Article ; Online: Remnant Cholesterol and Common Carotid Artery Intima-Media Thickness in Community Population with Normal Low-Density Lipoprotein Cholesterol.
Cerebrovascular diseases (Basel, Switzerland)
2023 Volume 52, Issue 4, Page(s) 487–494
Abstract: Introduction: Remnant cholesterol is a risk factor for cardiovascular disease, especially when low-density lipoprotein cholesterol (LDL-C) levels are normal. However, there are few studies on the relationship between remnant cholesterol and subclinical ... ...
| Abstract | Introduction: Remnant cholesterol is a risk factor for cardiovascular disease, especially when low-density lipoprotein cholesterol (LDL-C) levels are normal. However, there are few studies on the relationship between remnant cholesterol and subclinical atherosclerosis. Common carotid artery intima-media thickness (cIMT) is an imaging marker of subclinical atherosclerosis. This study aimed to investigate the relationship between remnant cholesterol and cIMT in a community population with normal LDL-C. Methods: This study is a retrospective analysis; 1,101 community population with available carotid artery imaging and fasting lipid data with LDL-C <4.1 mmol/L were included in this analysis. Remnant cholesterol was calculated as total cholesterol minus LDL-C minus high-density lipoprotein cholesterol. Abnormal cIMT was defined as maximum cIMT value ≥1 mm. Logistic regression was used to assess the relationships between remnant cholesterol levels and abnormal cIMT. Results: As the remnant cholesterol level increased from the lowest to the highest quartile, the rate of abnormal cIMT increased from 24.5% to 38.6% (p trend <0.001) in the community population with normal LDL-C level. In the unadjusted model, the odds ratios (ORs, 95% confidence intervals) in the highest quartile group were 1.937 (1.338-2.803) for abnormal cIMT compared with the lowest quartile. The multivariable-adjusted ORs (95% confidence intervals) for the highest versus lowest quartile of remnant cholesterol were 2.132 (1.420-3.202) for abnormal cIMT. Conclusion: Elevated fasting remnant cholesterol levels were positively associated with abnormal cIMT in community population with normal LDL-C levels. Remnant cholesterol may be an important indicator of risk stratification in community population with normal LDL-C level. |
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| MeSH term(s) | Humans ; Carotid Intima-Media Thickness ; Cholesterol, LDL ; Retrospective Studies ; Cholesterol ; Atherosclerosis ; Carotid Artery, Common/diagnostic imaging ; Risk Factors ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/epidemiology ; Cholesterol, HDL |
| Chemical Substances | Cholesterol, LDL ; Cholesterol (97C5T2UQ7J) ; Cholesterol, HDL |
| Language | English |
| Publishing date | 2023-02-06 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1069462-6 |
| ISSN | 1421-9786 ; 1015-9770 |
| ISSN (online) | 1421-9786 |
| ISSN | 1015-9770 |
| DOI | 10.1159/000527704 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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