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Article ; Online: Macroscopic entanglement in optomechanical system induced by non-Markovian environment.

Zhao, Xinyu

2019 Volume 27, Issue 20, Page(s) 29082–29097

Abstract: In this paper, the non-Markovian dynamics of an optomechanical system is analyzed by using the non-Markovian quantum state diffusion (NMQSD) method. An exact solution is obtained for the system composed of a Fabry-Pérot (F-P) cavity with two movable ... ...

Abstract	In this paper, the non-Markovian dynamics of an optomechanical system is analyzed by using the non-Markovian quantum state diffusion (NMQSD) method. An exact solution is obtained for the system composed of a Fabry-Pérot (F-P) cavity with two movable mirrors without the linearization of the Hamiltonian. Based on the solution, we find that the memory effect of the non-Markovian environment can be used to generate macroscopic entanglement between two mirrors. In order to achieve the maximum entanglement generation, the non-Markovian properties of the environment have to be chosen carefully depending on the properties of the system. Then, we also show that the coherence (superposition) in the initial state may produce entanglement in the evolution. At last, we show the entanglement sudden death and revival significantly depend on the strength of the memory effect, and the entanglement revival can be only observed in non-Markovian case. Our treatment, as an example, paves a way to exactly solve a large category of optomechanical systems without the linearization of the Hamiltonian.
Language	English
Publishing date	2019-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.27.029082
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Article ; Online: Epilepsy and psychiatric comorbidities: A bidirectional mendelian randomization study.

Chu, Hongyuan / Wang, Bing / Zhao, Xinyu / Mu, Li

Journal of affective disorders

2024 Volume 350, Page(s) 774–783

Abstract: Study objectives: Psychiatric comorbidities are relatively common among patients with epilepsy; however, the underlying mechanisms of this association remain largely unknown. The objective of this Mendelian randomization (MR) study was to analyze the ... ...

Abstract	Study objectives: Psychiatric comorbidities are relatively common among patients with epilepsy; however, the underlying mechanisms of this association remain largely unknown. The objective of this Mendelian randomization (MR) study was to analyze the genetic correlations and causality underlying these reciprocal associations. Methods: Single-nucleotide polymorphisms associated with epilepsy (29,677 controls and 15,212 cases) and seven psychiatric comorbidities (485,436 controls and 269,495 cases) were identified from genome-wide association studies. Causal significance was estimated using inverse variance weighting. Sensitivity analyses included the weighted median, MR-Egger, and MR-PRESSO. The psychiatric comorbidities analyzed in this study included attention deficit hyperactivity disorder (ADHD), autism spectrum disorder, major depressive disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder (OCD), and anorexia nervosa. Results: Both forward and reverse genetic associations were observed for the selected psychiatric disorders. Notably, ADHD was significantly associated with an increased risk of generalized epilepsy (odds ratio [OR], 1.09; 95 % confidence interval [CI], 1.01-1.18; p = 0.013). However, MR-PRESSO detected the existence of pleiotropy (p = 0.001). Additionally, focal epilepsy was significantly associated with a higher risk of OCD (OR, 1.44; 95 % CI, 1.08-1.92; p = 0.013), and all sensitivity tests yielded favorably nonsignificant results. There was no significant genetic association between epilepsy and other examined psychiatric disorders. However, due to the detection of pleiotropy by MR-Egger and considerations related to the threshold for genetic instruments, a cautious approach is warranted in interpreting some of the results. Conclusions: This study revealed significant genetic causality between focal epilepsy and OCD, as well as between ADHD and generalized epilepsy. However, no casual significance was observed with other psychiatric comorbidities examined. Considering the inherent limitations of MR studies, further research is warranted to definitively clarify these genetic causal associations.
MeSH term(s)	Humans ; Autism Spectrum Disorder ; Depressive Disorder, Major ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Epilepsy/epidemiology ; Epilepsy/genetics ; Epilepsies, Partial ; Epilepsy, Generalized
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.01.178
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Zs.A 1485: Show issues

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Article ; Online: Ultra-Wide-Field Optical Coherence Tomography and Gaussian Curvature to Assess Macular and Paravascular Retinoschisis in High Myopia.

Zhao, Qing / Zhao, Xinyu / Luo, Yan / Yang, Zhikun

American journal of ophthalmology

2024 Volume 263, Page(s) 70–80

Abstract: Purpose: To evaluate the severity and related factors of macular retinoschisis (MRS) and paravascular retinoschisis (PVRS) in high myopia (HM) using ultra-wide-field optical coherence tomography (UWF-OCT) and a novel Gaussian curvature (K).: Design: ... ...

Abstract	Purpose: To evaluate the severity and related factors of macular retinoschisis (MRS) and paravascular retinoschisis (PVRS) in high myopia (HM) using ultra-wide-field optical coherence tomography (UWF-OCT) and a novel Gaussian curvature (K). Design: A cross-sectional study. Methods: Patients diagnosed with HM in Peking Union Medical College Hospital were recruited between January 2022 and November 2022. The presence and severity of retinoschisis, along with the three highest K values, were assessed using UWF-OCT and en face images. Logistic regressions were employed to identify factors associated with MRS, PVRS, and the severity of retinoschisis in the 24 × 20 mm scan region. Results: A total of 108 HM eyes from 55 patients were recruited. The highest Gaussian curvature (K1) was predominantly found in the vascular arcade (43, 40%). Multivariable logistic regression found that age and PVRS were significant risk factors for MRS occurrence (P < .05), while MRS and higher K1 were significantly associated with the presence of PVRS in HM patients (P < .05). The axial length (AL) and spherical equivalent were associated with the severity of MRS, while AL and K1 values were associated with the severity of retinoschisis in the 24 × 20 mm scan region (P < .05). Conclusions: An association existed between large Gaussian curvature and the presence of MRS and PVRS, as well as the severity of retinoschisis in a wide field of view. UWF-OCT, which enables visualization of the central and peripheral retinal areas, holds promise as an imaging technique for the early detection of extrafoveal retinoschisis.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2024.02.016
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Article ; Online: Tailored Composting and Fertilization Strategies Can Inspire the Transformation of Agriculture for Sustainable Development.

Zhao, Xinyu / Wang, Yan / Cai, Danmei / Xi, Beidou

Journal of agricultural and food chemistry

2024

Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.4c02708
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Zs.A 1172: Show issues

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Article ; Online: Effects of landfill void fraction and moisture content on the formation of aerobic areas in a semi-aerobic bioreactor.

Zhao, Xinyu / Zhang, Xin / Zhang, Xinyan

Waste management (New York, N.Y.)

2024 Volume 181, Page(s) 34–43

Abstract: The main disposal method for municipal solid waste (MSW), including the growing worldwide volumes of kitchen waste, involves transport to landfills. Because kitchen waste is mainly composed of organic matter and has a high moisture content, large amounts ...

Abstract	The main disposal method for municipal solid waste (MSW), including the growing worldwide volumes of kitchen waste, involves transport to landfills. Because kitchen waste is mainly composed of organic matter and has a high moisture content, large amounts of leachate and landfill gas are generated when it is sent to landfills. Therefore, rapid waste stabilization is essential. In this study, four semi-aerobic bioreactors (named NS, SS, MS, and LS) were established with void fractions of 33.76%, 39.84%, 44.62%, and 41.31%, respectively. The results showed that the void fractions of landfill directly affected the gas flow path. When the landfill void fraction was small (e.g., NS), most airflow traveled directly through the pipeline and minimal airflow entered the waste layer. When the landfill void fraction was large (e.g., MS), air easily entered the waste layer and some air flowed into the gas vent with the landfill gas. As the reaction proceeded, the void fraction gradually decreased due to gravity-induced sedimentation. During the water addition experiment, the voids were occupied by water, leading to formation of an anaerobic area. Among the four bioreactors, only MS had negligible formation of an anaerobic zone in the center. Methane (CH
MeSH term(s)	Bioreactors ; Waste Disposal Facilities ; Refuse Disposal/methods ; Aerobiosis ; Solid Waste/analysis
Chemical Substances	Solid Waste
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2024.03.027
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Article ; Online: Algorithm for real-time defect detection of micro pipe inner surface: erratum.

Zhao, Xinyu / Wu, Bin

Applied optics

2022 Volume 60, Issue 36, Page(s) 11256

Abstract: This erratum serves to correct an error in Appl. Opt.60, 9167 (2021).APOPAI0003-693510.1364/AO.438287. ...

Abstract	This erratum serves to correct an error in Appl. Opt.60, 9167 (2021).APOPAI0003-693510.1364/AO.438287.
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.446639
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Article ; Online: Thermal and Near-Infrared Light-Responsive Hydrogel Actuators with Spatiotemporally Developed Polypyrrole Patterns.

Zhao, Xinyu / Jiang, Jinqiang / Liu, Zhongwen / Liu, Zhaotie / Li, Guo

ACS applied materials & interfaces

2024 Volume 16, Issue 7, Page(s) 9286–9292

Abstract: Conjugated polymers are commonly adopted to develop electro- and photoresponsive materials due to their superior electronic conductivity and phototothermal convertibility. However, they are usually homogeneously polymerized within the network, which ... ...

Abstract	Conjugated polymers are commonly adopted to develop electro- and photoresponsive materials due to their superior electronic conductivity and phototothermal convertibility. However, they are usually homogeneously polymerized within the network, which makes their functionalities challenging to spatiotemporally modulate. In this work, we report a convenient and extensible method to develop polypyrrole patterns in a thermally responsive sodium alginate/poly(
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c17885
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Article ; Online: Scavenging Glyoxal and Methylglyoxal by Synephrine and Neohesperidin from Flowers of

Liang, Yu / Zhao, Xinyu / Xu, Yujia / Lu, Yonglin / Lv, Lishuang

Journal of agricultural and food chemistry

2024 Volume 72, Issue 14, Page(s) 8027–8038

Abstract: There is considerable research evidence that α-dicarbonyl compounds, including glyoxal (GO) and methylglyoxal (MGO), are closely related to many chronic diseases. In this work, after comparison of the capture capacity, reaction pathway, and reaction rate ...

Abstract	There is considerable research evidence that α-dicarbonyl compounds, including glyoxal (GO) and methylglyoxal (MGO), are closely related to many chronic diseases. In this work, after comparison of the capture capacity, reaction pathway, and reaction rate of synephrine (SYN) and neohesperidin (NEO) on GO/MGO
MeSH term(s)	Humans ; Animals ; Mice ; Pyruvaldehyde ; Glyoxal ; Synephrine ; Tandem Mass Spectrometry ; Magnesium Oxide ; Flowers ; Citrus ; Hesperidin/analogs & derivatives
Chemical Substances	Pyruvaldehyde (722KLD7415) ; Glyoxal (50NP6JJ975) ; Synephrine (PEG5DP7434) ; neohesperidin (OA5C88H3L0) ; Magnesium Oxide (3A3U0GI71G) ; Hesperidin (E750O06Y6O)
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.4c00923
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Zs.A 1172: Show issues

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Article ; Online: Proteomics insights into fragile X syndrome: Unraveling molecular mechanisms and therapeutic avenues.

Abbasi, Diana A / Berry-Kravis, Elizabeth / Zhao, Xinyu / Cologna, Stephanie M

Neurobiology of disease

2024 Volume 194, Page(s) 106486

Abstract: Fragile X Syndrome (FXS) is a neurodevelopment disorder characterized by cognitive impairment, behavioral challenges, and synaptic abnormalities, with a genetic basis linked to a mutation in the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene that ... ...

Abstract	Fragile X Syndrome (FXS) is a neurodevelopment disorder characterized by cognitive impairment, behavioral challenges, and synaptic abnormalities, with a genetic basis linked to a mutation in the FMR1 (Fragile X Messenger Ribonucleoprotein 1) gene that results in a deficiency or absence of its protein product, Fragile X Messenger Ribonucleoprotein (FMRP). In recent years, mass spectrometry (MS) - based proteomics has emerged as a powerful tool to uncover the complex molecular landscape underlying FXS. This review provides a comprehensive overview of the proteomics studies focused on FXS, summarizing key findings with an emphasis on dysregulated proteins associated with FXS. These proteins span a wide range of cellular functions including, but not limited to, synaptic plasticity, RNA translation, and mitochondrial function. The work conducted in these proteomic studies provides a more holistic understanding to the molecular pathways involved in FXS and considerably enhances our knowledge into the synaptic dysfunction seen in FXS.
MeSH term(s)	Humans ; Fragile X Syndrome/genetics ; Fragile X Syndrome/therapy ; Fragile X Syndrome/metabolism ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/metabolism ; Proteomics ; Gene Expression Regulation
Chemical Substances	Fragile X Mental Retardation Protein (139135-51-6) ; FMR1 protein, human
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2024.106486
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Article ; Online: Methods, bioinformatics tools and databases in ecDNA research: An overview.

Zhao, Xinyu / Zhao, Huan / Liu, Yupeng / Guo, Zhiyun

Computers in biology and medicine

2023 Volume 167, Page(s) 107680

Abstract: Extrachromosomal DNA (ecDNA), derived from chromosomes, is a cancer-specific circular DNA molecule. EcDNA drives tumor initiation and progression, which is associated with poor clinical outcomes and drug resistance in a wide range of cancers. Although ... ...

Abstract	Extrachromosomal DNA (ecDNA), derived from chromosomes, is a cancer-specific circular DNA molecule. EcDNA drives tumor initiation and progression, which is associated with poor clinical outcomes and drug resistance in a wide range of cancers. Although ecDNA was first discovered in 1965, tremendous technological revolutions in recent years have provided crucial new insights into its key biological functions and regulatory mechanisms. Here, we provide a thorough overview of the methods, bioinformatics tools, and database resources used in ecDNA research, mainly focusing on their performance, strengths, and limitations. This study can provide important reference for selecting the most appropriate method in ecDNA research. Furthermore, we offer suggestions for the current bioinformatics analysis of ecDNA and provide an outlook to the future research.
MeSH term(s)	Humans ; DNA/genetics ; Computational Biology ; Neoplasms/genetics ; Neoplasms/pathology ; Oncogenes
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2023.107680
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