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Article ; Online: Spatial-temporal distribution and source analysis of atmospheric particulate-bound cadmium from 1998 to 2021 in China.

Huang, Wei / Sun, Donglei / Zhao, Tianhe / Long, Keyan / Zhang, Zunzhen

2024 Volume 46, Issue 2, Page(s) 44

Abstract: Cadmium (Cd) is one of the most serious atmospheric heavy metal pollutants in China. ... ...

Abstract	Cadmium (Cd) is one of the most serious atmospheric heavy metal pollutants in China. PM
MeSH term(s)	Cadmium ; China ; Coal ; Dust ; Environmental Pollutants
Chemical Substances	Cadmium (00BH33GNGH) ; Coal ; Dust ; Environmental Pollutants
Language	English
Publishing date	2024-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-023-01788-1
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Article ; Online: Oxidative Stress Induced by Arsenite is Involved in YTHDF2 Phase Separation.

Man, Jin / Zhang, Qian / Zhao, Tianhe / Sun, Donglei / Sun, Weilian / Long, Keyan / Zhang, Zunzhen

Biological trace element research

2023 Volume 202, Issue 3, Page(s) 885–899

Abstract: ... YTH ... ...

Abstract	YTH N
MeSH term(s)	Humans ; Acetylcysteine/pharmacology ; Arsenites/toxicity ; Phase Separation ; Oxidative Stress ; RNA-Binding Proteins/genetics
Chemical Substances	Acetylcysteine (WYQ7N0BPYC) ; arsenite (N5509X556J) ; Arsenites ; YTHDF2 protein, human ; RNA-Binding Proteins
Language	English
Publishing date	2023-06-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-023-03728-7
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Zs.B 2323: Show issues

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Zhao, Tianhe / Sun, Donglei / Long, Keyan / Xiong, Wenxiao / Man, Jin / Zhang, Qian / Zhang, Zunzhen

Journal of hazardous materials

2023 Volume 465, Page(s) 133329

Abstract: ... ...

Abstract	N
MeSH term(s)	Humans ; Antioxidants/metabolism ; Arsenic/toxicity ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase-1/metabolism ; Carcinogenesis/chemically induced ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Oxidation-Reduction ; Homeostasis ; Methyltransferases/metabolism ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism ; Adenosine/analogs & derivatives
Chemical Substances	Antioxidants ; Arsenic (N712M78A8G) ; Reactive Oxygen Species ; Superoxide Dismutase-1 (EC 1.15.1.1) ; N-methyladenosine (CLE6G00625) ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-) ; FTO protein, human (EC 1.14.11.33) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2023-12-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.133329
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Article ; Online: N6-methyladenosine upregulates ribosome biogenesis in environmental carcinogenesis

Zhao, Tianhe / Sun, Donglei / Long, Keyan / Lemos, Bernardo / Zhang, Qian / Man, Jin / Zhao, Manyu / Zhang, Zunzhen

Science of the Total Environment. 2023 July, v. 881 p.163428-

2023

Abstract: Many trace metal pollutants in surface water, the atmosphere, and soil are carcinogenic, and ribosome biogenesis plays an important role in the carcinogenicity of heavy metals. However, the contradiction between upregulated ribosome biogenesis and ... ...

Abstract	Many trace metal pollutants in surface water, the atmosphere, and soil are carcinogenic, and ribosome biogenesis plays an important role in the carcinogenicity of heavy metals. However, the contradiction between upregulated ribosome biogenesis and decreased ribosomal DNA copy number in environmental carcinogenesis is not fully understood. Here, from a perspective of the most predominant and abundant RNA epigenetic modification, N⁶-methyladenosine (m⁶A), we explored the reason behind this contradiction at the post-transcriptional level using arsenite-induced skin carcinogenesis models both in vitro and in vivo. Based on the m⁶A microarray assay and a series of experiments, we found for the first time that the elevated m⁶A in arsenite-induced transformation is mainly enriched in the genes regulating ribosome biogenesis. m⁶A upregulates ribosome biogenesis post-transcriptionally by stabilizing ribosomal proteins and modulating non-coding RNAs targeting ribosomal RNAs and proteins, leading to arsenite-induced skin carcinogenesis. Using multi-omics analysis of human subjects and experimental validation, we identified an unconventional role of a well-known key proliferative signaling node AKT1 as a vital mediator between m⁶A and ribosome biogenesis in arsenic carcinogenesis. m⁶A activates AKT1 and transmits proliferative signals to ribosome biogenesis, exacerbating the upregulation of ribosome biogenesis in arsenite-transformed keratinocytes. Similarly, m⁶A promotes cell proliferation by upregulating ribosome biogenesis in cell transformation induced by carcinogenic heavy metals (chromium and nickel). Importantly, inhibiting m⁶A reduces ribosome biogenesis. Targeted inhibition of m⁶A-upregulated ribosome biogenesis effectively prevents cell transformation induced by trace metals (arsenic, chromium, and nickel). Our results reveal the mechanism of ribosome biogenesis upregulated by m⁶A in the carcinogenesis of trace metal pollutants. From the perspective of RNA epigenetics, our study improves our understanding of the contradiction between upregulated ribosome biogenesis and decreased ribosomal DNA copy number in the carcinogenesis of environmental carcinogens.
Keywords	RNA ; arsenic ; biogenesis ; carcinogenesis ; carcinogenicity ; cell proliferation ; chromium ; environment ; epigenetics ; humans ; keratinocytes ; microarray technology ; multiomics ; nickel ; ribosomal DNA ; ribosomes ; soil ; surface water ; Heavy metal contaminants ; m6A ; Ribosomal proteins ; AKT1
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.163428
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Long non-coding RNA ROR confers arsenic trioxide resistance to HepG2 cells by inhibiting p53 expression.

Li, Xinyang / Sun, Donglei / Zhao, Tianhe / Zhang, Zunzhen

European journal of pharmacology

2020 Volume 872, Page(s) 172982

Abstract: Arsenic trioxide is an effective drug in the treatment of hematologic malignancies, but it has no obvious therapeutic effect on liver cancer. Long non-coding RNA ROR is a newly found long-noncoding RNA that has been reported to get involved in the ... ...

Abstract	Arsenic trioxide is an effective drug in the treatment of hematologic malignancies, but it has no obvious therapeutic effect on liver cancer. Long non-coding RNA ROR is a newly found long-noncoding RNA that has been reported to get involved in the regulation of chemo-resistance in multiple cancers. However, whether and how long non-coding RNA ROR gets involved in the resistance to arsenic trioxide in liver cancer has not been explored. In this study, We found that cellular apoptosis was increased by arsenic trioxide in liver cancer HepG2 cells; P53 expression was also increased by arsenic trioxide at both mRNA level and protein level, indicating that P53-dependent apoptosis is the main mechanism for arsenic trioxide to induce cytotoxicity in liver cancer HepG2 cells. Meanwhile, we found an obvious increase in the level of long non-coding RNA ROR in arsenic trioxide-treated HepG2 cells. By measuring the level of reactive oxygen species, glutathione, superoxide dismutase, and malondialdehyde, the product of lipid peroxidation, we further demonstrated that oxidative stress was a potential factor for both the activation of P53 expression and the increase in long non-coding RNA ROR expression. Through the knock-down of long non-coding RNA ROR by siRNA, we revealed that the activated long non-coding RNA ROR ameliorated arsenic trioxide-induced apoptosis by inhibiting P53 expression. Together, our study reported that long non-coding RNA ROR conferred arsenic trioxide resistance to liver cancer cells through inhibiting P53 expression, and long non-coding RNA ROR might be a novel sensitizing target for liver cancer treatment.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Arsenic Trioxide/pharmacology ; Arsenic Trioxide/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Gene Knockdown Techniques ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Small Interfering/metabolism ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Antineoplastic Agents ; Linc-RNA-RoR, human ; RNA, Long Noncoding ; RNA, Small Interfering ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Arsenic Trioxide (S7V92P67HO)
Language	English
Publishing date	2020-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2020.172982
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Zs.A 522: Show issues

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Article: [Comparative Analysis of Direct Drinking Water and the Relevant Sanitation Standards in China].

Wang, Ting / Sun, Dong-Lei / Zhao, Tian-He / Zhang, Zun-Zhen

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2021 Volume 52, Issue 5, Page(s) 729–734

Abstract: Along with the economic and technological development and growing demand for high-quality drinking water, direct drinking water has gained general popularity in China. However, no authoritative policy has been issued, giving a clear definition of direct ... ...

Abstract	Along with the economic and technological development and growing demand for high-quality drinking water, direct drinking water has gained general popularity in China. However, no authoritative policy has been issued, giving a clear definition of direct drinking water and existing standards and regulations concerning direct drinking water are not definitive in nature. Existing water quality parameters are not well supported and sometimes even contradict each other. We elaborated, in this paper, the history of direct drinking water in China and systematically reviewed the existing regulations and standards related to direct drinking water. We also compared and analyzed the important microbiology, toxicology, sensory perception and general chemistry parameters in the standards. This paper is the first ever attempt at an in-depth analysis of the chaotic state of the direct drinking water industry. We have also highlighted the problems in the current standards and regulations for direct drinking water. Our study provides a basis for market regulation and the supervision and management of direct drinking water. In addition, the paper provides helpful information for laying down a definition of direct drinking water, calling for and approving of project proposals concerning the establishment of national standards for direct drinking water, and actually formulating the standards. We have made a number of suggestions: A. defining direct drinking water clearly and formulating the national standards for direct drinking water as soon as possible; B. conducting research on water quality benchmarks to provide scientific support for the formulation of the national standards for direct drinking water; C. giving more attention to the formulation of standards concerning microbiology parameters and their limits and giving consideration to the inclusion of parameters concerning viruses.
MeSH term(s)	China ; Drinking Water ; Sanitation ; Water Pollutants, Chemical/analysis ; Water Quality
Chemical Substances	Drinking Water ; Water Pollutants, Chemical
Language	Chinese
Publishing date	2021-10-07
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20210660101
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Zs.B 2708: Show issues

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Article ; Online: Triclosan down-regulates fatty acid synthase through microRNAs in HepG2 cells.

Sun, Donglei / Zhao, Tianhe / Long, Keyan / Wu, Mei / Zhang, Zunzhen

European journal of pharmacology

2021 Volume 907, Page(s) 174261

Abstract: Triclosan is a promising candidate of fatty acid synthase (FASN) inhibitor by blocking FASN activity, but its effect on FASN expression and the underling epigenetic mechanism remain elusive. In this study, the effect of triclosan on FASN mRNA and protein ...

Abstract	Triclosan is a promising candidate of fatty acid synthase (FASN) inhibitor by blocking FASN activity, but its effect on FASN expression and the underling epigenetic mechanism remain elusive. In this study, the effect of triclosan on FASN mRNA and protein expressions in human HepG2 cells and the regulatory role of microRNAs (miRNAs) in the downregulation of FASN induced by triclosan were explored through experiments and bioinformatics analysis. The results showed that triclosan not only directly inhibited FASN activity, but also significantly decreased FASN mRNA and protein levels in human liver HepG2 cells. Nine miRNAs targeting FASN mRNA degradation were identified by miRNA prediction tools, and the expression levels of these nine miRNAs were then detected by real-time quantitative PCR. Triclosan significantly increased the expressions of the six miRNAs, namely miR-15a, miR-107, miR-195, miR-424, miR-497 and miR-503, leading to the downregulation of FASN. Further investigation revealed that the six triclosan-upregulated miRNAs played an important regulatory role in lipid metabolism and cell cycle by gene ontology annotations and pathway analysis. Consistent with the results of bioinformatics analyses, triclosan significantly reduced the intracellular lipid content by triglyceride assay, oil red O, BODIPY 493/503 and Nile Red staining, thereby inhibiting the growth of HepG2 cells through apoptosis. Taken together, our study reveals that triclosan downregulates FASN expression through a variety of miRNAs, providing new insight for triclosan as a FASN inhibitor candidate to regulate lipid metabolism in human hepatoma cells.
MeSH term(s)	Down-Regulation ; Fatty Acid Synthases ; Hep G2 Cells ; Humans ; MicroRNAs ; Triclosan
Chemical Substances	MicroRNAs ; Triclosan (4NM5039Y5X) ; Fatty Acid Synthases (EC 2.3.1.85)
Language	English
Publishing date	2021-06-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2021.174261
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Article: [Mechanism of Triclosan in the Treatment of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology].

Zuo, Chao / Sun, Dong-Lei / Zhao, Tian-He / Wang, Jing-Jing / Zhang, Zun-Zhen

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2022 Volume 44, Issue 2, Page(s) 253–261

Abstract: Objective To explore the potential targets of triclosan in the treatment of nonalcoholic fatty liver disease(NAFLD) and to provide new clues for the future research on the application of triclosan. Methods The targets of triclosan and NAFLD were obtained ...

Abstract	Objective To explore the potential targets of triclosan in the treatment of nonalcoholic fatty liver disease(NAFLD) and to provide new clues for the future research on the application of triclosan. Methods The targets of triclosan and NAFLD were obtained via network pharmacology.The protein-protein interaction network was constructed with the common targets shared by triclosan and NAFLD.The affinity of triclosan to targets was verified through molecular docking.Gene ontology(GO) annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment were carried out to analyze the key targets and the potential mechanism of action.NAFLD model was established by feeding male C57BL/6J mice with high-fat diet for 12 weeks.The mice were randomly assigned into a model group and a triclosan group [400 mg/(kg·d),gavage once a day for 8 weeks].The hematoxylin-eosin(HE) staining was used for observation of the pathological changes and oil red O staining for observation of fat deposition in mouse liver.Western blotting was employed to detect the protein level of peroxisome proliferator-activated receptor alpha(PPARα) in the liver tissue. Results Triclosan and NAFLD had 34 common targets,19 of which may be the potential targets for the treatment,including albumin(ALB),PPARα,mitogen-activated protein kinase 8(MAPK8),and fatty acid synthase.Molecular docking predicted that ALB,PPARα,and MAPK8 had good binding ability to triclosan.KEGG pathway enrichment showcased that the targets were mainly enriched in peroxisome proliferator-activated receptor signaling pathway,in which ALB and MAPK8 were not involved.Triclosan alleviated the balloon-like change and lipid droplet vacuole,decreased the lipid droplet area,and up-regulated the expression level of PPARα in mouse liver tissue. Conclusion PPARα is a key target of triclosan in the treatment of NAFLD,which may be involved in fatty acid oxidation through the peroxisome proliferator activated receptor signaling pathway.
MeSH term(s)	Animals ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Network Pharmacology ; Non-alcoholic Fatty Liver Disease/drug therapy ; PPAR alpha/metabolism ; PPAR alpha/therapeutic use ; Triclosan/metabolism ; Triclosan/pharmacology ; Triclosan/therapeutic use
Chemical Substances	PPAR alpha ; Triclosan (4NM5039Y5X)
Language	Chinese
Publishing date	2022-05-11
Publishing country	China
Document type	Journal Article
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
DOI	10.3881/j.issn.1000-503X.14189
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Article ; Online: N

Zhao, Tianhe / Sun, Donglei / Xiong, Wenxiao / Man, Jin / Zhang, Qian / Zhao, Manyu / Zhang, Zunzhen

Journal of hazardous materials

2022 Volume 445, Page(s) 130468

Abstract: High-profile RNA epigenetic modification ... ...

Abstract	High-profile RNA epigenetic modification N
Language	English
Publishing date	2022-11-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.130468
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Article ; Online: N

Zhao, Tianhe / Sun, Donglei / Long, Keyan / Lemos, Bernardo / Zhang, Qian / Man, Jin / Zhao, Manyu / Zhang, Zunzhen

The Science of the total environment

2023 Volume 881, Page(s) 163428

Abstract	Many trace metal pollutants in surface water, the atmosphere, and soil are carcinogenic, and ribosome biogenesis plays an important role in the carcinogenicity of heavy metals. However, the contradiction between upregulated ribosome biogenesis and decreased ribosomal DNA copy number in environmental carcinogenesis is not fully understood. Here, from a perspective of the most predominant and abundant RNA epigenetic modification, N
MeSH term(s)	Ribosomes/metabolism ; Adenosine/analogs & derivatives ; Arsenic/toxicity ; Metals, Heavy/toxicity ; Proto-Oncogene Proteins c-akt/metabolism ; Carcinogenesis ; Male ; Animals ; Mice ; Environmental Pollutants/toxicity
Chemical Substances	N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567) ; Arsenic (N712M78A8G) ; Metals, Heavy ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Environmental Pollutants
Language	English
Publishing date	2023-04-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.163428
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