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Article: Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases.

Yu, Linyuan / Zhao, Yongliang / Zhao, Yongli

2023 Volume 14, Page(s) 1240820

Abstract: ... Rhubarb ... ...

Abstract	Rhubarb palmatum
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1240820
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Water-in-Water Emulsions Stabilized by Silica Janus Nanosheets.

Hu, Bintao / Zhao, Yongliang / Ye, Zhangfan / Wang, Haitao

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 16, Page(s) e2206215

Abstract: Water-in-water (w/w) emulsions have been recognized for their broad applications in foods, cosmetics, and biomedical engineering. In this work, silica Janus nanosheets (JNs) with polyacrylic acid (PAA) chains grafted on one surface via crushing ... ...

Abstract	Water-in-water (w/w) emulsions have been recognized for their broad applications in foods, cosmetics, and biomedical engineering. In this work, silica Janus nanosheets (JNs) with polyacrylic acid (PAA) chains grafted on one surface via crushing functional silica foams, and used silica JNs as Pickering stabilizer to produce stable water-in-water (w/w) emulsions from the aqueous two-phase system (ATPS) containing methacrylic acid (MAA) and NaCl are prepared. The interfacial area of w/w emulsions increases linearly with the concentration of silica JNs, and the interfacial coverage of nanosheets is calculated to be about 98%. After polymerizing w/w emulsions prepared from MAA/NaCl ATPS, it is found that silica JNs are entrapped at the interface of w/w emulsions with the smooth PAA-grafted surface located toward MAA-rich phase due to their specific interaction. These results show that functional silica JNs can be used as a promising amphiphilic Pickering stabilizer to produce well-defined w/w emulsions for numerous application fields.
Language	English
Publishing date	2023-01-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202206215
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Article ; Online: Performance analysis on the parabolic trough solar receiver-reactor of methanol decomposition reaction under off-design conditions and during dynamic processes

Zhang, Peiye / Liu, Ming / Zhao, Yongliang / Yan, Junjie

Renewable Energy. 2023 Mar., v. 205 p.583-597

2023

Abstract: Parabolic Trough Solar Receiver-Reactor (PTSRR) of Methanol Decomposition Reaction process (MDR), which can achieve chemical storage and efficient utilization of solar energy, has gained increasing attention recently. To comprehensively study the ... ...

Abstract	Parabolic Trough Solar Receiver-Reactor (PTSRR) of Methanol Decomposition Reaction process (MDR), which can achieve chemical storage and efficient utilization of solar energy, has gained increasing attention recently. To comprehensively study the performance of PTSRR of MDR under off-design conditions and during dynamic processes, a model of PTSRR-MDR is developed and validated. Detailed energy and exergy analysis model are developed to figure out the irreversibility distribution. Results indicate that exergy destructions caused by solar concentrating and thermochemical reaction processes limit the improvement of exergy efficiency, which account 39.32% and 18.32%, respectively, under 800 DNI. When DNI step decreases from 800 to 400 W m⁻², the methanol conversion rate decreases from 90.0% to 40.9% in ∼400 s. The solar-to-chemical exergy efficiency increases from 16.39% to 32.80% immediately, then decreases to the lowest value in 30 s, and rises to 11.23%. The efficiency is lower than the stable value transiently because the exergy stored in solid phase is partly destructed when converted to chemical exergy. Then, dynamic performance under DNI step increase is studied. Due to thermal inertia, additional chemical energy and exergy are gained or lost, compared to the ideal process. The results may provide some guidance for further efficient operation control.
Keywords	exergy ; methanol ; models ; solar collectors ; solar energy ; Parabolic trough solar receiver-reactor ; Methanol decomposition ; Solar-thermal-chemical conversion ; Dynamic simulation ; Energy and exergy analysis
Language	English
Dates of publication	2023-03
Size	p. 583-597.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2023.01.097
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Influence of renewable energy infrastructure, Chinese outward FDI, and technical efficiency on ecological sustainability in belt and road node economies

Zhang, Zhuo / Zhao, Yongliang / Cai, Haiya / Ajaz, Tahseen

Renewable Energy. 2023 Mar., v. 205 p.608-616

2023

Abstract: Renewable energy infrastructure is highly interrelated to environmental sustainability and the accomplishment of sustainable development goals. A significant portion of China's outward foreign direct investment (FDI) has been allocated to energy ... ...

Abstract	Renewable energy infrastructure is highly interrelated to environmental sustainability and the accomplishment of sustainable development goals. A significant portion of China's outward foreign direct investment (FDI) has been allocated to energy production and transmission across the Belt and Road Initiative (BRI) region. Therefore, we examine the influence of renewable energy infrastructure, China's outward FDI, and the host country's technical efficiency on ecological sustainability. This research uses the cross-sectional autoregressive distributive lag (CS-ARDL) model to address the issues of parameter and cross-sectional heterogeneity. The findings show that renewable energy infrastructure and technical efficiency significantly reduce carbon emissions in the long run. Likewise, FDI inflows and economic growth increase emissions in the BRI region due to higher energy consumption. Moreover, the direct effect of FDI on environmental quality is negative, while the indirect impact through moderation of FDI and renewable energy infrastructure leads to lower emissions. These results implied that the reallocation of inward FDI in energy infrastructure neutralizes the negative consequences, improves energy efficiency, and resultantly lower emissions. Therefore, it opens new policy implications that we focus more on investing FDI in the energy infrastructure sector.
Keywords	carbon ; energy efficiency ; environmental quality ; foreign direct investment ; infrastructure ; issues and policy ; renewable energy sources ; sustainable development ; China ; Renewable energy ; China's FDI ; Technical efficiency ; BRI economies
Language	English
Dates of publication	2023-03
Size	p. 608-616.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2023.01.060
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Article ; Online: RECQL4 Modulates MDR1 Expression and Chemoresistance-Response.

Zhao, Yongliang

Cancer research

2016 Volume 76, Issue 24, Page(s) 7291

MeSH term(s)	ATP-Binding Cassette, Sub-Family B, Member 1 ; Drug Resistance, Neoplasm ; Humans ; RecQ Helicases
Chemical Substances	ATP-Binding Cassette, Sub-Family B, Member 1 ; RecQ Helicases (EC 3.6.4.12)
Language	English
Publishing date	2016--15
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-16-2638
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Article ; Online: Evaluation of factors influencing long-term and textbook outcomes in laparoscopic gastrectomy.

Lin, Xia / Tan, Chenjun / Wu, Weigao / Liang, Chenglong / Qian, Feng / Zhao, Yongliang

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2024 Volume 50, Issue 3, Page(s) 108002

Abstract: Background: Textbook outcome (TO) in gastric cancer surgery is a multidimensional measure of surgical quality. However, its impact on long-term survival after laparoscopic gastrectomy (LG) is unclear. This study aims to evaluate TO in LG, assess its ... ...

Abstract	Background: Textbook outcome (TO) in gastric cancer surgery is a multidimensional measure of surgical quality. However, its impact on long-term survival after laparoscopic gastrectomy (LG) is unclear. This study aims to evaluate TO in LG, assess its hospital-level relevance, and examine its association with long-term survival. Methods: In this retrospective cohort study, we analyzed 2278 consecutive gastric cancer patients who underwent laparoscopic gastrectomy (LG) from January 2004 to December 2017. We determined TO achievement rates, compared preoperative and intraoperative variables between TO and non-TO groups, identified independent predictors of TO, and assessed long-term oncologic outcomes using Kaplan-Meier analysis and Cox regression. Results: A total of 1540 LG patients were analyzed, with 994 (64.5%) achieving TO. The least frequently achieved metric was 'hospital stays ≤21 days' (83.4%), followed by 'lymph nodes retrieved ≥15' (84.0%). Factors independently associated with reduced TO likelihood included age ≥65 years, BMI ≥25, ASA III, conversion to open surgery, operation time ≥260 min, and estimated blood loss ≥150 ml. Furthermore, TO was independently linked to improved 5-year overall survival (OS) and disease-free survival (DFS) (HR 0.519 [0.443-0.609] and HR 0.517 [0.443-0.604], respectively). Conclusion: Implementing the TO concept in LG provides a benchmark for achieving improved prognoses and empowers surgeons to devise strategies for enhancing surgical care quality.
MeSH term(s)	Humans ; Aged ; Retrospective Studies ; Stomach Neoplasms/pathology ; Prognosis ; Gastrectomy/methods ; Laparoscopy/methods ; Treatment Outcome
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2024.108002
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effect and mechanism of H. pylori in regulation of REDD1 expression in gastric mucosa

YAN Zongbao / MAO Fangyuan / SHAN Zhiguo / ZHAO Yongliang / ZHUANG Yuan

Di-san junyi daxue xuebao, Vol 44, Iss 5, Pp 413-

2022 Volume 420

Abstract: Objective Regulated in development and DNA damage responses-1 (REDD1) is a conserved and ubiquitous protein, and is induced in response to multiple stimuli. However, its regulation, function and clinical relevance in Helicobacter pylori (H. pylori)- ... ...

Abstract	Objective Regulated in development and DNA damage responses-1 (REDD1) is a conserved and ubiquitous protein, and is induced in response to multiple stimuli. However, its regulation, function and clinical relevance in Helicobacter pylori (H. pylori)-associated gastritis are presently unknown. The study aimed to investigate its expression and regulation mechanism in H. pylori infection. Methods C57 mice and gastric epithelial cells (AGS cells) were respectively infected with H. pylori to establish infected models. Then the expression of REDD1 at mRNA and protein levels was detected by quantitative PCR, immunohistochemical staining and Western blotting. The mechanism of REDD1 up-regulation induced by H. pylori infection was investigated by transfection with signaling pathway inhibitor, plasmid or dual-luciferase reporting analysis in cell models. Results The expression of REDD1 was increased in gastric mucosa of the H. pylori-infected mice than the un-infected ones. Compared with the wild-type strain of H. pylori, the strain with cagA knockout (△cagA H. pylori 11637 cells) showed decreased effect on the upregulation of REDD1 (P < 0.05). H. pylori infection induced up-regulation of REDD1 in AGS cells in a time-, cagA- and pathogen dose-dependent manner (P < 0.05). Blocking of P38/MAPKp38 signaling pathway could significantly inhibit the upregulation of REDD1 induced by the infection (P < 0.05). Conclusion H. pylori induces the up-regulation of REDD1 through activation of phosphorylated cagA in MAPKp38 pathway in the gastric mucosa of mouse with H. pylori infection.
Keywords	helicobacter pylori ; regulated in development and dna damage responses-1 ; mapk ; p38 ; Medicine (General) ; R5-920
Subject code	570
Language	Chinese
Publishing date	2022-03-01T00:00:00Z
Publisher	Editorial Office of Journal of Third Military Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lentinan protects cardiomyocytes against hypoxia-induced injury by regulation of microRNA-22/Sirt1.

Zhang, Shaohui / Zhao, Yongliang

publication RETRACTED

Artificial cells, nanomedicine, and biotechnology

2019 Volume 47, Issue 1, Page(s) 3938–3946

Abstract: Myocardial ischemia is a serious disease which threatens human's life. Lentinan (LEN) possesses multiple biological properties: anticancer, antibacterial, antiviral and antioxidant effects. Our study investigated the effects of LEN on hypoxia-stimulated ... ...

Abstract	Myocardial ischemia is a serious disease which threatens human's life. Lentinan (LEN) possesses multiple biological properties: anticancer, antibacterial, antiviral and antioxidant effects. Our study investigated the effects of LEN on hypoxia-stimulated cardiomyocytes and the underlying mechanism. Primary neonatal rat ventricular cardiomyocytes (PNCM) were isolated from neonate rat pups. PNCM and H9c2 cells were stimulated by hypoxia and treated by LEN. Cell viability and apoptosis were detected by cell counting kit-8 and flow cytometry, respectively. Moreover, apoptotic factors were examined by western blot. Phosphatidylinositol 3'-kinase (PI3K)/protein kinase B (AKT) and β-catenin pathways related proteins were analyzed by western blot. Furthermore, the expression of microRNA-22 (miR-22) was detected by qRT-PCR. Altered expression of miR-22 and silenced information regulator 1 (Sirt1) was achieved by transfection. The relationship between miR-22 and Sirt1 was verified by luciferase assay. We found that LEN promoted cell viability and decreased apoptosis which led to the contrary results with what hypoxia induced. Moreover, LEN decreased the ratio of Bax to Bcl-2 and the level of cleaved caspase-3, as well as activated PI3K/AKT and β-catenin. LEN decreased the expression of miR-22 which was upregulated by hypoxia. miR-22 overexpression broken the promoting effects led by LEN. Moreover, Sirt1 was verified to be a target of miR-22. Silence of Sirt1 led to the opposite results with LEN. In conclusion, LEN relieved hypoxia-induced cellular injuries evidenced by increasing viability and decreasing apoptosis via down-regulation of miR-22, which was accompanied by activation of PI3K/AKT and β-catenin pathways. Highlights Lentinan alleviates hypoxia-induced injuries of PNCM and H9c2 cells; microRNA-22 expression is decreased by lentinan; Lentinan reduces hypoxia-induced injury by microRNA-22 downregulation; Lentinan regulates PI3K/AKT and Wnt/β-catenin by regulation of microRNA-22/Sirt1.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Cell Hypoxia/drug effects ; Cytoprotection/drug effects ; Down-Regulation/drug effects ; Lentinan/pharmacology ; MicroRNAs/genetics ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; Sirtuin 1/metabolism ; Wnt Signaling Pathway/drug effects
Chemical Substances	MIRN22 microRNA, rat ; MicroRNAs ; Lentinan (37339-90-5) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Sirtuin 1 (EC 3.5.1.-)
Language	English
Publishing date	2019-10-03
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	2723095-8
ISSN	2169-141X ; 2169-1401
ISSN (online)	2169-141X
ISSN	2169-1401
DOI	10.1080/21691401.2019.1666863
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Article ; Online: Electrically conductive porous MXene-polymer composites with ultralow percolation threshold via Pickering high internal phase emulsion templating strategy.

Zheng, Zheng / Zhao, Yongliang / Ye, Zhangfan / Hu, Jianhua / Wang, Haitao

Journal of colloid and interface science

2022 Volume 618, Page(s) 290–299

Abstract: Hypothesis: Constructing a segregated network in electrically conductive polymer composites (ECPCs) is an effective method to lower the electrical percolation threshold. The segregated network structure can be formed naturally via polymerizing Pickering ...

Abstract	Hypothesis: Constructing a segregated network in electrically conductive polymer composites (ECPCs) is an effective method to lower the electrical percolation threshold. The segregated network structure can be formed naturally via polymerizing Pickering high internal phase emulsions (HIPEs) because solid particles are assembled at water-oil interfaces. However, most Pickering stabilizers show poor electrical conductivity. In this work, we propose a facile method to prepare lightweight ECPCs with well-controlled segregated structure via Ti Experiments: Hydrophilic Ti Findings: Surface modified Ti
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2022.03.086
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Article ; Online: Cd

Zhao, Yanfang / Zhao, Yongliang / Guo, Ziyang / Zhou, Dan / Yuan, Shuai / Zhang, Xueqiong / Chu, Haibin

ChemistryOpen

2023 Volume 12, Issue 2, Page(s) e202200176

Abstract: Three crystal complexes were designed and synthesised through the solvothermal method, with ... ...

Abstract	Three crystal complexes were designed and synthesised through the solvothermal method, with Cu
Language	English
Publishing date	2023-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2655605-4
ISSN	2191-1363 ; 2191-1363
ISSN (online)	2191-1363
ISSN	2191-1363
DOI	10.1002/open.202200176
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