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  1. Article: LONG-TERM BLOOD PRESSURE VARIABILITY IN STRENGTH AND ENDURANCE PROFESSIONAL ATHLETES WITH OFFICE PREHYPERTENSION OVER ANNUAL TRAINING MACROCYCLE.

    Ataman, Y / Brizhataia, I / Zharkova, A / Moiseenko, I / Ovechkin, D

    Georgian medical news

    2022  , Issue 326, Page(s) 7–11

    Abstract: Considering the high spreading of arterial hypertension (AH) in professional athletes involved in different types of physical activities, as well as the high probability of its development in individuals with high normal blood pressure (BP), we aimed at ... ...

    Abstract Considering the high spreading of arterial hypertension (AH) in professional athletes involved in different types of physical activities, as well as the high probability of its development in individuals with high normal blood pressure (BP), we aimed at investigating the daily profile of BP during three periods of annual training summer macrocycle: the preparation, competitive and transition ones. The investigation included 30 athletes having levels of systolic BP ≥130 and <140; as well as diastolic BP ≥ 85 and <90 mmHg during a thorough office examination in the preparation phase, who were divided into two groups without changes on age, sex, the duration of the sporting career depending on the type of a performed physical activity - strength (Str) and endurance (End). The athletes underwent office BP measurements and home BP monitoring (over the course of 3-7 days (M=5.2 (0.9) days), medical consultations, anthropometric and clinical examinations on each phase of the macrocycle. Although symptoms of chronic stress and autonomic dysfunction were quite common in athletes with prehypertension, still the emergence of the detected symptoms didn't differ significantly between two groups under investigation. When comparing the average values of office and home BP, the differences between Str-group and End-group regarding all indicators during the competitive phase have been identified. In particular, the levels of home diastolic BP differ the most - in Str-group they amounted to 91.1 (5.5) mm Hg, whereas in Endgroup to 83.7 (5.9) mm Hg (р=0.002). Nevertheless, the average maximum home systolic BP in Str-group has exceeded the high normal limit and accounted for 142.5 (10.2) mm Hg, in End-group the same parameter was 133.1 (7.6) mm Hg (р=0.019). The spreading of hypertension during preparation, competitive and transition periods in the Str-group has consecutively accounted for 20%, 53.3% and 13.3%.; in End-group the BP has accounted for 6.7%, 13.3% and 6.7% respectively, herewith during the competitive phase that indicator in Str-group was much higher (р=0.02), and the relative risk of developing hypertension during the competitive phase equaled 4 (р=0.048). Therefore, the increase of AH frequency and the level of BP in athletes involved in strength exercises isn't supported by an increase of autonomic symptoms development in comparison to the athletes performing endurance exercises, i.e. the frequency of asymptomatic, masked cases has a tendency to rise. To detect hypertension in time, we suggest performing home BP monitoring for athletes with high normal blood pressure during the competitive period.
    MeSH term(s) Athletes ; Blood Pressure/physiology ; Blood Pressure Monitoring, Ambulatory ; Humans ; Hypertension/diagnosis ; Prehypertension/diagnosis
    Language English
    Publishing date 2022-07-21
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics of Medical Evacuation by Train in Ukraine, 2022.

    Walravens, Stig / Zharkova, Albina / De Weggheleire, Anja / Burton, Marie / Cabrol, Jean-Clément / Lee, James S

    JAMA network open

    2023  Volume 6, Issue 6, Page(s) e2319726

    Abstract: Importance: The 2022 war in Ukraine severely affected access to health care for patients in the conflict-affected regions and limited options for medical evacuation. Air transport, a common method of medical evacuation in war zones, was unsafe due to ... ...

    Abstract Importance: The 2022 war in Ukraine severely affected access to health care for patients in the conflict-affected regions and limited options for medical evacuation. Air transport, a common method of medical evacuation in war zones, was unsafe due to the conflict of 2 modernized military forces that were in possession of aircraft and surface-to-air weapons; therefore, Médecins Sans Frontières, in collaboration with the Ukrainian railway company and Ukrainian health agencies, addressed this by initiating medical evacuation via medically customized trains.
    Objective: To describe the implementation of medical evacuation trains aimed at improving the access to health care for war-affected patients.
    Design, setting, and participants: This case series describes the remodeling of 2 trains used for medical evacuation in a conflict zone during the war in Ukraine. The study was conducted from March 30 to November 30, 2022. One train had minimal adjustments and could be rapidly deployed to address the most pressing humanitarian needs, while the other underwent major structural modifications to provide intensive care capacity. The report details the medical capabilities of the trains, the organization of referrals, and operational challenges encountered. Additionally, it includes a case series on the characteristics of patients transported in the initial 8 months, based on routinely collected programmatic descriptive data of all patients transported by the medical trains.
    Results: In 8 months, 2481 patients (male-female ratio, 1.07; male, 1136 [46%]; female 1058 [43%]; missing data, 287 [12%]; median age, 63 years [range, 0-98 years]) were evacuated from 11 cities near the Ukrainian conflict frontline to safer areas. Initially, the trains predominantly evacuated trauma patients, but over the course of the war, the patient characteristics changed with more medical and nonacute conditions, and fewer trauma patients. The main reason for entry into the intensive care unit train carriage was for close monitoring and observation, and the main interventions performed were primarily for respiratory failure.
    Conclusions and relevance: The findings of this study suggest that medical evacuation in a war zone by converted trains is possible and can improve access to health care for war-affected patients. The presence of intensive care capacity on board allows for transport of more severely ill or injured individuals. However, the target population should not be limited to trauma patients, as health care institutions affected host a much broader population whose needs and urgency for evacuation may change over time.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Ukraine ; Aircraft ; Intensive Care Units ; Critical Care ; Military Personnel
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.19726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: VENTRICULAR REPOLARIZATION MEASURES IN PROFESSIONAL AND AMATEUR ATHLETES WITH HIGH NORMAL ARTERIAL PRESSURE.

    Brizhatyi, A / Ataman, Y / Brizhataia, I / Korzh, V / Zharkova, A / Moiseenko, I / Ovechkin, D

    Georgian medical news

    2020  , Issue 298, Page(s) 123–128

    Abstract: There is merely little data regarding changes in repolarization among professional athletes with prehypertension, especially in comparison with amateur athletes. It was previously shown that disturbances of repolarization may have an important role in ... ...

    Abstract There is merely little data regarding changes in repolarization among professional athletes with prehypertension, especially in comparison with amateur athletes. It was previously shown that disturbances of repolarization may have an important role in the development of cardiac changes in athletes and be observed in a number of conditions, such as ventricular hypertrophy, channelopathies, and aortic aneurysm. Therefore, in this study, it has been aimed to compare the ventricular repolarization measures in professional and amateur athletes with high normal arterial pressure.Thirty professional and thirty amateur all-around track and field athletes were enrolled in this project. According to the level of sport activities and the presence of HNBP, all athletes were divided into 4 groups. The first group consisted of professional athletes with normal and optimal blood pressure (NOBP) values (<130/80 mmHg, total of 21 persons), the second group was formed by 9 professional athletes with HNBP (≥130/85 mmHg), the following 3rd (17 persons) and 4th (13 persons) groups were composed by amateur athletes with the level of arterial blood pressure up to 130/85 mmHg and higher respectively. We have indicated that professional athletes with upper normal values of blood pressure have an extension of the TpTe interval compared to other groups of athletes, the average value of this indicator comprised 86 ± 10.94 ms, which, however, was below the dangerous level of >100 ms. This group of people also showed an increase in the ratio of TpTe/QT values (p=0.001) in the absence of a significant difference in S-Tpc intervals (p=0.605). These changes indicate an increase in transmural dispersion of repolarization with the development of left ventricular remodeling of professional athletes with upper normal values of blood pressure. In order to establish a connection between the revealed features of repolarization and non-functional overreaching/overtraining and altered autonomic cardiovascular activity with sympathetic activation syndrome, other pathogenesis features, their clinical and prognostic value, further examinations are required.
    MeSH term(s) Athletes ; Blood Pressure/physiology ; Heart Ventricles/physiopathology ; Humans ; Hypertension/physiopathology ; Ventricular Remodeling
    Language English
    Publishing date 2020-03-06
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: People with Disabilities in Ukraine - A Call for Action.

    Patwary, Muhammad Mainuddin / Polack, Sarah / Zharkova, Albina / Swed, Sarya / Shoib, Sheikh

    Prehospital and disaster medicine

    2022  , Page(s) 1–2

    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025975-2
    ISSN 1945-1938 ; 1049-023X
    ISSN (online) 1945-1938
    ISSN 1049-023X
    DOI 10.1017/S1049023X22002400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Refugees and Mental health crisis in Ukraine.

    Shoib, Sheikh / Zharkova, Albina / Pal, Arghya / Jain, Nikhil / Saleem, Sheikh Mohd / Kolesnyk, Pavlo

    Asian journal of psychiatry

    2022  Volume 74, Page(s) 103169

    MeSH term(s) Humans ; Mental Health ; Refugees ; Ukraine/epidemiology
    Language English
    Publishing date 2022-05-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2022.103169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Correlation between long-term proton pump ingibitor use, homocysteine and lipoproteins serum concentrations in patients with comorbidity of ischemic heart disease and acid peptic disease].

    Zharkova, A / Orlovsky, V

    Georgian medical news

    2012  , Issue 213, Page(s) 22–26

    Abstract: Present article is devoted to the study of the correlation between vitamin B12 serum level, hyperhomocysteinaemia and dyslipidemia. During research there were discovered that the lowest vitamin B12 serum level and the highest homocysteine serum level ... ...

    Abstract Present article is devoted to the study of the correlation between vitamin B12 serum level, hyperhomocysteinaemia and dyslipidemia. During research there were discovered that the lowest vitamin B12 serum level and the highest homocysteine serum level have been registrated in associated pathology (ischemic heart disease and acid peptic disease according to long-term proton pump inhibitor use) patients. It was shown evident correlation between that changes and dyslipidemia. Тhe complex therapy that includes parenteral B12 supplementation leads to more effective correction of hyperhomocysteinaemia and dyslipidemia in patients with comorbidity of ischemic heart disease and acid peptic disease with long-term use of proton pump inhibitors.
    MeSH term(s) Cholesterol/blood ; Comorbidity ; Dyslipidemias/blood ; Homocysteine/blood ; Humans ; Hyperhomocysteinemia/blood ; Hyperhomocysteinemia/drug therapy ; Infusions, Parenteral ; Lipoproteins, LDL/blood ; Myocardial Ischemia/blood ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/physiopathology ; Peptic Ulcer/blood ; Peptic Ulcer/drug therapy ; Peptic Ulcer/epidemiology ; Proton Pump Inhibitors/adverse effects ; Proton Pump Inhibitors/therapeutic use ; Time Factors ; Vitamin B 12/administration & dosage ; Vitamin B 12/blood ; Vitamin B 12/therapeutic use ; Vitamin B 12 Deficiency/blood ; Vitamin B 12 Deficiency/chemically induced
    Chemical Substances Lipoproteins, LDL ; Proton Pump Inhibitors ; Homocysteine (0LVT1QZ0BA) ; Cholesterol (97C5T2UQ7J) ; Vitamin B 12 (P6YC3EG204)
    Language Russian
    Publishing date 2012-12
    Publishing country Georgia (Republic)
    Document type Controlled Clinical Trial ; English Abstract ; Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [ANALYSIS OF THE ASSOCIATION BETWEEN THR83ALA POLYMORPHISM OF MATRIX GLA-PROTEIN GENE AND LOWER EXTREMITY ARTERIAL CALCIFICATION].

    Ataman, Yu / Еrmolenko, Т / Grek, A / Zharkova, A / Ovechkin, D

    Georgian medical news

    2016  , Issue 252, Page(s) 73–79

    Abstract: Lower extremity arterial calcification (AC) is a common pathological process that has independent significance in the pathogenesis of many cardiovascular diseases. There is evidence that development of AC associated with Thr83Ala polymorphism of matrix ... ...

    Abstract Lower extremity arterial calcification (AC) is a common pathological process that has independent significance in the pathogenesis of many cardiovascular diseases. There is evidence that development of AC associated with Thr83Ala polymorphism of matrix GLA-protein gene. The objective of this study was to examine the association between Thr83Ala polymorphism of matrix Cla protein (MGP) gene and AC in male and female subjects of the Ukrainian population. 40 AC and 40 healthy controls were recruited to the study. MGP exon 4 Thr83Ala polymorphism (rs 4236) was examined using the polymerase chain reaction with subsequent restriction fragment length polymorphism analysis. The obtained data show that the substitution of threonin by alanine at position 83 in a molecule of MGP can affect its functional characteristics and anticalcinogenic properties. The distribution of homozygous carriers of a major allelic variant, and heterozygous and homozygous minor allele variants of Thr83Ala polymorphism in patients with AC was 40,0%, 47,5%, and 12,5% respectively. The corresponding distribution of variants in the control group was 32,5%, 42,5% and 25,0% (p=0,352 by χ2 -test). In women who are carriers of Ala/Ala-variant, CA occurs more rarely than in men with the same genotype (p=0,036 by χ2 -test). The substitution of threonine by alanine due to MGP exon 4 Thr83Ala polymorphism is related to a decrease in the likelihood of CA in female persons in the Ukrainian population.
    MeSH term(s) Aged ; Calcinosis/genetics ; Calcium-Binding Proteins/genetics ; Case-Control Studies ; Extracellular Matrix Proteins/genetics ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Leg/blood supply ; Male ; Peripheral Arterial Disease/genetics ; Polymorphism, Single Nucleotide ; Sex Factors ; Matrix Gla Protein
    Chemical Substances Calcium-Binding Proteins ; Extracellular Matrix Proteins
    Language Russian
    Publishing date 2016-04-26
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Micro pixelated halide perovskite photodiodes fabricated with ultraviolet laser scribing

    Morozov, A. P. / Gostishchev, P. A. / Zharkova, A. / Vasilev, A. A. / Aleksandrov, A. E. / Tameev, A. R. / Ishteev, A. R. / Didenko, S. I. / Saranin, D. S.

    2023  

    Abstract: In this study, we present a complex investigation for miniaturizing of perovskite photodiodes (PPDs) in various geometries with use of ultraviolet laser scribing (UV-LS). Employing a 355 nm (3.5 eV) pulsed laser at 30 kHz, we successfully manufactured ... ...

    Abstract In this study, we present a complex investigation for miniaturizing of perovskite photodiodes (PPDs) in various geometries with use of ultraviolet laser scribing (UV-LS). Employing a 355 nm (3.5 eV) pulsed laser at 30 kHz, we successfully manufactured PPDs with pixel configurations of 70x130 um2, 520x580 um2, and 2000x2000 um2. The utilization of UV-LS has a proven efficiency in achieving relevant diode characteristics, such as low dark currents and high shunt resistance, as well as ultrafast response. The multi-step scribing cycle provided precise patterning of perovskite photodiodes (PPDs) in a string design. The dark current densities demonstrated exceptional uniformity, ranging from 10-10 A/cm2 for 2000x2000 um2 pixelated PPDs to 10-9 A/cm2 for the 70x130 um2 configuration. The string PPDs, consisting of 10 pixels per string, displayed homogenous dark current values, ensuring effective isolation between devices. Under green light illumination (540 nm), all PPD types exhibited a broad Linear Dynamic Range (LDR). Specifically, LDR values reached 110 dB, 117 dB, and 136 dB for 70x130, 520x580, and 2000x2000 devices, respectively, spanning an illumination intensity range from 2*10-3 mW/cm2 to 2 mW/cm2. High responsivity values up to 0.38 A/W, depending on the PPDs geometry, highlight the potential of laser scribing devices for sensing in the visible range. The calculated specific detectivity performance (from 1011 to 1013 Jones) surpasses commercial analogs, while the sub-microsecond response of 70x130 um2 and 520x580 um2 miniaturized devices underscores their suitability for precise time resolution detection systems.
    Keywords Physics - Optics
    Subject code 621
    Publishing date 2023-12-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Steps towards implementing evidence-based screening in family medicine in Ukraine: SWOT-analysis of an approach of multidimensional empowerment.

    Kolesnyk, Pavlo / Frese, Thomas / Vinker, Shlomo / Shushman, Ivanna / Zharkova, Albina / Messaadi, Nassir / Kolesnyk, Andriy / Bayen, Sabine

    BMC family practice

    2021  Volume 22, Issue 1, Page(s) 20

    Abstract: Background: The purpose of this study is to forward the implementation of an operational evidence-based state screening program of common diseases in Ukraine, where currently no state-based and evidence-based screening (EBS) exists. EBS should be ... ...

    Abstract Background: The purpose of this study is to forward the implementation of an operational evidence-based state screening program of common diseases in Ukraine, where currently no state-based and evidence-based screening (EBS) exists. EBS should be performed by Family Doctors in a primary care setting and concern prevalent diseases in adults, such as: obesity (BMI), hypertension (BP measurement), diabetes (glycaemia), dyslipidemia (cholesterol/lipids), colon cancer (FOBT/colonoscopy), breast cancer (mammography), STIs (chlamydia, syphilis), HIV, HBV, HCV (i.e. serology or other rapid tests), HPV (swabs), cervical cancer (test Pap). depression (i.e., PHQ-9), and smoking (i.e., Fagerstrom).
    Methods: Four needs-based research actions were led among citizens and healthcare professionals, based on multidimensional empowerment. Internal Strengths and Weaknesses of the ongoing implementation process were identified through these studies, whereas external Opportunities and Threats were determined by the present socio-cultural and political context. This SWOT analysis is likely to guide future state-based initiatives to accomplish EBS implementation in Ukraine.
    Results: Internal Strengths are the bottom-up multidimensional empowerment approach, teaching of EBS and the development of an internet-based platform "Screening adviser" to assist shared decision making for person-centred EBS programs. Internal Weaknesses identified for the Family Doctors are a heterogeneous screening and the risk of decreasing motivation to screen. External Opportunities include the ongoing PHC reform, the existent WONCA and WHO support, and the existence of EBS programs in Europe. External Threats are the lack of national guidelines, not fully introduced gate keeping system, the vulnerable socio-economic situation, the war situation in the East of Ukraine and the Covid-19 pandemic.
    Conclusions: We started EBS implementation through research actions, based on a multidimensional empowerment of citizens, HCP and in EBS pathways involved stakeholder teams, to foster a sustainable operational human resource to get involved in that new EBS pathway to implement. The presented SWOT-analysis of this ongoing implementation process allows to plan and optimize future steps towards a state based and supports EBS program in Ukraine.
    MeSH term(s) Armed Conflicts ; COVID-19 ; Evidence-Based Medicine ; Family Practice ; Female ; Humans ; Male ; Mass Screening/organization & administration ; State Medicine ; Ukraine/epidemiology
    Language English
    Publishing date 2021-01-14
    Publishing country England
    Document type Journal Article
    ISSN 1471-2296
    ISSN (online) 1471-2296
    DOI 10.1186/s12875-021-01367-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Hyperhomocysteinemia and cardiovascular risk profile in ischemic heart disease and acid peptic disease comorbidity patients].

    Zharkova, A V / Orlovs'kyĭ, V F

    Likars'ka sprava

    2014  , Issue 1-2, Page(s) 35–39

    Abstract: Present article is devoted to the study of the clinic features of ischemic heart desease associated with acid peptic disease. It was shown the more evident increase of myocardial infarction risk in associated pathology patients. Such results have to be ... ...

    Abstract Present article is devoted to the study of the clinic features of ischemic heart desease associated with acid peptic disease. It was shown the more evident increase of myocardial infarction risk in associated pathology patients. Such results have to be caused by the special risk factor. As such factor we desided to study the hyperhomosysteinemia. During research there were discovered that the lowest vitamin B12 serum level and the highest homocysteine serum level have been registrated in associated pathology (ischemic heart disease and acid peptic disease according to long-term proton pump inhibitor use) patients. It was shown evident correlation between that changes and dyslipidemia.
    MeSH term(s) Case-Control Studies ; Cholesterol/blood ; Gastroesophageal Reflux/blood ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/drug therapy ; Gastroesophageal Reflux/epidemiology ; Homocysteine/blood ; Humans ; Hyperhomocysteinemia/blood ; Hyperhomocysteinemia/complications ; Hyperhomocysteinemia/epidemiology ; Myocardial Ischemia/blood ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/etiology ; Peptic Ulcer/blood ; Peptic Ulcer/complications ; Peptic Ulcer/drug therapy ; Peptic Ulcer/epidemiology ; Proton Pump Inhibitors/administration & dosage ; Proton Pump Inhibitors/adverse effects ; Proton Pump Inhibitors/therapeutic use ; Risk Assessment ; Risk Factors ; Triglycerides/blood ; Vitamin B 12/blood
    Chemical Substances Proton Pump Inhibitors ; Triglycerides ; Homocysteine (0LVT1QZ0BA) ; Cholesterol (97C5T2UQ7J) ; Vitamin B 12 (P6YC3EG204)
    Language Ukrainian
    Publishing date 2014-01
    Publishing country Ukraine
    Document type English Abstract ; Journal Article
    ZDB-ID 40876-1
    ISSN 1019-5297 ; 0049-6804
    ISSN 1019-5297 ; 0049-6804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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