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Article: 患者门户系统在老年冠心病慢病远程管理中的应用及效果.

Wen, Fangyuan / DU, Guanghui / Tian, Feng / Zhao, Xiaojuan

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2024 Volume 55, Issue 2, Page(s) 418–424

Abstract: Objective: To investigate the application of personal health record (PHR) and chronic disease management platform established on the basis of patient portal system (PPS) in managing older adults with coronary heart disease and to examine the effect on ... ...

Title translation	Application and Effect of Patient Portal System in the Remote Management of Chronic Diseases for Older Adults With Coronary Heart Disease.
Abstract	Objective: To investigate the application of personal health record (PHR) and chronic disease management platform established on the basis of patient portal system (PPS) in managing older adults with coronary heart disease and to examine the effect on patients' self-care ability, coping mode, and quality of life. Methods: A total of 532 elderly patients with coronary heart disease were included in the study. All the participants enrolled were admitted to a tertiary-care hospital between January 2019 and June 2021. They were randomly assigned to the study group (269 cases) and the control group (263 cases). Patients in the control group were discharged with the routine discharge procedures and received the routine follow-up care. On the other hand, patients in the study group were discharged and followed up through the PHR and chronic disease management platform established on the basis of PPS. After 6 months, 12 months, and 18 months of patient management, the Exercise of Self-Care Agency (ESCA) Scale, Medical Coping Modes Questionnaire (MCMQ) and Seattle Angina Questionnaire (SAQ) were used to evaluate the patients' self-care ability, coping mode, and quality of life, respectively. The patient management effects of the two groups were analyzed. Results: Before the management programs started, there was no statistically significant difference in the scores for the scales between the two groups of patients. After 6 months, 12 months, and 18 months of patient management, the ESCA scores of both groups were higher than those before patient management started ( Conclusion: The PHR and chronic disease management platform established on the basis of PPS can increase the convenient access to medical care among elderly patients with coronary heart disease, which is conducive to improving their self-care ability, coping mode, and quality of life. In addition, the patient management effect is good.
MeSH term(s)	Humans ; Quality of Life ; Coronary Disease/therapy ; Aged ; Chronic Disease ; Patient Portals ; Male ; Female ; Self Care ; Surveys and Questionnaires ; Adaptation, Psychological ; Disease Management
Language	Chinese
Publishing date	2024-02-08
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial ; English Abstract
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20240360503
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Zs.B 2708: Show issues

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Article: Correlation of Folic Acid Metabolic Gene Polymorphisms, Homocysteine, Vitamin B12, and Red Blood Cell Folate with Adverse Pregnancy Outcomes.

Zhao, Xiaojuan / Yang, Linlin / Wang, Meigui / Zhang, Xueru

Alternative therapies in health and medicine

2023

Abstract: Objective: This study aims to investigate the relationship between folic acid (FA) metabolic gene polymorphisms, homocysteine (Hcy), vitamin B12 (Vit B12), and red blood cell folate (RBCF) with adverse pregnancy. The findings of this study can help in ... ...

Abstract	Objective: This study aims to investigate the relationship between folic acid (FA) metabolic gene polymorphisms, homocysteine (Hcy), vitamin B12 (Vit B12), and red blood cell folate (RBCF) with adverse pregnancy. The findings of this study can help in the prevention and treatment of adverse pregnancy in the future. Methods: 118 pregnant women admitted to Qingdao Central Hospital between August 2020 and October 2022 were selected for retrospective analysis, including 62 cases of normal delivery (control group, CG) and 56 cases of adverse pregnancy (research group, RG). The single nucleotide polymorphisms of MTHFR C677T, MTHFR A1298C, and MTRR A66G gene loci were tested in both cohorts. Besides, differences in Hcy, Vit B12, and RBCF levels were observed, as well as Hcy, Vit B12, and RBCF alterations in different genotype carriers in the research group. Results: An elevated proportion of MTHFR 677TT-type gene and MTRR 66GG-type gene carriers and a lower proportion of MTRR 66GG-type gene carriers were found in the research group (χ2 = 4.458, 4.238, 4.206, P = .035, .040, .040). As indicated by the Logistic regression analysis, carriers of MTHFR 677TT and MTRR 66GG gene had an increased risk of adverse pregnancy outcomes (95%CI=2.881-5.942, 1.427-3.809, P < .001), while MTRR 66AG carriers had a decreased risk (95%CI=0.124-1.849, P < .001). Finally, Hcy levels of MTHFR 677TT and MTRR 66GG gene carriers increased, while Vit B12 and RBCF decreased; the opposite was true for MTRR 66AG gene carriers (P < .001). Conclusions: FA metabolic gene polymorphisms, Hcy, Vit B12, and RBCF are closely related to adverse pregnancy outcomes, which is of great significance for future clinical evaluation of adverse pregnancy.
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Choline alleviated perinatal fluoride exposure‐induced learning and memory impairment through α4β2 nAChRs and α7 nAChRs in offspring mice

Zhao, Yangfei / Zhao, Xiaojuan / Wang, Jundong

Environmental Toxicology. 2023 Mar., v. 38, no. 3 p.511-521

2023

Abstract: Fluoride pollution is widely present in the living environment. As a critical period of brain development, the perinatal period is extremely vulnerable to fluoride. Studies have found that choline can protect the brain's memory and enhance the ability to ...

Abstract	Fluoride pollution is widely present in the living environment. As a critical period of brain development, the perinatal period is extremely vulnerable to fluoride. Studies have found that choline can protect the brain's memory and enhance the ability to focus. However, the effect of choline on perinatal fluoride‐induced nerve damage remains unclear. Therefore, 32 Kunming newly conceived female mice and their offspring mice were randomly divided into control, NaF, LC + NaF, and HC + NaF groups, and the HE staining, Y‐maze test, RT‐PCR, western blotting, immunohistochemistry, etc. were used in this study. The results showed that fluoride decreased the brain organ coefficients and brain protein content (p < 0.05, p < 0.01), and caused histomorphological damage in the hippocampus and cortex, which suggested that fluoride affected the development of the brain and damaged the brain. Moreover, the results of the Y‐maze test showed that fluoride increased the number of learning days, error reaction time, and total reaction time, and decreased the AchE activity in the brain (p < 0.05, p < 0.01), which indicated that fluoride reduced the learning and memory ability of the mice. Besides, the results showed that fluoride decreased the mRNA and protein expression levels of α4β2 nAChRs and α7 nAChRs in the hippocampus and cortex (p < 0.05, p < 0.01). However, perinatal choline supplementation reversed the aforementioned fluoride‐induced changes. In short, these results demonstrated that choline alleviated perinatal fluoride‐induced learning and memory impairment, which will provide a rationale for the mitigation and prevention of fluoride‐induced brain damage.
Keywords	brain damage ; choline ; cortex ; ecotoxicology ; females ; fluorides ; hippocampus ; immunohistochemistry ; memory ; memory disorders ; nerve tissue ; perinatal period ; pollution ; progeny ; protein content ; protein synthesis
Language	English
Dates of publication	2023-03
Size	p. 511-521.
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23692
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Highly sensitive and selective SERS detection of caspase-3 during cell apoptosis based on the target-induced hotspot effect.

Zhuang, Yueyuan / Dong, Han / Liu, Tianqing / Zhao, Yongmei / Xu, Yan / Zhao, Xiaojuan / Sun, Dan

The Analyst

2024 Volume 149, Issue 2, Page(s) 490–496

Abstract: Caspase-3 is an important biomarker for the process of apoptosis, which is a key target for cancer treatment. Due to its low concentration in single cells and the structural similarity of caspase family proteins, it is exceedingly challenging to ... ...

Abstract	Caspase-3 is an important biomarker for the process of apoptosis, which is a key target for cancer treatment. Due to its low concentration in single cells and the structural similarity of caspase family proteins, it is exceedingly challenging to accurately determine the intracellular caspase-3 during apoptosis
MeSH term(s)	Caspase 3 ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Apoptosis ; Biosensing Techniques/methods ; Peptides ; Spectrum Analysis, Raman/methods
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; Gold (7440-57-5) ; Peptides
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an01721d
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Zs.A 2423: Show issues

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Article ; Online: Comparison of postoperative complications in mediastinal lymph node dissection versus mediastinal lymph node sampling for early stage non-small cell lung cancer: Protocol for a systematic review and meta-analysis.

Chen, Qiao / Li, Weijuan / Cai, Ningning / Chen, Weiwei / Zhao, Xiaojuan / Huang, Xiongfeng

PloS one

2024 Volume 19, Issue 2, Page(s) e0298368

Abstract: Introduction: Lung cancer is the primary cause of cancer-related deaths worldwide, with high rates of morbidity and mortality. The most effective treatment for early stage (I-II) non-small cell lung cancer (NSCLC) is surgical resection. However, the ... ...

Abstract	Introduction: Lung cancer is the primary cause of cancer-related deaths worldwide, with high rates of morbidity and mortality. The most effective treatment for early stage (I-II) non-small cell lung cancer (NSCLC) is surgical resection. However, the extent of mediastinal lymph nodes removal required and the impact of their removal remains controversial. This systematic review and meta-analysis aimed to evaluate the postoperative complications in patients with stage I-II NSCLC who received mediastinal lymph node dissection (MLND) or mediastinal lymph node sampling (MLNS). Methods and analysis: According to the predefined inclusion criteria, we will conduct a comprehensive search for randomized controlled trials (RCTs) and observational studies examining the postoperative complications of MLND compared to MLNS in patients with stage I-II NSCLC. The search will be performed across multiple databases including PubMed, Embase, the Cochrane Library, CNKI, WanFang, Sinomed, VIP, Duxiu, and Web of Science from inception to February 2024. Additionally, relevant literature references will be retrieved and hand searching of pertinent journals will be conducted. Screening, data extraction, and quality assessment will be performed by two independent reviewers. Review Manager 5.4 will be applied in analyzing and synthesizing. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assess the quality of evidence for the whole RCTs and used Newcastle-Ottawa scale to assess the methodologic quality of observational studies. Ethics and dissemination: This study did not include personal information. Ethical approval was not required for this study. This study is based on a secondary analysis of the literature, so ethical review approval is not required. The final report will be published in a peer-reviewed journal. Conclusion: This systematic review will contribute to compare the safety and survival benefits of these two surgical techniques for the treatment of early stage NSCLC, to further guide the selection of surgical approaches. Trial registration: The protocol of the systematic review has been registered on Open Science Framework, with a registration number of DOI https://doi.org/10.17605/OSF.IO/N2Y5D.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Neoplasm Staging ; Systematic Reviews as Topic ; Meta-Analysis as Topic ; Lung Neoplasms/pathology ; Lymph Node Excision/adverse effects ; Lymph Node Excision/methods ; Small Cell Lung Carcinoma/pathology ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Postoperative Complications/pathology
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298368
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Article ; Online: Diagnostic value of high-frequency ultrasound combined with fine needle aspiration cytology and BRAF gene for papillary thyroid microcarcinoma.

Li, Chuang / Zhao, Xiaojuan / Zhao, Jingge / Zhao, Jing / An, Lemei / Wu, Gang

Cellular and molecular biology (Noisy-le-Grand, France)

2024 Volume 70, Issue 3, Page(s) 187–191

Abstract: We attempted to evaluate clinical application value of high-frequency ultrasound (HFUS), fine needle aspiration cytology (FNAC), BRAF gene, and combination of HFUS, FNAC, and BRAF gene in diagnosing papillary thyroid microcarcinoma (PTMC). The 150 ... ...

Abstract	We attempted to evaluate clinical application value of high-frequency ultrasound (HFUS), fine needle aspiration cytology (FNAC), BRAF gene, and combination of HFUS, FNAC, and BRAF gene in diagnosing papillary thyroid microcarcinoma (PTMC). The 150 patients with thyroid minimal lesions who underwent HFUS, FNAC and BRAF gene testing before surgery in our hospital from June 2020 to December 2021 were selected as research subjects. Patients were divided into two groups based on postoperative pathological results. The consistency of diagnostic results of HFUS, FNAC, and BRAF gene and their combination with those of pathological examination, diagnostic efficacy of HFUS, FNAC and BRAF gene combined detection and individual detection for PTMC lymph node metastasis, and diagnostic value of HFUS, FNAC and BRAF gene combined detection and individual detection for PTMC lymph node metastasis received analysis and comparison. The consistency of diagnostic results of combined detection with pathological examination exhibited elevation relative to that of HFUS, FNAC and BRAF gene detection alone (P < 0.05). The negative predictive value, sensitivity and accuracy of combined detection exhibited elevation relative to individual detection (P < 0.05). The AUC of combined detection in diagnosing PTMC lymph node metastasis exhibited elevation relative to that of HFUS and BRAF gene alone (P < 0.05). HFUS combined with FNAC and BRAF genes possesses high diagnostic value, with high diagnostic sensitivity, specificity, and accuracy. Thus, combined detection for PTMC before surgery can accurately determine whether lymph node metastasis occurs, reduce occurrence of missed diagnosis and misdiagnosis, and thus improve diagnostic precision.
MeSH term(s)	Humans ; Proto-Oncogene Proteins B-raf/genetics ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/diagnostic imaging ; Biopsy, Fine-Needle/methods ; Female ; Male ; Carcinoma, Papillary/genetics ; Carcinoma, Papillary/pathology ; Carcinoma, Papillary/diagnostic imaging ; Middle Aged ; Adult ; Ultrasonography/methods ; Lymphatic Metastasis ; Aged ; Cytology
Chemical Substances	Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1)
Language	English
Publishing date	2024-03-31
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2024.70.3.28
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Zs.A 3812: Show issues

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Article ; Online: Extraction, separation and kinetics of phenylethanosides from

Feng, Chuanhua / Guo, Huiling / Zhao, Xiaojuan / Tang, Xiaolin / Xiong, Yaokun

Preparative biochemistry & biotechnology

2023 Volume 53, Issue 8, Page(s) 978–987

Abstract: In this paper, the total phenylethanosides (TPS) were extracted efficiently by an innovative extraction technology--deep eutectic solvent-based ultrasound-assisted extraction (DES-UAE) ... ...

Abstract	In this paper, the total phenylethanosides (TPS) were extracted efficiently by an innovative extraction technology--deep eutectic solvent-based ultrasound-assisted extraction (DES-UAE) from
MeSH term(s)	Solvents ; Flavonoids ; Deep Eutectic Solvents ; Plantago ; Methanol ; Kinetics ; Water ; Technology ; Ethanol ; Plant Extracts
Chemical Substances	Solvents ; Flavonoids ; Deep Eutectic Solvents ; Methanol (Y4S76JWI15) ; Water (059QF0KO0R) ; Ethanol (3K9958V90M) ; Plant Extracts
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1322522-4
ISSN	1532-2297 ; 1082-6068
ISSN (online)	1532-2297
ISSN	1082-6068
DOI	10.1080/10826068.2022.2163257
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Article: Early-Onset Diabetes Mellitus in Chromosome 8p11.2 Deletion Syndrome Combined With Becker Muscular Dystrophy - A Case Report.

Cao, Conghui / Wang, Xiaoli / Zhao, Xiaojuan

Frontiers in endocrinology

2022 Volume 13, Page(s) 914863

Abstract: Background: Chromosome 8p11.2 includes several key genes in development such as the : Case description: A 20-year-old man with a 1-year history of diabetes mellitus was admitted to the Endocrinology Clinic. Physical examination revealed the ... ...

Abstract	Background: Chromosome 8p11.2 includes several key genes in development such as the Case description: A 20-year-old man with a 1-year history of diabetes mellitus was admitted to the Endocrinology Clinic. Physical examination revealed the dysmorphic facial features, and broad and foreshortened halluces. Laboratory examination indicated spherocytosis anemia, and hypogonadotropic hypogonadism. Bone mineral density analysis showed decreased bone density in the lumbar vertebrae. Brain CT showed calcification. Whole-exome sequencing revealed a 7.05-Mb deletion in 8p11 containing 43 OMIM genes, and a large in-frame deletion of exons 48-55 in the DMD gene. Metformin was given to the patient after which his blood glucose was well controlled. HCG was injected subcutaneously and was supplemented with calcium and vitamin D, which led to an improvement in the patient's quality of life. Conclusion: We report a rare case of 8p11.2 deletion syndrome with unique phenotypes, and early-onset diabetes. It is challenging for endocrinologists to simultaneously reconcile a combination of these diseases across multiple disciplines. We discussed the influencing factors of early-onset diabetes in this patient and speculated that it was caused by complex interactions of known and unknown genetic backgrounds and environmental factors.
MeSH term(s)	Chromosomes ; Diabetes Mellitus/genetics ; Exons ; Humans ; Muscular Dystrophy, Duchenne/genetics ; Quality of Life ; Sodium-Phosphate Cotransporter Proteins, Type III/genetics ; Spherocytosis, Hereditary/genetics
Chemical Substances	SLC20A2 protein, human ; Sodium-Phosphate Cotransporter Proteins, Type III
Language	English
Publishing date	2022-07-25
Publishing country	Switzerland
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.914863
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Article ; Online: Choline alleviated perinatal fluoride exposure-induced learning and memory impairment through α4β2 nAChRs and α7 nAChRs in offspring mice.

Zhao, Yangfei / Zhao, Xiaojuan / Wang, Jundong

Environmental toxicology

2022 Volume 38, Issue 3, Page(s) 511–521

Abstract	Fluoride pollution is widely present in the living environment. As a critical period of brain development, the perinatal period is extremely vulnerable to fluoride. Studies have found that choline can protect the brain's memory and enhance the ability to focus. However, the effect of choline on perinatal fluoride-induced nerve damage remains unclear. Therefore, 32 Kunming newly conceived female mice and their offspring mice were randomly divided into control, NaF, LC + NaF, and HC + NaF groups, and the HE staining, Y-maze test, RT-PCR, western blotting, immunohistochemistry, etc. were used in this study. The results showed that fluoride decreased the brain organ coefficients and brain protein content (p < 0.05, p < 0.01), and caused histomorphological damage in the hippocampus and cortex, which suggested that fluoride affected the development of the brain and damaged the brain. Moreover, the results of the Y-maze test showed that fluoride increased the number of learning days, error reaction time, and total reaction time, and decreased the AchE activity in the brain (p < 0.05, p < 0.01), which indicated that fluoride reduced the learning and memory ability of the mice. Besides, the results showed that fluoride decreased the mRNA and protein expression levels of α4β2 nAChRs and α7 nAChRs in the hippocampus and cortex (p < 0.05, p < 0.01). However, perinatal choline supplementation reversed the aforementioned fluoride-induced changes. In short, these results demonstrated that choline alleviated perinatal fluoride-induced learning and memory impairment, which will provide a rationale for the mitigation and prevention of fluoride-induced brain damage.
MeSH term(s)	Mice ; Pregnancy ; Animals ; Female ; Fluorides/toxicity ; Choline/pharmacology ; Choline/metabolism ; Memory Disorders/chemically induced ; Memory Disorders/prevention & control ; Hippocampus/metabolism
Chemical Substances	Fluorides (Q80VPU408O) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23692
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Article ; Online: Empirical prediction of patent pledge financing of pharmaceutical enterprises-A case study in Jiangsu China.

Zhao, Xiaojuan / Liu, Yunhua

PloS one

2020 Volume 15, Issue 6, Page(s) e0233601

Abstract: Financing by patent pledge is an important way for small- and medium-sized pharmaceutical enterprises to address financing problems. In this study, eight indexes are analyzed considering both the pledge patent value and pledger credit value. And a ... ...

Abstract	Financing by patent pledge is an important way for small- and medium-sized pharmaceutical enterprises to address financing problems. In this study, eight indexes are analyzed considering both the pledge patent value and pledger credit value. And a prediction model for the patent pledge financing amount for pharmaceutical enterprises is constructed for the first time using the analytic hierarchy process and the fuzzy comprehensive evaluation method. Three levels of financing amount are concluded through the prediction model and prediction results corresponding with the financing amount are displayed. This model was designed to help small- and medium-sized pharmaceutical enterprises get access to financing through patent pledge to relieve their financial stress. At the same time, it provides guides for pledgees and policymakers to improve the efficiency and quality of patent pledge. This work is reliable and valid in that it constructs this prediction model based on systematical data from official data sources.
MeSH term(s)	China ; Drug Industry/economics ; Forecasting/methods ; Healthcare Financing ; Humans ; Models, Theoretical ; Technology, Pharmaceutical/economics
Language	English
Publishing date	2020-06-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0233601
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