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Article ; Online: An unfolding/aggregation kinetic instructed rational design towards improving graft degree of glycation for myofibrillar protein.

Chai, Jiale / Zhao, Xue / Xu, Yujuan / Xu, Xinglian

2024 Volume 446, Page(s) 138876

Abstract: Glycation is an effective strategy for the application of myofibrillar protein (MP) in beverage formulas by improving water solubility. In conventional glycation, the efficiency was limited as MP-saccharides conjugates mostly produced at low temperature ... ...

Abstract	Glycation is an effective strategy for the application of myofibrillar protein (MP) in beverage formulas by improving water solubility. In conventional glycation, the efficiency was limited as MP-saccharides conjugates mostly produced at low temperature due to thermosensitivity. This study was aimed to explore unfolding/aggregation kinetics of MP, including aggregate behavior, structural characteristics, and micromorphology, which guided the selection of temperature for glycation. It was shown that 40 °C/47.5 °C were critical temperature for MP unfolding/aggregation, respectively. Accordingly, an innovative technology of glycation (cyclic continuous glycation, CCG) was established by combining such temperatures. The results confirmed that cyclic continuous heating (CCH) inhibited excessive exposure of sulfhydryl and hydrophobic groups impeding protein aggregation. Importantly, it was revealed that rational designed CCG promoted covalent binding of MP to glucose by regulating unfolding-aggregation balance, exhibiting higher glycation degree. Overall, CCG-modified MP is expected to motivate the application of meat proteins in food formulations.
MeSH term(s)	Muscle Proteins/chemistry ; Maillard Reaction
Chemical Substances	Muscle Proteins
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138876
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Article: Effects of Wooden Breast Myopathy on Meat Quality Characteristics of Broiler Pectoralis Major Muscle and Its Changes with Intramuscular Connective Tissue.

Bian, Tianjiao / Xing, Tong / Zhao, Xue / Xu, Xinglian

Foods (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: This study aimed to investigate the effect of wooden breast (WB) myopathy on chemical composition, meat quality attributes and physiochemical characteristics of intramuscular connective tissue (IMCT) of broiler pectoralis major (PM) muscle. Thirty-six ... ...

Abstract	This study aimed to investigate the effect of wooden breast (WB) myopathy on chemical composition, meat quality attributes and physiochemical characteristics of intramuscular connective tissue (IMCT) of broiler pectoralis major (PM) muscle. Thirty-six fillets were classified into varying degrees of WB condition, including normal, moderate and severe. Results show that WB myopathy altered the collagen profile in PM muscle by increasing total collagen content and decreasing collagen solubility. The composition of macromolecules in IMCT, including hydroxylysyl pyridoxine cross-linking, decorin and glycosaminoglycans, were increased with the severity of WB myopathy. Differential scanning calorimetry analysis indicated higher denaturation temperatures and lower denaturation enthalpy of IMCT for WB. Secondary structures of α-helix and β-sheet in the IMCT of WB were changed to β-turn and random coil. In addition, chemical composition and meat quality attributes showed a correlation with collagen profile and IMCT characteristics. Overall, this study emphasizes the effect of WB myopathy on IMCT and their contributions to meat quality variation.
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13040507
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Article ; Online: Escape Rooms in Nursing Education: A Systematic Review.

Zhao, Xue / Brand, Gabrielle / Kovach, Nicole / Bonnamy, James

Nurse educator

2024

Abstract: Background: Escape rooms (ERs) are being increasingly used in nursing education as an active and game-based learning method.: Purpose: To conduct a systematic review to synthesize evidence on the current use of ERs in nursing education.: Methods: ... ...

Abstract	Background: Escape rooms (ERs) are being increasingly used in nursing education as an active and game-based learning method. Purpose: To conduct a systematic review to synthesize evidence on the current use of ERs in nursing education. Methods: A mixed methods systematic review was performed to identify and synthesize existing literature. Five databases were searched in July 2023. Descriptive and thematic analysis were used to synthesize quantitative and qualitative data, respectively. Results: A total of 333 studies were found after searching 5 databases. After 2 independent reviews, a total of 57 studies were identified across 5 countries. There were 16 qualitative studies, 34 quantitative studies, and 7 mixed methods studies. Four main themes were identified. Conclusions: ERs are widely used across different topics and settings in nursing education and are enjoyed by the majority of participants; however, more rigorous research is needed to confirm whether ERs improve learning outcomes.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1034267-9
ISSN	1538-9855 ; 0363-3624
ISSN (online)	1538-9855
ISSN	0363-3624
DOI	10.1097/NNE.0000000000001641
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Article ; Online: Porous Poly(ionic Liquid) Membrane with Metal Nanoparticle Gradient: A Smart Actuator for Visualizing Chemical Reactions.

Zhao, Xue-Jing / Liu, Si-Hua / Sun, Jian-Ke

Macromolecular rapid communications

2024 Volume 45, Issue 8, Page(s) e2300676

Abstract: Poly(ionic liquid) (PIL)-based porous membranes are extensively investigated as soft polymer actuators. While PILs have shown significant advancements in membrane fabrication and stabilization of metal nanoparticles (MNPs), research on integrating MNPs ... ...

Abstract	Poly(ionic liquid) (PIL)-based porous membranes are extensively investigated as soft polymer actuators. While PILs have shown significant advancements in membrane fabrication and stabilization of metal nanoparticles (MNPs), research on integrating MNPs into porous membranes to achieve actuation behavior under multiple stimuli is limited. Herein, this work presents a new paradigm for designing a porous PIL-polyacrylic acid (PAA) membrane with a distinct MNP gradient via a top-bottom diffusion approach involving a metal salt precursor solution and NaBH
MeSH term(s)	Ionic Liquids/chemistry ; Metal Nanoparticles/chemistry ; Porosity ; Polymers/chemistry ; Acrylic Resins/chemistry ; Membranes, Artificial ; Hydrogen Peroxide/chemistry ; Catalysis ; Surface Properties ; Particle Size
Chemical Substances	Ionic Liquids ; Polymers ; Acrylic Resins ; carbopol 940 (4Q93RCW27E) ; Membranes, Artificial ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2024-01-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1475027-2
ISSN	1521-3927 ; 1022-1336
ISSN (online)	1521-3927
ISSN	1022-1336
DOI	10.1002/marc.202300676
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Article ; Online: Infrared Spectrum and Principal Component Analysis of Heavy Tar Cut by Different Fractions from Tar-Rich Coal

Zhonghua Zhang / Zhao Xue / Hao Shu

ACS Omega, Vol 9, Iss 1, Pp 1352-

2023 Volume 1361

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Study on the Use of Milieu Teaching to Promote Overseas Marketers' Communication Skills and Confidence in Language Learning.

Jia, Simeng / Zhao, Xue

Frontiers in psychology

2022 Volume 13, Page(s) 923812

Abstract: Language plays an extremely important role for people in terms of engaging in various learning activities. Due to the progress of network technologies, it is an immediate goal for enterprises to take a completely new development direction with the ... ...

Abstract	Language plays an extremely important role for people in terms of engaging in various learning activities. Due to the progress of network technologies, it is an immediate goal for enterprises to take a completely new development direction with the application of network technology. Nevertheless, they encounter many difficulties in carrying out overseas marketing such as localization transformation, jet lag, lack of professional marketers, problems with sellers' product quality, problems with customers' credit checks, international payment problems, and logistics and delivery problems. These problems mainly result from a difference in language families. The current study was conducted as an experimental study with the participation of overseas marketers in Hebei province. Milieu teaching was implemented with an experimental group and traditional teaching was maintained in the control group for a 20-week (3 h per week) experimental procedure. The research results revealed significantly positive effects of (1) milieu teaching on communication skills, (2) milieu teaching on language learning confidence, and (3) communication skills on language learning confidence. Based on the results, it can be stated that the study is expected to help effectively enhance the communication skills and language learning confidence of overseas marketers to achieve the goals of promoting oral expression and language-use skills.
Language	English
Publishing date	2022-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.923812
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Article ; Online: Overexpression of HOXB13 predicts poor prognosis in patients with colon cancer.

Gao, Da-Zhi / Zhao, Xue-Feng

Asian journal of surgery

2022 Volume 45, Issue 12, Page(s) 2788–2789

MeSH term(s)	Humans ; Homeodomain Proteins/genetics ; Colonic Neoplasms/surgery ; Prognosis
Chemical Substances	Homeodomain Proteins ; HOXB13 protein, human
Language	English
Publishing date	2022-06-14
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.06.029
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Article ; Online: Effect of Oxygen-Glucose Deprivation of Microglia-Derived Exosomes on Hippocampal Neurons: A Study on miR-124 and Inflammatory Cytokines.

Zhu, Yizhen / Zhao, Xue / Liu, Ruojing / Yang, Dan / Ge, Guo

Journal of molecular histology

2024

Abstract: Stroke is a cerebrovascular disease that threatens human health. Developing safe and effective drugs and finding therapeutic targets has become an urgent scientific problem. The aim of this study was to investigate the effect of oxygen-glucose ... ...

Abstract	Stroke is a cerebrovascular disease that threatens human health. Developing safe and effective drugs and finding therapeutic targets has become an urgent scientific problem. The aim of this study was to investigate the effect of oxygen-glucose deprivation of the microglia-derived exosome on hippocampal neurons and its relationship to miR-124 in the exosome. We incubated hippocampal neurons with exosomes secreted by oxygen-glucose deprivation/ reoxygenation (OGD/R) microglia. The levels of glutamic acid (GLU) and gamma-aminobutyric acid (GABA) in the culture supernatant were detected by ELISA. CCK-8 was used to measure neuronal survival rates. The mRNA levels of TNF-α and IL-6 were detected by RT-qPCR to evaluate the effect of exosomes on neurons. RT-qPCR was then used to detect miR-124 in microglia and their secreted exosomes. Finally, potential targets of miR-124 were analyzed through database retrieval, gene detection with dual luciferase reporters, and western blotting experiments. The results showed that the contents of GLU, TNF-α and IL-6 mRNA increased in the supernatant of cultured hippocampal neurons, the content of GABA decreased, and the survival rate of neurons decreased. Oxygen-glucose deprivation increases miR-124 levels in microglia and their released exosomes. miR-124 acts as a target gene on cytokine signaling suppressor molecule 1(SOCS1), while miR-124 inhibitors reduce the expression of TNF-α and IL-6 mRNA in neurons. These results suggest that oxygen- and glucose-deprived microglia regulate inflammatory cytokines leading to reduced neuronal survival, which may be achieved by miR-124 using SOCS1 as a potential target.
Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2144021-9
ISSN	1567-2387 ; 1567-2379
ISSN (online)	1567-2387
ISSN	1567-2379
DOI	10.1007/s10735-024-10193-6
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Article ; Online: A dual amplified gold nanoparticle-based biosensor for ultrasensitive and selective detection of fibrin.

Gong, Wenyue / Zhang, Yuanfu / Chen, Yawei / Zhao, Xue / Wang, Shuhao

Luminescence : the journal of biological and chemical luminescence

2024 Volume 39, Issue 5, Page(s) e4764

Abstract: Ultrasensitive, selective, and non-invasive detection of fibrin in human serum is critical for disease diagnosis. So far, the development of high-performance and ultrasensitive biosensors maintains core challenges for biosensing. Herein, we designed a ... ...

Abstract	Ultrasensitive, selective, and non-invasive detection of fibrin in human serum is critical for disease diagnosis. So far, the development of high-performance and ultrasensitive biosensors maintains core challenges for biosensing. Herein, we designed a novel ribbon nanoprobe for ultrasensitive detection of fibrin. The probe contains gold nanoparticles (AuNPs) that can not only link with homing peptide Cys-Arg-Glu-Lys-Ala (CREKA) to recognize fibrin but also carry long DNA belts to form G-quadruplex-based DNAzyme, catalyzing the chemiluminescence of luminol-hydrogen peroxide (H
MeSH term(s)	Gold/chemistry ; Biosensing Techniques ; Metal Nanoparticles/chemistry ; Fibrin/chemistry ; Fibrin/analysis ; Humans ; DNA, Catalytic/chemistry ; Hydrogen Peroxide/chemistry ; Hydrogen Peroxide/analysis ; Limit of Detection ; Luminol/chemistry ; G-Quadruplexes
Chemical Substances	Gold (7440-57-5) ; Fibrin (9001-31-4) ; DNA, Catalytic ; Hydrogen Peroxide (BBX060AN9V) ; Luminol (5EXP385Q4F)
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1470995-8
ISSN	1522-7243 ; 1522-7235 ; 1099-1271
ISSN (online)	1522-7243
ISSN	1522-7235 ; 1099-1271
DOI	10.1002/bio.4764
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Article ; Online: CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells.

Pan, Yipeng / You, Bo / Zhao, Xue / Zhang, Shanxin / Li, Wei

BMC cancer

2024 Volume 24, Issue 1, Page(s) 525

Abstract: Background: Regorafenib, a multi-targeted kinase inhibitor, has been used in the treatment of Hepatocellular carcinoma (HCC). The purpose of this study is to investigate the mechanism of Regorafenib in HCC.: Methods: Regorafenib's impact on the ... ...

Abstract	Background: Regorafenib, a multi-targeted kinase inhibitor, has been used in the treatment of Hepatocellular carcinoma (HCC). The purpose of this study is to investigate the mechanism of Regorafenib in HCC. Methods: Regorafenib's impact on the sensitivity of HCC cells was assessed using CCK8. Differential gene expression analysis was performed by conducting mRNA sequencing after treatment with Regorafenib. The m6A methylation status of CHOP and differential expression of m6A methylation-related proteins were assessed by RIP and Western Blot. To explore the molecular mechanisms involved in the therapeutic effects of Regorafenib in HCC and the impact of METTL14 and CHOP on Regorafenib treatment, we employed shRNA/overexpression approaches to transfect METTL14 and CHOP genes, as well as conducted in vivo experiments. Results: Treatment with Regorafenib led to a notable decrease in viability and proliferation of SK-Hep-1 and HCC-LM3 cells. The expression level of CHOP was upregulated after Regorafenib intervention, and CHOP underwent m6A methylation. Among the m6A methylation-related proteins, METTL14 exhibited the most significant downregulation. Mechanistic studies revealed that Regorafenib regulated the cell cycle arrest in HCC through METTL14-mediated modulation of CHOP, and the METTL14/CHOP axis affected the sensitivity of HCC to Regorafenib. In vivo, CHOP enhanced the anticancer effect of Regorafenib. Conclusion: The inhibition of HCC development by Regorafenib is attributed to its modulation of m6A expression of CHOP, mediated by METTL14, and the METTL14/CHOP axis enhances the sensitivity of HCC to Regorafenib. These findings provide insights into the treatment of HCC and the issue of drug resistance to Regorafenib.
MeSH term(s)	Humans ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/metabolism ; Phenylurea Compounds/pharmacology ; Phenylurea Compounds/therapeutic use ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Liver Neoplasms/metabolism ; Mice ; Animals ; Cell Line, Tumor ; Cell Cycle Checkpoints/drug effects ; Methyltransferases/metabolism ; Methyltransferases/genetics ; Transcription Factor CHOP/metabolism ; Transcription Factor CHOP/genetics ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Drug Resistance, Neoplasm/genetics ; Xenograft Model Antitumor Assays ; Mice, Nude ; Adenosine/analogs & derivatives
Chemical Substances	regorafenib (24T2A1DOYB) ; Pyridines ; Phenylurea Compounds ; METTL14 protein, human (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; Transcription Factor CHOP (147336-12-7) ; DDIT3 protein, human ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-12275-w
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