Article: Free fatty acid receptors in the endocrine regulation of glucose metabolism: Insight from gastrointestinal-pancreatic-adipose interactions.
2022 Volume 13, Page(s) 956277
Abstract: Glucose metabolism is primarily controlled by pancreatic hormones, with the coordinated assistance of the hormones from gastrointestine and adipose tissue. Studies have unfolded a sophisticated hormonal gastrointestinal-pancreatic-adipose interaction ... ...
Abstract | Glucose metabolism is primarily controlled by pancreatic hormones, with the coordinated assistance of the hormones from gastrointestine and adipose tissue. Studies have unfolded a sophisticated hormonal gastrointestinal-pancreatic-adipose interaction network, which essentially maintains glucose homeostasis in response to the changes in substrates and nutrients. Free fatty acids (FFAs) are the important substrates that are involved in glucose metabolism. FFAs are able to activate the G-protein coupled membrane receptors including GPR40, GPR120, GPR41 and GPR43, which are specifically expressed in pancreatic islet cells, enteroendocrine cells as well as adipocytes. The activation of FFA receptors regulates the secretion of hormones from pancreas, gastrointestine and adipose tissue to influence glucose metabolism. This review presents the effects of the FFA receptors on glucose metabolism |
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MeSH term(s) | Adipose Tissue/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Fatty Acids, Nonesterified/metabolism ; Glucose/metabolism ; Humans ; Pancreas/metabolism ; Pancreatic Hormones/metabolism ; Receptors, G-Protein-Coupled/metabolism |
Chemical Substances | Fatty Acids, Nonesterified ; Pancreatic Hormones ; Receptors, G-Protein-Coupled ; Glucose (IY9XDZ35W2) |
Language | English |
Publishing date | 2022-09-28 |
Publishing country | Switzerland |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2592084-4 |
ISSN | 1664-2392 |
ISSN | 1664-2392 |
DOI | 10.3389/fendo.2022.956277 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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