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  1. Article ; Online: IL-6 receptor inhibition is not associated with body weight or composition: Mendelian randomisation study.

    Zhao, Sizheng Steven

    Clinical rheumatology

    2024  Volume 43, Issue 4, Page(s) 1411–1412

    MeSH term(s) Humans ; Body Weight ; Risk Factors
    Language English
    Publishing date 2024-03-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-024-06915-6
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  2. Article ; Online: Examining the link between TNF inhibition and alopecia areata using Mendelian randomization.

    Zhao, Sizheng Steven

    Clinical rheumatology

    2023  Volume 43, Issue 2, Page(s) 819–820

    MeSH term(s) Humans ; Alopecia Areata/drug therapy ; Alopecia Areata/genetics ; Mendelian Randomization Analysis ; Etanercept
    Chemical Substances Etanercept (OP401G7OJC)
    Language English
    Publishing date 2023-08-09
    Publishing country Germany
    Document type Letter
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-023-06734-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vitamin D is associated with reduced risk of Sjögren's syndrome: a Mendelian randomization study.

    Zhao, Sizheng Steven / Burgess, Stephen

    Rheumatology (Oxford, England)

    2023  Volume 63, Issue 2, Page(s) e32–e33

    MeSH term(s) Humans ; Vitamin D ; Sjogren's Syndrome/genetics ; Sjogren's Syndrome/complications ; Mendelian Randomization Analysis ; Vitamins ; Genetic Predisposition to Disease
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2023-07-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead356
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  4. Article ; Online: Cholesteryl ester transfer protein inhibition is associated with reduced risk of Sjögren's syndrome.

    Zhao, Sizheng Steven / Dyball, Sarah

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 9, Page(s) e258–e259

    MeSH term(s) Humans ; Cholesterol Ester Transfer Proteins ; Sjogren's Syndrome ; Lipoproteins, HDL/metabolism
    Chemical Substances Cholesterol Ester Transfer Proteins ; Lipoproteins, HDL
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Human genetic evidence supports Fibroblast Growth Factor 21 (FGF21) as a novel therapeutic target for gout.

    Zhao, Sizheng Steven / Cuthbertson, Daniel J / Alam, Uazman

    Rheumatology (Oxford, England)

    2024  

    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae210
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  6. Article ; Online: Genetically proxied IL-6 receptor inhibition and risk of polymyalgia rheumatica.

    Zhao, Sizheng Steven / Gill, Dipender

    Annals of the rheumatic diseases

    2022  

    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2022-222578
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  7. Article ; Online: IL-6 receptor inhibition and risk of sarcoidosis: a Mendelian randomization study.

    Zhao, Sizheng Steven / Baker, Matthew C / Galloway, James B

    Rheumatology (Oxford, England)

    2023  Volume 63, Issue 4, Page(s) e118–e119

    MeSH term(s) Humans ; Mendelian Randomization Analysis ; Receptors, Interleukin-6/genetics ; Risk Factors ; Genetic Predisposition to Disease ; Sarcoidosis/genetics ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide
    Chemical Substances Receptors, Interleukin-6
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The association between comorbidities and disease activity in spondyloarthritis - A narrative review.

    Bosch, Philipp / Zhao, Sizheng Steven / Nikiphorou, Elena

    Best practice & research. Clinical rheumatology

    2023  Volume 37, Issue 3, Page(s) 101857

    Abstract: Comorbidities, including cardiovascular disease, osteoporosis, and depression, are more prevalent in patients with spondyloarthritis (SpA) than in the general population. Clinical and laboratory markers of disease activity are associated with numerous of ...

    Abstract Comorbidities, including cardiovascular disease, osteoporosis, and depression, are more prevalent in patients with spondyloarthritis (SpA) than in the general population. Clinical and laboratory markers of disease activity are associated with numerous of these comorbidities, and studies suggest that the treatment of SpA can have a positive impact on comorbidities; conversely, managing comorbidities can improve disease activity. Therefore, the screening of comorbidities is considered a core component of a rheumatology consultation, and treatment should be performed in liaison with other health professionals (e.g. general physicians). Validated tools and questionnaires can be used for not only the detection but also the monitoring of potential comorbidities. Understanding whether a comorbidity is a separate disease entity, linked to SpA or its treatment, or an extra-musculoskeletal manifestation of the disease is important to identify the most appropriate treatment options.
    MeSH term(s) Humans ; Spondylarthritis/epidemiology ; Spondylarthritis/drug therapy ; Comorbidity ; Osteoporosis/epidemiology ; Cardiovascular Diseases/epidemiology ; Biomarkers ; Arthritis, Psoriatic/drug therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-08-03
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2023.101857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cardiovascular safety of genetically proxied interleukin-5 inhibition: A mendelian randomization study.

    Alton, Philip / Hughes, David M / Zhao, Sizheng Steven

    Respiratory investigation

    2023  Volume 61, Issue 2, Page(s) 149–152

    Abstract: Interleukin-5 (IL-5) inhibitors have revolutionized the management of eosinophilic asthma. However, IL-5 is thought to play a protective role in atherosclerosis, and cardiovascular safety data for IL-5i are scarce. We used population-level data to ... ...

    Abstract Interleukin-5 (IL-5) inhibitors have revolutionized the management of eosinophilic asthma. However, IL-5 is thought to play a protective role in atherosclerosis, and cardiovascular safety data for IL-5i are scarce. We used population-level data to examine the association between genetically proxied IL-5i and the risk of cardiovascular diseases. Genetic instruments for IL-5i were selected from a genome-wide association study of eosinophil count in 563,946 individuals. Genetic association data for coronary artery disease were obtained from 60,801 cases, 40,585 stroke cases, 7988 venous thromboembolism cases, and up to 406,111 controls. We used the inverse-variance weighted method and a series of sensitivity analyses. Nine genetic variants were selected to instrument IL-5i. Genetically proxied IL-5i was not associated with the risk of coronary heart disease (OR 0.82, 95%CI 0.65-1.03), stroke (OR 1.10; 0.95-1.27), or venous thromboembolism (OR 0.87; 0.64-1.17). We found no genetic evidence to suggest that IL-5i affects the risk of adverse cardiovascular and thromboembolic events.
    MeSH term(s) Humans ; Interleukin-5 ; Genome-Wide Association Study ; Mendelian Randomization Analysis/methods ; Venous Thromboembolism ; Stroke/genetics ; Cardiovascular Diseases ; Polymorphism, Single Nucleotide
    Chemical Substances Interleukin-5
    Language English
    Publishing date 2023-01-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2022.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Disentangling the relationship between depression and chronic widespread pain: A Mendelian randomisation study.

    Zhao, Sizheng Steven / Holmes, Michael V / Alam, Uazman

    Seminars in arthritis and rheumatism

    2023  Volume 60, Page(s) 152188

    Abstract: Objective: Depression and chronic widespread pain (CWP) frequently coexist, but whether depression is an independent causal risk factor for CWP, and/or vice versa, remains unclear. We investigated the bidirectional causal relationship between depression ...

    Abstract Objective: Depression and chronic widespread pain (CWP) frequently coexist, but whether depression is an independent causal risk factor for CWP, and/or vice versa, remains unclear. We investigated the bidirectional causal relationship between depression and CWP.
    Methods: We performed a two-sample Mendelian randomisation (MR) study to estimate the causal relationship between genetically predicted depression (170,756 cases, 329,443 controls) and risk of CWP (6,914 cases, 242,929 controls), and the effect of CWP on depression susceptibility, using large population-level genetic data. We used a new MR method, Causal Analysis Using Summary Effect estimates (CAUSE), which allows for sample overlap, in addition to traditional MR and sensitivity analyses.
    Results: For each doubling in odds of genetic liability to depression, the risk of chronic widespread pain was increased (OR 1.004, 95% credible interval 1.003-1.005; p = 7.3 × 10
    Conclusions: This study provides evidence in support of a bidirectional causal relationship between depression and increased risk of chronic widespread pain, whilst overcoming the major limitations of previous epidemiological studies. Interventions for depression may be an effective strategy to prevent or reduce the burden of chronic widespread pain and vice versa.
    MeSH term(s) Humans ; Depression/genetics ; Chronic Pain/epidemiology ; Chronic Pain/genetics ; Risk Factors ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2023-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2023.152188
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