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  1. AU="Zhao, Zhu-Xiang"
  2. AU="Pinto, B Mario"
  3. AU="Rech, Lavinia"
  4. AU="Li, Wen-Yan"
  5. AU="Taricco, C"
  6. AU="Hewitson, M"
  7. AU=Sismondo Sergio
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  11. AU="Rafał Poręba"
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  26. AU="Hubner, P"
  27. AU="Suppanz, Ida"
  28. AU="Maria do Rosário Gondim Peixoto"
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  30. AU="Bhattacharya, Joyeeta"
  31. AU="Gabriela Lopez‐Gonzalez"
  32. AU="South, Andrew M."
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  34. AU="Gillet, Jean‐François"
  35. AU="McKee, Mary"
  36. AU="Hajar Vaseghi"
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  38. AU="R. Kappenberger"
  39. AU="Sempoux, Christine" AU="Sempoux, Christine"
  40. AU=Choi Wonseon
  41. AU=Gudowska-Sawczuk Monika AU=Gudowska-Sawczuk Monika
  42. AU="Roufosse, Florence"
  43. AU=Rugolotto Silvana
  44. AU="Herron, Benjamin"
  45. AU="Fernández Menéndez, Jorge"
  46. AU="Nguyen, Hang Tt"
  47. AU="Tahiri, M"
  48. AU=Zhang Ying-Ying
  49. AU="Warkaye, Samson"
  50. AU="Bavor, Claire"

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  1. Artikel: GRIK3 deficiency promotes non-small cell lung cancer progression by the regulation of the UBE2C/CDK1/Wnt signaling pathway.

    Liu, Jun / Zhao, Zhu-Xiang / Li, Bin-Kai / Zhao, Zi-Wen

    American journal of cancer research

    2023  Band 13, Heft 5, Seite(n) 2066–2075

    Abstract: Glutamate ionotropic receptor kainate type subunit 3 (GRIK3) is a predominant excitatory neurotransmitter receptor in the mammalian brain. While it is known that GRIK3 is involved in normal neurophysiologic processes, its biological functions in tumor ... ...

    Abstract Glutamate ionotropic receptor kainate type subunit 3 (GRIK3) is a predominant excitatory neurotransmitter receptor in the mammalian brain. While it is known that GRIK3 is involved in normal neurophysiologic processes, its biological functions in tumor progression are still poorly understood due to limited investigation. In this study, we reported for the first time that GRIK3 expression was downregulated in non-small cell lung cancer (NSCLC) tissues as compared to paracarcinoma tissues. Additionally, we observed that GRIK3 expression was strongly correlated with the prognosis of NSCLC patients. We also noted that GRIK3 suppressed the cell proliferation and migration capability of NSCLC cells, thereby inhibiting xenografts growth and metastasis. Mechanistically, GRIK3 deficiency increased the expression of ubiquitin-conjugating enzyme E2 C (UBE2C) and cyclin-dependent kinase 1 (CDK1), which resulted in the activation of the Wnt signaling pathway and enhanced NSCLC progression. Our findings suggest that GRIK3 plays a role in regulating NSCLC progression and that its expression may serve as an independent prognostic indicator for NSCLC patients.
    Sprache Englisch
    Erscheinungsdatum 2023-05-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
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  2. Artikel: Comparison of Azvudine and Nirmatrelvir/Ritonavir and Combined Use in Patients with COVID-19.

    Hu, Cheng-Yi / Cui, Wen-Shuai / Lei, Yi / Tang, Yu-Wen / Zhang, Yan-Yan / Su, Qi-Min / Peng, Fang / Zeng, Yun-Fei / Song, Jia-Lin / Luo, Cheng-Na / Zhou, Yan / Li, Xin-Yan / Zhao, Zhu-Xiang

    Infection and drug resistance

    2023  Band 16, Seite(n) 7797–7808

    Abstract: Purpose: To compare the effectiveness of azvudine and nirmatrelvir/ritonavir for the treatment of coronavirus disease (COVID-19).: Patients and methods: We conducted a retrospective analysis of data from 576 patients with COVID-19, comprising 195 ... ...

    Abstract Purpose: To compare the effectiveness of azvudine and nirmatrelvir/ritonavir for the treatment of coronavirus disease (COVID-19).
    Patients and methods: We conducted a retrospective analysis of data from 576 patients with COVID-19, comprising 195 patients without antiviral therapy, 226 patients treated with azvudine, 114 patients treated with nirmatrelvir/ritonavir, and 41 patients were treated with azvudine and nirmatrelvir/ritonavir concurrently. We compared their symptoms, mortality rates, and the length and cost of hospitalization.
    Results: The incidence of symptoms was similar in patients treated with azvudine and in those treated with nirmatrelvir/ritonavir. However, among patients experiencing weakness, the duration of weakness was significantly shorter in the azvudine group than in the nirmatrelvir/ritonavir group (P=0.029). Mortality did not differ significantly between the azvudine group and the nirmatrelvir/ritonavir group (18.14% vs.10.53%, P=0.068). Among "severe patients", the mortality rate was markedly lower in patients treated with nirmatrelvir/ritonavir than in patients treated with azvudine (16.92% vs.32.17%, P=0.026). In patients with hepatic insufficiency, those treated with nirmatrelvir/ritonavir had substantially lower mortality than those treated with azvudine (15.09% vs.34.25%, P=0.016). In addition, patients treated with nirmatrelvir/ritonavir had longer hospital stays (P=0.002) and higher hospital costs (P<0.001) than those receiving azvudine. Compared with patients treated with nirmatrelvir/ritonavir or azvudine alone, patients taking nirmatrelvir/ritonavir and azvudine concurrently had no significant improvement in survival (P>0.05), length of stay (P>0.05), or hospital costs (P>0.05).
    Conclusion: Azvudine is recommended for patients with non-severe COVID-19 with weakness. Nirmatrelvir/ritonavir is recommended for patients with severe COVID-19, to reduce mortality, and it could be the best choice for patients with hepatic insufficiency. The concurrent use of nirmatrelvir/ritonavir and azvudine in patients with COVID-19 could be not recommended.
    Sprache Englisch
    Erscheinungsdatum 2023-12-22
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S433186
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Characteristics of patients with SARS-COV-2 PCR re-positivity after recovering from COVID-19.

    Hu, Cheng-Yi / Lei, Yi / Tang, Yu-Wen / Cui, Wen-Shuai / Wu, Pei-Lian / Li, Yan-Fang / Zhou, Yan / Li, Xin-Yan / Cui, Hao / Xiao, Lu-Shan / Zhao, Zhu-Xiang

    Epidemiology and infection

    2023  Band 151, Seite(n) e34

    Abstract: The purpose of this study was to analyse the clinical characteristics of patients with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) PCR re-positivity after recovering from coronavirus disease 2019 (COVID-19). Patients ( ...

    Abstract The purpose of this study was to analyse the clinical characteristics of patients with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) PCR re-positivity after recovering from coronavirus disease 2019 (COVID-19). Patients (
    Mesh-Begriff(e) Humans ; COVID-19 ; SARS-CoV-2 ; COVID-19 Vaccines ; COVID-19 Testing ; Polymerase Chain Reaction
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-02-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268823000249
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Public Health Measures During the COVID-19 Pandemic Reduce the Spread of Other Respiratory Infectious Diseases.

    Hu, Cheng-Yi / Tang, Yu-Wen / Su, Qi-Min / Lei, Yi / Cui, Wen-Shuai / Zhang, Yan-Yan / Zhou, Yan / Li, Xin-Yan / Wang, Zhong-Fang / Zhao, Zhu-Xiang

    Frontiers in public health

    2021  Band 9, Seite(n) 771638

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) COVID-19 ; Communicable Diseases/epidemiology ; Humans ; Pandemics ; Public Health ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-11-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2021.771638
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Pneumonia caused by extensive drug-resistant Acinetobacter baumannii among hospitalized patients: genetic relationships, risk factors and mortality.

    Li, Yu Jun / Pan, Chu Zhi / Fang, Chang Quan / Zhao, Zhu Xiang / Chen, Hui Ling / Guo, Peng Hao / Zhao, Zi Wen

    BMC infectious diseases

    2017  Band 17, Heft 1, Seite(n) 371

    Abstract: Background: The clonal spread of multiple drug-resistant Acinetobacter baumannii is an emerging problem in China. We analysed the molecular epidemiology of Acinetobacter baumanni isolates at three teaching hospitals and investigated the risk factors, ... ...

    Abstract Background: The clonal spread of multiple drug-resistant Acinetobacter baumannii is an emerging problem in China. We analysed the molecular epidemiology of Acinetobacter baumanni isolates at three teaching hospitals and investigated the risk factors, clinical features, and outcomes of hospital-acquired pneumonia caused by extensive drug-resistant Acinetobacter baumannii (XDRAB) infection in Guangzhou, China.
    Methods: Fifty-two A. baumannii isolates were collected. Multilocus sequence typing (MLST) was used to assess the genetic relationships among the isolates. The bla
    Results: Most of the 52 A. baumannii isolates (N = 37, 71.2%) were collected from intensive care units (ICUs). The respiratory system was the most common bodily site from which A. baumannii was recovered (N = 45, 86.5%). Disc diffusion classified the isolates into 17 multidrug-resistant (MDR) and 35 extensively drug-resistant (XDR) strains. MLST grouped the A. baumannii isolates into 5 existing sequence types (STs) and 7 new STs. ST195 and ST208 accounted for 69.2% (36/52) of the isolates. The clonal relationship analysis showed that ST195 and ST208 belonged to clonal complex (CC) 92. According to the sequence-based typing (SBT) of the bla
    Conclusions: ST195 may be the most common ST in Guangzhou, China, and may serve as a severe epidemic marker. SBT of bla
    Mesh-Begriff(e) Acinetobacter Infections/drug therapy ; Acinetobacter Infections/microbiology ; Acinetobacter Infections/mortality ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/genetics ; Acinetobacter baumannii/pathogenicity ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Case-Control Studies ; China/epidemiology ; Drug Resistance, Bacterial/genetics ; Female ; Hospital Mortality ; Hospitals, Teaching ; Humans ; Intensive Care Units ; Male ; Microbial Sensitivity Tests ; Molecular Epidemiology ; Multilocus Sequence Typing ; Pneumonia, Bacterial/drug therapy ; Pneumonia, Bacterial/epidemiology ; Pneumonia, Bacterial/mortality ; Pulmonary Disease, Chronic Obstructive/microbiology ; Pulmonary Disease, Chronic Obstructive/mortality ; Retrospective Studies ; Risk Factors ; beta-Lactamases/genetics
    Chemische Substanzen Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; beta-lactamase OXA-51, Acinetobacter baumannii (EC 3.5.2.6)
    Sprache Englisch
    Erscheinungsdatum 2017-05-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-017-2471-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: [Oxide synthase recombinant adenovirus. Construction of replication-deficient human endothelial nitric].

    Zhao, Zhu-Xiang / Li, Bing / Ran, Pi-Xin

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2004  Band 20, Heft 4, Seite(n) 400–1, 414

    Mesh-Begriff(e) Adenoviridae/genetics ; Cell Line ; Genetic Vectors ; Humans ; Nitric Oxide Synthase Type III/genetics ; Virus Replication
    Chemische Substanzen NOS3 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Sprache Chinesisch
    Erscheinungsdatum 2004-11
    Erscheinungsland China
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1000-6834
    ISSN 1000-6834
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Effects of a combination of amlodipine and imipenem on 42 clinical isolates of Acinetobacter baumannii obtained from a teaching hospital in Guangzhou, China.

    Li, Yu jun / Pan, Chu zhi / Zhao, Zi wen / Zhao, Zhu xiang / Chen, Hui ling / Lu, Wei bo

    BMC infectious diseases

    2013  Band 13, Seite(n) 548

    Abstract: Background: The clonal spread of Acinetobacter baumannii is a global problem, and carbapenems, such as imipenem, remain the first-choice agent against A. baumannii. Using synergy to enhance the antibiotic activity of carbapenems could be useful. Here, ... ...

    Abstract Background: The clonal spread of Acinetobacter baumannii is a global problem, and carbapenems, such as imipenem, remain the first-choice agent against A. baumannii. Using synergy to enhance the antibiotic activity of carbapenems could be useful. Here, amlodipine (AML) was tested alone and with imipenem against A. baumannii isolates.
    Methods: Forty-two isolates of A. baumannii were collected. Multilocus sequence typing (MLST) assessed the genetic relationship of the isolates. The resistance phenotypes were determined using disc diffusion. The minimum inhibitory concentrations (MICs) of the drugs were determined by broth microdilution. The combined effects of the drugs were determined by a checkerboard procedure. Metallo-β-lactamase (MBL) was determined using the MBL Etest.
    Results: Forty-two A. baumannii isolates were collected from 42 patients who were mostly older than 65 years and had long inpatient stays (≥ 7 days). A. baumannii was mostly recovered from the respiratory system (N = 35, 83.3%). Most patients (N = 27, 64.3%) received care in intensive care units (ICUs). Disc diffusion testing demonstrated that A. baumannii susceptibility to polymyxin B was 100%, while susceptibility to other antimicrobial agents was less than 30%, classifying the isolates into 10 MDR and 32 XDR strains. MLST grouped the A. baumannii isolates into 4 existing STs and 6 new STs. STn4 carried allele G1, with a T → C mutation at nt3 on the gpi111 locus. STn5 carried allele A1, possessing A → C mutations at nt156 and nt159 on the gltA1 locus. ST195 and ST208 accounted for 68.05% (29/42) of the isolates. Clonal relation analysis showed that ST195 and ST208 belonged to clonal complex (CC) 92. The inhibitory concentration of imipenem ranged from 0.5 to 32 μg/ml, and that of AML ranged from 40 to 320 μg/ml. In combination, the susceptibility rate of A. baumannii isolates increased from 16.7% to 54.8% (P = 0.001). In the checkerboard procedure, half of the isolates (N = 21, 50.0%) demonstrated synergy or partial synergy with the drug combination. The MBL Etest revealed that 1 A. baumannii strain (N = 1, 2.4%) produced MBL.
    Conclusions: CC92 was the major clone spreading in our hospital. AML improved the activity of imipenem against A. baumannii isolates in vitro but did not inhibit MBL.
    Mesh-Begriff(e) Acinetobacter Infections/epidemiology ; Acinetobacter Infections/microbiology ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/enzymology ; Acinetobacter baumannii/isolation & purification ; Aged ; Amlodipine/pharmacology ; Anti-Bacterial Agents/pharmacology ; China/epidemiology ; Drug Therapy, Combination ; Female ; Hospitals, Teaching ; Humans ; Imipenem/pharmacology ; Male ; Microbial Sensitivity Tests ; beta-Lactamases/biosynthesis ; beta-Lactamases/genetics
    Chemische Substanzen Anti-Bacterial Agents ; Amlodipine (1J444QC288) ; Imipenem (71OTZ9ZE0A) ; beta-Lactamases (EC 3.5.2.6)
    Sprache Englisch
    Erscheinungsdatum 2013-11-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/1471-2334-13-548
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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