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Article ; Online: Bioinformatics Analysis Reveals the Vital Role of AKR1B1 in Immune Infiltration and Clinical Outcomes of Gastric Cancer.

Zhao, Zhiyue / Hao, Zhibin / Zhang, Zheng / Zhan, Xianbao

2023 Volume 42, Issue 7, Page(s) 372–389

Abstract: Infiltrated immune cells are an important constitute of tumor microenvironment, which exert complex effects on gastric cancer (GC) pathogenesis and progression. By using weighted gene co-expression network analysis, integrating the data from The Cancer ... ...

Abstract	Infiltrated immune cells are an important constitute of tumor microenvironment, which exert complex effects on gastric cancer (GC) pathogenesis and progression. By using weighted gene co-expression network analysis, integrating the data from The Cancer Genome Atlas-stomach adenocarcinoma and GSE62254, we identify Aldo-Keto Reductase Family 1 Member B (AKR1B1) as a hub gene for immune regulation in GC. Notably, AKR1B1 is associated with higher immune infiltration and worse histologic grade of GC. In addition, AKR1B1 is an independent factor for predicting the survival rate of GC patients.
MeSH term(s)	Humans ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Tumor Microenvironment/genetics ; Aldehyde Reductase/genetics
Chemical Substances	AKR1B1 protein, human (EC 1.1.1.21) ; Aldehyde Reductase (EC 1.1.1.21)
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1024454-2
ISSN	1557-7430 ; 0198-0238 ; 1044-5498
ISSN (online)	1557-7430
ISSN	0198-0238 ; 1044-5498
DOI	10.1089/dna.2022.0644
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Article ; Online: Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial.

Wang, Bibo / Wang, Neng / Zhao, Zhiyue / Huang, Shengxi / Shen, Qiang / Liu, Sheng / Zhou, Pingsheng / Lu, Lu / Qian, Guojun

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6639

Abstract: Many patients who underwent hepatic percutaneous microwave ablation (MWA) reported experiencing pain during the procedure. This study utilized a well-designed multicentral, randomized, and placebo-controlled format to investigate the effects of ... ...

Abstract	Many patients who underwent hepatic percutaneous microwave ablation (MWA) reported experiencing pain during the procedure. This study utilized a well-designed multicentral, randomized, and placebo-controlled format to investigate the effects of Butorphanol. Patients who underwent MWA were randomly assigned to either Butorphanol or normal saline group. The primary outcomes of the study were assessed by measuring the patients' intraoperative pain levels using a 10-point visual analog scale (VAS). Secondary outcomes included measuring postoperative pain levels at the 6-h mark (VAS) and evaluating comprehensive pain assessment outcomes. A total of 300 patients were divided between the control group (n = 100) and the experimental group (n = 200). Butorphanol showed statistically significant reductions in intraoperative pain levels compared to the placebo during surgery (5.00 ± 1.46 vs. 3.54 ± 1.67, P < 0.001). Significant differences were observed in postoperative pain levels at the 6-h mark and in the overall assessment of pain (1.39 + 1.21 vs. 0.65 + 0.81, P < 0.001). Butorphanol had a significant impact on reducing the heart rate of patients. The empirical evidence supports the effectiveness of Butorphanol in reducing the occurrence of visceral postoperative pain in patients undergoing microwave ablation for hepatic tumor. Furthermore, the study found no noticeable impact on circulatory and respiratory dynamics.
MeSH term(s)	Humans ; Butorphanol/therapeutic use ; Butorphanol/pharmacology ; Visceral Pain/chemically induced ; Microwaves/adverse effects ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Liver Neoplasms/drug therapy
Chemical Substances	Butorphanol (QV897JC36D)
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56876-8
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Article: Selective Production of Phenol-Rich Bio-Oil From Corn Straw Waste by Direct Microwave Pyrolysis Without Extra Catalyst.

Zhao, Zhiyue / Jiang, Zhiwei / Xu, Hong / Yan, Kai

Frontiers in chemistry

2021 Volume 9, Page(s) 700887

Abstract: We report a sustainable strategy to cleanly address biomass waste with high-value utilization. Phenol-rich bio-oil is selectively produced by direct pyrolysis of biomass waste corn straw (CS) without use of any catalyst in a microwave device. The effects ...

Abstract	We report a sustainable strategy to cleanly address biomass waste with high-value utilization. Phenol-rich bio-oil is selectively produced by direct pyrolysis of biomass waste corn straw (CS) without use of any catalyst in a microwave device. The effects of temperature and power on the yield and composition of pyrolysis products are investigated in detail. Under microwave irradiation, a very fast pyrolysis rate and bio-oil yield as high as 46.7 wt.% were obtained, which were competitive with most of the previous results. GC-MS analysis showed that temperature and power (heating rate) had great influences on the yield of bio-oil and the selectivity of phenolic compounds. The optimal selectivity of phenols in bio-oil was 49.4 area% by adjusting the operating parameters. Besides, we have made detailed statistics on the change trend of some components and different phenols in bio-oil and given the law and reason of their change with temperature and power. The
Language	English
Publishing date	2021-07-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2021.700887
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Article ; Online: microRNA-221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease.

Yao, Yufang / Zhao, Zhiyue / Zhang, Fubo / Miao, Na / Wang, Nan / Xu, Xin / Yang, Chaoping

Brain and behavior

2023 Volume 13, Issue 3, Page(s) e2921

Abstract: Background: Parkinson's disease (PD) is one of the most common systemic neurodegenerative diseases and is related to the loss of dopaminergic neurons in the substantia nigra. Several studies verified that microRNA (miRNAs) targeting the Bim/Bax/caspase- ... ...

Abstract	Background: Parkinson's disease (PD) is one of the most common systemic neurodegenerative diseases and is related to the loss of dopaminergic neurons in the substantia nigra. Several studies verified that microRNA (miRNAs) targeting the Bim/Bax/caspase-3 signaling axis is involved in the apoptosis of dopaminergic neurons in substantia nigra. In this study, we aimed to explore the role of miR-221 in PD. Methods: To examine the function of miR-221 in vivo, we used a well-established 6-OHDA-induced PD mouse model. Then we conducted adenovirus-mediated miR-221 overexpression in the PD mice. Results: Our results showed that miR-221 overexpression improved motor behavior of the PD mice. We demonstrated that overexpression of miR-221 reduced the loss of dopaminergic neurons in the substantia nigra striatum by promoting their antioxidative and antiapoptosis capacities. Mechanistically, miR-221 targets Bim, thus inhibiting Bim and Bax caspase-3 mediated apoptosis signaling pathways. Conclusion: Our findings suggest miR-221 participates in the pathological process of PD and might be a potential drug target and provide new insight into PD treatment.
MeSH term(s)	Mice ; Animals ; Parkinson Disease/metabolism ; Dopaminergic Neurons/metabolism ; Caspase 3/metabolism ; bcl-2-Associated X Protein/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Apoptosis ; Substantia Nigra/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; bcl-2-Associated X Protein ; MicroRNAs ; MIRN221 microRNA, mouse
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.2921
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Article ; Online: cVEMP and VAT for the diagnosis of vestibular migraine.

Yao, Yufang / Zhao, Zhiyue / Qi, Xiaoyuan / Jia, Hongning / Zhang, Lihua

European journal of clinical investigation

2021 Volume 52, Issue 1, Page(s) e13657

Abstract: Background: Although the diagnostic criteria of vestibular migraine (VM) have already been defined, various clinical manifestations of VM and the lack of pathognomonic biomarker result in high rate of misdiagnosis and mismanagement. A timely and ... ...

Abstract	Background: Although the diagnostic criteria of vestibular migraine (VM) have already been defined, various clinical manifestations of VM and the lack of pathognomonic biomarker result in high rate of misdiagnosis and mismanagement. A timely and accurate diagnosis tool for the evaluation of VM is highly needed. Objective: The current study aims to investigate the potential feasibility of cervical vestibular evoked myogenic potential (cVEMP) and vestibular autorotation test (VAT) as a diagnosis tool for VM. Methods: A total of 211 subjects were recruited into the current study with all subjects meeting the inclusion and exclusion criteria. The subjects were divided into 3 groups: healthy control group, general migraine group and VM group. Test of cVEMP and VAT was conducted in all the groups, and the generated data were statistically compared. Results: Compared with the other two groups, cVEMP P13-N23 amplitudes of VM patients showed a significant decline. Mean latency values of the VM group had no significant difference in comparison with other groups. Asymmetry ratios showed increased level in VM patients compared to the control groups, without significant difference. VAT results showed that all the horizontal gain, horizontal phase, vertical gain and vertical phase differ from the other two groups to varying degrees at higher frequency. Conclusion: cVEMP and VAT have potential usage in the assessment of VM and can serve as powerful tool in diagnosis of VM.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Migraine Disorders/complications ; Migraine Disorders/diagnosis ; Migraine Disorders/physiopathology ; Vertigo/complications ; Vertigo/diagnosis ; Vertigo/physiopathology ; Vestibular Evoked Myogenic Potentials ; Vestibular Function Tests
Language	English
Publishing date	2021-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.13657
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Article ; Online: Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway.

Liu, Tao / Zhu, Shan / Yang, Yi / Qin, Wenxiao / Wang, Zijing / Zhao, Zhiyue / Wang, Xiang / Duan, Tian / Liu, Yang / Liu, Yan / Xia, Qingmei / Zhang, Han / Li, Nan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 171, Page(s) 116110

Abstract: Skin is susceptible to premature aging in response to ultraviolet (UV) radiation-induced oxidative stress, which can ultimately result in aberrant aging or age-related disorders. Accordingly, strategies that can be adopted to mitigate oxidative stress ... ...

Abstract	Skin is susceptible to premature aging in response to ultraviolet (UV) radiation-induced oxidative stress, which can ultimately result in aberrant aging or age-related disorders. Accordingly, strategies that can be adopted to mitigate oxidative stress may contribute to protecting skin from induced aging-related damage, thereby offering promising approaches for the treatment of skin diseases and disorders. In this regard, oroxylin A (OA), a natural flavonoid isolated from certain plants used in traditional Chinese medicine, is considered to have notable antioxidant, anti-inflammatory, and anti-apoptotic properties, and is often used to treat certain inflammatory diseases. To date, however, there has been comparatively little research on the effects of OA with respect skin aging. In this study, we utilized UV radiation-induced mouse and cellular models of aging to assess the efficacy of OA in protecting against skin aging. Subsequently, to elucidate the potential mechanisms underlying the protective effect of OA on skin aging, we performed molecular docking analysis to investigate the involvement of the anti-aging gene Sirt1, which was further confirmed on the basis of Sirt1 gene silencing. We accordingly demonstrated that by promoting an increase in the expression of Sirt1, OA can contribute to suppressing UV-induced skin photo-aging in cells/mice by reducing oxidative stress. Furthermore, we established that by activating Sirt1, OA can also promote the dissociation of Nrf2 from Keap1 and its subsequent nuclear translocation. Collectively, our findings in this study reveal OA to be an effective natural compound that can be administered to delay the aging of skin triggered by UV, both in vivo and in vitro, by binding to Sirt1 to promote the deacetylation and nuclear translocation of Nrf2, thereby contributing to a reduction in oxidative stress. These findings may this provide a therapeutic target for the prevention of skin aging or aging-induced skin diseases.
MeSH term(s)	Animals ; Mice ; Aging, Premature/drug therapy ; Flavonoids/pharmacology ; Kelch-Like ECH-Associated Protein 1/metabolism ; Molecular Docking Simulation ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Sirtuin 1/metabolism ; Skin Aging/drug effects ; Skin Diseases/drug therapy ; Ultraviolet Rays
Chemical Substances	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one (53K24Z586G) ; Flavonoids ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Sirt1 protein, mouse (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-)
Language	English
Publishing date	2024-01-09
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.116110
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Article ; Online: Hollow core–shell structure Co/C@MoSe2 composites for high-performance microwave absorption

Su, Jie / Nie, Zhuguang / Feng, Yang / Hu, Xingman / Li, Haiming / Zhao, Zhiyue / Zan, Shuyu / Qi, Shuhua

Composites Part A. 2022 Nov., v. 162 p.107140-

2022

Abstract: To address an increasingly serious electromagnetic radiation problem and the urgent need to develop lightweight, high-efficiency, and strong-attenuation electromagnetic wave absorbing (EMA) materials, a hollow core–shell Co/C@MoSe₂ composite structure ... ...

Abstract	To address an increasingly serious electromagnetic radiation problem and the urgent need to develop lightweight, high-efficiency, and strong-attenuation electromagnetic wave absorbing (EMA) materials, a hollow core–shell Co/C@MoSe₂ composite structure was prepared. Flower-like MoSe₂ was wrapped around the surface of Co/C composites after a hydrothermal reaction. The introduction of MoSe₂ and the designed hollow core–shell structure was beneficial for optimizing the electromagnetic characteristics of the composites. Owing to the magnetism of Co/C composites after high-temperature treatment, the composite materials were capable of magnetic dissipation. The introduced multiple-attenuation mechanisms, such as dielectric loss, magnetic loss, and conductive loss, contributed greatly to the incident electromagnetic wave attenuation. Among them, Co/C@MoSe₂-4 exhibited excellent electromagnetic wave absorption performance. When the matching thickness was 2.5 mm, the minimum reflection loss was −42 dB, and the effective absorption bandwidth was 5.1 GHz. This work provided a smart strategy for electromagnetic wave absorbers designing and commerical application.
Keywords	absorption ; electromagnetic radiation ; magnetism ; A. Nanocomposites ; A. Nano-structures ; E. Autoclave ; Microwave absorption
Language	English
Dates of publication	2022-11
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2012223-8
ISSN	1359-835X
ISSN	1359-835X
DOI	10.1016/j.compositesa.2022.107140
Database	NAL-Catalogue (AGRICOLA)

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Article: Nanofiber orodispersible films based on carboxymethyl curdlan and PEO: New delivery system for amlodipine besylate

Zhao, Zhiyue / Li, Yinghong / Wu, Jilei / Shi, Zhenyu / Zhao, Peiqing / Su, Hui / Wang, Qinghai / Jin, Lili

Colloids and surfaces. 2022 Feb. 20, v. 635

2022

Abstract: Curdlan has been considered as a promising food additive and eventually utilized in the fabrication of several drug delivery systems. But it has not been developed and utilized in orodispersible films due to its water insolubility. In this study, we ... ...

Abstract	Curdlan has been considered as a promising food additive and eventually utilized in the fabrication of several drug delivery systems. But it has not been developed and utilized in orodispersible films due to its water insolubility. In this study, we attempted to prepare composite nanofibers using carboxymethylation curdlan (CM-CD) to improve curdlan solubility. What is more, amlodipine besylate (AB), a dihydropyridine-derivative drugs to cure cardiovascular diseases was formulated with poly (ethylene oxide) (PEO) and CM-CD into the nanofiber orodispersible films (NOFs) via applying electrospinning technology. The NOFs were farther investigated with regard to their morphology, solid state and mechanical properties. The NOFs disintegration performance and dissolution behavior were also assessed before the pharmacokinetic evaluation. NMR and FT-IR showed that modified CM-CD have been obtained and uniform spinning solutions could be produced by using water/methanol mixture solvent. The SEM revealed that the composite nanofibers diameter were about 200–300 nm, and the fibers surface smoothly. AB was amorphously distributed in all these mats without drug and polymer interactions. Increasing CM-CD content in NOFs, mechanical property and disintegration and dissolution were significantly changed. In addition, the CM-CD/NOFs demonstrated a shorter Tₘₐₓ with a higher bioavailability compared to the commercial AB tablets. Overall, we propose nanofibers based on CM-CD as promising platforms for buccal mucosa drug delivery.
Keywords	bioavailability ; curdlan ; drugs ; food additives ; mechanical properties ; methanol ; mucosa ; nanofibers ; pharmacokinetics ; solvents ; water solubility
Language	English
Dates of publication	2022-0220
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2021.128096
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Article ; Online: [Basal cell nevus syndrome with Duchenne muscular dystrophy: a case report].

Tian, Zi-Yi / Ma, Wen / Zhao, Zhi-Yue / Li, Ming

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

2020 Volume 39, Issue 2, Page(s) 230–232

Abstract: Basal cell nevus syndrome (BCNS), also known as Gorlin-Goltz syndrome, is a rare autosomal dominant genetic disease. It is thought to be caused by a mutation in the PTCH1 gene, and its incidence is 1/57 000 to 1/256 000. The case of a 7-year-old patient ... ...

Abstract	Basal cell nevus syndrome (BCNS), also known as Gorlin-Goltz syndrome, is a rare autosomal dominant genetic disease. It is thought to be caused by a mutation in the PTCH1 gene, and its incidence is 1/57 000 to 1/256 000. The case of a 7-year-old patient with BCNS and Duchenne muscular dystrophy was reported in this paper.
MeSH term(s)	Basal Cell Nevus Syndrome/diagnosis ; Child ; Humans ; Muscular Dystrophy, Duchenne ; Mutation
Language	Chinese
Publishing date	2020-04-21
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	1202342-5
ISSN	2618-0456 ; 1000-1182
ISSN (online)	2618-0456
ISSN	1000-1182
DOI	10.7518/hxkq.2021.02.017
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Article: Mycoplasma pneumoniae

Sheng, Chu-Qiao / Yang, Chun-Feng / Ao, Yu / Zhao, Zhi-Yue / Li, Yu-Mei

Experimental and therapeutic medicine

2021 Volume 21, Issue 3, Page(s) 201

Abstract: Mycoplasma is one of the most common pathogens causing community-acquired pneumonia in pediatric patients. In recent years, the number of refractory or severe cases with drug resistance has been gradually increasing and cases that developed embolism ... ...

Abstract	Mycoplasma is one of the most common pathogens causing community-acquired pneumonia in pediatric patients. In recent years, the number of refractory or severe cases with drug resistance has been gradually increasing and cases that developed embolism after
Language	English
Publishing date	2021-01-11
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2021.9634
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