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Article ; Online: The Modeling Analysis and Effect of CHI3L1 and CD31-Marked Microvessel Density in the Occurrence and Development of Cervical Squamous Cell Carcinoma.

Qin, Yanzi / Zhao, Wenjun

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 3516335

Abstract: Background: Chitinase-3-like protein 1 (CHI3Ll) has been identified as a novel tumor marker in several cancers. The objective of this study was to detect the expression of Chitinase-3-like protein 1 (CHI3L1) and CD31-labeled microvessel density (MVD) in ...

Abstract	Background: Chitinase-3-like protein 1 (CHI3Ll) has been identified as a novel tumor marker in several cancers. The objective of this study was to detect the expression of Chitinase-3-like protein 1 (CHI3L1) and CD31-labeled microvessel density (MVD) in cervical squamous cell carcinoma (CSCC) and to assess its prognostic impact. Methods: Elivision™ plus immunohistochemical method was used to detect CHI3L1 expression and MVD in different cervical tissues. We analyzed the relationship between CHI3L1 and MVD in CSCC tissues and investigated the relationship between CHI3L1, MVD, and clinicopathological parameters. Univariate and multivariate survival analyses were performed to assess the impact on progression-free survival (PFS) and overall survival (OS). Results: The positive expression rate of CHI3L1 protein in CSCC tissues (69.9%, 72/103) was significantly higher than that in high-grade cervical intraepithelial lesions (53.3%, 32/60), low-grade cervical intraepithelial lesions (25%, 15/60), and normal cervical tissues (16.7%, 10/60). MVD values ranged from 6 to 64 in CSCC, and no microvascular formation was observed in normal cervical tissues, high-grade intraepithelial lesions, or low-grade intraepithelial lesions. The high expression of CHI3L1 and MVD was significantly correlated with the invasion depth, differentiation degree, vascular invasion, and lymph node metastasis of CSCC (all Conclusion: CHI3L1 may be involved in the progression of cervical cancer. Its high expression can promote neovascularization in the tumor microenvironment. CHI3L1 is a potential therapeutic target in the context of cervical cancer.
MeSH term(s)	Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Chitinase-3-Like Protein 1/genetics ; Female ; Humans ; Lymphatic Metastasis ; Microvascular Density ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Platelet Endothelial Cell Adhesion Molecule-1 ; Prognosis ; Tumor Microenvironment ; Uterine Cervical Neoplasms/genetics
Chemical Substances	CHI3L1 protein, human ; Chitinase-3-Like Protein 1 ; PECAM1 protein, human ; Platelet Endothelial Cell Adhesion Molecule-1
Language	English
Publishing date	2022-06-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/3516335
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Application of improved transformer based on weakly supervised in crowd localization and crowd counting.

Gao, Hui / Zhao, Wenjun / Zhang, Dexian / Deng, Miaolei

Scientific reports

2023 Volume 13, Issue 1, Page(s) 1144

Abstract: To the problem of the complex pre-processing and post-processing to obtain head-position existing in the current crowd localization method using pseudo boundary box and pre-designed positioning map, this work proposes an end-to-end crowd localization ... ...

Abstract	To the problem of the complex pre-processing and post-processing to obtain head-position existing in the current crowd localization method using pseudo boundary box and pre-designed positioning map, this work proposes an end-to-end crowd localization framework named WSITrans, which reformulates the weakly-supervised crowd localization problem based on Transformer and implements crowd counting. Specifically, we first perform global maximum pooling (GMP) after each stage of pure Transformer, which can extract and retain more detail of heads. In addition, we design a binarization module that binarizes the output features of the decoder and fuses the confidence score to obtain more accurate confidence score. Finally, extensive experiments demonstrate that the proposed method achieves significant improvement on three challenging benchmarks. It is worth mentioning that the WSITrans improves F1-measure by 4.0%.
MeSH term(s)	Benchmarking ; Electric Power Supplies ; Mental Processes
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-27299-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Knockdown of TRIM9 attenuates irinotecan‑induced intestinal mucositis in IEC‑6 cells by regulating DUSP6 expression via the P38 pathway.

Zhao, Wenjun / Wang, Qingming

Molecular medicine reports

2021 Volume 24, Issue 6

Abstract: Intestinal mucositis is a common side effect of cancer chemotherapy and it limits the dose of chemotherapy given to a patient. Tripartite motif family (TRIM) proteins have been reported to be implicated in the regulation of cancer chemotherapy. The ... ...

Abstract	Intestinal mucositis is a common side effect of cancer chemotherapy and it limits the dose of chemotherapy given to a patient. Tripartite motif family (TRIM) proteins have been reported to be implicated in the regulation of cancer chemotherapy. The present study aimed to investigate the effect of TRIM9 on irinotecan‑induced intestinal mucositis in the rat intestinal epithelial cell line IEC‑6. The expression of several TRIMs, such as TRIM1, TRIM9, TRIM18, TRIM36, TRIM46 and TRIM67, was examined. After TRIM9 knockdown or overexpression by lentivirus infection, cell proliferation and apoptosis, epithelial barrier tight‑junction proteins, inflammatory cytokines, transepithelial electrical resistance (TEER) and FITC dextran were measured. Treatment with irinotecan significantly inhibited cell proliferation and induced cell apoptosis, TRIM9 expression, intestinal mucosal barrier impairment, the levels of inflammatory cytokines and P38 phosphorylation in IEC‑6 cells, while the expression levels of epithelial barrier tight‑junction protein ZO‑1 and Claudin‑4 were decreased. Knockdown of TRIM9 partly counteracted the effect of irinotecan treatment, and inhibition of P38 potently reversed the effect of TRIM9 overexpression in IEC‑6 cells. Moreover, co‑immunoprecipitation showed an interaction between TRIM9 and DUSP6 in IEC‑6 cells, and overexpression of DUSP6 notably counteracted the effect of TRIM9 overexpression. The results demonstrated that TRIM9 knockdown may benefit patients with intestinal mucositis by inhibiting inflammatory cytokine expression and repairing intestinal barrier functions, which was probably due to inhibition of the activation of the P38 pathway via targeting DUSP6.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Carrier Proteins ; Cell Line ; Cell Proliferation ; Dual Specificity Phosphatase 6/genetics ; Dual Specificity Phosphatase 6/metabolism ; Epithelial Cells ; Intestinal Mucosa/metabolism ; Intestines/drug effects ; Irinotecan/pharmacology ; Mucositis/chemically induced ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Rats ; Tripartite Motif Proteins/genetics ; Tripartite Motif Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Carrier Proteins ; Nerve Tissue Proteins ; Trim9 protein, rat ; Tripartite Motif Proteins ; Irinotecan (7673326042) ; TRIM9 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; DUSP6 protein, human (EC 3.1.3.48) ; Dual Specificity Phosphatase 6 (EC 3.1.3.48) ; Dusp6 protein, rat (EC 3.1.3.48)
Language	English
Publishing date	2021-10-22
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2021.12507
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Research on College Students' Mobile Reading Behavior under the Framework of Information Behavior：Taking the Superstar Mobile Reading APP Platform as an Example

Zhao Wenjun / Sun Jinyu

Zhishi guanli luntan, Vol 5, Iss 1, Pp 10-

2020 Volume 23

Abstract: Purpose /significance］Taking the Superstar mobile reading APP as the research platform, this paper explores the behavioral rules of mobile reading for college students. So that, we can provide references and advice for mobile reading service providers ... ...

Abstract	［Purpose /significance］Taking the Superstar mobile reading APP as the research platform, this paper explores the behavioral rules of mobile reading for college students. So that, we can provide references and advice for mobile reading service providers to improve service quality.[ Method /process］Taking undergraduates as the research object , this paper adopted the method of questionnaire survey and in-depth interview to obtain the research data, used Excel, SPSS and other statistical tools for statistical analysis of the survey data.［Result /conclusion］At present, the mobile reading service provided by university libraries has such problems as low utilization rate, difficulty in meeting users' demands for resource content, and improvement in interactive experience. Then, the paper proposes some targeted strategies for improving the quality of mobile reading based on the conclusion of the investigation analysis．
Keywords	mobile reading ; Bibliography. Library science. Information resources ; Z
Subject code	028
Language	Chinese
Publishing date	2020-02-01T00:00:00Z
Publisher	LIS Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: What is effective classroom dialog? A comparative study of classroom dialog in Chinese expert and novice mathematics teachers' classrooms.

Zhao, Wenjun / Ma, Jing / Cao, Yiming

Frontiers in psychology

2022 Volume 13, Page(s) 964967

Abstract: Conducting effective classroom dialog is an important foundation for high-quality classrooms. This study investigates the characteristics of effective classroom dialog from the perspective of Chinese mathematics classrooms. Classroom videotapes from 40 ... ...

Abstract	Conducting effective classroom dialog is an important foundation for high-quality classrooms. This study investigates the characteristics of effective classroom dialog from the perspective of Chinese mathematics classrooms. Classroom videotapes from 40 expert and 33 novice teachers were selected from a national project and analyzed through a developed coding framework. Results showed that the dominant types of dialog in expert teachers' classrooms were related to Basic Knowledge, Construction, Analysis, and Personal Information. Compared to novice teachers, expert teachers' classrooms have a significantly lower proportion of dialog on Basic Knowledge and significantly higher proportions of dialog on Personal Information and Speculation. Based on expert teachers' classrooms, the characteristics of effective classroom dialog in the Chinese context were discussed. The analytical framework for classroom dialog developed in this study could be a powerful tool for subsequent research. Suggestions are provided on increasing the effectiveness of classroom dialog.
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.964967
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Images in Vascular Medicine: Chronic penetrating nail injury of the common carotid artery.

Wang, Xiang / Chu, Haiwei / Zhao, Wenjun

Vascular medicine (London, England)

2022 Volume 27, Issue 4, Page(s) 401–402

MeSH term(s)	Cardiology ; Carotid Artery, Common ; Humans ; Wounds, Penetrating/diagnostic imaging ; Wounds, Penetrating/surgery
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X211066968
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Book ; Online: A memory-efficient neural ODE framework based on high-level adjoint differentiation

Zhang, Hong / Zhao, Wenjun

2022

Abstract: Neural ordinary differential equations (neural ODEs) have emerged as a novel network architecture that bridges dynamical systems and deep learning. However, the gradient obtained with the continuous adjoint method in the vanilla neural ODE is not reverse- ...

Abstract	Neural ordinary differential equations (neural ODEs) have emerged as a novel network architecture that bridges dynamical systems and deep learning. However, the gradient obtained with the continuous adjoint method in the vanilla neural ODE is not reverse-accurate. Other approaches suffer either from an excessive memory requirement due to deep computational graphs or from limited choices for the time integration scheme, hampering their application to large-scale complex dynamical systems. To achieve accurate gradients without compromising memory efficiency and flexibility, we present a new neural ODE framework, PNODE, based on high-level discrete adjoint algorithmic differentiation. By leveraging discrete adjoint time integrators and advanced checkpointing strategies tailored for these integrators, PNODE can provide a balance between memory and computational costs, while computing the gradients consistently and accurately. We provide an open-source implementation based on PyTorch and PETSc, one of the most commonly used portable, scalable scientific computing libraries. We demonstrate the performance through extensive numerical experiments on image classification and continuous normalizing flow problems. We show that PNODE achieves the highest memory efficiency when compared with other reverse-accurate methods. On the image classification problems, PNODE is up to two times faster than the vanilla neural ODE and up to 2.3 times faster than the best existing reverse-accurate method. We also show that PNODE enables the use of the implicit time integration methods that are needed for stiff dynamical systems.
Keywords	Computer Science - Machine Learning
Subject code	518
Publishing date	2022-06-02
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Need for standardized evidence-based in trauma care report.

Zhao, Wen-Jun / Liu, Gui-E / Tian, Yuan / Li, Lei

Chinese journal of traumatology = Zhonghua chuang shang za zhi

2022 Volume 25, Issue 6, Page(s) 311

MeSH term(s)	Humans ; Trauma Centers ; Emergency Medical Services ; Wounds and Injuries/therapy
Language	English
Publishing date	2022-07-22
Publishing country	China
Document type	Editorial
ZDB-ID	2276839-7
ISSN	1008-1275
ISSN	1008-1275
DOI	10.1016/j.cjtee.2022.07.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High expression of ANRIL correlated with the poor prognosis in patients with cancer: A meta-analysis.

Liu, Yun / Zhu, Linqi / Zhao, Wenjun / Zhou, Yong / Shao, Shihe

Medicine

2022 Volume 101, Issue 36, Page(s) e30531

Abstract: Background: ANRIL, also called CDKN2B antisense RNA 1, is an important genetic susceptibility locus for cardiovascular diseases and associated with numerous pathologies, including several human cancers.: Objective: The relationship between ANRIL and ... ...

Abstract	Background: ANRIL, also called CDKN2B antisense RNA 1, is an important genetic susceptibility locus for cardiovascular diseases and associated with numerous pathologies, including several human cancers. Objective: The relationship between ANRIL and the clinical outcome or prognosis of cancer patients was analyzed in this meta-analysis. Methods: One thousand seven hundred eight cancer patients were selected in 23 studies from 3 databases (Pubmed, Cochrane Library, and EMBASE). Results: A fixed-effects model indicated that the high expression of ANRIL is obviously linked to poor overall survival (OS) (Hazard ratio [HR] = 1.77, 95% confidence interval [CI] = 1.57-2.00, P < .00001); the random-effects model revealed poor disease-free survival (DFS) (HR = 1.86, 95% CI: 1.46-2.37, P < .00001). A high level of ANRIL expression was also associated with the tumor size (small vs large, odds ratio [OR] = 0.57, 95% CI: 0.39-0.83, P = .003), TNM stage (I + II vs III + IV; OR = 0.40, 95% CI: 0.24-0.69, P = .0008), and lymph node metastasis (LNM) (Yes vs No, OR = 3.66, 95% CI: 1.46-9.17, P = .006). ANRIL was not related significantly to histologic differentiation compared to poor with moderate + well; the OR value is 0.74, 95% CI: 0.26-2.12, P = .58. In addition, evidence suggested that a high level of ANRIL was positively associated with human cancer type, follow-up time, and sample size. Conclusion: This meta-analysis demonstrated that ANRIL may be a valuable biomarker for predicting poor prognosis in cancer patients.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Disease-Free Survival ; Humans ; Lymphatic Metastasis ; Prognosis ; RNA, Long Noncoding/genetics
Chemical Substances	Biomarkers, Tumor ; RNA, Long Noncoding
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030531
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Article: Evaluation of Droplet Digital PCR for the Detection of Black Canker Disease in Tomato.

Wang, Li / Tian, Qian / Zhou, Pei / Zhao, Wenjun / Sun, Xianchao

Plant disease

2022 Volume 106, Issue 2, Page(s) 395–405

Abstract: Clavibacter ... ...

Abstract	Clavibacter michiganensis
MeSH term(s)	DNA Primers/genetics ; Lycopersicon esculentum/microbiology ; Plant Diseases/microbiology ; Real-Time Polymerase Chain Reaction ; Seeds/microbiology
Chemical Substances	DNA Primers
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-02-21-0317-RE
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