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Article: Effect of Sheng-Jiang Powder on Gut Microbiota in High-Fat Diet-Induced NAFLD.

Li, Juan / Hu, Qian / Xiao-Yu, Dai / Zhu, Lv / Miao, Yi-Fan / Kang, Hong-Xin / Zhao, Xian-Lin / Yao, Jia-Qi / Long, Dan / Tang, Wen-Fu / Wan, Mei-Hua

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 6697638

Abstract: Background and aims: Nonalcoholic fatty liver disease (NAFLD) is an alarming global health problem that is predicted to be the major cause of cirrhosis, hepatocellular carcinoma, and liver transplantation by next decade. Gut microbiota have been ... ...

Abstract	Background and aims: Nonalcoholic fatty liver disease (NAFLD) is an alarming global health problem that is predicted to be the major cause of cirrhosis, hepatocellular carcinoma, and liver transplantation by next decade. Gut microbiota have been revealed playing an important role in the pathogenesis of NAFLD. Sheng-Jiang Powder (SJP), an empirical Chinese medicine formula to treat NAFLD, showed great hepatoprotective properties, but the impact on gut microbiota has never been identified. Therefore, we performed this study to investigate the effect of SJP on gut microbiota in NAFLD mice. Methods: NAFLD was induced by 12 weeks' high-fat diet (HFD) feeding. Mice were treated with SJP/normal saline daily for 6 weeks. Blood samples were obtained for serum biochemical indices and inflammatory cytokines measurement. Liver tissues were obtained for pathological evaluation and oil red O staining. The expression of lipid metabolism-related genes was quantified by RT-PCR and Western blotting. Changes in gut microbiota composition were analyzed by the 16s rDNA sequencing technique. Results: HFD feeding induced significant increase in bodyweight and serum levels of TG, TC, ALT, and AST. The pathological examination revealed obvious hepatic steatosis in HFD feeding mice. Coadministration of SJP effectively protected against bodyweight increase and lipid accumulation in blood and liver. Increased expression of PPAR Conclusions: SJP is efficient in attenuating HFD-induced NAFLD, and it might be partly attributed to the regulation of gut microbiota.
Language	English
Publishing date	2020-11-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/6697638
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Article ; Online: Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis.

Zhang, Yu-Mei / Ren, Hong-Yu / Zhao, Xian-Lin / Li, Juan / Li, Jun-Yi / Wu, Fu-Sheng / Su, Hang / Tang, Wen-Fu

World journal of gastroenterology

2017 Volume 23, Issue 8, Page(s) 1367–1374

Abstract: Aim: To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in the liver of rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis.: Methods: Healthy male Sprague-Dawley rats ... ...

Abstract	Aim: To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in the liver of rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis. Methods: Healthy male Sprague-Dawley rats were randomly divided into a sham operation group (SOG); a model group (MG); and low-, median- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Different dosages (6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP. The tissue concentrations of aloe-emodin, rhein, emodin, chrysophanol, honokiol, rheo chrysophanol, magnolol, hesperidin, naringenin and naringin in the liver of the treated rats were detected by high-performance liquid chromatography tandem mass spectrometry. Alanine transaminase (ALT) and aspartate transaminase (AST) in serum, inflammatory mediators in the liver and pathological scores were evaluated. Results: The major components of DCQD were detected in the liver, and their concentrations increased dose-dependently. The high dose of DCQD showed a maximal effect in ameliorating the pathological damages, decreasing the pro-inflammatory mediators tumor necrosis factor-α and interleukin (IL)-6 and increasing anti-inflammatory mediators IL-4 and IL-10 in the liver. The pathological scores in the pancreas for the MG were significantly higher than those for the SOG ( Conclusion: DCQD could alleviate liver damage by altering the inflammatory response in rats with SAP based on the liver distribution of its components.
MeSH term(s)	Acute Disease ; Alanine Transaminase/blood ; Animals ; Anthraquinones/pharmacokinetics ; Aspartate Aminotransferases/blood ; Biphenyl Compounds/pharmacokinetics ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Emodin/pharmacokinetics ; Flavanones/pharmacokinetics ; Hesperidin/pharmacokinetics ; Inflammation ; Lignans/pharmacokinetics ; Liver/drug effects ; Liver/metabolism ; Male ; Pancreatitis/drug therapy ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry
Chemical Substances	Anthraquinones ; Biphenyl Compounds ; Da-Cheng-Qi ; Drugs, Chinese Herbal ; Flavanones ; Lignans ; magnolol (001E35HGVF) ; aloe emodin (C8IYT9CR7C) ; Hesperidin (E750O06Y6O) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; naringenin (HN5425SBF2) ; Emodin (KA46RNI6HN) ; chrysophanic acid (N1ST8V8RR2) ; naringin (N7TD9J649B) ; rhein (YM64C2P6UX)
Language	English
Publishing date	2017-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v23.i8.1367
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Article: Effect of Different-Volume Fluid Resuscitation on Organ Functions in Severe Acute Pancreatitis and Therapeutic Effect of

Yi, Xiao-Lin / Hu, Jing / Wu, Qiu-Ting / Zhang, Yu-Mei / Hu, Qian / Yuan, Ling / Miao, Yi-Fan / Chen, Huan / Zhu, Lv / Li, Juan / Zhao, Xian-Lin / Yao, Jia-Qi / Dai, Xiao-Yu / Wan, Mei-Hua / Tang, Wen-Fu

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 6408202

Abstract: Objective: To explore the effect of different-volume fluid resuscitation (FR) on organ functions in severe acute pancreatitis (SAP) and to elucidate the therapeutic effect and mechanism of : Methods: 1. Clinical study: retrospective analysis of ... ...

Abstract	Objective: To explore the effect of different-volume fluid resuscitation (FR) on organ functions in severe acute pancreatitis (SAP) and to elucidate the therapeutic effect and mechanism of Methods: 1. Clinical study: retrospective analysis of thirty-one patients about the effect of titrated fluid resuscitation protocol (TFR) on the occurrence of acute kidney injury (AKI) secondary to SAP. 2. Experimental study: rats ( Results: The occurrence of AKI, fluid volume, and fluid velocity in TFR group was lower than that in the control group. Logistic regression analysis showed that increased Marshall scores and fluid velocity were risk factors for predicting occurrence of AKI in SAP. Low-volume FR decreased the levels of blood urea nitrogen (BUN), serum creatinine (Cr), matrix metalloproteinase (MMP), and pathologic scores of the pancreas and kidney. High-volume FR increased ascites, MMPs, and kidney pathologic scores. Conclusion: TFR-associated lower fluid volume and velocity reduced the occurrence of AKI secondary to SAP. High volume might aggravate AKI via increased MMP release leading to endothelial glycocalyx damage and vascular endothelial dysfunction.
Language	English
Publishing date	2020-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/6408202
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Article: Therapeutic Effect of Chinese Herbal Ointment Liu-He-Dan in Patients with Acute Pancreatitis.

Wan, Mei-Hua / Zhao, Xian-Lin / Chen, Wei-Wei / Li, Juan / Guo, Hui / Xia, Qing / Tang, Wen-Fu

Chinese medical journal

2016 Volume 129, Issue 9, Page(s) 1128–1130

MeSH term(s)	Acute Disease ; C-Reactive Protein/analysis ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Interleukin-6/blood ; Ointments ; Pancreatitis/drug therapy ; Pancreatitis/immunology
Chemical Substances	Drugs, Chinese Herbal ; Interleukin-6 ; Liu-He-Dan ; Ointments ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2016-05-05
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127089-8
ISSN	0366-6999 ; 1002-0187
ISSN	0366-6999 ; 1002-0187
DOI	10.4103/0366-6999.180524
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Article: Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal micron Liuhe Pill ointment in rats.

Liu, Yi-ling / Zhao, Xian-lin / Li, Juan / Wan, Mei-hua / Chen, Guang-yuan / Chen, Wei-wei / Tang, Wen-fu

Chinese journal of integrative medicine

2015 Volume 21, Issue 12, Page(s) 922–927

Abstract: Objective: To explore the effect of acute pancreatitis (AP) on the pharmacokinetics of herbal ointment micron Liuhe Pill, MLHP) components in anesthetized rats.: Methods: Rats were randomly divided into a AP model group (n=6) and a normal group as a ... ...

Abstract	Objective: To explore the effect of acute pancreatitis (AP) on the pharmacokinetics of herbal ointment micron Liuhe Pill, MLHP) components in anesthetized rats. Methods: Rats were randomly divided into a AP model group (n=6) and a normal group as a control (n=6). The rat model of AP was induced by intraperitoneal injection of L-arginine in rats (15 mg/kg, twice, interval 1 h). Chinese herbal ointment MLHP was used externally on the belly after the 2nd injection for 48 h in both groups. Emodin, rhein, aloe emodin, physcion, chrysophanol from MLHP were detected and quantified in rat serum and pancreas (at 48 h) by high performance liquid chromatography-tandem mass spectrometry. Results: Among the five components, only emodin, aloe emodin and physcion from MLHP were detected in all rat serum and most of the rats' pancreas. Rhein and chrysophanol were not detected in both serum and pancreas. T1/2α of emodin and physcion in MLHP were obviously shorter in the AP model group than those in the normal group (P<0.05), while there was no difference for T1/2α of aloe emodin. The peak concentration and area under curve of all three components were much higher in the AP group than those in the normal group with MLHP in external application for 48 h (P<0.05). Furthermore, the mean residence time (MRT) and maximum plasma concentration (Tmax) of emodin and aloe emodin were obviously longer in the AP model group than those in the normal control group (P<0.05). There was no significant difference for Ka of all components between the two groups. Emodin could be detected in all rats' pancreas at 48 h in both groups, while its mean pancreatic concentration was higher in the AP model group than in the normal group (0.61±0.54 ng/mL, 0.42±0.37 ng/mL, respectively,P<0.05). Aloe emodin could be detected in all rats' pancreas at 48 h in both groups and their mean pancreatic concentration were similar (0.31±0.24 ng/mL, 0.33±0.17 ng/mL, respectively,P>0.05). Physcion could be detected in pancreas of most rats in the AP model while only two rats in the normal group. Conclusion: AP could significantly affect the pharmacokinetics of absorbed components of Chinese herbal MLHP ointment in rats.
MeSH term(s)	Acute Disease ; Animals ; Anthraquinones/analysis ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/pharmacokinetics ; Emodin/analysis ; Male ; Ointments ; Pancreatitis/metabolism ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Anthraquinones ; Drugs, Chinese Herbal ; Ointments ; Emodin (KA46RNI6HN) ; rhein (YM64C2P6UX)
Language	English
Publishing date	2015-12
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-015-2080-y
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Article: Pharmacokinetic and pharmacodynamic comparison of chinese herbal ointment liu-he-dan and micron liu-he-dan ointment in rats with acute pancreatitis.

Zhu, Shi-Feng / Chen, Wei-Wei / Xiang, Jin / Zhao, Xian-Lin / Wan, Mei-Hua / Yu, Qin / Liang, Mao-Zhi / Tang, Wen-Fu

Evidence-based complementary and alternative medicine : eCAM

2014 Volume 2014, Page(s) 389576

Abstract: Aim. To compare the pharmacokinetics and pharmacodynamics of herbal ointment Liu-He-Dan (LHD) and micron LHD (MLHD) in rats with acute pancreatitis (AP). Methods. Twenty rats were allocated into normal, AP, LHD, and MLHD groups. LHD or MLHD was applied ... ...

Abstract	Aim. To compare the pharmacokinetics and pharmacodynamics of herbal ointment Liu-He-Dan (LHD) and micron LHD (MLHD) in rats with acute pancreatitis (AP). Methods. Twenty rats were allocated into normal, AP, LHD, and MLHD groups. LHD or MLHD was applied on rats' abdomens. Plasma levels of emodin, rhein, aloe emodin, physcion, and chrysophanol were determined by high performance liquid chromatography-mass spectrometry-mass spectrometry (HPLC-MS-MS) at different time points, and the pharmacokinetic parameters were calculated. Serum amylase, TNF- α , IL-6, and IL-10 levels, and the pancreatic pathological scores were determined at 48 h after LHD or MLHD treatment. Results. T 1/2 α and area under the curve (AUC) of emodin in the MLHD group were lower than those in the LHD group, while T 1/2 α and AUC of aloe emodin in the MLHD group were higher than those in the LHD group (P < 0.05). T 1/2 α and T max of physcion in the MLHD group were significantly shorter than those in the LHD group (P < 0.05). Compared with the AP group, the amylase, malondialdehyde (MDA), TNF- α , and IL-6 levels decreased significantly after three days of treatment in LHD and MLHD groups, while the levels of superoxide dismutase (SOD), TNF- α , and the pancreatic pathological score, were similar. The pharmacodynamic parameters between the LHD and MLHD groups were similar. Conclusion. MLHD had better pharmacokinetics than, and similar pharmacodynamics to, LHD in the management of rats with AP, which indicated that MLHD might be substituted for LHD in the treatment of AP and thus reduce the amount of medicinal herbs used.
Language	English
Publishing date	2014-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2014/389576
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Article: Electroacupuncture Ameliorates Acute Lung Injury through Promoting Gastrointestinal Motility in Rats with Acute Pancreatitis.

Guo, Hui / Zhu, Shi-Feng / Zhang, Rong-Rong / Zhao, Xian-Lin / Wan, Mei-Hua / Tang, Wen-Fu

Evidence-based complementary and alternative medicine : eCAM

2014 Volume 2014, Page(s) 943596

Abstract: Objective. Gastrointestinal disfunction and acute lung injury (ALI) were common in acute pancreatitis (AP). The effect of electro-acupuncture (EA) on gastrointestinal motility and ALI in rats with AP was investigated to verify the theory of "lung and ... ...

Abstract	Objective. Gastrointestinal disfunction and acute lung injury (ALI) were common in acute pancreatitis (AP). The effect of electro-acupuncture (EA) on gastrointestinal motility and ALI in rats with AP was investigated to verify the theory of "lung and large intestine are interior exteriorly related" in traditional Chinese medicine. Methods. Male Sprague-Dawley rats were randomly divided into the normal group, model group, and EA group. AP model was established by three injections of 20% L-arginine at 1 h intervals. EA were applied to bilateral ST-25 and ST-36 for 30 minutes twice a day after modeling for 3 days. Arterial blood, pancreas, lung, and intestinal tissues were collected for detecting the inflammatory factors and histopathology. Intestinal propulsion rate (IPR) was also measured at 72 h. Results. EA treatment improved IPR and increased CCK-8 level compared with model group (P < 0.05). It lowered the serum levels of TNF- α and IL-6 and increased the level of IL-4 with no effect on IL-10. EA treatment reduced serum vasoactive intestinal peptide (VIP) and myeloperoxidase (MPO) level in the lung and the pathologic scores of pancreas, lung and intestine were decreased (P < 0.05). Conclusion. EA treatment could promote gastrointestinal motility through inhibiting VIP, and promoting CCK expression and regulate pro- and anti-inflammatory mediators to ameliorate ALI in AP.
Language	English
Publishing date	2014-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2014/943596
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Article ; Online: Optimal timing for the oral administration of Da-Cheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis.

Zhang, Yu-Mei / Zhu, Lin / Zhao, Xian-Lin / Chen, Huan / Kang, Hong-Xin / Zhao, Jian-Lei / Wan, Mei-Hua / Li, Juan / Zhu, Lv / Tang, Wen-Fu

World journal of gastroenterology

2017 Volume 23, Issue 39, Page(s) 7098–7109

Abstract: Aim: To identify the optimal oral dosing time of Da-Cheng-Qi decoction (DCQD) in rats with acute pancreatitis (AP) based on the pharmacokinetic and pharmacodynamic parameters.: Methods: First, 24 male Sprague-Dawley rats were divided into a sham- ... ...

Abstract	Aim: To identify the optimal oral dosing time of Da-Cheng-Qi decoction (DCQD) in rats with acute pancreatitis (AP) based on the pharmacokinetic and pharmacodynamic parameters. Methods: First, 24 male Sprague-Dawley rats were divided into a sham-operated group [NG(a)] and three model groups [4hG(a), 12hG(a) and 24hG(a)]. The NG(a) and model groups were administered DCQD (10 g/kg.BW) intragastrically at 4 h, 4 h, 12 h and 24 h, respectively, after AP models induced by 3% sodium taurocholate. Plasma samples were collected from the tails at 10 min, 20 min, 40 min, 1 h, 2 h, 4 h, 8 h, 12 h and 24 h after a single dosing with DCQD. Plasma and pancreatic tissue concentrations of the major components of DCQD were determined by high-performance liquid chromatography tandem mass spectroscopy. The pharmacokinetic parameters and serum amylase were detected and compared. Second, rats were divided into a sham-operated group [NG(b)] and three treatment groups [4hG(b), 12hG(b) and 24hG(b)] with three corresponding control groups [MG(b)s]. Blood and pancreatic tissues were collected 24 h after a single dosing with DCQD. Serum amylase, inflammatory cytokines and pathological scores of pancreatic tissues were detected and compared. Results: The concentrations of emodin, naringin, honokiol, naringenin, aloe-emodin, chrysophanol and rheochrysidin in the 12hG(a) group were higher than those in the 4hG(a) group in the pancreatic tissues ( Conclusion: Late-time dosing may have higher concentrations of the most major components of DCQD, with better pharmacokinetics and pharmacodynamics of anti-inflammation than early-time dosing, which showed the late time to be the optimal dosing time of DCQD for AP.
MeSH term(s)	Acute Disease ; Administration, Oral ; Amylases/blood ; Animals ; Biomarkers/blood ; Disease Models, Animal ; Drug Administration Schedule ; Interleukin-10/blood ; Interleukin-6/blood ; Male ; Pancreas/drug effects ; Pancreas/metabolism ; Pancreas/pathology ; Pancreatitis/blood ; Pancreatitis/chemically induced ; Pancreatitis/drug therapy ; Pancreatitis/pathology ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacokinetics ; Rats, Sprague-Dawley ; Taurocholic Acid
Chemical Substances	Biomarkers ; Interleukin-6 ; Plant Extracts ; dachengqi decoction ; Interleukin-10 (130068-27-8) ; Taurocholic Acid (5E090O0G3Z) ; Amylases (EC 3.2.1.-)
Language	English
Publishing date	2017-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v23.i39.7098
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Article ; Online: Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats.

Zhao, Xian-Lin / Xiang, Jin / Wan, Mei-Hua / Yu, Qin / Chen, Wei-wei / Chen, Guang-Yuan / Tang, Wen-Fu

Journal of ethnopharmacology

2013 Volume 145, Issue 1, Page(s) 94–99

Abstract: Ethnopharmacological relevance: Chinese herbal preparation of Liu-He-Dan ointment has been adapted for acute pancreatitis in external application for many years in West China.: Aim of the study: To investigate the effect of acute pancreatitis on the ... ...

Abstract	Ethnopharmacological relevance: Chinese herbal preparation of Liu-He-Dan ointment has been adapted for acute pancreatitis in external application for many years in West China. Aim of the study: To investigate the effect of acute pancreatitis on the pharmacokinetics of Liu-He-Dan ointment in rats while it was used externally on belly. Materials and methods: Twelve male Sprague-Dawley rats were randomly divided into acute pancreatitis model group (n=6) and normal group as a control (n=6). Chinese herbal Liu-He-Dan ointment was used externally on belly. Emodin, rhein, aloe emodin, physcion and chrysophanol in plasma and pancreas (at 48 h) were detected and quantified by liquid chromatography-tandem mass spectrometry. Amylase in plasma were determined with iodide process. Results: Among the five components, only emodin, aloe emodin and physcion from Liu-He-Dan were detected in plasma and pancreas. The absorption of each component was tended to decrease in acute pancreatitis group after topically management with Liu-He-Dan ointment on rats' abdomen. The T(max), C(max) and area under curve (AUC) of each component were distinctly lower in AP group than those in normal group (p<0.05). However, the T(1/2α) and mean retention time (MRT) of emodin lasted longer in acute pancreatitis group than those in normal group (p<0.05). There was no statistical difference in the MRT of aloe emodin and physcion between the two groups. Emodin could be detected in all rats' pancreas at 48 h in both groups, while its mean pancreatic concentration was higher in acute pancreatitis model group than in normal group (0.91 ± 0.68, 0.41 ± 0.36, respectively). Physcion could be detected in pancreas of most acute pancreatitis models, but not in normal rats. Aloe emodin was found in all pancreas from acute pancreatitis models while only one in normal group. The level of amylase in Liu-He-Dan group was obviously lower than that in the AP model group (p=0.0055). Conclusion: We concluded that acute pancreatitis may significantly affect the pharmacokinetics of Liu-He-Dan while external applied on belly, which indicated the dosage modification in AP. However, acute pancreatitis seems to promote the distribution of the detected components into pancreas. The ointment could help relieve the disease of pancreatitis.
MeSH term(s)	Administration, Cutaneous ; Amylases/metabolism ; Animals ; Anthraquinones/pharmacokinetics ; Arginine ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Emodin/analogs & derivatives ; Emodin/pharmacokinetics ; Male ; Ointments/administration & dosage ; Ointments/pharmacokinetics ; Pancreas/drug effects ; Pancreas/metabolism ; Pancreatitis/chemically induced ; Pancreatitis/metabolism ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Anthraquinones ; Drugs, Chinese Herbal ; Liu-He-Dan ; Ointments ; Arginine (94ZLA3W45F) ; aloe emodin (C8IYT9CR7C) ; Amylases (EC 3.2.1.-) ; physcione (H6PT94IV61) ; Emodin (KA46RNI6HN) ; rhein (YM64C2P6UX)
Language	English
Publishing date	2013-01-09
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2012.10.036
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Article: Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats

Zhao, Xian-Lin / Xiang, Jin / Wan, Mei-Hua / Yu, Qin / Chen, Wei-wei / Chen, Guang-Yuan / Tang, Wen-Fu

Journal of ethnopharmacology. 2013 Jan. 9, v. 145, no. 1

2013

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Chinese herbal preparation of Liu-He-Dan ointment has been adapted for acute pancreatitis in external application for many years in West China. AIM OF THE STUDY: To investigate the effect of acute pancreatitis on the ... ...

Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Chinese herbal preparation of Liu-He-Dan ointment has been adapted for acute pancreatitis in external application for many years in West China. AIM OF THE STUDY: To investigate the effect of acute pancreatitis on the pharmacokinetics of Liu-He-Dan ointment in rats while it was used externally on belly. MATERIALS AND METHODS: Twelve male Sprague-Dawley rats were randomly divided into acute pancreatitis model group (n=6) and normal group as a control (n=6). Chinese herbal Liu-He-Dan ointment was used externally on belly. Emodin, rhein, aloe emodin, physcion and chrysophanol in plasma and pancreas (at 48h) were detected and quantified by liquid chromatography–tandem mass spectrometry. Amylase in plasma were determined with iodide process. RESULTS: Among the five components, only emodin, aloe emodin and physcion from Liu-He-Dan were detected in plasma and pancreas. The absorption of each component was tended to decrease in acute pancreatitis group after topically management with Liu-He-Dan ointment on rats’ abdomen. The Tₘₐₓ, Cₘₐₓ and area under curve (AUC) of each component were distinctly lower in AP group than those in normal group (p<0.05). However, the T₁/₂α and mean retention time (MRT) of emodin lasted longer in acute pancreatitis group than those in normal group (p<0.05). There was no statistical difference in the MRT of aloe emodin and physcion between the two groups. Emodin could be detected in all rats’ pancreas at 48h in both groups, while its mean pancreatic concentration was higher in acute pancreatitis model group than in normal group (0.91±0.68, 0.41±0.36, respectively). Physcion could be detected in pancreas of most acute pancreatitis models, but not in normal rats. Aloe emodin was found in all pancreas from acute pancreatitis models while only one in normal group. The level of amylase in Liu-He-Dan group was obviously lower than that in the AP model group (p=0.0055). CONCLUSION: We concluded that acute pancreatitis may significantly affect the pharmacokinetics of Liu-He-Dan while external applied on belly, which indicated the dosage modification in AP. However, acute pancreatitis seems to promote the distribution of the detected components into pancreas. The ointment could help relieve the disease of pancreatitis.
Keywords	Aloe ; abdomen ; absorption ; emodin ; iodides ; mass spectrometry ; models ; ointments ; pancreas ; pancreatitis ; pharmacokinetics ; rats ; China
Language	English
Dates of publication	2013-0109
Size	p. 94-99.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2012.10.036
Database	NAL-Catalogue (AGRICOLA)

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