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  1. Article: Pathogenesis and signaling pathways related to iodine-refractory differentiated thyroid cancer.

    Zhao, Simeng / Zhao, Yuejia / Zhao, Yongfu / Wang, Guangzhi

    Frontiers in endocrinology

    2024  Volume 14, Page(s) 1320044

    Abstract: Thyroid cancer is the most common malignant neoplasm within the endocrine system and the field of head and neck surgery. Although the majority of thyroid cancers, more than 90%, are well-differentiated thyroid carcinomas with a favourable prognosis, the ... ...

    Abstract Thyroid cancer is the most common malignant neoplasm within the endocrine system and the field of head and neck surgery. Although the majority of thyroid cancers, more than 90%, are well-differentiated thyroid carcinomas with a favourable prognosis, the escalating incidence of this disease has contributed to an increasing number of patients with a propensity for recurrent disease, rapid disease progression, and poor or no response to conventional treatments. These clinical challenges are commonly attributed to alterations in key thyroid oncogenes or signaling pathways, thereby initiating tumour cell dedifferentiation events, accompanied by reduced or virtually absent expression of the sodium/iodine symporter (NIS). As a result, the disease evolves into iodine-refractory differentiated thyroid cancer (RAIR-DTC), an entity that is insensitive to conventional radioiodine therapy. Despite being classified as a differentiated thyroid cancer, RAIR-DTC has an extremely poor clinical prognosis, with a 10-year survival rate of less than 10%. Therefore, it is of paramount importance to comprehensively elucidate the underlying pathogenesis of RAIR-DTC and provide specific targeted interventions. As the pathogenic mechanisms of RAIR-DTC remain elusive, here we aim to review recent advances in understanding the pathogenesis of RAIR-DTC and provide valuable insights for the development of future molecularly targeted therapeutic approaches.
    MeSH term(s) Humans ; Iodine/therapeutic use ; Iodine Radioisotopes/therapeutic use ; Thyroid Neoplasms/pathology ; Adenocarcinoma/drug therapy ; Signal Transduction
    Chemical Substances Iodine (9679TC07X4) ; Iodine Radioisotopes
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1320044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 16S rRNA sequencing-based evaluation of the protective effects of Hua-Zhuo-Jie-Du on rats with chronic atrophic gastritis

    Zhou, Pingping / Yang, Tianxiao / Xu, Miaochan / Zhao, Yuejia / Shen, Pengpeng / Wang, Yangang

    BMC Complement Med Ther. 2022 Dec., v. 22, no. 1 p.71-71

    2022  

    Abstract: BACKGROUND: Disturbance of the intestinal flora is a pathogenic factor for chronic atrophic gastritis (CAG). Hua-Zhuo-Jie-Du (HZJD) has been shown to be an effective Chinese herbal preparation for treating CAG. However, the effects of HZJD on the ... ...

    Abstract BACKGROUND: Disturbance of the intestinal flora is a pathogenic factor for chronic atrophic gastritis (CAG). Hua-Zhuo-Jie-Du (HZJD) has been shown to be an effective Chinese herbal preparation for treating CAG. However, the effects of HZJD on the intestinal flora of CAG is unclear. In this study, we probed the regulating effects of HZJD on intestinal microbes in CAG rats using 16S rRNA gene sequencing. METHODS: High-performance liquid chromatography (HPLC) analysis was used to perform quality control of HZJD preparations. We then administered 1-methyl-3-nitro-1-nitrosoguanidine (200 μg/ml) to Sprague–Dawley rats to establish a CAG model. HZJD and vitacoenzyme were administered orally to these rats over a 10 week period. Hematoxylin and eosin (H&E) staining was performed to observe the histopathology of CAG rats. A rarefaction curve, species accumulation curve, Chao1 index, and ACE index were calculated to assess the alpha diversity. Principal component analysis (PCA), non-metric multi-dimensional scaling (NMDS), and unweighted pair group method with arithmetic mean (UPGMA) were conducted to examine the beta diversity. The LEfSe method was used to identify differential bacteria. Differential function analysis used PCA based on KEGG function prediction. RESULTS: HPLC showed that our HZJD preparation method was feasible. H&E staining showed that HZJD significantly improved the pathological state of the gastric mucosa in CAG rats. The rarefaction curve and species accumulation curve showed that the sequencing data were reasonable. The Chao1 and ACE indices were significantly increased in CAG rats compared to the N group. Following HZJD and vitacoenzyme treatment, the Chao1 and ACE indices were decreased. PCA, NMDS, and UPGMA results showed that the M group was separated from the N, HZJD, and V groups, and LEfSe results showed that the relative abundance of Akkermansia, Oscillospira, Prevotella, and CF231 were significantly higher in the N group. Proteobacteria and Escherichia were significantly enriched in the M group, Allobaculum, Bacteroides, Jeotgalicoccus, Corynebacterium, and Sporosarcina were significantly enriched in the V group, and Firmicutes, Lactobacillus, and Turicibacter were significantly enriched in the HZJD group. CONCLUSION: HZJD exhibited a therapeutic effect on the intestinal flora of CAG rats.
    Keywords Bacteroides ; Corynebacterium ; Escherichia ; Jeotgalicoccus ; Lactobacillus ; Oscillospira ; Prevotella ; Sporosarcina ; complement ; eosin ; gastric mucosa ; gastritis ; genes ; high performance liquid chromatography ; histopathology ; intestinal microorganisms ; intestines ; models ; pathological processes and conditions ; prediction ; principal component analysis ; quality control ; species diversity ; therapeutics
    Language English
    Dates of publication 2022-12
    Size p. 71.
    Publishing place BioMed Central
    Document type Article ; Online
    ISSN 2662-7671
    DOI 10.1186/s12906-022-03542-z
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: 16S rRNA sequencing-based evaluation of the protective effects of Hua-Zhuo-Jie-Du on rats with chronic atrophic gastritis.

    Zhou, Pingping / Yang, Tianxiao / Xu, Miaochan / Zhao, Yuejia / Shen, Pengpeng / Wang, Yangang

    BMC complementary medicine and therapies

    2022  Volume 22, Issue 1, Page(s) 71

    Abstract: Background: Disturbance of the intestinal flora is a pathogenic factor for chronic atrophic gastritis (CAG). Hua-Zhuo-Jie-Du (HZJD) has been shown to be an effective Chinese herbal preparation for treating CAG. However, the effects of HZJD on the ... ...

    Abstract Background: Disturbance of the intestinal flora is a pathogenic factor for chronic atrophic gastritis (CAG). Hua-Zhuo-Jie-Du (HZJD) has been shown to be an effective Chinese herbal preparation for treating CAG. However, the effects of HZJD on the intestinal flora of CAG is unclear. In this study, we probed the regulating effects of HZJD on intestinal microbes in CAG rats using 16S rRNA gene sequencing.
    Methods: High-performance liquid chromatography (HPLC) analysis was used to perform quality control of HZJD preparations. We then administered 1-methyl-3-nitro-1-nitrosoguanidine (200 μg/ml) to Sprague-Dawley rats to establish a CAG model. HZJD and vitacoenzyme were administered orally to these rats over a 10 week period. Hematoxylin and eosin (H&E) staining was performed to observe the histopathology of CAG rats. A rarefaction curve, species accumulation curve, Chao1 index, and ACE index were calculated to assess the alpha diversity. Principal component analysis (PCA), non-metric multi-dimensional scaling (NMDS), and unweighted pair group method with arithmetic mean (UPGMA) were conducted to examine the beta diversity. The LEfSe method was used to identify differential bacteria. Differential function analysis used PCA based on KEGG function prediction.
    Results: HPLC showed that our HZJD preparation method was feasible. H&E staining showed that HZJD significantly improved the pathological state of the gastric mucosa in CAG rats. The rarefaction curve and species accumulation curve showed that the sequencing data were reasonable. The Chao1 and ACE indices were significantly increased in CAG rats compared to the N group. Following HZJD and vitacoenzyme treatment, the Chao1 and ACE indices were decreased. PCA, NMDS, and UPGMA results showed that the M group was separated from the N, HZJD, and V groups, and LEfSe results showed that the relative abundance of Akkermansia, Oscillospira, Prevotella, and CF231 were significantly higher in the N group. Proteobacteria and Escherichia were significantly enriched in the M group, Allobaculum, Bacteroides, Jeotgalicoccus, Corynebacterium, and Sporosarcina were significantly enriched in the V group, and Firmicutes, Lactobacillus, and Turicibacter were significantly enriched in the HZJD group.
    Conclusion: HZJD exhibited a therapeutic effect on the intestinal flora of CAG rats.
    MeSH term(s) Animals ; Gastric Mucosa ; Gastritis, Atrophic/drug therapy ; Gastritis, Atrophic/pathology ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S/genetics ; Rats ; Rats, Sprague-Dawley
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-022-03542-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Adolescent Haze-Related Knowledge Level Study: A Cross-Sectional Survey With Sensitivity Analysis.

    Zhao, Qingchun / Zhao, Yuejia / Dou, Hongzhe / Lu, Yanrong / Chen, Yanhong / Tao, Lingwei

    Frontiers in public health

    2020  Volume 8, Page(s) 229

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adolescent ; Air Pollution ; China/epidemiology ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Schools ; Surveys and Questionnaires
    Language English
    Publishing date 2020-07-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.00229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Developing and Testing the Validity and Reliability of the Brief Adolescent Respiratory System Health Assessment Scale-Student Version in a Chinese Sample.

    Tao, Lingwei / Gao, Yana / Dou, Hongzhe / Wu, Xuekun / Yan, Lu / Liu, Danyang / Zhao, Yuejia / Zhao, Qingchun / Wang, Peiyu / Zhang, Yumei

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 713066

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2021-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.713066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Developing and Testing the Reliability and Validity of the Brief Haze Weather Health Protection Behavior Assessment Scale-Adolescent Version (BHWHPBAS-AV).

    Zhao, Qingchun / Yang, Chun / Tang, Shanshan / Zhao, Yuejia / Dou, Hongzhe / Chen, Yanhong / Lu, Yanrong / Tao, Lingwei

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 498885

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2020-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.498885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Brief adult respiratory system health status scale-community version (BARSHSS-CV): developing and evaluating the reliability and validity.

    Dou, Hongzhe / Zhao, Yuejia / Chen, Yanhong / Zhao, Qingchun / Xiao, Bo / Wang, Yan / Zhang, Yonghe / Chen, Zhiguo / Guo, Jie / Tao, Lingwei

    BMC health services research

    2018  Volume 18, Issue 1, Page(s) 683

    Abstract: Background: The evaluation of respiratory system health status in hospitalized patients is usually based on many laboratory examinations and imaging examinations. Medical examinations require a lot of manpower, material resources, financial resources, ... ...

    Abstract Background: The evaluation of respiratory system health status in hospitalized patients is usually based on many laboratory examinations and imaging examinations. Medical examinations require a lot of manpower, material resources, financial resources, and may cause a certain degree of mechanical damage and radiation damage. It is not easily used widely and economically to assess the respiratory health status of community adults. Therefore, researchers developed a brief adult respiratory system health status scale-community version (BARSHSS-CV) and tested its reliability and validity.
    Methods: Using clinical characteristics and pathogenic factors of respiratory system diseases as a theoretical basis and through reference to relevant literature, researchers developed an initial scale. A randomized cluster sampling strategy was used to recruit adults in the communities of Baoding City, Shijiazhuang City, Cangzhou city and Chifeng City in China. Researchers randomly selected 1 district from each city. Subsequently, 4 communities were respectively randomly selected from 4 districts. Then, researchers conducted the questionnaire survey in 4 communities. Finally, researchers investigated 615 community adults. 584 valid questionnaires were recovered. By applying exploratory factor analysis, confirmatory factor analysis, content validity index, Cronbach's α coefficient, mean inter-item correlation coefficient and test-retest reliability, researchers tested the reliability and validity of scale and created the final BARSHSS-CV.
    Results: BARSHSS-CV Cronbach's α=0.951, content validity = 0.933, test-retest reliability = 0.963 and factor cumulative contribution rate = 67.168% by exploratory factor analysis. By confirmatory factor analysis, Chi square value (χ2) was 442.117, degrees of freedom (df) was 161, Chi square value/degrees of freedom (χ2 /df) was 2.746, root-mean-square error of approximation (RMSEA) was 0.065, goodness of fit index (GFI) was 0.902, incremental fit index (IFI) was 0.955, comparative fit index (CFI) was 0.955, normed fit index (NFI) was 0.931, Tueker-Lewis index (TLI) was 0.947. BARSHSS-CV consisted of 20 items and 3 dimensions.
    Conclusions: BARSHSS-CV with good test-retest reliability and content/construct validity is a brief and economical tool for assessing the state of respiratory system amongst adult communities. BARSHSS-CV may help medical staff in community primary medical institutions quickly, conveniently and economically assess the status of respiratory system and the main problems of respiratory system in community adults.
    MeSH term(s) Adolescent ; Adult ; Aged ; China ; Factor Analysis, Statistical ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Psychometrics ; Reproducibility of Results ; Research Personnel ; Respiratory Tract Diseases/diagnosis ; Severity of Illness Index ; Surveys and Questionnaires/standards ; Young Adult
    Language English
    Publishing date 2018-09-03
    Publishing country England
    Document type Evaluation Studies ; Journal Article ; Multicenter Study ; Validation Studies
    ISSN 1472-6963
    ISSN (online) 1472-6963
    DOI 10.1186/s12913-018-3505-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Development and testing of the reliability and validity of the adolescent haze related knowledge awareness assessment scale (AHRKAAS).

    Dou, Hongzhe / Zhao, Yuejia / Chen, Yanhong / Zhao, Qingchun / Xiao, Bo / Wang, Yan / Zhang, Yonghe / Chen, Zhiguo / Guo, Jie / Tao, Lingwei

    BMC public health

    2018  Volume 18, Issue 1, Page(s) 734

    Abstract: Background: Haze leads to many direct serious public health impacts. Understanding haze related knowledge can not only help adolescents organize health protection awareness to prevent the harmful effects that haze has on the body, but also promote their ...

    Abstract Background: Haze leads to many direct serious public health impacts. Understanding haze related knowledge can not only help adolescents organize health protection awareness to prevent the harmful effects that haze has on the body, but also promote their normal growth and development.
    Methods: By considering, as the theoretical basis, the reasons behind the formation of haze and the underlying mechanisms of the diseases that it causes, in addition to also investigating extensive literature references, our research team developed the Adolescent Haze Related Knowledge Awareness Assessment Scale (AHRKAAS-I). After 6 experts reviewed AHRKAAS-I, and 6 adolescents tested the scale, the research team further revised and improved AHRKAAS-I to form AHRKAAS-II. After which, researchers randomly selected 2 districts from the 20 districts of Baoding, and subsequently randomly selected 2 middle schools from these 2 districts. Conducting a stratified cluster sampling method, considering class as a unit, the research team randomly selected 22 classes. Finally, a total of 1100 adolescents were investigated and 1034 valid questionnaires were recovered. By analyzing the data of 1034 valid questionnaires, the researchers tested the reliability and validity of the scale and obtained the final scale (AHRKAAS).
    Results: AHRKAAS Cronbach's α=0.923, content validity = 0.940, criterion validity = 0.444, and factor cumulative contribution rate = 66.178% by exploratory factor analysis. Using confirmatory factor analysis, Chi square value = 662.780, degrees of freedom = 242, Chi square value/degrees of freedom = 2.739, root-mean-square error of approximation = 0.049, goodness of fit index = 0.929, adjusted goodness of fit index = 0.905, comparative fit index = 0.964, normed fit index = 0.944, and Tueker-Lewis index = 0.955. AHRKAAS consisted of 25 items and 4 dimensions.
    Conclusion: AHRKAAS with a good reliability and validity can be used to assess the cognition level of haze related knowledge among the adolescents, help medical workers and coordinators in schools when conducting targeted behavior interventions. Furthermore, it can be used for health guidance for adolescents relating to the health prevention of haze.
    MeSH term(s) Adolescent ; Air Pollution/adverse effects ; China ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2018-06-14
    Publishing country England
    Document type Journal Article
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/s12889-018-5638-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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