LIVIVO - Search results -

Search results

Result 1 - 10 of total 43

Search options

Article ; Online: Emodin Blocks mPTP Opening and Improves LPS-Induced HMEC-1 Cell Injury by Upregulation of ATP5A1.

Di, Tietao / He, Limin / Shi, Qing / Chen, Lu / Zhu, Lei / Zhao, Sisi / Zhang, Chunling

2024 Volume 21, Issue 5, Page(s) e202301916

Abstract: Background: Emodin has been shown to exert anti-inflammatory and cytoprotective effects. Our study aimed to identify a novel anti-inflammatory mechanism of emodin.: Methods: An LPS-induced model of microvascular endothelial cell (HMEC-1) injury was ... ...

Abstract	Background: Emodin has been shown to exert anti-inflammatory and cytoprotective effects. Our study aimed to identify a novel anti-inflammatory mechanism of emodin. Methods: An LPS-induced model of microvascular endothelial cell (HMEC-1) injury was constructed. Cell proliferation was examined using a CCK-8 assay. The effects of emodin on reactive oxygen species (ROS), cell migration, the mitochondrial membrane potential (MMP), and the opening of the mitochondrial permeability transition pore (mPTP) were evaluated. Actin-Tracker Green was used to examine the relationship between cell microfilament reconstruction and ATP5A1 expression. The effects of emodin on the expression of ATP5A1, NALP3, and TNF-α were determined. After treatment with emodin, ATP5A1 and inflammatory factors (TNF-α, IL-1, IL-6, IL-13 and IL-18) were examined by Western blotting. Results: Emodin significantly increased HMEC-1 cell proliferation and migration, inhibited the production of ROS, increased the mitochondrial membrane potential, and blocked the opening of the mPTP. Moreover, emodin could increase ATP5A1 expression, ameliorate cell microfilament remodeling, and decrease the expression of inflammatory factors. In addition, when ATP5A1 was overexpressed, the regulatory effect of emodin on inflammatory factors was not significant. Conclusion: Our findings suggest that emodin can protect HMEC-1 cells against inflammatory injury. This process is modulated by the expression of ATP5A1.
MeSH term(s)	Emodin/pharmacology ; Emodin/chemistry ; Lipopolysaccharides/pharmacology ; Humans ; Cell Proliferation/drug effects ; Up-Regulation/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Cell Movement/drug effects ; Reactive Oxygen Species/metabolism ; Mitochondrial Proton-Translocating ATPases/metabolism ; Mitochondrial Permeability Transition Pore/metabolism ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Membrane Transport Proteins/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Cell Line ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301916
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- Full text online
- Order with fees

Article: Application and the Effect of the Triple Prerehabilitation Nursing Model in the Perioperative Period of Knee Arthroplasty in Diabetic Patients.

Zhao, Sisi / Peng, Lingjun / Mo, Tingting / Ruan, Qianzi

publication RETRACTED

Emergency medicine international

2022 Volume 2022, Page(s) 1858631

Abstract: Objective: The aim of the study was to explore the application and the effect of the triple prerehabilitation nursing model in the perioperative period of knee arthroplasty in diabetic patients.: Methods: The prospectively included 60 patients with ... ...

Abstract	Objective: The aim of the study was to explore the application and the effect of the triple prerehabilitation nursing model in the perioperative period of knee arthroplasty in diabetic patients. Methods: The prospectively included 60 patients with diabetes who underwent total knee replacement were admitted from August 2021 to April 2022 and were divided into 2 groups according to the (1 : 1) ratio. The control group was mainly given routine nursing care. On the basis of the control group, the observation group received triple prerehabilitation nursing. The postoperative knee flexion, hospital for the special surgery knee score (HSS), the daily living ability (Barthel) score, the modified fall efficacy scale (MFES) score, the recovery of the lower-limb muscle strength, and the incidence of complications were compared between the two groups. Results: The knee flexion degree and lower-limb muscle recovery of the observation group were better than those of the control group at 3 d, 7 d, and 14 d after operation ( Conclusion: The triple prerehabilitation nursing care for diabetic patients undergoing total knee replacement can promote the recovery of limb function.
Language	English
Publishing date	2022-08-12
Publishing country	Egypt
Document type	Journal Article ; Retracted Publication
ZDB-ID	2596429-X
ISSN	2090-2859 ; 2090-2840
ISSN (online)	2090-2859
ISSN	2090-2840
DOI	10.1155/2022/1858631
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: A 3D Compensation Method for the Systematic Errors of Kinect V2

Li, Chang / Li, Bingrui / Zhao, Sisi

Remote Sensing. 2021 Nov. 15, v. 13, no. 22

2021

Abstract: To reduce the 3D systematic error of the RGB-D camera and improve the measurement accuracy, this paper is the first to propose a new 3D compensation method for the systematic error of a Kinect V2 in a 3D calibration field. The processing of the method is ...

Abstract	To reduce the 3D systematic error of the RGB-D camera and improve the measurement accuracy, this paper is the first to propose a new 3D compensation method for the systematic error of a Kinect V2 in a 3D calibration field. The processing of the method is as follows. First, the coordinate system between the RGB-D camera and 3D calibration field is transformed using 3D corresponding points. Second, the inliers are obtained using the Bayes SAmple Consensus (BaySAC) algorithm to eliminate gross errors (i.e., outliers). Third, the parameters of the 3D registration model are calculated by the iteration method with variable weights that can further control the error. Fourth, three systematic error compensation models are established and solved by the stepwise regression method. Finally, the optimal model is selected to calibrate the RGB-D camera. The experimental results show the following: (1) the BaySAC algorithm can effectively eliminate gross errors; (2) the iteration method with variable weights could better control slightly larger accidental errors; and (3) the 3D compensation method can compensate 91.19% and 61.58% of the systematic error of the RGB-D camera in the depth and 3D directions, respectively, in the 3D control field, which is superior to the 2D compensation method. The proposed method can control three types of errors (i.e., gross errors, accidental errors and systematic errors) and model errors and can effectively improve the accuracy of depth data.
Keywords	algorithms ; calibration ; cameras ; models ; regression analysis
Language	English
Dates of publication	2021-1115
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs13224583
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: A Ca

Piao, Yinglan / Li, Shizhen / Chen, Yiduo / Zhao, Sisi / Piao, Zhongyun / Wang, Haiping

Horticulture research

2023 Volume 11, Issue 1, Page(s) uhad261

Abstract: Clubroot disease caused ... ...

Abstract	Clubroot disease caused by
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article
ISSN	2662-6810
ISSN	2662-6810
DOI	10.1093/hr/uhad261
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Identification of Key Genes and Pathways in the Hippocampus after Traumatic Brain Injury: Bioinformatics Analysis and Experimental Validation.

Zeng, Hai / Zhao, Sisi / Pang, Zhao / Wang, Shiqi / Cao, Luxi / Zhang, Yimin

Journal of integrative neuroscience

2023 Volume 22, Issue 2, Page(s) 44

Abstract: Background: Traumatic brain injury (TBI) is a common brain injury with a high morbidity and mortality. The complex injury cascade triggered by TBI can result in permanent neurological dysfunction such as cognitive impairment. In order to provide new ... ...

Abstract	Background: Traumatic brain injury (TBI) is a common brain injury with a high morbidity and mortality. The complex injury cascade triggered by TBI can result in permanent neurological dysfunction such as cognitive impairment. In order to provide new insights for elucidating the underlying molecular mechanisms of TBI, this study systematically analyzed the transcriptome data of the rat hippocampus in the subacute phase of TBI. Methods: Two datasets (GSE111452 and GSE173975) were downloaded from the Gene Expression Omnibus (GEO) database. Systematic bioinformatics analyses were performed, including differentially expressed genes (DEGs) analysis, gene set enrichment analysis (GSEA), Gene Ontology (GO) enrichment analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, protein-protein interaction (PPI) network construction, and hub gene identification. In addition, hematoxylin and eosin (HE), Nissl, and immunohistochemical staining were performed to assess the injured hippocampus in a TBI rat model. The hub genes identified by bioinformatics analyses were verified at the mRNA expression level. Results: A total of 56 DEGs were shared in the two datasets. GSEA results suggested significant enrichment in the MAPK and PI3K/Akt pathways, focal adhesion, and cellular senescence. GO and KEGG analyses showed that the common DEGs were predominantly related to immune and inflammatory processes, including antigen processing and presentation, leukocyte-mediated immunity, adaptive immune response, lymphocyte-mediated immunity, phagosome, lysosome, and complement and coagulation cascades. A PPI network of the common DEGs was constructed, and 15 hub genes were identified. In the shared DEGs, we identified two transcription co-factors and 15 immune-related genes. The results of GO analysis indicated that these immune-related DEGs were mainly enriched in biological processes associated with the activation of multiple cells such as microglia, astrocytes, and macrophages. HE and Nissl staining results demonstrated overt hippocampal neuronal damage. Immunohistochemical staining revealed a marked increase in the number of Iba1-positive cells in the injured hippocampus. The mRNA expression levels of the hub genes were consistent with the transcriptome data. Conclusions: This study highlighted the potential pathological processes in TBI-related hippocampal impairment. The crucial genes identified in this study may serve as novel biomarkers and therapeutic targets, accelerating the pace of developing effective treatments for TBI-related hippocampal impairment.
MeSH term(s)	Animals ; Rats ; Phosphatidylinositol 3-Kinases ; Brain Injuries, Traumatic/genetics ; Computational Biology/methods ; Hippocampus ; RNA, Messenger
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; RNA, Messenger
Language	English
Publishing date	2023-03-30
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2136427-8
ISSN	0219-6352
ISSN	0219-6352
DOI	10.31083/j.jin2202044
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6117: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Possible effects of Treponema pallidum infection on human vascular endothelial cells.

Xie, Bibo / Zhao, Tie / Zhao, Sisi / Zhou, Jie / Zhao, Feijun

Journal of clinical laboratory analysis

2022 Volume 36, Issue 4, Page(s) e24318

Abstract: Pathogens can affect host cells in various ways, and the same effect can be found in the Treponema pallidum acting on the endothelium of host vessels, and the mechanism is often complex and multiple. Based on the existing T. pallidum of a cognitive ... ...

Abstract	Pathogens can affect host cells in various ways, and the same effect can be found in the Treponema pallidum acting on the endothelium of host vessels, and the mechanism is often complex and multiple. Based on the existing T. pallidum of a cognitive framework, the first concerns involving T. pallidum or the bacteria protein directly acted on vascular endothelial cells of the host, the second concerns mainly involved in the process of T. pallidum infection in vivo blood lipid change, secretion of cytokines and the interactions between immune cells indirectly. Through both direct and indirect influence, this study explores the role of host by T. pallidum infect in the process of the vascular endothelium.
MeSH term(s)	Endothelial Cells ; Endothelium, Vascular ; Globus Pallidus ; Humans ; Syphilis ; Treponema ; Treponema pallidum
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.24318
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2471: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Engineering Functional DNA-Protein Conjugates for Biosensing, Biomedical, and Nanoassembly Applications.

Zhao, Dan / Kong, Yuhan / Zhao, Sisi / Xing, Hang

Topics in current chemistry (Cham)

2020 Volume 378, Issue 3, Page(s) 41

Abstract: DNA and protein are the most important two classes of biomacromolecules forming the basis of life. The conjugation of the two using crosslinking chemistries enables a combination of molecular recognition, enzymatic catalysis, and Watson-Crick ... ...

Abstract	DNA and protein are the most important two classes of biomacromolecules forming the basis of life. The conjugation of the two using crosslinking chemistries enables a combination of molecular recognition, enzymatic catalysis, and Watson-Crick hybridization properties. The DNA-protein conjugate with combined properties enables a broad range of applications, such as sensitive and selective bioassays, therapeutic agents, and building blocks for programmable nanoassemblies. In this review, we survey the conjugates from the aspects of conjugation chemistries as well as applications in biomedical and nanotechnology fields. We highlight the functions of both biological moieties of a conjugate for target binding and signal transduction in bioassays. We also review the use of DNA-protein conjugates for the construction of a variety of functional and dynamic nanostructures, from isolated hybrid cages to three-dimensional (3D) protein crystalline lattices. Moreover, these conjugates have been used as carriers to deliver enzymes or functional nucleic acids for disease treatments and gene editing.
MeSH term(s)	Animals ; Biomedical Research ; Biosensing Techniques ; DNA/chemistry ; DNA/metabolism ; Humans ; Nanostructures/chemistry ; Nanotechnology ; Protein Engineering ; Proteins/chemistry ; Proteins/metabolism
Chemical Substances	Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2020-05-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2848485-X
ISSN	2364-8961 ; 2365-0869
ISSN (online)	2364-8961
ISSN	2365-0869
DOI	10.1007/s41061-020-00305-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Boosted Photocatalytic Performance for Antibiotics Removal with Ag/PW

Shi, Hongfei / Wang, Haoshen / Zhang, Enji / Qu, Xiaoshu / Li, Jianping / Zhao, Sisi / Gao, Huajing / Chen, Zhe

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 19

Abstract: Photocatalyst is the core of photocatalysis and directly determines photocatalytic performance. However, low quantum efficiency and low utilization of solar energy are important technical problems in the application of photocatalysis. In this work, a ... ...

Abstract	Photocatalyst is the core of photocatalysis and directly determines photocatalytic performance. However, low quantum efficiency and low utilization of solar energy are important technical problems in the application of photocatalysis. In this work, a series of polyoxometalates (POMs) [H
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Titanium/chemistry ; Nanoparticles ; Light ; Tetracycline ; Catalysis
Chemical Substances	Anti-Bacterial Agents ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE) ; Tetracycline (F8VB5M810T)
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28196831
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Insight into the invasion process and immune-protective evaluation of Tp0971, a membrane lipoprotein from

Zhang, Xiaohong / Duan, Junxia / Wang, Yali / Xie, Bibo / Zhou, Jie / Zhao, Sisi / Yin, Weiguo / Liu, Peng / Zhao, Feijun

Microbiology spectrum

2023 Volume 11, Issue 6, Page(s) e0004723

Abstract: Importance: The past two decades have seen a worldwide resurgence in infections caused ... ...

Abstract	Importance: The past two decades have seen a worldwide resurgence in infections caused by
MeSH term(s)	Animals ; Humans ; Treponema pallidum/genetics ; Syphilis/prevention & control ; Spirochaetales ; Lipoproteins ; Vaccines
Chemical Substances	Lipoproteins ; Vaccines
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00047-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A Biomimetic Approach for Spatially Controlled Cell Membrane Engineering Using Fusogenic Spherical Nucleic Acid.

Lin, Minjie / Chen, Yuanyuan / Zhao, Sisi / Tang, Rui / Nie, Zhou / Xing, Hang

Angewandte Chemie (International ed. in English)

2021 Volume 61, Issue 1, Page(s) e202111647

Abstract: Engineering of the cell plasma membrane using functional DNA is important for studying and controlling cellular behaviors. However, most efforts to apply artificial DNA interactions on cells are limited to external membrane surface due to the lack of ... ...

Abstract	Engineering of the cell plasma membrane using functional DNA is important for studying and controlling cellular behaviors. However, most efforts to apply artificial DNA interactions on cells are limited to external membrane surface due to the lack of suitable synthetic tools to engineer the intracellular side, which impedes many applications in cell biology. Inspired by the natural extracellular vesicle-cell fusion process, we have developed a fusogenic spherical nucleic acid construct to realize robust DNA functionalization on both external and internal cell surfaces via liposome fusion-based transport (LiFT) strategy, which enables applications including the construction of heterotypic cell assembly for programmed signaling pathway and detection of intracellular metabolites. This approach can engineer cell membranes in a highly efficient and spatially controlled manner, allowing one to build anisotropic membrane structures with two orthogonal DNA functionalities.
MeSH term(s)	Biomimetic Materials/chemistry ; Cell Engineering ; Cell Membrane/chemistry ; DNA/chemistry ; HeLa Cells ; Humans ; Liposomes/chemistry ; Particle Size
Chemical Substances	Liposomes ; DNA (9007-49-2)
Language	English
Publishing date	2021-11-25
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202111647
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito