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Article ; Online: Analysis of Radioactive Iodine Trapping Mechanism by Zinc-Based Metal-Organic Frameworks with Various N-Containing Carboxylate Ligands.

Yu, Rui-Li / Li, Qian-Fan / Li, Zhen-Le / Wang, Xiao-Yu / Xia, Liang-Zhi

ACS applied materials & interfaces

2023 Volume 15, Issue 29, Page(s) 35082–35091

Abstract: This study aimed to develop effective adsorbents for capturing radioactive iodine in nuclear power waste gas. Two zinc metal-organic frameworks (Zn-MOFs) were synthesized and found to have favorable properties such as a large surface area, thermal ... ...

Abstract	This study aimed to develop effective adsorbents for capturing radioactive iodine in nuclear power waste gas. Two zinc metal-organic frameworks (Zn-MOFs) were synthesized and found to have favorable properties such as a large surface area, thermal stability, surface rich in π-electron-containing nitrogen, and redox potential. Adsorption experiments revealed maximum capacities of 1.25 and 1.96 g g
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c07032
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Article: Influence of Structural Parameters of Intermittent Discharge Equipment on Hole Fertilization Performance

Zhang, Kang / Wu, Xue Mei / Song, Zhu Jun / Zhang, FuiGui / Zhen, Le

Journal of the ASABE. , v. 65, no. 2

2022

Abstract: HighlightsIntermittent fertilizer discharge equipment was designed to realize hole fertilizer application.The optimal structure of the fluted discharge roller was three grooves with conical cross-sections.This study provides a reference for the design of ...

Abstract	HighlightsIntermittent fertilizer discharge equipment was designed to realize hole fertilizer application.The optimal structure of the fluted discharge roller was three grooves with conical cross-sections.This study provides a reference for the design of equipment and control systems for hole fertilizer application.Abstract. Fertilizers are necessary for high crop yields. In mechanized application of starter fertilizer for tobacco, discharging the fertilizer immediately below the seedlings promotes root growth and nutrient uptake, resulting in a high utilization rate. This placement is called hole fertilizer application and is fertilizer-saving and environment-friendly. To meet the requirements of hole fertilizer application for crops with specific plant spacing, equipment to intermittently discharge fertilizer has been designed based on the structure of a fluted roller. To explore the influence of the structural and working parameters of the intermittent discharge equipment on the uniformity of hole fertilization and the accuracy of marking fertilizer positions, the fertilizer discharge process and marking process were simulated using a discrete element method based on theoretical analysis. The optimal combination of parameters was a tapered circular groove shape with three grooves, the rotational speed of the fluted roller was 30 rpm, and the center distance between two material bins was 40 cm. In the simulation, the coefficient of variation for single-hole fertilizer application was 3.39%, and the marking error was 1.86 cm. Bench tests were performed using the optimal combination of parameters to verify the simulation results. The intermittent discharge equipment was able to achieve hole fertilizer application and mark the fertilizer position. The coefficient of variation for single-hole fertilizer application was 4.35%, and the marking error was 1.95 cm. The bench tests proved that the discrete element method was feasible for optimizing the equipment parameters. This study provides a reference for developing hole fertilizer application equipment and control systems to improve fertilizer use efficiency. Keywords: Fertilizer performance, Groove structure, Hole fertilizer application, Intermittent fertilizer discharge, Structural parameter.s
Keywords	application equipment ; equipment design ; fertilizer application ; mechanization ; nutrient uptake ; root growth ; starter fertilizers ; tobacco
Language	English
Size	p. 357-366.
Publishing place	American Society of Agricultural and Biological Engineers (ASABE)
Document type	Article
ISSN	2769-3287
DOI	10.13031/ja.14552
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Article: A mechanistic review on aerobic denitrification for nitrogen removal in water treatment

Hao, Zhen-Le / Ali, Amjad / Ren, Yi / Su, Jun-Feng / Wang, Zhao

Science of the total environment. 2022 July 13,

2022

Abstract: The traditional biological nitrogen removal technology consists of two steps: nitrification by autotrophs in aerobic circumstances and denitrification by heterotrophs in anaerobic situations; however, this technology requires a huge area and stringent ... ...

Abstract	The traditional biological nitrogen removal technology consists of two steps: nitrification by autotrophs in aerobic circumstances and denitrification by heterotrophs in anaerobic situations; however, this technology requires a huge area and stringent environmental conditions. Researchers reached the conclusion that the denitrification process could also be carried out in aerobic circumstances with the discovery of aerobic denitrification. The aerobic denitrification process is carried out by aerobic denitrifying bacteria (ADB), most of which are heterotrophic bacteria that can metabolize various forms of nitrogen compounds under aerobic conditions and directly convert ammonia nitrogen to N₂ for discharge from the system. Despite the fact that there is no universal agreement on the mechanism of aerobic denitrification, this article reviewed four current explanations for the denitrification mechanism of ADB, including the microenvironment theory, theory of enzyme, electron transport bottlenecks theory, and omics study, and summarized the parameters affecting the denitrification efficiency of ADB in terms of carbon source, temperature, dissolved oxygen (DO), and pH. It also discussed the current status of the application of aerobic denitrification in practical processes. Following the review, the difficulties of present aerobic denitrification technology are outlined and future research options are highlighted. This review may help to improve the design of current wastewater treatment facilities by utilizing ADB for effective nitrogen removal and provide the engineers with relevant references.
Keywords	ammonium nitrogen ; autotrophs ; carbon ; denitrification ; electron transfer ; enzymes ; heterotrophs ; nitrification ; nitrogen ; oxygen ; pH ; temperature ; wastewater treatment
Language	English
Dates of publication	2022-0713
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.157452
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Article ; Online: A mechanistic review on aerobic denitrification for nitrogen removal in water treatment.

Hao, Zhen-Le / Ali, Amjad / Ren, Yi / Su, Jun-Feng / Wang, Zhao

The Science of the total environment

2022 Volume 847, Page(s) 157452

Abstract	The traditional biological nitrogen removal technology consists of two steps: nitrification by autotrophs in aerobic circumstances and denitrification by heterotrophs in anaerobic situations; however, this technology requires a huge area and stringent environmental conditions. Researchers reached the conclusion that the denitrification process could also be carried out in aerobic circumstances with the discovery of aerobic denitrification. The aerobic denitrification process is carried out by aerobic denitrifying bacteria (ADB), most of which are heterotrophic bacteria that can metabolize various forms of nitrogen compounds under aerobic conditions and directly convert ammonia nitrogen to N
MeSH term(s)	Aerobiosis ; Ammonia ; Bacteria, Aerobic/metabolism ; Carbon/metabolism ; Denitrification ; Heterotrophic Processes ; Nitrification ; Nitrites/metabolism ; Nitrogen/metabolism ; Oxygen ; Waste Water/chemistry ; Water Purification
Chemical Substances	Nitrites ; Waste Water ; Carbon (7440-44-0) ; Ammonia (7664-41-7) ; Nitrogen (N762921K75) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-07-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.157452
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Article ; Online: Hydrocortisone Mitigates Alzheimer's-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation.

Li, Jinran / Chen, Long / Liu, Sai / Sun, Yuan / Zhen, Le / Zhu, Zheying / Wang, Guangji / Li, Xinuo

Cells

2023 Volume 12, Issue 19

Abstract: Alzheimer's disease (AD), an age-related degenerative disorder, is characterized by β-amyloid deposition, abnormal phosphorylation of tau proteins, synaptic dysfunction, neuroinflammation, and oxidative stress. Despite extensive research, there are no ... ...

Abstract	Alzheimer's disease (AD), an age-related degenerative disorder, is characterized by β-amyloid deposition, abnormal phosphorylation of tau proteins, synaptic dysfunction, neuroinflammation, and oxidative stress. Despite extensive research, there are no medications or therapeutic interventions to completely treat and reverse AD. Herein, we explore the potential of hydrocortisone (HC), a natural and endogenous glucocorticoid known to have potent anti-inflammatory properties, in an Aβ
MeSH term(s)	Humans ; Mice ; Animals ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Hydrocortisone/pharmacology ; Neuroinflammatory Diseases ; Cognitive Dysfunction/drug therapy ; Oxidative Stress
Chemical Substances	Amyloid beta-Peptides ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2023-09-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12192348
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Article ; Online: Development and validation for bioanalysis of VK2809, its active metabolite VK2809A and glutathione-conjugated metabolite MB06588 in rat liver using LC-MS/MS.

Xu, Si-Tao / Jin, Hao-Wen / Jin, Xin / Xu, Bi-Xin / Zhang, Yu / Xie, Tao / Wang, Guangji / Wang, Jiankun / Zhen, Le

Journal of pharmaceutical and biomedical analysis

2023 Volume 234, Page(s) 115595

Abstract: VK2809 is a promising drug candidate in Phase II clinical trials for the treatment of non-alcoholic steatohepatitis (NASH). It is a prodrug with a HepDirect strategy, which can achieve selective hepatic metabolic activation, generating an active ... ...

Abstract	VK2809 is a promising drug candidate in Phase II clinical trials for the treatment of non-alcoholic steatohepatitis (NASH). It is a prodrug with a HepDirect strategy, which can achieve selective hepatic metabolic activation, generating an active metabolite VK2809A as a potent and selective agonist for thyroid hormone receptor beta (TRβ), a concomitant reactive metabolite VK2809B, and a glutathione (GSH) conjugate MB06588. Currently, there is no convenient and sensitive bioanalytical method for the simultaneous determination of the above three metabolites. Herein, we established an LC-MS/MS method to separate VK2809 and its metabolites on the XSelect HSS T3 column and quantified them in negative electrospray ionization mode. Subsequently, several factors were investigated such as the use of 60% acetonitrile for homogenization to stabilize the analytes, the addition of 20 mM glutathione for the derivation of VK2809B, and the protein precipitation with methanol containing Sobetirome as the internal standard (IS). The method exhibited good linearity for all compounds (19.4-388.4 nM for VK2809; 27.4-2744.4 nM for VK2809A and 10.6-211.0 nM for MB06588) with great correlation coefficients (r > 0.996). The method validation also demonstrated acceptable precision (RSD < 13.0% for VK2809, RSD < 7.9% for VK2809A, RSD < 14.4% for MB06588) and accuracy (92.7%-103% for VK2809, 91.2%-107.3% for VK2809A, 96%-106.7% for MB06588). The matrix effect, recovery, and stability were also suitable to determine all the analytes. This method is suitable for the bioanalysis of VK2809 and its metabolites and has been successfully applied to the study of intrahepatic exposure in rats. It is expected to be further practiced in drug design, optimization, and metabolism study in the following research.
MeSH term(s)	Rats ; Animals ; Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Organophosphonates ; Liver ; Reproducibility of Results
Chemical Substances	2-((3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methyl)-4-(3-chlorophenyl)-2-oxido(1,3,2)dioxaphosphonane ; Organophosphonates
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115595
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Article: Synthesis of indole-fused scaffolds via [3+3] cyclization reaction of 2-indolylmethanols with quinone imines

Qin, Lu-Zhe / Cheng, Ya-Long / Wen, Xiaoan / Xu, Qing-Long / Zhen, Le

Tetrahedron. 2021 Jan. 01, v. 77

2021

Abstract: A formal [3 + 3] cyclization reaction of 2-indolylmethanols with quinones was realized to furnish indole-fused scaffolds in moderate to excellent yields. This protocol was proceeded smoothly under acid condition, with high high yields and broad substrate ...

Abstract	A formal [3 + 3] cyclization reaction of 2-indolylmethanols with quinones was realized to furnish indole-fused scaffolds in moderate to excellent yields. This protocol was proceeded smoothly under acid condition, with high high yields and broad substrate scope.
Keywords	cyclization reactions ; imines ; protocols ; quinones ; synthesis ; yields
Language	English
Dates of publication	2021-0101
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-light
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2020.131742
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Article ; Online: In pursuit of feedback activation: New insights into redox-responsive hydropersulfide prodrug combating oxidative stress.

Xu, Bi-Xin / Hu, Tian-Yu / Du, Jin-Biao / Xie, Tao / Xu, Ya-Wen / Jin, Xin / Xu, Si-Tao / Jin, Hao-Wen / Wang, Guangji / Wang, Jiankun / Zhen, Le

Redox biology

2024 Volume 72, Page(s) 103130

Abstract: Redox-responsive hydropersulfide prodrugs are designed to enable a more controllable and efficient hydropersulfide (RSSH) supply and to thoroughly explore their biological and therapeutic applications in oxidative damage. To obtain novel activation ... ...

Abstract	Redox-responsive hydropersulfide prodrugs are designed to enable a more controllable and efficient hydropersulfide (RSSH) supply and to thoroughly explore their biological and therapeutic applications in oxidative damage. To obtain novel activation patterns triggered by redox signaling, we focused on NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1), a canonical antioxidant enzyme, and designed NQO1-activated RSSH prodrugs. We also performed a head-to-head comparison of two mainstream structural scaffolds with solid quantitative analysis of prodrugs, RSSH, and metabolic by-products by LC-MS/MS, confirming that the perthiocarbamate scaffold was more effective in intracellular prodrug uptake and RSSH production. The prodrug was highly potent in oxidative stress management against cisplatin-induced nephrotoxicity. Strikingly, this prodrug possessed potential feedback activation properties by which the delivered RSSH can further escalate the prodrug activation via NQO1 upregulation. Our strategy pushed RSSH prodrugs one step further in the pursuit of efficient release in biological matrices and improved druggability against oxidative stress.
MeSH term(s)	Prodrugs/pharmacology ; Prodrugs/chemistry ; Oxidative Stress/drug effects ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Oxidation-Reduction/drug effects ; Sulfides/chemistry ; Sulfides/pharmacology ; Humans ; Animals ; Tandem Mass Spectrometry ; Cisplatin/pharmacology ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Mice
Chemical Substances	Prodrugs ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; Sulfides ; persulfides ; NQO1 protein, human (EC 1.6.5.2) ; Cisplatin (Q20Q21Q62J) ; Antioxidants
Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2024.103130
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Article ; Online: Diethyl Azodicarboxylate-Promoted Oxidative [3 + 2] Cycloaddition for the Synthesis of Pyrrolo[2,1-

Xu, Ya-Wen / Wang, Jiankun / Wang, Guangji / Zhen, Le

The Journal of organic chemistry

2020 Volume 86, Issue 1, Page(s) 91–102

Abstract: A novel metal-free protocol for the effective and efficient construction of pyrrolo[2,1- ...

Abstract	A novel metal-free protocol for the effective and efficient construction of pyrrolo[2,1-
Language	English
Publishing date	2020-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.0c01567
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Article: Diethyl Azodicarboxylate-Promoted Oxidative [3 + 2] Cycloaddition for the Synthesis of Pyrrolo[2,1-a]isoquinolines

Xu, Ya-Wen / Wang, Jiankun / Wang, Guangji / Zhen, Le

Journal of organic chemistry. 2020 Dec. 07, v. 86, no. 1

2020

Abstract: A novel metal-free protocol for the effective and efficient construction of pyrrolo[2,1-a]isoquinolines via a diethyl azodicarboxylate (DEAD)-promoted oxidative [3 + 2] cycloaddition/aromatization tandem reaction is described. Instead of the reported two- ...

Abstract	A novel metal-free protocol for the effective and efficient construction of pyrrolo[2,1-a]isoquinolines via a diethyl azodicarboxylate (DEAD)-promoted oxidative [3 + 2] cycloaddition/aromatization tandem reaction is described. Instead of the reported two-component oxidation systems, DEAD, as the sole oxidant, could smoothly transfer the tertiary amines to azomethine ylides via oxidation-deprotonation tandem process. The reaction proceeded with a broad substrate scope, giving rise to products in moderate to good isolated yields.
Keywords	aromatization ; cycloaddition reactions ; isoquinolines ; organic chemistry ; oxidants ; oxidation
Language	English
Dates of publication	2020-1207
Size	p. 91-102.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.0c01567
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