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Article: Immunoenhancing Effects of Cyclina sinensis Pentadecapeptide through Modulation of Signaling Pathways in Mice with Cyclophosphamide-Induced Immunosuppression

Zhao, Rui / Jiang, Xiao-Xia / Zhao, Qiao-Ling / Ye, Han-Wei / Lin, Yi / Huang, Ju / Tang, Yun-Ping

Marine drugs. 2022 Aug. 31, v. 20, no. 9

2022

Abstract: Our study aimed to investigate the immune-enhancing mechanism of the pentadecapeptide (RVAPEEHPVEGRYLV) from Cyclina sinensis (SCSP) in a cyclophosphamide (CTX)-induced murine model of immunosuppression. Our results showed that SCSP treatment ... ...

Abstract	Our study aimed to investigate the immune-enhancing mechanism of the pentadecapeptide (RVAPEEHPVEGRYLV) from Cyclina sinensis (SCSP) in a cyclophosphamide (CTX)-induced murine model of immunosuppression. Our results showed that SCSP treatment significantly increased mouse body weight, immune organ indices, and the production of serum IL-6, IL-1β, and tumor necrosis factor (TNF)-α in CTX-treated mice. In addition, SCSP treatment enhanced the proliferation of splenic lymphocytes and peritoneal macrophages, as well as phagocytosis of the latter in a dose-dependent manner. Moreover, SCSP elevated the phosphorylation levels of p38, ERK, JNK, PI3K and Akt, and up-regulated IKKα, IKKβ, p50 NF-κB and p65 NF-κB protein levels, while down-regulating IκBα protein levels. Our results indicate that SCSP has immune-enhancing activities, and that it can activate the MAPK/NF-κB and PI3K/Akt pathways to enhance immunity in CTX-induced immunosuppressed mice.
Keywords	animal models ; blood serum ; body weight ; cyclophosphamide ; dose response ; immunosuppression ; interleukin-6 ; macrophages ; mice ; phagocytosis ; phosphatidylinositol 3-kinase ; phosphorylation ; tumor necrosis factors
Language	English
Dates of publication	2022-0831
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2175190-0
ISSN	1660-3397
ISSN	1660-3397
DOI	10.3390/md20090560
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparative analysis of the quantitative parameter method and elasticity color mode method for real-time shear wave elastography in the diagnosis of benign and malignant solid breast lesions.

Xue, Shan-Shan / Zhao, Qiao-Ling / Ruan, Li-Tao / Wang, Fei-Qian / Zhou, Can / Sheng, Wei

Tumori

2021 Volume 108, Issue 6, Page(s) 578–585

Abstract: Objective: To examine the performance of real-time shear wave elastography (RT-SWE) in routine clinical practice.: Methods: This was a prospective study of 500 patients. The elasticity color mode method was judged by a four-mode system. The ... ...

Abstract	Objective: To examine the performance of real-time shear wave elastography (RT-SWE) in routine clinical practice. Methods: This was a prospective study of 500 patients. The elasticity color mode method was judged by a four-mode system. The quantitative parameter method was used to measure the modulus of elasticity of the lesions. Pathologic reports were used as a gold standard to comparatively analyze the diagnostic performance of the two methods. Results: A total of 553 tumors were detected. The average mode value and the modulus of elasticity (E Conclusions: The shear wave quantitative parameter method and the elasticity color mode method showed similar performances in the diagnosis of benign and malignant breast masses. The elasticity color mode method is convenient and intuitive, whereas the quantitative parameter method can be used to objectively assess the lesions when it is difficult to score the elasticity of an image, but could not be relied on alone.
MeSH term(s)	Female ; Humans ; Elasticity Imaging Techniques/methods ; Ultrasonography, Mammary/methods ; Prospective Studies ; Sensitivity and Specificity ; Reproducibility of Results ; Breast/diagnostic imaging ; Breast/pathology ; Elasticity ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Diagnosis, Differential
Language	English
Publishing date	2021-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/03008916211048239
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Ud II Zs.43: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A 14-amino acids deletion in BmShadow results to non-moult on the 2nd instar in the bivoltine silkworm, Bombyx mori.

Zhu, Juan / Chen, Yan-Rong / Geng, Tao / Tang, Shun-Ming / Zhao, Qiao-Ling / Shen, Xing-Jia

Gene

2021 Volume 777, Page(s) 145450

Abstract: The Bombyx mori Shadow gene (BmShadow) belongs to the superfamily of cytochrome P450 genes. To elucidate the function of the BmShadow gene and its association with diapause, we employed the CRISPR/Cas9 system to knock out the BmShadow gene in the ... ...

Abstract	The Bombyx mori Shadow gene (BmShadow) belongs to the superfamily of cytochrome P450 genes. To elucidate the function of the BmShadow gene and its association with diapause, we employed the CRISPR/Cas9 system to knock out the BmShadow gene in the bivoltine strain Qiufeng. The mutant (BmShadow
MeSH term(s)	Amino Acids/metabolism ; Animals ; Bombyx/genetics ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Ecdysterone/genetics ; Ecdysterone/metabolism ; Insect Proteins/genetics ; Larva/genetics ; Molting/genetics
Chemical Substances	Amino Acids ; Drosophila Proteins ; Insect Proteins ; Ecdysterone (5289-74-7) ; Cytochrome P-450 Enzyme System (9035-51-2) ; sad protein, Drosophila (EC 1.13.-)
Language	English
Publishing date	2021-01-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2021.145450
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Article: A 14-amino acids deletion in BmShadow results to non-moult on the 2nd instar in the bivoltine silkworm, Bombyx mori

Zhu, Juan / Chen, Yan-Rong / Geng, Tao / Tang, Shun-Ming / Zhao, Qiao-ling / Shen, Xing-Jia

Gene. 2021 Apr. 20, v. 777

2021

Abstract	The Bombyx mori Shadow gene (BmShadow) belongs to the superfamily of cytochrome P450 genes. To elucidate the function of the BmShadow gene and its association with diapause, we employed the CRISPR/Cas9 system to knock out the BmShadow gene in the bivoltine strain Qiufeng. The mutant (BmShadow⁻/⁻) was obtained in G₂, exhibiting a 42-base deletion corresponded exactly to the amino acids regions from positions 155 to 168. The larvae of BmShadow⁻/⁻ cannot moult at the pre-moulting stage of the 2nd instar. When the BmShadow⁻/⁻ larvae were fed with 20E analogue at the late stage of the 2nd instar, they were rescued and developed into the 3rd instar. Rescue experiments indicated that the 20E concentration of BmShadow⁻/⁻ larvae was significantly lower than that in WT larvae, and the 20E concentration of BmShadow⁻/⁻ larvae which fed 20E analogue was restored to normal levels. Interestingly, the BmShadow⁻/⁻ larvae could not moult on the 1st instar when they hatched from eggs after being stored at 5 °C for 40 days or after hibernation, suggesting that the 20E transported from the mother was partially consumed in the diapause maintenance phase. Our study confirmed that BmShadow is involved in 20E synthesis and a 14-amino acids region from position 155 to 168 was essential for its function, also there appears to be no other compensation pathway in vivo, which offered an important potential target locus for the control of silkworm development and the biological control of agricultural and forestry pests.
Keywords	Bombyx mori ; CRISPR-Cas systems ; biological control ; cytochrome P-450 ; diapause ; forestry ; genes ; hibernation ; instars ; loci ; molting ; mutants ; silkworms
Language	English
Dates of publication	2021-0420
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2021.145450
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunoenhancing Effects of

Zhao, Rui / Jiang, Xiao-Xia / Zhao, Qiao-Ling / Ye, Han-Wei / Lin, Yi / Huang, Ju / Tang, Yun-Ping

Marine drugs

2022 Volume 20, Issue 9

Abstract: Our study aimed to investigate the immune-enhancing mechanism of the pentadecapeptide (RVAPEEHPVEGRYLV) ... ...

Abstract	Our study aimed to investigate the immune-enhancing mechanism of the pentadecapeptide (RVAPEEHPVEGRYLV) from
MeSH term(s)	Animals ; Cyclophosphamide/toxicity ; I-kappa B Kinase/metabolism ; I-kappa B Kinase/pharmacology ; Immunosuppression Therapy ; Interleukin-6 ; Mice ; NF-KappaB Inhibitor alpha/metabolism ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Interleukin-6 ; NF-kappa B ; Tumor Necrosis Factor-alpha ; NF-KappaB Inhibitor alpha (139874-52-5) ; Cyclophosphamide (8N3DW7272P) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; I-kappa B Kinase (EC 2.7.11.10)
Language	English
Publishing date	2022-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md20090560
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Article: Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older.

Bai, Xiao-Fang / Wang, Huan / Zhao, Qiao-Ling

World journal of diabetes

2015 Volume 13, Issue 3, Page(s) 251–259

Abstract: Background: Protein glycosylated hemoglobin, hemoglobin A1c (HbA1c) binds hemoglobin (Hb) in red blood cells to blood glucose. However, the relationship between Hb and HbA1c remains unclear.: Aim: To elucidate their relationship in a nondiabetic ... ...

Abstract	Background: Protein glycosylated hemoglobin, hemoglobin A1c (HbA1c) binds hemoglobin (Hb) in red blood cells to blood glucose. However, the relationship between Hb and HbA1c remains unclear. Aim: To elucidate their relationship in a nondiabetic population aged ≥ 16 years in the United States, using data from the 1999-2018 National Health and Nutrition Examination Survey. Methods: This study was based on data from 44560 adults aged ≥ 16 years, excluding those with diabetes. The relationship was estimated using a multivariate regression. We also used piecewise linear regression for subgroup analysis based on age and sex stratification and analysis of the threshold effects of Hb on HbA1c. Results: Hb and HbA1c levels were negatively correlated in the unadjusted model (β = -0.01; 95%CI: -0.01, -0.01). The correlation was significantly negative when the regression model was minimally regulated and stratified by age and sex, and remained negative when the model was further regulated (more than 10%) to identify covariates with the HbA1c level influence estimates. In subgroup analyses based on age and sex stratification, the association remained negative when the covariates were controlled. A nonlinear relationship was observed between them when the Hb levels reached the tipping point (13.2 g/dL) (adjusted odds ratio, -0.04; 95%CI: -0.05, -0.03) and when the Hb levels exceeded 13.2 g/dL (adjusted odds ratio, -0.10; 95%CI: -0.10, -0.09). Conclusion: Our study shows that normal Hb levels are negatively correlated with HbA1c in nondiabetic Americans aged ≥ 16 years.
Language	English
Publishing date	2015-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2583471-X
ISSN	1948-9358
ISSN	1948-9358
DOI	10.4239/wjd.v13.i3.251
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Article: Mixotrophic cultivation of microalgae coupled with anaerobic hydrolysis for sustainable treatment of municipal wastewater in a hybrid system of anaerobic membrane bioreactor and membrane photobioreactor

Gao, Feng / Yang, Zi-Yan / Zhao, Qiao-Ling / Chen, Dong-Zhi / Li, Chen / Liu, Mei / Yang, Jin-Sheng / Liu, Jun-Zhi / Ge, Ya-Ming / Chen, Jian-Meng

Bioresource technology. 2021 Oct., v. 337

2021

Abstract: This study investigated the possibility of coupling anaerobic hydrolysis in an anaerobic membrane bioreactor (AnMBR) with mixotrophic microalgae cultivation in a membrane photobioreactor (MPBR) for the sustainable treatment of municipal wastewater. Using ...

Abstract	This study investigated the possibility of coupling anaerobic hydrolysis in an anaerobic membrane bioreactor (AnMBR) with mixotrophic microalgae cultivation in a membrane photobioreactor (MPBR) for the sustainable treatment of municipal wastewater. Using the hydrolyzed wastewater discharged from AnMBR, Chlorella pyrenoidosa in MPBR grew in a mixotrophic mode and realized rapid growth. During the stable operation, MPBR achieved average carbon capture rate of 42.82 mg L⁻¹ d⁻¹ and algal lipid production rate of 19.66 mg L⁻¹ d⁻¹. The average reduction in TN, TP, and TOC during stable operation was 96.7%, 98.0%, and 95.9%, respectively. Mass balance analysis showed that the overall system captured 14.76 mg of carbon from the atmosphere per liter of wastewater treated. Therefore, this AnMBR-MPBR hybrid system simultaneously realized advanced treatment of municipal wastewater, efficient production of algal lipid, and carbon capture from atmosphere, and thus has a good potential in the sustainable treatment of municipal wastewater.
Keywords	Chlorella pyrenoidosa ; carbon ; hydrolysis ; lipids ; membrane bioreactors ; microalgae ; municipal wastewater ; photobioreactors
Language	English
Dates of publication	2021-10
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2021.125457
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Article ; Online: Mixotrophic cultivation of microalgae coupled with anaerobic hydrolysis for sustainable treatment of municipal wastewater in a hybrid system of anaerobic membrane bioreactor and membrane photobioreactor.

Gao, Feng / Yang, Zi-Yan / Zhao, Qiao-Ling / Chen, Dong-Zhi / Li, Chen / Liu, Mei / Yang, Jin-Sheng / Liu, Jun-Zhi / Ge, Ya-Ming / Chen, Jian-Meng

Bioresource technology

2021 Volume 337, Page(s) 125457

Abstract	This study investigated the possibility of coupling anaerobic hydrolysis in an anaerobic membrane bioreactor (AnMBR) with mixotrophic microalgae cultivation in a membrane photobioreactor (MPBR) for the sustainable treatment of municipal wastewater. Using the hydrolyzed wastewater discharged from AnMBR, Chlorella pyrenoidosa in MPBR grew in a mixotrophic mode and realized rapid growth. During the stable operation, MPBR achieved average carbon capture rate of 42.82 mg L
MeSH term(s)	Anaerobiosis ; Biomass ; Chlorella ; Hydrolysis ; Microalgae ; Photobioreactors ; Waste Water
Chemical Substances	Waste Water
Language	English
Publishing date	2021-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2021.125457
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Article: Synthesis of polymethylene-b-poly(vinyl acetate) block copolymer via visible light induced radical polymerization and its application

Wang, HeYing / Xu, Fang / Cui, Kun / Zhang, Hao / Huang, Jin / Zhao, QiaoLing / Jiang, Tao / Ma, Zhi

RSC advances. 2017 Sept. 01, v. 7, no. 67

2017

Abstract: New well-defined amphiphilic polymethylene-b-poly(vinyl acetate) (PM-b-PVAc) diblock copolymers were synthesized via a tandem strategy combining polyhomologation of ylides, chain-end functionalization and a visible light induced degenerative iodine ... ...

Abstract	New well-defined amphiphilic polymethylene-b-poly(vinyl acetate) (PM-b-PVAc) diblock copolymers were synthesized via a tandem strategy combining polyhomologation of ylides, chain-end functionalization and a visible light induced degenerative iodine transfer polymerization using decacarbonyldimanganese (Mn2(CO)10). Firstly, an iodo terminated polymethylene (PM-I) was prepared by polyhomologation of ylides initiated by a new organic borane based on catecholborane followed by functional group transformation using iodine as the end-capping reagent. Then, a series of amphiphilic PM-b-PVAc diblock copolymers with controlled molecular weight (Mn = 5530–17 020 g mol−1) and relatively narrow molecular weight distribution (Đ = 1.31–1.45) were obtained efficiently through a visible light induced degenerative iodine transfer polymerization of vinyl acetate (VAc) using PM-I as macroinitiator in the presence of Mn2(CO)10 under weak visible light irradiation at 40 °C. The micelles of such an amphiphilic diblock copolymer formed in tetrahydrofuran were observed by transmission electron microscopy (TEM). Moreover, the fabrication of porous films using PM-b-PVAc diblock copolymers via a static breath-figure process was investigated.
Keywords	composite polymers ; iodine ; irradiation ; light ; micelles ; moieties ; molecular weight ; polymerization ; tetrahydrofuran ; transmission electron microscopy ; vinyl acetate
Language	English
Dates of publication	2017-0901
Size	p. 42484-42490.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c7ra06908a
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Article ; Online: A triptycene-based microporous organic polymer bearing tridentate ligands and its application in Suzuki-Miyaura cross-coupling reaction.

Wen, Qiang / Zhou, Tian-You / Zhao, Qiao-Ling / Fu, Jie / Ma, Zhi / Zhao, Xin

Macromolecular rapid communications

2015 Volume 36, Issue 4, Page(s) 413–418

Abstract: A triptycene-based microporous organic polymer (MOP) in which 2,6-bis(benzimidazol-2-yl)pyridine (bbp) is incorporated as linkage and coordination site is designed and synthesized. Pd(II) ions are further immobilized in this MOP through the coordination ... ...

Abstract	A triptycene-based microporous organic polymer (MOP) in which 2,6-bis(benzimidazol-2-yl)pyridine (bbp) is incorporated as linkage and coordination site is designed and synthesized. Pd(II) ions are further immobilized in this MOP through the coordination interactions between Pd(II) ion and nitrogen atoms of bbp. The resulting material shows high stability and exhibits excellent heterogeneously catalytic activity for the Suzuki-Miyaura cross-coupling reaction. Its high efficiency can be maintained after being reused for a number of cycles.
MeSH term(s)	Anthracenes/chemistry ; Catalysis ; Ligands ; Palladium/chemistry ; Photoelectron Spectroscopy ; Polymers/chemical synthesis ; Polymers/chemistry ; Porosity
Chemical Substances	Anthracenes ; Ligands ; Polymers ; Palladium (5TWQ1V240M) ; triptycene (CL32869MEP)
Language	English
Publishing date	2015-02
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1475027-2
ISSN	1521-3927 ; 1022-1336
ISSN (online)	1521-3927
ISSN	1022-1336
DOI	10.1002/marc.201400593
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