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  1. Article ; Online: Sexually concordant selection on floral traits despite greater opportunity for selection through male fitness

    Hou, Meng / Opedal, Øystein H. / Zhao, Zhi‐Gang

    New Phytologist. 2024 Jan., v. 241, no. 2 p.926-936

    2024  

    Abstract: Pollinators are important drivers of floral trait evolution, yet plant populations are not always perfectly adapted to their pollinators. Such apparent maladaptation may result from conflicting selection through male and female sexual functions in ... ...

    Abstract Pollinators are important drivers of floral trait evolution, yet plant populations are not always perfectly adapted to their pollinators. Such apparent maladaptation may result from conflicting selection through male and female sexual functions in hermaphrodites. We studied sex‐specific mating patterns and phenotypic selection on floral traits in Aconitum gymnandrum. After genotyping 1786 offspring, we partitioned individual fitness into sex‐specific selfed and outcrossed components and estimated phenotypic selection acting through each. Relative fitness increased with increasing mate number, and more so for male function. This led to greater opportunity for selection through outcrossed male fitness, though patterns of phenotypic selection on floral traits tended to be similar, and with better support for selection through female rather than male fitness components. We detected directional selection through one or more fitness component for larger flower number, larger flowers, and more negative nectar gradients within inflorescences. Our results are consistent with Bateman's principles for sex‐specific mating patterns and illustrate that, despite the expected difference in opportunity for selection, patterns of variation in selection across traits can be rather similar for the male and female sexual functions. These results shed new light on the effect of sexual selection on the evolution of floral traits.
    Keywords Aconitum ; females ; floral characteristics ; flowers ; genotyping ; males ; nectar ; phenotypic selection ; progeny ; sexual selection
    Language English
    Dates of publication 2024-01
    Size p. 926-936.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.19370
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  2. Article: Knowledge structure and global trends of machine learning in stroke over the past decade: A scientometric analysis.

    Wu, Mingfen / Yu, Kefu / Zhao, Zhigang / Zhu, Bin

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24230

    Abstract: Objective: Machine learning (ML) models have been widely applied in stroke prediction, diagnosis, treatment, and prognosis assessment. We aimed to conduct a comprehensive scientometrics analysis of studies related to ML in stroke and reveal its current ... ...

    Abstract Objective: Machine learning (ML) models have been widely applied in stroke prediction, diagnosis, treatment, and prognosis assessment. We aimed to conduct a comprehensive scientometrics analysis of studies related to ML in stroke and reveal its current status, knowledge structure, and global trends.
    Methods: All documents related to ML in stroke were retrieved from the Web of Science database on March 15, 2023. We refined the documents by including only original articles and reviews in the English language. The literature published over the past decade was imported into scientometrics software for influence detection and collaborative network analysis.
    Results: 2389 related publications were included. The annual publication outputs demonstrated explosive growth, with an average growth rate of 63.99 %. Among the 90 countries/regions involved, the United States (729 articles) and China (636 articles) were the most productive countries. Frontiers in Neurology was the most prolific journal with 94 articles. 234 highly cited articles, each with more than 31 citations, were detected. Keyword analysis revealed a total of 5333 keywords, with a predominant focus on the application of ML models in the early diagnosis, classification, and prediction of "acute ischemic stroke" and "atrial fibrillation-related stroke". The keyword "classification" had the first and longest burst, spanning from 2013 to 2018. 'Upport vector machine' got the strongest burst strength with 6.2. Keywords such as 'mechanical thrombectomy', 'expression', and 'prognosis' experienced bursts in 2022 and have continued to be prominent.
    Conclusion: The applications of ML in stroke are increasingly diverse and extensive, with researchers showing growing interest over the past decade. However, the clinical application of ML in stroke is still in its early stages, and several limitations and challenges need to be addressed for its widespread adoption in clinical practice.
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: UHPLC-MS/MS for plasma lamotrigine analysis and comparison with a homogenous enzyme immunoassay.

    Shi, Xiaoxu / Zhang, Dongjie / Zhao, Zhigang / Mei, Shenghui

    Bioanalysis

    2024  Volume 16, Issue 4, Page(s) 233–243

    Abstract: Aims: ...

    Abstract Aims:
    MeSH term(s) Humans ; Lamotrigine ; Tandem Mass Spectrometry/methods ; Chromatography, High Pressure Liquid/methods ; Anticonvulsants ; Immunoenzyme Techniques ; Immunoassay/methods ; Reproducibility of Results
    Chemical Substances Lamotrigine (U3H27498KS) ; Anticonvulsants
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio-2023-0183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Review on Abrasive Machining Technology of SiC Ceramic Composites.

    Zhang, Huiyun / Zhao, Zhigang / Li, Jiaojiao / Ye, Linzheng / Liu, Yao

    Micromachines

    2024  Volume 15, Issue 1

    Abstract: Ceramic matrix composites have the advantages of low density, high specific strength, high specific die, high-temperature resistance, wear resistance, chemical corrosion resistance, etc., which are widely used in aerospace, energy, transportation, and ... ...

    Abstract Ceramic matrix composites have the advantages of low density, high specific strength, high specific die, high-temperature resistance, wear resistance, chemical corrosion resistance, etc., which are widely used in aerospace, energy, transportation, and other fields. CMCs have become an important choice for engine components and other high-temperature component manufacturing. However, ceramic matrix composite is a kind of multi-phase structure, anisotropy, high hardness material, due to the brittleness of the ceramic matrix, the weak bonding force between fiber and matrix, and the anisotropy of composite material. Burr, delamination, tearing, chips, and other surface damage tend to generate in the machining, resulting in surface quality and strength decline. This paper reviewed the latest abrasive machining technology for SiC ceramic composites. The characteristics and research directions of the main abrasive machining technology, including grinding, laser-assisted grinding, ultrasonic-assisted grinding, and abrasive waterjet machining, are introduced first. Then, the commonly used numerical simulation research for modeling and simulating the machining of ceramic matrix composites is briefly summarized. Finally, the processing difficulties and research hotspots of ceramic matrix composites are summarized.
    Language English
    Publishing date 2024-01-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi15010106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Biochemical Composition and Quality of Adult Chinese Mitten Crab

    Wang, Shihui / Luo, Liang / Zhang, Rui / Guo, Kun / Zhao, Zhigang

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Saline-alkaline aquaculture has become an important breakthrough in expanding the space available for aquaculture in China. However, the biochemical composition and quality ... ...

    Abstract Saline-alkaline aquaculture has become an important breakthrough in expanding the space available for aquaculture in China. However, the biochemical composition and quality of
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13030362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Constructing lactylation-related genes prognostic model to effectively predict the disease-free survival and treatment responsiveness in prostate cancer based on machine learning.

    Pan, Jinyou / Zhang, Jianpeng / Lin, Jingwei / Cai, Yinxin / Zhao, Zhigang

    Frontiers in genetics

    2024  Volume 15, Page(s) 1343140

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2024.1343140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Prescription trends and dosing appropriateness analysis of novel oral anticoagulants in ischemic stroke patients: a retrospective study of 9 cities in China.

    Wu, Mingfen / Jiang, Hailun / Yu, Kefu / Zhao, Zhigang / Zhu, Bin

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1304139

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1304139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Population Pharmacokinetics of Lamotrigine and Its N2-Glucuronide Metabolite in Chinese Patients with Epilepsy.

    Yang, Hua / Zhang, Dongjie / Wei, Shifeng / Zhao, Zhigang / Mei, Shenghui

    Therapeutic drug monitoring

    2024  

    Abstract: Background: Lamotrigine is a new antiepileptic drug with substantial interindividual variability in its pharmacokinetics and therapeutic responses. This study aimed to develop population pharmacokinetic (PPK) models of lamotrigine and its N2-glucuronide ...

    Abstract Background: Lamotrigine is a new antiepileptic drug with substantial interindividual variability in its pharmacokinetics and therapeutic responses. This study aimed to develop population pharmacokinetic (PPK) models of lamotrigine and its N2-glucuronide metabolites for model-informed individualized therapy.
    Methods: A total of 353 plasma concentrations from Chinese patients with epilepsy receiving oral lamotrigine were used to develop a population PPK model using a nonlinear mixed effects modeling method. One- and two-compartment models were applied to the nonmetabolite and metabolite model, respectively. Forward addition and backward elimination were used to establish the final model. Model validation was performed using standard goodness-of-fit, bootstrap, visual predictive checks, and normalized prediction distribution errors. Finally, simulations were performed to propose lamotrigine dosages in different situations to achieve trough concentrations within the reference interval (2.5-15 mg/L).
    Results: For both final population PPK models, coadministration with valproic acid (VPA) or enzyme inducer, and body weight significantly affected lamotrigine clearance. The final models for lamotrigine clearance were and for nonmetabolite and metabolite models, respectively. The precision of the PPK parameters was acceptable, and the models exhibited good predictability. Monte Carlo simulations revealed that the lamotrigine dosage administered to patients combined with an enzyme inducer must be tripled that administered with VPA to reach the target trough concentration.
    Conclusions: Variability in the pharmacokinetics of lamotrigine is large. Coadministration of VPA or an enzyme inducer and body weight are the most important factors in lamotrigine clearance in Chinese patients with epilepsy. The developed population PPK models might support further optimization of lamotrigine dosing regimens.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424443-6
    ISSN 1536-3694 ; 0163-4356
    ISSN (online) 1536-3694
    ISSN 0163-4356
    DOI 10.1097/FTD.0000000000001207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1503: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Genetic and molecular mechanisms of reproductive isolation in the utilization of heterosis for breeding hybrid rice.

    Wang, Chaolong / Yu, Xiaowen / Wang, Jian / Zhao, Zhigang / Wan, Jianmin

    Journal of genetics and genomics = Yi chuan xue bao

    2024  

    Abstract: Heterosis, also known as hybrid vigor, is commonly observed in rice crosses. The hybridization of rice species or subspecies exhibits robust hybrid vigor, however, the direct harnessing of this vigor is hindered by reproductive isolation. Here, we review ...

    Abstract Heterosis, also known as hybrid vigor, is commonly observed in rice crosses. The hybridization of rice species or subspecies exhibits robust hybrid vigor, however, the direct harnessing of this vigor is hindered by reproductive isolation. Here, we review recent advances in the understanding of the molecular mechanisms governing reproductive isolation in inter-subspecific and inter-specific hybrids. This review encompasses the genetic model of reproductive isolation within and among Oryza sativa species, emphasizing the essential role of mitochondria in this process. Additionally, we delve into the molecular intricacies governing the interaction between mitochondria and autophagosomes, elucidating their significant contribution to reproductive isolation. Furthermore, our exploration extends to comprehending the evolutionary dynamics of reproductive isolation and speciation in rice. Building on these advances, we offer a forward-looking perspective on how to overcome the challenges of reproductive isolation and facilitate the utilization of heterosis in future hybrid rice breeding endeavors.
    Language English
    Publishing date 2024-02-05
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2374568-X
    ISSN 1873-5533 ; 1673-8527
    ISSN (online) 1873-5533
    ISSN 1673-8527
    DOI 10.1016/j.jgg.2024.01.007
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  10. Article ; Online: Risk factors associated with high-dose methotrexate induced toxicities.

    Li, Wenshu / Mo, Jiayi / Yang, Zhilin / Zhao, Zhigang / Mei, Shenghui

    Expert opinion on drug metabolism & toxicology

    2024  Volume 20, Issue 4, Page(s) 263–274

    Abstract: Introduction: High-dose methotrexate (HDMTX) therapy poses challenges in various neoplasms due to individualized pharmacokinetics and associated adverse effects. Our purpose is to identify early risk factors associated with HDMTX-induced toxicities, ... ...

    Abstract Introduction: High-dose methotrexate (HDMTX) therapy poses challenges in various neoplasms due to individualized pharmacokinetics and associated adverse effects. Our purpose is to identify early risk factors associated with HDMTX-induced toxicities, paving the way for personalized treatment.
    Areas covered: A systematic review of PubMed and Cochrane databases was conducted for articles from inception to July 2023. Eligible studies included reviews, clinical trials, and real-world analyses. Irrelevant studies were excluded, and manual searches and citation reviews were performed. Factors such as MTX exposure, drug interactions, demographics, serum albumin, urine pH, serum calcium, and genetic polymorphisms affecting MTX transport (e.g. SLCO1B1), intracellular folate metabolism (MTHFR), cell development (ARID5B), metabolic pathways (UGT1A1, PNPLA3), as well as epigenetics were identified.
    Expert opinion: This comprehensive review aids researchers and clinicians in early identification of HDMTX toxicity risk factors. By understanding the multifaceted risk factors associated with hematologic malignancies, personalized treatment approaches can be tailored to optimize therapeutic outcomes.
    MeSH term(s) Humans ; Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Interactions ; Hematologic Neoplasms/drug therapy ; Methotrexate/adverse effects ; Methotrexate/administration & dosage ; Polymorphism, Genetic ; Precision Medicine/methods ; Risk Factors
    Chemical Substances Antimetabolites, Antineoplastic ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2024.2332366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6264: Show issues Location:
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