Article ; Online: Dynamic changes of circulating soluble PD-1/PD-L1 and its association with patient survival in immune checkpoint blockade-treated melanoma.
International immunopharmacology
2023 Volume 118, Page(s) 110092
Abstract: Immune checkpoint PD-1 and its ligand PD-L1 lead to T cell exhaustion, and a high level of circulating soluble PD-L1 at baseline indicates a poor prognosis in melanoma and other solid tumor types. Here we show that the dynamic changes of circulating ... ...
| Abstract | Immune checkpoint PD-1 and its ligand PD-L1 lead to T cell exhaustion, and a high level of circulating soluble PD-L1 at baseline indicates a poor prognosis in melanoma and other solid tumor types. Here we show that the dynamic changes of circulating soluble PD-1 and PD-L1 across the course of immune checkpoint blockades (ICBs) and their changes associate with patient survival in melanoma in a retrospective study. A high change of soluble PD-L1 level at a time-point but not PD-1 significantly increased the mortality, whereas a high change of soluble PD-1/PD-L1 ratio significantly reduced the mortality. After the initial immunotherapy, both soluble PD-1 and PD-L1 increased. However, the change pattern of soluble PD-L1 level was particularly dependent on patients' survival status. These findings indicate that the magnitudes of circulating soluble PD-L1 and PD-1/PD-L1 ratio changes over the time may reflect the patients' response to ICBs or the progression of the disease and predict the survival in melanoma patients treated with ICBs. |
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| MeSH term(s) | Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; B7-H1 Antigen/metabolism ; Retrospective Studies ; Melanoma ; Immunotherapy |
| Chemical Substances | Immune Checkpoint Inhibitors ; B7-H1 Antigen |
| Language | English |
| Publishing date | 2023-03-31 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 2043785-7 |
| ISSN | 1878-1705 ; 1567-5769 |
| ISSN (online) | 1878-1705 |
| ISSN | 1567-5769 |
| DOI | 10.1016/j.intimp.2023.110092 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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