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  1. Article ; Online: The effects of partially or fully linked boron with a cross-linking structure of an organic precursor on the purity and morphology of ZrB

    Yang, Xi / Han, Weijian / Zhao, Tong / Li, Ruixing

    RSC advances

    2024  Volume 14, Issue 2, Page(s) 889–901

    Abstract: From a chemical infrastructure perspective, it is important to ensure that all ions constituting a target product, ...

    Abstract From a chemical infrastructure perspective, it is important to ensure that all ions constituting a target product,
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra06932j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Potassium channel-related epilepsy: Pathogenesis and clinical features.

    Zhao, Tong / Wang, Le / Chen, Fang

    Epilepsia open

    2024  

    Abstract: Variants in potassium channel-related genes are one of the most important mechanisms underlying abnormal neuronal excitation and disturbances in the cellular resting membrane potential. These variants can cause different forms of epilepsy, which can ... ...

    Abstract Variants in potassium channel-related genes are one of the most important mechanisms underlying abnormal neuronal excitation and disturbances in the cellular resting membrane potential. These variants can cause different forms of epilepsy, which can seriously affect the physical and mental health of patients, especially those with refractory epilepsy or status epilepticus, which are common among pediatric patients and are potentially life-threatening. Variants in potassium ion channel-related genes have been reported in few studies; however, to our knowledge, no systematic review has been published. This study aimed to summarize the epilepsy phenotypes, functional studies, and pharmacological advances associated with different potassium channel gene variants to assist clinical practitioners and drug development teams to develop evidence-based medicine and guide research strategies. PubMed and Google Scholar were searched for relevant literature on potassium channel-related epilepsy reported in the past 5-10 years. Various common potassium ion channel gene variants can lead to heterogeneous epilepsy phenotypes, and functional effects can result from gene deletions and compound effects. Administration of select anti-seizure medications is the primary treatment for this type of epilepsy. Most patients are refractory to anti-seizure medications, and some novel anti-seizure medications have been found to improve seizures. Use of targeted drugs to correct aberrant channel function based on the type of potassium channel gene variant can be used as an evidence-based pathway to achieve precise and individualized treatment for children with epilepsy. PLAIN LANGUAGE SUMMARY: In this article, the pathogenesis and clinical characteristics of epilepsy caused by different types of potassium channel gene variants are reviewed in the light of the latest research literature at home and abroad, with the expectation of providing a certain theoretical basis for the diagnosis and treatment of children with this type of disease.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2470-9239
    ISSN (online) 2470-9239
    DOI 10.1002/epi4.12934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: miR-143 promotes cell proliferation, invasion and migration via directly binding to BRD2 in lens epithelial cells.

    Chen, You / Zhao, Tong / Han, Mengyu / Chen, Yi

    American journal of translational research

    2024  Volume 16, Issue 2, Page(s) 446–457

    Abstract: Objective: Cataract causes the greatest number of blindnesses worldwide. This study aims to investigate the role of miR-143 in lens epithelial cells.: Methods: Clustering analysis was conducted to systematically compare miRNA expression levels across ...

    Abstract Objective: Cataract causes the greatest number of blindnesses worldwide. This study aims to investigate the role of miR-143 in lens epithelial cells.
    Methods: Clustering analysis was conducted to systematically compare miRNA expression levels across cataract and myopia. The levels of miR-143 and Bromodomain containing 2 (BRD2) were determined using real-time quantitative PCR (RT-qPCR) assay in lens epithelial cells. Transwell and wound healing assays were conducted to detect cell invasive and migratory abilities. The regulation relationship between MiR-143 and BRD2 was assessed using dual-luciferase reporter gene assays. BRD2 was knocked down using siRNA-BRD2, and siRNA-BRD2, and miR-143 inhibitors were transfected into cells with lipofectamine 2000.
    Results: Through retrieving five databases, 2690 miRNAs were selected. Volcano plot results demonstrated that 200 miRNAs were differentially expressed between cataract and myopia, in which 152 miRNAs were upregulated and 48 miRNAs downregulated in myopia compared with cataract. MiR-143 was upregulated in cataract compared with myopia (P<0.05). MiR-143 inhibitor suppressed the proliferation, invasion and migration of lens epithelial cells (all P<0.05). Luciferase reporter assays confirmed that BRD2 was a miR-143 target gene in SRA01/04 cells. Knockdown of BRD2 promoted SRA01/04 cell proliferation, invasion and migration (all P<0.05). In addition, silencing of BRD2 partially reversed the functions of miR-143 inhibitor on proliferation, invasion and migration (all P<0.05).
    Conclusion: MiR-143 suppresses lens epithelial cell proliferation, invasion and migration by regulating BRD2, which may support a novel therapeutic strategy for cataract patients.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploring the Nonlinear Relationship between Renewable Energy Consumption and Economic Growth in the Context of Global Climate Change.

    Feng, Yuting / Zhao, Tong

    International journal of environmental research and public health

    2022  Volume 19, Issue 23

    Abstract: In recent years, the impact of global climate change has increasingly revealed that energy transformation has become an indispensable part of achieving carbon neutrality. Thus, the relationship between energy transformation and economic growth has become ...

    Abstract In recent years, the impact of global climate change has increasingly revealed that energy transformation has become an indispensable part of achieving carbon neutrality. Thus, the relationship between energy transformation and economic growth has become the focus of academic attention. This study examines energy transition issues by using the panel threshold method. It explores the nonlinear impact of renewable energy consumption on economic growth, identifies various factors that lead to this nonlinear impact, and verifies its threshold effect. A comprehensive analysis reveals the following. (1) Overall, renewable energy consumption inhibits real gross domestic product (GDP) growth, but, in the long run, the negative impact becomes positive. (2) The threshold effect of energy consumption intensity (EI) is significant, with a threshold value of approximately 3.213. This means that when EI ≤ 3.213, renewable energy consumption promotes economic growth. However, EI > 3.213 indicates that this impact is significantly negative, which means that advancing the energy transition at this time may occur at the expense of real GDP growth. (3) There is also a significant threshold effect in energy transformation, with a threshold value of approximately 6.456. Similarly, when energy consumption transition (ET) ≤ 6.456, renewable energy consumption dampens real economic growth, and the economic cost of promoting renewable energy consumption is greater at this time. Alternatively, when ET > 6.456, this impact is significant at the 1 percent level and significantly positive. (4) There is also a significant threshold effect for emerging technologies, with a threshold value of approximately 1.367. When ET ≤ 1.367, renewable energy consumption dampens real economic growth, and the economic cost of promoting renewable energy consumption is greater. When ET > 1.367, the impact is significantly positive at the 1% level. To promote the positive development of economic growth, climate change, and energy transition, the nonlinear relationship studied in this paper can fill the gaps in existing research in theory and provide a theoretical basis for the government to adopt different policies at different stages of the energy transition to lay the foundation for improving global climate change in practice.
    MeSH term(s) Economic Development ; Climate Change ; Carbon Dioxide/analysis ; Renewable Energy ; Gross Domestic Product
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192315647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A road surface image dataset with detailed annotations for driving assistance applications.

    Zhao, Tong / Wei, Yintao

    Data in brief

    2022  Volume 43, Page(s) 108483

    Abstract: The preview of the road surface states is essential for improving the safety and the ride comfort of autonomous vehicles. The created dataset in this data article consists of 370151 road surface images captured under a wide range of road and weather ... ...

    Abstract The preview of the road surface states is essential for improving the safety and the ride comfort of autonomous vehicles. The created dataset in this data article consists of 370151 road surface images captured under a wide range of road and weather conditions in China. The original pictures are acquired with a vehicle-mounted camera and then the patches containing only the road surface area are cropped. The friction level, material, and unevenness properties of each road image are annotated in detail. This large-scale dataset is useful for developing vision-based road sensing modules to improve the performance of the driving assistance systems. Also, deep-learning experts can regard this dataset as a comparing benchmark for their algorithms. The dataset is available at [1].
    Language English
    Publishing date 2022-07-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2022.108483
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  6. Article ; Online: Detection and prediction of pathogenic microorganisms in aquaculture (Zhejiang Province, China).

    Zhao, Tong / Shen, Zhencai / Zhong, Ping / Zou, Hui / Han, Mingming

    Environmental science and pollution research international

    2024  Volume 31, Issue 5, Page(s) 8210–8222

    Abstract: The detection and prediction of pathogenic microorganisms play a crucial role in the sustainable development of the aquaculture industry. Currently, researchers mainly focus on the prediction of water quality parameters such as dissolved oxygen for early ...

    Abstract The detection and prediction of pathogenic microorganisms play a crucial role in the sustainable development of the aquaculture industry. Currently, researchers mainly focus on the prediction of water quality parameters such as dissolved oxygen for early warning. To provide early warning directly from the pathogenic source, this study proposes an innovative approach for the detection and prediction of pathogenic microorganisms based on yellow croaker aquaculture. Specifically, a method based on quantitative polymerase chain reaction (qPCR) is designed to detect the Cryptocaryon irritans (Cri) pathogenic microorganisms. Furthermore, we design a predictive combination model for small samples and high noise data to achieve early warning. After performing wavelet analysis to denoise the data, two data augmentation strategies are used to expand the dataset and then combined with the BP neural network (BPNN) to build the fusion prediction model. To ensure the stability of the detection method, we conduct repeatability and sensitivity tests on the designed qPCR detection technique. To verify the validity of the model, we compare the combined BPNN to long short-term memory (LSTM). The experimental results show that the qPCR method provides accurate quantitative measurement of Cri pathogenic microorganisms, and the combined model achieves a good level. The prediction model demonstrates higher accuracy in predicting Cri pathogenic microorganisms compared to the LSTM method, with evaluation indicators including mean absolute error (MAE), recall rate, and accuracy rate. Especially, the accuracy of early warning is increased by 54.02%.
    MeSH term(s) Animals ; Neural Networks, Computer ; Water Quality ; Aquaculture ; China ; Perciformes
    Language English
    Publishing date 2024-01-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-31612-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A road surface image dataset with detailed annotations for driving assistance applications

    Zhao, Tong / Wei, Yintao

    Data in Brief. 2022 July 20,

    2022  

    Abstract: The preview of the road surface states is essential for improving the safety and the ride comfort of autonomous vehicles. The created dataset in this data article consists of 370151 road surface images captured under a wide range of road and weather ... ...

    Abstract The preview of the road surface states is essential for improving the safety and the ride comfort of autonomous vehicles. The created dataset in this data article consists of 370151 road surface images captured under a wide range of road and weather conditions in China. The original pictures are acquired with a vehicle-mounted camera and then the patches containing only the road surface area are cropped. The friction level, material, and unevenness properties of each road image are annotated in detail. This large-scale dataset is useful for developing vision-based road sensing modules to improve the performance of the driving assistance systems. Also, deep-learning experts can regard this dataset as a comparing benchmark for their algorithms. The dataset is available at [1].
    Keywords cameras ; data collection ; friction ; surface area ; weather ; China
    Language English
    Dates of publication 2022-0720
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 2786545-9
    ISSN 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2022.108483
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Effects of pegylated recombinant human granulocyte colony-stimulating factor on lymphocytes and white blood cells of patients with malignant tumor.

    Zhao, Tong / Wang, Yuejun / Zhou, Deqing / Zhang, Weike

    Open life sciences

    2023  Volume 18, Issue 1, Page(s) 20220590

    Abstract: We investigated the effect of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) on lymphocytes and white blood cells of patients with malignant tumors. After PEG-rhG-CSF treatment, the count of lymphocytes increased in 66 ... ...

    Abstract We investigated the effect of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) on lymphocytes and white blood cells of patients with malignant tumors. After PEG-rhG-CSF treatment, the count of lymphocytes increased in 66 cases, remained unchanged in 2 cases, and decreased in 20 cases. The difference in lymphocyte count before and after treatment was statistically significant (
    Language English
    Publishing date 2023-04-12
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2817958-4
    ISSN 2391-5412 ; 2391-5412
    ISSN (online) 2391-5412
    ISSN 2391-5412
    DOI 10.1515/biol-2022-0590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of

    Zhao, Tong / Liu, Fang / Li, Yongjun

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1082620

    Abstract: Background: The effects of : Methods: Patients diagnosed with both GERD and HP were included. High-resolution esophageal manometry (HRM), 24-h esophageal pH monitoring, and the Gastroesophageal Reflux Disease Questionnaire (GerdQ) were performed ... ...

    Abstract Background: The effects of
    Methods: Patients diagnosed with both GERD and HP were included. High-resolution esophageal manometry (HRM), 24-h esophageal pH monitoring, and the Gastroesophageal Reflux Disease Questionnaire (GerdQ) were performed before and after the successful eradication of HP, and the data were compared using statistical analysis.
    Results: Sixty-eight patients diagnosed with both GERD and HP were included. The After HP eradication group showed significantly decreased median distal contractile integral (DCI) [610.40 (847.45) vs. 444.90 (559.60)] and significantly increased median inefficient esophageal motility (IEM) [36.00 (50.00) vs. 60.00 (57.00)] in the HRM compared with those of the Before HP eradication group, indicating that HP eradication reduced esophageal peristalsis. The 24-h esophageal pH monitoring showed that the longest reflux event, the percentage of time that the pH was <4, the number of reflux episodes, and the DeMeester score were all significantly different between the Before and After HP eradication groups (P < 0.05), suggesting that HP eradication increased esophageal acid exposure. The After HP eradication group also had a significantly higher GerdQ score than that of the Before HP eradication group (P < 0.05).
    Conclusions: HP eradication reduced esophageal peristalsis, enhanced esophageal acid exposure, and aggravated GERD symptoms, suggesting that HP infection may be a protective factor for GERD.
    MeSH term(s) Humans ; Helicobacter pylori ; Gastroesophageal Reflux ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Manometry ; Prospective Studies
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1082620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Synthesis-Controlled Polymorphism and Anion Solubility in the Sodium-Ion Conductor Na

    Zhao, Tong / Kraft, Marvin A / Zeier, Wolfgang G

    Inorganic chemistry

    2023  Volume 62, Issue 30, Page(s) 11737–11745

    Abstract: Motivated by the significant transport property improvement of the anion-substituted lithium metal halides, a series of anion mixed solid solutions of ... ...

    Abstract Motivated by the significant transport property improvement of the anion-substituted lithium metal halides, a series of anion mixed solid solutions of Na
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c01579
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