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Article ; Online: Phytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT

Zhao, Qiulong / Liu, Jin / Chen, Li / Gao, Zhao / Lin, Muhai / Wang, Yun / Xiao, Zhe / Chen, Yi / Huang, Xi

2024 Volume 323, Page(s) 117703

Abstract: Ethnopharmacological relevance: Fructus Aurantii (FA), a well-known phytomedicine, has been employed to evoke antidepressant and prokinetic multi-functions. Therein, systematically identifying bioactive components and the referred mechanism is essential ...

Abstract	Ethnopharmacological relevance: Fructus Aurantii (FA), a well-known phytomedicine, has been employed to evoke antidepressant and prokinetic multi-functions. Therein, systematically identifying bioactive components and the referred mechanism is essential for FA. Aim of the study: This study was planned to answer "2 W" (What and Why), such as which components and pathways contribute to FA's multi-functions. We aimed to identify bioactive compounds as the key for opening the lock of FA's multi-functions, and the molecule mechanisms are their naturally matched lock cylinder. Materials and methods: The phytochemical content of FA extract was determined, and the compounds were identified in rats pretreated with FA using liquid chromatography with mass spectrometry (LC-MS). The contribution strategy was used to assess bioactive compounds' efficacy (doses = their content in FA) in model rats with the mechanism. The changes in functional brain regions were determined via 7.0 T functional magnetic resonance imaging-blood oxygen level-dependent (fMRI-BOLD). Result: Eight phytochemicals' content was detected, and merely six components were identified in rats in vivo. Meranzin hydrate + hesperidin (MH), as the primary contributor of FA, exerted antidepressant and prokinetic effects (improvement of indexes for immobility time, gastric emptying, intestinal transit, CRH, ghrelin, ACTH, DA, NA, 5-HT, CORT, and 5-HT Conclusion: Absorbed MH accounts for FA's anti-depressant and prokinetic efficacy in acutely-stressed rats, primarily via 5-HT
MeSH term(s)	Rats ; Animals ; Rats, Sprague-Dawley ; Serotonin ; Receptors, Ghrelin ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Drugs, Chinese Herbal/pharmacology
Chemical Substances	Serotonin (333DO1RDJY) ; Receptors, Ghrelin ; Antidepressive Agents ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117703
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Article: Pharmacokinetic Study of Coadministration with Cefuroxime Sodium for Injection Influencing ReDuNing Injection-Derived Seven Phytochemicals and Nine Metabolites in Rats

Zhao, Qiulong / Wang, Chunxue / Cheng, Jiaxin / Yan, Hui / Wang, Ling / Qian, Dawei / Duan, Jinao

Journal of Analytical Methods in Chemistry (Online). 2022 July 2, v. 2022

2022

Abstract: According to the sixth edition of China’s “New Coronavirus Diagnosis and Treatment Plan (NCDTP),” ReDuNing injection (RDN) was firstly introduced to treat severe and critical COVID-19, whereas its combination with broad-spectrum antibiotics was suggested ...

Abstract	According to the sixth edition of China’s “New Coronavirus Diagnosis and Treatment Plan (NCDTP),” ReDuNing injection (RDN) was firstly introduced to treat severe and critical COVID-19, whereas its combination with broad-spectrum antibiotics was suggested to take with extreme caution and full reasons. Therefore, we aim to describe the pharmacokinetics of seven active phytochemicals and semiquantification of nine relevant metabolites in ReDuNing injection (RDN) after combining with cefuroxime sodium (CNa) for injection in rat plasma. Male Sprague–Dawley rats were randomly assigned to six groups, and they were intravenously administered, respectively, with different prescriptions of RDN (2 mL/kg) and CNa (225 mg/kg). At different time points (0.03, 0.08, 0.17, 0.24, 0.33, 0.50, 0.67, 1, and 6 h) after administration, the drug concentrations of iridoids glycosides, organic acids, and metabolites in rat plasma were determined using ultrahigh-pressure liquid chromatography coupled with linear ion rap-orbitrap tandem mass spectrometry (UHPLC–LTQ–Orbitrap–MS), and main pharmacokinetic parameters were estimated by noncompartment model. The results showed that there were differences in pharmacokinetic parameters, AUC₍₀₋ₜ₎, T₁/₂, Cₘₐₓ, CL of iridoids glycosides, and organic acids, after the intravenous administration of the different combinations of RDN and CNa. Moreover, different combinations of the injections also resulted in different curves of relative changes of each metabolite. The obtained results suggested that RDN and CNa existed pharmacokinetic drug–herb interactions in rats. The findings not only lay the foundation for evaluating the safety of RDN injection combined with CNa but also make contributions to clinically applying RDN injection combined with CNa, which works potentially against severe forms of COVID-19.
Keywords	COVID-19 infection ; Orthocoronavirinae ; cefuroxime ; chemistry ; glycosides ; intravenous injection ; iridoids ; liquid chromatography ; males ; metabolites ; models ; pharmacokinetics ; phytochemicals ; rats ; sodium ; tandem mass spectrometry ; China
Language	English
Dates of publication	2022-0702
Publishing place	Hindawi
Document type	Article
ZDB-ID	2654178-6
ISSN	2090-8873 ; 2090-8865
ISSN (online)	2090-8873
ISSN	2090-8865
DOI	10.1155/2022/2565494
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Article ; Online: Letter to the Editor in response to the articles 'Lianhuaqingwen exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2)' and 'Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway.'

Huang, Xi / Zhao, Qiulong / Xia, Liang / Shi, Shaoqi

Pharmacological research

2020 Volume 163, Page(s) 105289

MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19 ; Drugs, Chinese Herbal ; Humans ; NF-kappa B/metabolism ; SARS-CoV-2 ; Signal Transduction/drug effects
Chemical Substances	Anti-Inflammatory Agents ; Antiviral Agents ; Drugs, Chinese Herbal ; NF-kappa B ; lianhuaqingwen
Keywords	covid19
Language	English
Publishing date	2020-11-13
Publishing country	Netherlands
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2020.105289
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Zs.A 721: Show issues

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Article: Pharmacokinetic Study of Coadministration with Cefuroxime Sodium for Injection Influencing ReDuNing Injection-Derived Seven Phytochemicals and Nine Metabolites in Rats.

Zhao, Qiulong / Wang, Chunxue / Cheng, Jiaxin / Yan, Hui / Wang, Ling / Qian, Dawei / Duan, Jinao

Journal of analytical methods in chemistry

2022 Volume 2022, Page(s) 2565494

Abstract: According to the sixth edition of China's "New Coronavirus Diagnosis and Treatment Plan (NCDTP)," ReDuNing injection (RDN) was firstly introduced to treat severe and critical COVID-19, whereas its combination with broad-spectrum antibiotics was suggested ...

Abstract	According to the sixth edition of China's "New Coronavirus Diagnosis and Treatment Plan (NCDTP)," ReDuNing injection (RDN) was firstly introduced to treat severe and critical COVID-19, whereas its combination with broad-spectrum antibiotics was suggested to take with extreme caution and full reasons. Therefore, we aim to describe the pharmacokinetics of seven active phytochemicals and semiquantification of nine relevant metabolites in ReDuNing injection (RDN) after combining with cefuroxime sodium (CNa) for injection in rat plasma. Male Sprague-Dawley rats were randomly assigned to six groups, and they were intravenously administered, respectively, with different prescriptions of RDN (2 mL/kg) and CNa (225 mg/kg). At different time points (0.03, 0.08, 0.17, 0.24, 0.33, 0.50, 0.67, 1, and 6 h) after administration, the drug concentrations of iridoids glycosides, organic acids, and metabolites in rat plasma were determined using ultrahigh-pressure liquid chromatography coupled with linear ion rap-orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS), and main pharmacokinetic parameters were estimated by noncompartment model. The results showed that there were differences in pharmacokinetic parameters, AUC
Language	English
Publishing date	2022-07-02
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2654178-6
ISSN	2090-8873 ; 2090-8865
ISSN (online)	2090-8873
ISSN	2090-8865
DOI	10.1155/2022/2565494
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Article ; Online: Absorbed Bioactive Compounds Replicate Guanxin II-Induced Endothelium-Associated in/ex vivo Vasodilation.

Xu, Min / Liu, Hao / Su, Meng-Qing / Li, Lan / Yu, Ai-Ling / Chen, Ken / Huang, Yun-Ke / Zhao, Qiu-Long / Huang, Wen-Ya / Huang, Xi

Chinese journal of integrative medicine

2024 Volume 30, Issue 5, Page(s) 387–397

Abstract: Objective: To develop an interference-free and rapid method to elucidate Guanxin II (GX II)'s representative vasodilator absorbed bioactive compounds (ABCs) among enormous phytochemicals.: Methods: The contents of ferulic acid, tanshinol, and ... ...

Abstract	Objective: To develop an interference-free and rapid method to elucidate Guanxin II (GX II)'s representative vasodilator absorbed bioactive compounds (ABCs) among enormous phytochemicals. Methods: The contents of ferulic acid, tanshinol, and hydroxysafflor yellow A (FTA) in GX II/rat serum after the oral administration of GX II (30 g/kg) were detected using ultra-performance liquid chromatography-mass spectrometry. Totally 18 rats were randomly assigned to the control group (0.9% normal saline), GX II (30 g/kg) and FTA (5, 28 and 77 mg/kg) by random number table method. Diastolic coronary flow velocity-time integral (VTI), i.e., coronary flow or coronary flow-mediated dilation (CFMD), and endothelium-intact vascular tension of isolated aortic rings were measured. After 12 h of exposure to blank medium or 0.5 mmol/L H Results: PGSDS effectively eliminates false responses caused by crude GX II preparations. When doses equaled the contents in GX II/its post-dose serum, FTA accounted for 98.17% of GX II -added CFMD and 92.99% of PGSDS-reduced vascular tension. In ECs, FTA/PGSDS was found to have significant antioxidant (lower MDA and higher SOD, P<0.01) and endothelial function-protective (lower VEGF, ET-1, P<0.01) effects. The increases in aortic relaxation, endothelial NO levels and phosphorylated PI3K/Akt/eNOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester (L-NA, eNOS inhibitor) and wortmannin (PI3K/AKT inhibitor), respectively, indicating an endothelium-dependent vasodilation via the PI3K/AKT-eNOS pathway (P<0.01). Conclusion: This study provides a strategy for rapidly and precisely elucidating GX II's representative in/ex vivo cardioprotective absorbed bioactive compounds (ABCs)-FTA, suggesting its potential in advancing precision ethnomedicine.
MeSH term(s)	Animals ; Vasodilation/drug effects ; Male ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Rats, Sprague-Dawley ; Rats ; Proto-Oncogene Proteins c-akt/metabolism ; Nitric Oxide/metabolism ; Vasodilator Agents/pharmacology ; Vasodilator Agents/pharmacokinetics ; Coumaric Acids/pharmacology ; Coumaric Acids/pharmacokinetics ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Nitric Oxide Synthase Type III/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Nitric Oxide (31C4KY9ESH) ; Vasodilator Agents ; Coumaric Acids ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
Language	English
Publishing date	2024-02-02
Publishing country	China
Document type	Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-024-3651-6
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Zs.A 5823: Show issues

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Article: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress

Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

RSC advances. 2022 Feb. 04, v. 12, no. 8

2022

Abstract: Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and ... ...

Abstract	Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized via UFLC-Q-TOF MS/MS and UFLC-QQQ MS/MS. Then, the 12 major absorbed Cs in the depressed rats after oral XYSJW administration were chosen to further investigate its pharmacokinetic profile by UFLC-QQQ MS/MS. This study provides a systematic approach for the rapid and qualitative analysis of absorbed Cs in depressed rats and investigating the pharmacokinetics of XYSJW. More importantly, our work provides key information on the chemical and pharmacokinetic profiles of XYSJW in vitro and in vivo, which may benefit its therapeutic efficacy and further pharmacological studies involving this formulation.
Keywords	Oriental traditional medicine ; anorexia ; electrospray ionization mass spectrometry ; hospitals ; liquid chromatography ; pharmacokinetics ; qualitative analysis ; tandem mass spectrometry ; therapeutics
Language	English
Dates of publication	2022-0204
Size	p. 4455-4468.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d1ra08778a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress.

Shan, Chenxiao / Li, Jia / Sun, Bo / Zhou, Runze / Xu, Min / Zhao, Qiulong / Ren, Ping / Wen, Hongmei / Huang, Xi

RSC advances

2022 Volume 12, Issue 8, Page(s) 4455–4468

Abstract	Xiao-Yao-San-Jia-Wei (XYSJW) is a commonly prescribed formulation for depression and anorexia in the Jiang Su Province Hospital of Chinese Medicine. Unfortunately, the proper dosage of this formulation is still unclear due to its limited chemical and pharmacokinetic profiles. Thus, in the present study, a sensitive, precise, and rapid procedure for the identification of absorbed compounds (Cs) in the plasma of depressed rats together with a pharmacokinetic analysis was established with the help of ultra-flow liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF MS/MS) and ultra-flow liquid chromatography coupled with electrospray ionization triple quadrupole tandem mass spectrometry (UFLC-QQQ MS/MS). Based on the characteristic fragmentation, neutral loss, mass defect filter, relevant literature and reference standards, 225 Cs in the XYSJW extract and 20 Cs in the plasma of the depressed rats were tentatively recognized
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra08778a
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Article ; Online: Quantitative analysis of nutrients for nucleosides, nucleobases, and amino acids hidden behind five distinct regions-derived Poria cocos using ultra-performance liquid chromatography coupled with triple-quadrupole linear ion-trap tandem mass spectrometry.

Zhao, Qiulong / Bian, Xiaokun / Shan, Chenxiao / Cheng, Jiaxin / Wang, Chunxue / Xu, Yi / Xu, Min / Yan, Hui / Qian, Dawei / Duan, Jinao

Journal of separation science

2022 Volume 45, Issue 22, Page(s) 4039–4051

Abstract: Poria cocos is an edible fungus used as a health product and traditional Chinese medicinal preparation. Nevertheless, little is known about its nutrients. In this study, ultra-high performance liquid chromatography coupled with triple-quadrupole linear ... ...

Abstract	Poria cocos is an edible fungus used as a health product and traditional Chinese medicinal preparation. Nevertheless, little is known about its nutrients. In this study, ultra-high performance liquid chromatography coupled with triple-quadrupole linear ion-trap tandem mass spectrometry was conducted to quantify nucleosides, nucleobases, and amino acids in 32 batches of Poria cocos samples collected from Anhui, Sichuan, Hubei, Hunan, and Guizhou. Subsequently, the linearity, precision, repeatability, stability, and recovery of our methods were validated. Samples from different regions were clearly separated by partial least squares discriminant analysis and cluster analysis. Our results suggested that Poria cocos samples from different geographical environments differed in nucleosides, nucleobases, and amino acids. The plot of variable importance for projection disclosed differential compositions of L-Leucine, Uridine, L-Asparagine, L-Glutamine, L-phenylalanine, L-Ornithine monohydrochloride, L-Hydroxyproline, Taurine, and Inosine in Poria cocos from five regions. We found the highest content of total analytes, total amino acids, and total non-essential amino acids in Poria cocos from Anhui, total essential amino acids in the Sichuan samples, and total nucleosides in the Hunan samples. Overall, we determined the content of Poria cocos-derived nucleosides, nucleobases, and amino acids, providing the foothold for further chemical mining and use of Poria cocos.
MeSH term(s)	Wolfiporia/chemistry ; Tandem Mass Spectrometry/methods ; Nucleosides/analysis ; Amino Acids/analysis ; Principal Component Analysis ; Chromatography, High Pressure Liquid/methods ; Nutrients/analysis ; Poria/chemistry
Chemical Substances	Nucleosides ; Amino Acids
Language	English
Publishing date	2022-09-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202200516
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Article ; Online: Letter to the Editor in response to the articles ‘Lianhuaqingwen exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2)’ and ‘Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway.’

Huang, Xi / Zhao, Qiulong / Xia, Liang / Shi, Shaoqi

Pharmacological Research

2020 , Page(s) 105289

Keywords	Pharmacology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	1043-6618
DOI	10.1016/j.phrs.2020.105289
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quantitative analysis of nutrients for nucleosides, nucleobases, and amino acids hidden behind five distinct regions‐derived Poria cocos using ultra‐performance liquid chromatography coupled with triple‐quadrupole linear ion‐trap tandem mass spectrometry

Zhao, Qiulong / Bian, Xiaokun / Shan, Chenxiao / Cheng, Jiaxin / Wang, Chunxue / Xu, Yi / Xu, Min / Yan, Hui / Qian, Dawei / Duan, Jinao

Journal of Separation Science. 2022 Nov., v. 45, no. 22 p.4039-4051

2022

Abstract: Poria cocos is an edible fungus used as a health product and traditional Chinese medicinal preparation. Nevertheless, little is known about its nutrients. In this study, ultra‐high performance liquid chromatography coupled with triple‐quadrupole linear ... ...

Abstract	Poria cocos is an edible fungus used as a health product and traditional Chinese medicinal preparation. Nevertheless, little is known about its nutrients. In this study, ultra‐high performance liquid chromatography coupled with triple‐quadrupole linear ion‐trap tandem mass spectrometry was conducted to quantify nucleosides, nucleobases, and amino acids in 32 batches of Poria cocos samples collected from Anhui, Sichuan, Hubei, Hunan, and Guizhou. Subsequently, the linearity, precision, repeatability, stability, and recovery of our methods were validated. Samples from different regions were clearly separated by partial least squares discriminant analysis and cluster analysis. Our results suggested that Poria cocos samples from different geographical environments differed in nucleosides, nucleobases, and amino acids. The plot of variable importance for projection disclosed differential compositions of L‐Leucine, Uridine, L‐Asparagine, L‐Glutamine, L‐phenylalanine, L‐Ornithine monohydrochloride, L‐Hydroxyproline, Taurine, and Inosine in Poria cocos from five regions. We found the highest content of total analytes, total amino acids, and total non‐essential amino acids in Poria cocos from Anhui, total essential amino acids in the Sichuan samples, and total nucleosides in the Hunan samples. Overall, we determined the content of Poria cocos‐derived nucleosides, nucleobases, and amino acids, providing the foothold for further chemical mining and use of Poria cocos.
Keywords	Poria ; asparagine ; chemical species ; cluster analysis ; discriminant analysis ; edible fungi ; glutamine ; inosine ; leucine ; nucleobases ; phenylalanine ; quantitative analysis ; separation ; tandem mass spectrometry ; taurine ; ultra-performance liquid chromatography ; uridine ; China
Language	English
Dates of publication	2022-11
Size	p. 4039-4051.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202200516
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