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  1. Article ; Online: Prognostic assessment of C‑reactive protein and neutrophil to lymphocyte ratio in patients with non-small cell lung cancer.

    Zhao, Tingting

    Wiener klinische Wochenschrift

    2022  Volume 134, Issue 19-20, Page(s) 705–711

    Abstract: Objective: To investigate the prognostic assessment of inflammatory factor serum C‑reactive protein CRP and neutrophil to lymphocyte ratio NLR value in patients with non-small cell lung cancer NSCLC.: Methods: A retrospective analysis was conducted ... ...

    Abstract Objective: To investigate the prognostic assessment of inflammatory factor serum C‑reactive protein CRP and neutrophil to lymphocyte ratio NLR value in patients with non-small cell lung cancer NSCLC.
    Methods: A retrospective analysis was conducted for 475 patients with NSCLC who visited our hospital with complete follow-up data from January 2017 to 1 January 2019. The changes of serum CRP, NLR levels in patients with NSCLC of different stages, as well as the changes in the levels of the two indexes before and after chemotherapy in patients with advanced stage were compared using t tests with SPSS19.0 software. Serum CRP and NLR were divided into low and high groups with median intercept values and the relationship between inflammation score index and tumor progression-free survival time (PFS) was analyzed retrospectively. Clinical factors that may affect disease prognosis were included in the proportional hazards (COX) regression model for multifactorial prognostic analysis.
    Results: Pretreatment serum levels of NLR and CRP were significantly higher in non-operated patients relative to preoperative levels in surgical patients. Advanced patients had higher levels of both indexes than locally advanced patients. After chemotherapy, the levels of the two indexes reaching remission were significantly lower than those before chemotherapy. The levels of the two indexes in patients with stable disease after chemotherapy were not statistically significant compared with those before chemotherapy, and the levels of the two indexes in the group with progressive disease after chemotherapy were significantly higher than those before chemotherapy. The results of PFS survival analyses showed that PFS was prolonged in the low score CRP and the low score NLR group, compared with the high score group. Multifactorial prognostic analysis showed that smoking, CRP and NLR were risk factors for PFS prognosis in patients with NSCLC.
    Conclusion: Serum CRP and NLR are effective predictors of poor prognosis in patients with NSCLC.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Neutrophils/pathology ; Prognosis ; C-Reactive Protein ; Retrospective Studies ; Lung Neoplasms/diagnosis ; Lymphocytes/pathology
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-07-06
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-022-02049-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 902: Show issues Location:
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  2. Article: Modified Gexia-Zhuyu Tang inhibits gastric cancer progression by restoring gut microbiota and regulating pyroptosis.

    Zhao, Tingting / Yu, Zhijian

    Cancer cell international

    2024  Volume 24, Issue 1, Page(s) 21

    Abstract: Background: Gexia-Zhuyu Tang (GZT), a traditional Chinese medicine formula, is used to treat a variety of diseases. However, its roles in gastric cancer (GC) remain unclear.: Objective: The aim of this study was to explore the roles and underlying ... ...

    Abstract Background: Gexia-Zhuyu Tang (GZT), a traditional Chinese medicine formula, is used to treat a variety of diseases. However, its roles in gastric cancer (GC) remain unclear.
    Objective: The aim of this study was to explore the roles and underlying molecular mechanisms of modified GZT in GC.
    Methods: The effects of modified GZT on GC were investigated by constructing mouse xenograft models with MFC cell line. The fecal samples from low-dose, high-dose, and without modified GZT treatment groups were collected for the 16S rRNA gene sequencing and fecal microbiota transplantation (FMT). Histopathological alterations of mice were evaluated using the hematoxylin-eosin (HE). Immunohistochemical (IHC) analysis with Ki67 and GSDMD was performed to measure tissue cell proliferation and pyroptosis, respectively. Proteins associated with pyroptosis, invasion, and metastasis were detected by Western blotting. Enzyme-linked immunosorbent assay (ELISA) was used to assess inflammation-related factors levels.
    Results: Modified GZT inhibited GC tumor growth and reduced metastasis and invasion-related proteins expression levels, including CD147, VEGF, and MMP-9. Furthermore, it notably promoted caspase-1-dependent pyroptosis, as evidenced by a dose-dependent increase in TNF-α, IL-1β, IL-18, and LDH levels, along with elevated protein expression of NLRP3, ASC, and caspase-1. Additionally, modified GZT increased species abundance and diversity of the intestinal flora. FMT assay identified that modified GZT inhibited GC tumor progression through regulation of intestinal flora.
    Conclusions: Modified GZT treatment may promote pyroptosis by modulating gut microbiota in GC. This study identifies a new potential approach for the GC clinical treatment.
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-024-03215-6
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  3. Book ; Online ; Thesis: Microplastic effects on soil properties: direct and indirect effects as a single factor and interaction with other global change factors

    Zhao, Tingting [Verfasser]

    2023  

    Author's details Tingting Zhao
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language English
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Analysis of Clinical Characteristics and Resuscitation Outcomes of Adult Patients with In-hospital Cardiac Arrest

    ZHAO Tingting / ZHAO Yuanyuan / XING Jihong

    Xiehe Yixue Zazhi, Vol 14, Iss 3, Pp 536-

    2023  Volume 542

    Abstract: Objective To analyze the clinical features and resuscitation outcome of adult patients with cardiac arrest (CA) in intensive care unit, and discuss the related factors affecting the success rate of cardiopulmonary resuscitation in adult patients with CA. ...

    Abstract Objective To analyze the clinical features and resuscitation outcome of adult patients with cardiac arrest (CA) in intensive care unit, and discuss the related factors affecting the success rate of cardiopulmonary resuscitation in adult patients with CA. Methods The clinical data of CA patients in the intensive care unit of the First Hospital of Jilin University from September 2019 to December 2020 were retrospectively analyzed. According to the outcome indicators, the patients were divided into return of spontaneous circulation (ROSC) group and non-ROSC group, survival-discharge group and death group. The relevant factors affecting resuscitation outcome were discussed. Results A total of 351 patients with CA were included in this study, including 206 males and 145 females; the median age was 63 years. There were 191 patients with cardiogenic CA and 267 patients with non-defibrillation rhythm (cardiac arrest and no electrical activity) at the onset of CA. After treatment with CPR, 152 patients had ROSC, of whom 42 survived and were discharged. Univariate Logistic regression analysis showed that coronary artery disease, non-defibrillation rhythm, no defibrillation rhythm during resuscitation, no electric defibrillation, and no emergency endotracheal intubation were the possible factors that reduced the incidence of ROSC. Young age, CPR duration ≤30 min, and small cumulative dose of epinephrine were the possible factors that increased the incidence of ROSC. Non-cardiogenic etiology, non-defibrillable rhythm, no electric defibrillation, and no defibrillable rhythm during resuscitation decreased the likelihood of survival and discharge, whereas CPR duration ≤30 min and a small cumulative dose of epinephrine increased the likelihood of survival and discharge. Multivariate Logistic regression analysis showed that CPR duration > 30 min was an independent risk factor for ROSC, and young age, emergency tracheal intubation, and small cumulative epinephrine dose were independent protective factors for ROSC. CPR duration ...
    Keywords cardiac arrest ; cardiopulmonary resuscitation ; return of spontaneous circulation ; Medicine ; R
    Subject code 610
    Language Chinese
    Publishing date 2023-05-01T00:00:00Z
    Publisher Editorial Office of Medical Journal of Peking Union Medical College Hospital
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Potential therapeutic role of STRT1 in age- related hearing loss.

    Zhao, Tingting / Tian, Guangyong

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 984292

    Abstract: Age-related hearing loss (ARHL) is a major public health burden worldwide that profoundly affects the daily life of elderly people. Silent information regulator 1 (SIRT1 or Sirtuin1), known as a regulator of the cell cycle, the balance of oxidation/ ... ...

    Abstract Age-related hearing loss (ARHL) is a major public health burden worldwide that profoundly affects the daily life of elderly people. Silent information regulator 1 (SIRT1 or Sirtuin1), known as a regulator of the cell cycle, the balance of oxidation/antioxidant and mitochondrial function, has been proven to have anti-aging and life-extending effects, and its possible connection with ARHL has received increasing attention in recent years. This paper provides an overview of research on the connection between SIRT1 and ARHL. Topics cover both the functions of SIRT1 and its important role in ARHL. This review concludes with a look at possible research directions for ARHL in the future.
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.984292
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  6. Article: Editorial: Molecular Pathophysiology of Diabetes-Related Organ Injury.

    Zhao, Tingting / Zhou, Qin

    Frontiers in medicine

    2022  Volume 9, Page(s) 875444

    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.875444
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  7. Article ; Online: 18F-FDG PET/CT Findings of Tibia Metastasis From Endometrial Adenocarcinoma.

    Chen, Jian / Ma, Liqiong / Zhao, Tingting / Yang, Jiqin / Li, Yanmei

    Clinical nuclear medicine

    2024  Volume 49, Issue 3, Page(s) 237–239

    Abstract: Abstract: Bone metastases from endometrial carcinoma are rare, especially when the bone is the sole metastatic site. A 55-year-old woman with a history of endometrial carcinoma was referred for FGD PET/CT scan due to pain in the left knee. The images ... ...

    Abstract Abstract: Bone metastases from endometrial carcinoma are rare, especially when the bone is the sole metastatic site. A 55-year-old woman with a history of endometrial carcinoma was referred for FGD PET/CT scan due to pain in the left knee. The images showed that multiple lesions with intense activity were detected in the left tibia. Histopathological examination and immunohistochemistry of the left tibial lesion confirmed metastases from the endometrial adenocarcinoma.
    MeSH term(s) Female ; Humans ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Fluorodeoxyglucose F18 ; Tibia/diagnostic imaging ; Tibia/pathology ; Endometrial Neoplasms/diagnostic imaging ; Endometrial Neoplasms/pathology ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/secondary
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005053
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    Zs.A 1276: Show issues Location:
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  8. Article ; Online: 18 F-FAPI-04 PET/CT in a Case of Primary Gastric Plasmacytoma.

    Dong, Yiyuan / Zhao, Tingting / Ma, Liqiong / Dong, Aisheng / Zhao, Qian

    Clinical nuclear medicine

    2024  

    Abstract: Abstract: Primary plasmacytoma of the stomach is very rare. We describe contrast-enhanced CT and 18 F-FAPI-04 PET/CT findings in a patient with primary gastric plasmacytoma and Helicobacter pylori infection. The gastric tumor appeared as a large ... ...

    Abstract Abstract: Primary plasmacytoma of the stomach is very rare. We describe contrast-enhanced CT and 18 F-FAPI-04 PET/CT findings in a patient with primary gastric plasmacytoma and Helicobacter pylori infection. The gastric tumor appeared as a large hypervascular polypoid mass on contrast-enhanced CT and showed intense 18 F-FAPI-04 uptake with SUV max of 11.8 on 18 F-FAPI-04 PET/CT.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005065
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  9. Article ; Online: Cellular plasticity and fate determination in gastric carcinogenesis.

    He, Zheng / Hu, Xiao-Hai / He, Tian-Yu / Zhao, Ting-Ting

    iScience

    2024  Volume 27, Issue 4, Page(s) 109465

    Abstract: Cellular plasticity serves as a crucial biological phenomenon in humans, integral to tissue repair and maintenance of dynamic environmental homeostasis post-injury. However, dysregulated activation of this beneficial mechanism can pave the way for ... ...

    Abstract Cellular plasticity serves as a crucial biological phenomenon in humans, integral to tissue repair and maintenance of dynamic environmental homeostasis post-injury. However, dysregulated activation of this beneficial mechanism can pave the way for tumorigenesis and cancer progression. In this review, we synthesize recent advancements concerning the properties and roles of gastric epithelial cells, with a special emphasis on cellular plasticity and fate specification during the progress of gastric tumorigenesis. Notably, the attribute of stemness is not exclusive to gastric stem cells but also extends to differentiated cells in gastric units. We delve into the extent of plasticity and changes in cellular fate that contribute to malignant transformation in both stem and mature cells within the stomach. Moreover, we explore matrix-epithelial interactions, immunological modulation, and epigenomic alterations throughout the course of gastric tumorigenesis. A comprehensive understanding of the underlying cellular mechanisms governing plasticity and fate decisions could catalyze the development of innovative approaches for cancer prevention and antineoplastic therapies.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109465
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  10. Article ; Online: Analysis of the effect of comprehensive physical and mental nursing for patients with acute cerebral infarction in intravenous thrombolytic therapy.

    Zhang, Yun / Wang, Mingxia / Zhao, Tingting / Zhang, Jing / Shen, Zequn

    The International journal of neuroscience

    2024  , Page(s) 1–8

    Abstract: Background: To evaluate the efficacy of comprehensive physical and mental nursing for patients with acute cerebral infarction (ACI) undergoing intravenous thrombolytic therapy and its impact on patients' quality of life and psychological state.: ... ...

    Abstract Background: To evaluate the efficacy of comprehensive physical and mental nursing for patients with acute cerebral infarction (ACI) undergoing intravenous thrombolytic therapy and its impact on patients' quality of life and psychological state.
    Methods: A total of 200 patients with ACI, admitted to our hospital between December 2018 and December 2019, were included in the study. They were randomly assigned to either the control group or the experimental group using a random number table. The control group received routine care (basic care such as monitoring vital signs, assisting with daily activities, administering medications, and providing comfort measures), while the experimental group received comprehensive physical and mental nursing (physical care, phsycological surpport, education and conceling). Various parameters including quality of life index (QLI) scores, mental status scale in non-psychiatric settings (MSSNS) scores, self-rating anxiety scale (SAS) scores, self-rating depression scale (SDS) scores, National Institute of Health Stroke Scale (NIHSS) scores, changes in hemodynamic indicators, and incidence of adverse events during intravenous thrombolysis were compared between the two groups.
    Results: The experimental group had higher QLI scores and lower MSSNS, SAS, SDS, and NIHSS scores compared to the control group (
    Conclusion: Comprehensive physical and mental nursing for patients with ACI undergoing intravenous thrombolysis improves nursing efficacy, nursing satisfaction, quality of life, and patients' psychological state. These findings highlight the importance of implementing holistic nursing interventions to optimize patient outcomes in ACI management.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 3061-2
    ISSN 1563-5279 ; 1543-5245 ; 0020-7454
    ISSN (online) 1563-5279 ; 1543-5245
    ISSN 0020-7454
    DOI 10.1080/00207454.2023.2300322
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