Result 1 - 10 of total 23
2017
| Author's details | William Rongxuan Zhao |
|---|---|
| Language | English |
| Size | Online-Ressource |
| Publishing place | Sheffield |
| Document type | Book ; Online |
| Database | Special collection on veterinary medicine and general parasitology |
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2021 Volume 9, Page(s) 622254
Abstract: Background: ...
| Abstract | Background: |
|---|---|
| Language | English |
| Publishing date | 2021-06-11 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2711999-3 |
| ISSN | 2296-2360 |
| ISSN | 2296-2360 |
| DOI | 10.3389/fped.2021.622254 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2018 Volume 122, Issue 3, Page(s) 276–282
Abstract: Objective: To review observational human, murine, and interventional trial studies that have examined the gut microbiome in food allergy, and to provide perspective on future investigations in this field.: Data sources: A review of the published ... ...
| Abstract | Objective: To review observational human, murine, and interventional trial studies that have examined the gut microbiome in food allergy, and to provide perspective on future investigations in this field. Data sources: A review of the published literature was performed with PubMed, and clinical studies catalogued at ClinicalTrials.gov were also reviewed. Study selections: The most recent relevant studies, seminal works, and topical clinical trials were selected. Results: Gut dysbiosis likely precedes the development of food allergy, and the timing of such dysbiosis is critical. Gut microbiota associated with individual food allergies may be distinct. Murine models support the importance of gut microbiota in shaping immune maturation and tolerance. Gut microbiota may affect food allergy susceptibility by modulating type 2 immunity, influencing immune development and tolerance, regulating basophil populations, and promoting intestinal barrier function. Ongoing and future interventional trials of probiotics, prebiotics, synbiotics, and fecal microbiota transfer will help translate our understanding of the gut microbiome in food allergy to clinical practice. Future work in this area will include deepening of current research foci, as well as expansion of efforts to include the virome, mycobiome, and interactions between the microbiome, host, and environment. Robust and consistent study designs, multidimensional profiling, and systems biology approaches will enable this future work. Conclusion: By advancing research on the microbiome in food allergy, we can further our understanding of food allergy and derive new approaches for its prevention and therapy. |
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| MeSH term(s) | Animals ; Food Hypersensitivity/microbiology ; Gastrointestinal Microbiome ; Humans |
| Language | English |
| Publishing date | 2018-12-20 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review |
| ZDB-ID | 1228189-x |
| ISSN | 1534-4436 ; 0003-4738 ; 1081-1206 |
| ISSN (online) | 1534-4436 |
| ISSN | 0003-4738 ; 1081-1206 |
| DOI | 10.1016/j.anai.2018.12.012 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uh III Zs.136: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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BMJ open quality
2023 Volume 12, Issue 1
Abstract: Background: Over-ordering of daily laboratory tests adversely affects patient care through hospital-acquired anaemia, patient discomfort, burden on front-line staff and unnecessary downstream testing. This remains a prevalent issue despite the 2013 ... ...
| Abstract | Background: Over-ordering of daily laboratory tests adversely affects patient care through hospital-acquired anaemia, patient discomfort, burden on front-line staff and unnecessary downstream testing. This remains a prevalent issue despite the 2013 Choosing Wisely recommendation to minimise unnecessary daily labs. We conducted a systematic review of the literature to identify interventions targeting unnecessary laboratory testing. Methods: We systematically searched MEDLINE, EMBASE, Cochrane Central and SCOPUS databases to identify interventions focused on reducing daily complete blood count, complete metabolic panel and basic metabolic panel labs. We defined interventions as 'effective' if a statistically significant reduction was attained and 'highly effective' if a reduction of ≥25% was attained. Results: The search yielded 5646 studies with 41 articles that met inclusion criteria. We grouped interventions into one or more categories: audit and feedback, cost display, education, electronic medical record (EMR) change, and policy change. Most interventions lasted less than a year and used a multipronged approach. All five strategies were effective in most studies with EMR change being the most commonly used independent strategy. EMR change and policy change were the strategies most frequently reported as effective. EMR change was the strategy most frequently reported as highly effective. Conclusion: Our analysis identified five categories of interventions targeting daily laboratory testing. All categories were effective in most studies, with EMR change being most frequently highly effective. Prospero registration number: CRD42021254076. |
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| MeSH term(s) | Humans ; Inpatients ; Unnecessary Procedures ; Clinical Laboratory Techniques |
| Language | English |
| Publishing date | 2023-03-23 |
| Publishing country | England |
| Document type | Systematic Review ; Journal Article |
| ISSN | 2399-6641 |
| ISSN (online) | 2399-6641 |
| DOI | 10.1136/bmjoq-2022-002128 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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The Journal of allergy and clinical immunology
2023 Volume 152, Issue 6, Page(s) 1569–1580
Abstract: Background: Rising rates of peanut allergy (PA) motivate investigations of its development to inform prevention and therapy. Microbiota and the metabolites they produce shape food allergy risk.: Objective: We sought to gain insight into gut ... ...
| Abstract | Background: Rising rates of peanut allergy (PA) motivate investigations of its development to inform prevention and therapy. Microbiota and the metabolites they produce shape food allergy risk. Objective: We sought to gain insight into gut microbiome and metabolome dynamics in the development of PA. Methods: We performed a longitudinal, integrative study of the gut microbiome and metabolome of infants with allergy risk factors but no PA from a multicenter cohort followed through mid-childhood. We performed 16S rRNA sequencing, short chain fatty acid measurements, and global metabolome profiling of fecal samples at infancy and at mid-childhood. Results: In this longitudinal, multicenter sample (n = 122), 28.7% of infants developed PA by mid-childhood (mean age 9 years). Lower infant gut microbiome diversity was associated with PA development (P = .014). Temporal changes in the relative abundance of specific microbiota and gut metabolite levels significantly differed in children who developed PA. PA-bound children had different abundance trajectories of Clostridium sensu stricto 1 sp (false discovery rate (FDR) = 0.015) and Bifidobacterium sp (FDR = 0.033), with butyrate (FDR = 0.045) and isovalerate (FDR = 0.036) decreasing over time. Metabolites associated with PA development clustered within the histidine metabolism pathway. Positive correlations between microbiota, butyrate, and isovalerate and negative correlations with histamine marked the PA-free network. Conclusion: The temporal dynamics of the gut microbiome and metabolome in early childhood are distinct for children who develop PA. These findings inform our thinking on the mechanisms underlying and strategies for potentially preventing PA. |
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| MeSH term(s) | Child ; Child, Preschool ; Humans ; Infant ; Butyrates ; Feces/microbiology ; Gastrointestinal Microbiome/genetics ; Metabolome ; Peanut Hypersensitivity ; RNA, Ribosomal, 16S/genetics ; Longitudinal Studies |
| Chemical Substances | Butyrates ; RNA, Ribosomal, 16S |
| Language | English |
| Publishing date | 2023-08-22 |
| Publishing country | United States |
| Document type | Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 121011-7 |
| ISSN | 1097-6825 ; 1085-8725 ; 0091-6749 |
| ISSN (online) | 1097-6825 ; 1085-8725 |
| ISSN | 0091-6749 |
| DOI | 10.1016/j.jaci.2023.08.012 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uh III Zs.92: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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bioRxiv : the preprint server for biology
2024
Abstract: ... ...
| Abstract | TP53 |
|---|---|
| Language | English |
| Publishing date | 2024-02-14 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2023.06.28.546977 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2022 Volume 13, Page(s) 927856
Abstract: Background: Stroke is a major cause of mortality and long-term physical and cognitive impairment. This study aims to: (1) examine the prevalence of depressive symptoms, disability and pain among Chinese adults with stroke; (2) test the associations of ... ...
| Abstract | Background: Stroke is a major cause of mortality and long-term physical and cognitive impairment. This study aims to: (1) examine the prevalence of depressive symptoms, disability and pain among Chinese adults with stroke; (2) test the associations of functional limitations and body pain with occurrence of depressive symptoms; (3) investigate gender and urban-rural disparities in these associations. Methods: This study utilized the data from the China Health and Retirement Longitudinal Study in 2018, involving 969 patients with stroke among 17,970 participants aged ≥ 45 years. Depressive symptoms were assessed using the 10-item Center for Epidemiologic Studies Depression (CES-D) Scale. We performed multivariable logistic regression models to estimate the associations between activities of daily life (ADL), instrumental activities of daily life (IADL) and pain with depressive symptoms. Results: Depressive symptoms were found among 40.2% of stroke patients, with a higher prevalence in females (48.2%) than males (32.7%). Prevalence of ADL limitations, IADL limitations and pain among stroke patients were 39.2, 49.8 and 14.0%, respectively. ADL and IADL limitations and pain were more prevalent among females and residents in rural areas. Multivariable regression analyses showed a significant association between ADL limitation (OR = 1.535, 95% CI = 1.168, 2.018), IADL limitation (OR = 1.666, 95% CI = 1.260, 2.203) and pain (OR = 2.122, 95% CI = 1.466, 3.073) with depressive symptoms. Stratified analyses revealed stronger associations among urban residents. Females had a higher association of ADL and IADL with depressive symptoms but similar in that of pain to the males. The impact of ADL and IADL in male patients is higher than in females, but the impact of pain on depressive symptoms is higher in female patients. Conclusion: Depressive symptoms are common amongst post-stroke patients in China and are significantly associated with functional disability and physical pain. Our findings have implications for practitioners on the early assessment of pain and depression after stroke. Future research should explore effective intervention measures for physical-mental stroke complications. |
|---|---|
| Language | English |
| Publishing date | 2022-09-12 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2564218-2 |
| ISSN | 1664-0640 |
| ISSN | 1664-0640 |
| DOI | 10.3389/fpsyt.2022.927856 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Clinical trials (London, England)
2007 Volume 4, Issue 3, Page(s) 286–291
Abstract: In analysing clinical trials designed to show superiority of one treatment compared to another, it is standard to use an intention to treat analytic approach. In active-controlled noninferiority studies, this is not standard, due to concerns that such an ...
| Abstract | In analysing clinical trials designed to show superiority of one treatment compared to another, it is standard to use an intention to treat analytic approach. In active-controlled noninferiority studies, this is not standard, due to concerns that such an analysis will inflate the chance of falsely rejecting the null hypothesis, accepting therapeutic noninferiority when it is not justified. The reasons for using intention to treat (ITT) approaches in superiority studies include a desire to capture all information on study subjects, a need to prevent bias, and assurance that comparative groups are, on average, equivalent in prognostic factors. In this commentary, we argue that these same justifications carry over to noninferiority studies, and that for those and other reasons it should be the preferred analytic approach. We review regulatory guidelines, and propose a number of approaches to minimizing the potential disadvantages of the ITT approach in the noninferiority setting. |
|---|---|
| MeSH term(s) | Bias ; Humans ; Patient Dropouts ; Patient Selection ; Randomized Controlled Trials as Topic/methods ; Randomized Controlled Trials as Topic/statistics & numerical data |
| Language | English |
| Publishing date | 2007 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2138796-5 |
| ISSN | 1740-7745 |
| ISSN | 1740-7745 |
| DOI | 10.1177/1740774507079443 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5831: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Clinical cancer research : an official journal of the American Association for Cancer Research
2017 Volume 23, Issue 11, Page(s) 2869–2879
Abstract: Purpose: ...
| Abstract | Purpose: |
|---|---|
| Language | English |
| Publishing date | 2017-06-01 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1225457-5 |
| ISSN | 1557-3265 ; 1078-0432 |
| ISSN (online) | 1557-3265 |
| ISSN | 1078-0432 |
| DOI | 10.1158/1078-0432.CCR-16-1742 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4223: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2024 , Page(s) 111523
Abstract: Background: In patients with severe traumatic brain injury (TBI), clinicians must balance preventing venous thromboembolism (VTE) with the risk of intracranial hemorrhagic expansion (ICHE). We hypothesized that low molecular weight heparin (LMWH) would ... ...
| Abstract | Background: In patients with severe traumatic brain injury (TBI), clinicians must balance preventing venous thromboembolism (VTE) with the risk of intracranial hemorrhagic expansion (ICHE). We hypothesized that low molecular weight heparin (LMWH) would not increase risk of ICHE or VTE as compared to unfractionated heparin (UH) in patients with severe TBI. Methods: Patients ≥ 18 years of age with isolated severe TBI (AIS ≥ 3), admitted to 24 level I and II trauma centers between January 1, 2014 to December 31, 2020 and who received subcutaneous UH and LMWH injections for chemical venous thromboembolism prophylaxis (VTEP) were included. Primary outcomes were VTE and ICHE after VTEP initiation. Secondary outcomes were mortality and neurosurgical interventions. Entropy balancing (EBAL) weighted competing risk or logistic regression models were estimated for all outcomes with chemical VTEP agent as the predictor of interest. Results: 984 patients received chemical VTEP, 482 UH and 502 LMWH. Patients on LMWH more often had pre-existing conditions such as liver disease (UH vs LMWH 1.7 % vs. 4.4 %, p = 0.01), and coagulopathy (UH vs LMWH 0.4 % vs. 4.2 %, p < 0.001). There were no differences in VTE or ICHE after VTEP initiation. There were no differences in neurosurgical interventions performed. There were a total of 29 VTE events (3 %) in the cohort who received VTEP. A Cox proportional hazards model with a random effect for facility demonstrated no statistically significant differences in time to VTE across the two agents (p = 0.44). The LMWH group had a 43 % lower risk of overall ICHE compared to the UH group (HR = 0.57: 95 % CI = 0.32-1.03, p = 0.062), however was not statistically significant. Conclusion: In this multi-center analysis, patients who received LMWH had a decreased risk of ICHE, with no differences in VTE, ICHE after VTEP initiation and neurosurgical interventions compared to those who received UH. There were no safety concerns when using LMWH compared to UH. Level of evidence: Level III, Therapeutic Care Management. |
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| Language | English |
| Publishing date | 2024-04-09 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 218778-4 |
| ISSN | 1879-0267 ; 0020-1383 |
| ISSN (online) | 1879-0267 |
| ISSN | 0020-1383 |
| DOI | 10.1016/j.injury.2024.111523 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 778: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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