, Yunlei

    Alimentary pharmacology & therapeutics

    2023  Volume 57, Issue 2, Page(s) 272–273

    MeSH term(s) Humans ; Hepatitis C, Chronic/complications ; Non-alcoholic Fatty Liver Disease/complications ; Risk Factors
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17294
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  3. Article ; Online: Comparison of mortality outcomes in individuals with MASLD and/or MAFLD.

    Zhao, Qianwen / Deng, Yunlei

    Journal of hepatology

    2023  Volume 80, Issue 2, Page(s) e62–e64

    Language English
    Publishing date 2023-08-12
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.08.003
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  4. Article ; Online: Education and income are associated with long-term outcome in the metabolic dysfunction-associated steatotic liver disease population.

    Zhao, Qianwen / Deng, Yunlei

    Geriatrics & gerontology international

    2023  Volume 23, Issue 12, Page(s) 975–976

    MeSH term(s) Humans ; Fatty Liver/epidemiology ; Educational Status ; Metabolic Diseases
    Language English
    Publishing date 2023-10-31
    Publishing country Japan
    Document type Letter
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14719
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  5. Article ; Online: Metabolic associated fatty liver disease and sarcopenia additively increase mortality: a real-world study.

    Zhao, Qianwen / Yin, Yifan / Deng, Yunlei

    Nutrition & diabetes

    2023  Volume 13, Issue 1, Page(s) 21

    Abstract: Background and aims: Sarcopenia is associated with worse prognosis for non-alcoholic fatty liver disease (NAFLD). However, disease progression in the MAFLD-related sarcopenia is largely unknown. We aimed to clarify the relationship between MAFLD and/or ... ...

    Abstract Background and aims: Sarcopenia is associated with worse prognosis for non-alcoholic fatty liver disease (NAFLD). However, disease progression in the MAFLD-related sarcopenia is largely unknown. We aimed to clarify the relationship between MAFLD and/or sarcopenia with mortality and liver fibrosis in the real world.
    Methods: A total of 13,692 individuals were selected from the third National Health and Nutrition Examination Surveys and linked mortality until December 2019. MAFLD is diagnosed based on a radiologically diagnosed hepatic steatosis and the presence of any one of the following three conditions: overweight/obesity, diabetes mellitus (DM), or metabolic dysregulation. Sarcopenia is defined by weight-adjusted skeletal muscle mass.
    Results: The mean age was 43.7 ± 15.97 years, and 47.3% of the individuals were male. MAFLD was diagnosed in 4207/13,692 (30.73%) participants, and the proportion of sarcopenic was 19.42% amongst subjects with MAFLD. The mean follow-up duration was of 23.7 ± 7.62 years. MAFLD (aHR 1.152, 95% CI 1.070-1.241) and sarcopenia (aHR 1.123, 95% CI 1.042-1.210) were related to increased all-cause mortality in MAFLD after adjustment for age, sex, race, marital status, education, and smoking. Stratified analysis revealed that MAFLD and sarcopenia additively increased the risk of mortality (aHR 1.247, 95% CI 1.132-1.373) and liver fibrosis (aOR 2.296, 95% CI 1.718-3.069 assessed by NFS score >0.676; aOR 2.218, 95% CI 1.788-2.752 assessed by FIB-4 score >1.3) in fully adjusted models (P < 0.001 for all).
    Conclusion: Sarcopenia in individuals with MAFLD portends increased mortality and significant liver fibrosis. Novel therapeutic strategies targeting at increasing skeletal muscle mass should be explored for patients with MAFLD.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Female ; Non-alcoholic Fatty Liver Disease/complications ; Sarcopenia ; Educational Status ; Liver Cirrhosis/complications ; Obesity/complications
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2609314-5
    ISSN 2044-4052 ; 2044-4052
    ISSN (online) 2044-4052
    ISSN 2044-4052
    DOI 10.1038/s41387-023-00250-6
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  6. Article ; Online: Note sur l’acquisition des voyelles du français par les apprenants chinois avec la L2 anglais

    LUO Xiaoliang / ZHAO Qianwen

    SHS Web of Conferences, Vol 78, p

    2020  Volume 07003

    Abstract: Les apprenants chinois ont souvent de grandes difficultés de prononciation lorsqu'ils apprennent le français. Ces difficultés ne sont pas seulement liées à leur langue maternelle : l’anglais joue également un rôle important dû au système éducatif chinois. ...

    Abstract Les apprenants chinois ont souvent de grandes difficultés de prononciation lorsqu'ils apprennent le français. Ces difficultés ne sont pas seulement liées à leur langue maternelle : l’anglais joue également un rôle important dû au système éducatif chinois. Croyant que l'anglais serait plus proche du français, certains apprenants chinois cherchent des prononciations similaires dans la langue anglaise alors que certains sons français existent phonétiquement en chinois. Dans cet article, nous nous concentrons sur l’acquisition des voyelles du français et essayons de déterminer les influences de la L1 et de la L2 respectivement, en nous basant sur un corpus constitué d’enregistrements des apprenants ayant des profils homogènes.
    Keywords Social Sciences ; H
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
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  7. Article ; Online: Association between dietary inflammatory index and risk of fatty liver disease: A systematic review and meta-analysis.

    Zhao, Qianwen / Deng, Yunlei / Gong, Rong / Chen, Ting / Yang, Li

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 56, Issue 4, Page(s) 541–550

    Abstract: Aims: This meta-analysis aimed to investigate the correlation between dietary inflammatory index (DII) and risks of fatty liver disease.: Methods: A comprehensive systematic literature search was conducted to select studies published from database ... ...

    Abstract Aims: This meta-analysis aimed to investigate the correlation between dietary inflammatory index (DII) and risks of fatty liver disease.
    Methods: A comprehensive systematic literature search was conducted to select studies published from database inception to 6 September 2023 from five databases. Observational studies examining the association between elevated DII levels and the prevalence of fatty liver disease/liver fibrosis were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using either random-effects or fixed-effect models.
    Results: In total, 10 studies comprising 242,006 participants were included in the meta-analysis. Individuals with higher DII had a significantly increased risk of fatty liver disease (OR 1.63; 95% CI 1.08-2.45) and liver fibrosis (OR 1.15; 95% CI 1.09-1.21) compared to those with lower DII.
    Conclusions: This meta-analysis demonstrated an association between higher DII and increased odds of fatty liver disease. However, additional prospective studies are required to further address this question.
    MeSH term(s) Humans ; Risk Factors ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/etiology ; Diet/adverse effects ; Liver Cirrhosis/etiology ; Liver Cirrhosis/complications ; Odds Ratio
    Language English
    Publishing date 2023-10-07
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.09.024
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    Zs.A 1134: Show issues Location:
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  8. Article ; Online: DDIT4 S-Nitrosylation Aids p38-MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production.

    Li, Zilong / Zhao, Qianwen / Lu, Yunjie / Zh, Yangxi

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Volume 9, Issue 13, Page(s) e2201652

    Language English
    Publishing date 2022-05-05
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202201652
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  9. Book ; Online: Design Project of an Open-Source, Low-Cost, and Lightweight Robotic Manipulator for High School Students

    Huang, Isabella / Zhao, Qianwen / Fontaine, Maxine / Wang, Long

    2023  

    Abstract: In recent years, there is an increasing interest in high school robotics extracurriculars such as robotics clubs and robotics competitions. The growing demand is a result of more ubiquitous open-source software and affordable off-the-shelf hardware kits, ...

    Abstract In recent years, there is an increasing interest in high school robotics extracurriculars such as robotics clubs and robotics competitions. The growing demand is a result of more ubiquitous open-source software and affordable off-the-shelf hardware kits, which significantly help lower the barrier for entry-level robotics hobbyists. In this project, we present an open-source, low-cost, and lightweight robotic manipulator designed and developed by a high school researcher under the guidance of a university faculty and a Ph.D. student. We believe the presented project is suitable for high school robotics research and educational activities. Our open-source package consists of mechanical design models, mechatronics specifications, and software program source codes. The mechanical design models include CAD (Computer Aided Design) files that are ready for prototyping (3D printing technology) and serve as an assembly guide accommodated with a complete bill of materials. Electrical wiring diagrams and low-level controllers are documented in detail as part of the open-source software package. The educational objective of this project is to enable high school student teams to replicate and build a robotic manipulator. The engineering experience that high school students acquire in the proposed project is full-stack, including mechanical design, mechatronics, and programming. The project significantly enriches their hands-on engineering experience in a project-based environment. Throughout this project, we discovered that the high school researcher was able to apply multidisciplinary knowledge from K-12 STEM courses to build the robotic manipulator. The researcher was able to go through a system engineering design and development process and obtain skills to use professional engineering tools including SolidWorks and Arduino microcontrollers.

    Comment: Submitted to ASEE Zone 1 Conference, under review
    Keywords Computer Science - Robotics
    Subject code 629
    Publishing date 2023-02-21
    Publishing country us
    Document type Book ; Online
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  10. Article ; Online: Effect of salting and dehydration treatments on the physicochemical and gel properties of hen and duck egg yolks, plasma and granules.

    Su, Yujie / Sun, Yuanyuan / Chang, Cuihua / Li, Junhua / Cai, Yundan / Zhao, Qianwen / Huang, Zijian / Xiong, Wen / Gu, Luping / Yang, Yanjun

    Journal of the science of food and agriculture

    2024  

    Abstract: Background: Salted hen egg yolks are less oily and less flavorful than salted duck egg yolks. However, hen eggs have a more adequate market supply and have a broader application prospect than duck eggs. In the present study, egg yolks, plasma, and ... ...

    Abstract Background: Salted hen egg yolks are less oily and less flavorful than salted duck egg yolks. However, hen eggs have a more adequate market supply and have a broader application prospect than duck eggs. In the present study, egg yolks, plasma, and granules were dehydrated by adding 1% NaCl to simulate traditional curing process of salted egg yolk. The changes in the pickling process of hen egg yolks (HEY) and duck egg yolks (DEY) plasma and granules were compared to reveal the gelation mechanism and the underlying causes of quality differences in salted HEY and DEY. Salted HEY can be compared with the changes in DEY during the pickling process to provide a theoretical basis for the quality improvement of salted HEY to salted DEY.
    Results: The results showed that both plasma and granules were involved in gel formation, but exhibited different aggregation behaviors. Based on the intermolecular forces, the HEY proteins achieved aggregation mainly through hydrophobic interactions and DEY proteins mainly through covalent binding. According to spin-spin relaxation time, HEY gels immobilized a large amount of lipid and interacted strongly with lipids. DEY gels showed much free lipid and had weak interaction with lipid. The microstructure showed that HEY proteins were easily unfolded to form a homogeneous three-dimensional gel network structure after salting, whereas heterogeneous aggregates were formed to hinder the gel development in DEY. Changes in protein secondary structure content showed that pickling can promote the transformation of the α-helices to β-sheets structure in HEY gels, whereas more α-helices structure was formed in DEY gels.
    Conclusion: The present study has demonstrated that different gelation behaviors of hen and duck egg yolk proteins (especially in plasma) through salting treatment led to the difference in the quality of salted HEY and DEY. © 2024 Society of Chemical Industry.
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.13434
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