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Article ; Online: Study on the relationship between knee injury recovery and traditional Chinese medicine constitution of young male amateur cyclist in Hainan island cycling league

Yi-Zhen Han

Journal of Hainan Medical University, Vol 26, Iss 5, Pp 54-

2020 Volume 58

Abstract: Objective: To study the relationship between the recovery of knee joint injury and traditional Chinese medicine constitution of young male amateur cyclist in Hainan. Methods: 720 young male amateur cyclists were selected from the tour nanli lake national ...

Abstract	Objective: To study the relationship between the recovery of knee joint injury and traditional Chinese medicine constitution of young male amateur cyclist in Hainan. Methods: 720 young male amateur cyclists were selected from the tour nanli lake national wetland park cycling race and Hainan international tourism island cycling league (ding 'an station) in 2019. According to the classification criteria of TCM constitutions in classification and determination of TCM constitutions revised by the Chinese association of traditional Chinese medicine in April 2009, the TCM constitutions were divided into mild constitution group and Yin deficiency constitution group. Standard Kujala knee pain questionnaire was used to evaluate knee joint function in pinyin and Yin deficiency groups. To observe the relationship between TCM constitution and functional injury and recovery degree of knee joint. Results：Body mass index (BMI) of Yin deficiency quality was lower than that of pinyin deficiency quality (P<0.01). Score of knee flexion and extension degree was higher in Yin deficiency quality 30 minutes before the race (P<0.05). The score of Yin deficiency quality was lower after 30 minutes of squatting (P<0.01) and jumping (P<0.05). The total score of knee joint was higher 5 days after the race (P<0.01). The knee flexion and extension (P<0.05) and jump (P<0.05) were higher in the pre-race and post-race scores. Conclusion：There is a high correlation between the constitution of traditional Chinese medicine and the degree of functional injury and recovery of knee joint. The degree of post-game sports injury is higher and the recovery of post-game sports injury is faster. Therefore, different sports protection schemes can be formulated for different constitutions in bicycle RACES to reduce the occurrence of sports injuries and accelerate the recovery time of sports injuries.
Keywords	cyclists ; knee injury ; traditional chinese medicine physique ; Medicine ; R
Subject code	796
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Modified U-Net Model for Predicting the Sea Surface Salinity over the Western Pacific Ocean

Xuewei Zhang / Ning Zhao / Zhen Han

Remote Sensing, Vol 15, Iss 1684, p

2023 Volume 1684

Abstract: The prediction of oceanic features is always an important issue in oceanography, where deep learning has been proven to be a useful tool. In this study, we applied the improved U-net model to predict the monthly sea surface salinity (SSS) over the ... ...

Abstract	The prediction of oceanic features is always an important issue in oceanography, where deep learning has been proven to be a useful tool. In this study, we applied the improved U-net model to predict the monthly sea surface salinity (SSS) over the western Pacific (WP) Ocean, and the model was designed to use the SSSs from six consecutive months to predict the SSS in the next month. The monthly satellite-based SSSs in 2015–2020 were used for model training, and the data collected after January 2021 were used to evaluate the model’s predictive abilities. The results showed that the predicted SSSs represented the general patterns of SSSs over the WP region. However, the small-scale features were smoothed out in the model, and the temporal variations were also not well captured, especially over the East China Sea and Yellow Sea (ECS&YS) region. To further evaluate the potential of the U-net model, a more specific model was conducted for the ECS&YS region (Domain 2), which successfully predicted both spatial and temporal variations in the SSSs, including the spreading and retreating of the low-salinity tongue. Based on the comparison between the two domains and sensitivity experiments, we found that the prediction biases were contributed by the spatial distributions of the SSSs, the domain size, and the filter numbers. In addition, further multi-step prediction experiments suggested that our U-net model could also be used for long-time prediction, and we have examined up to five months. Overall, this study demonstrated the great ability and potential of the U-net model for predicting SSS, even though only a few trainable data are available.
Keywords	deep learning ; ConvLSTM ; U-net ; sea surface salinity ; western Pacific ; prediction ; Science ; Q
Subject code	551
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Meta-analysis of efficacy of Taohong Siwu Decoction in the treatment of diabetic peripheral neuropathy

Yi-Zhen Han / Zhen Wang

Journal of Hainan Medical University, Vol 27, Iss 17, Pp 47-

2021 Volume 54

Abstract: Objective: To evaluate the clinical efficacy of combined/single use of Taohong Siwu decoction in the treatment for diabetic peripheral neuropathy(DPN) by meta-analysis. Methods: Database were searched electronically from the time databases established to ...

Abstract	Objective: To evaluate the clinical efficacy of combined/single use of Taohong Siwu decoction in the treatment for diabetic peripheral neuropathy(DPN) by meta-analysis. Methods: Database were searched electronically from the time databases established to November 2020 to collect randomized controlled trials of Taohong Siwu decoction combined with non-specific therapy for DPN in Chinese or English. The trial was assessed by 2 researchers independently, RevMan 5.3 software was used for meta-analysis. Results: A total of 13 studies included 970 patients. Meta-analysis showed that the combined/single use of Taohong Siwu decoction can further improve median sensory nerve velocity〔MD=4.86, 95% CI (2.70, 7.03), P＜0.00001〕, and the curative effect〔OR=4.35, 95% CI (3.1, 6.06), P＜0.00001〕, increase the velocity of the motor nerve〔MD=6.84,95% CI (6.14, 7.55), P＜0.00001〕,and the velocity of the sensory nerve〔MD=7.46, 95% CI (5.84, 9.08), P＜0.00001〕, decrease TCM syndrome score 〔MD=-5.61, 95% CI (-6.63, -4.60), P＜0.00001〕, and fasting blood-glucose〔MD=-0.24, 95% CI (-0.37, -0.11), P＜0.00001〕. The GRADE showed B level of evidence. Conclusion: Combined/single use of Taohong Siwu decoction in the treatment for DPN is effective. The safety is not clear, and more high-quality clinical studies are expected to be included to provide evidence support.
Keywords	taohong siwu decoction ; diabetic peripheral neuropathy ; curative effect ; meta-analysis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The time-frequency analysis of the acoustic signal produced in underwater discharges based on Variational Mode Decomposition and Hilbert–Huang Transform

Zhen Han / Xiaobing Zhang / Bing Yan / Liang Qiao / Zhigang Wang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract The experiments of underwater discharges in an anechoic pool were carried out and analysis of the time-frequency characteristics of the acoustic signals was conducted based on Variational Mode Decomposition and Hilbert–Huang Transform (VMD-HHT). ...

Abstract	Abstract The experiments of underwater discharges in an anechoic pool were carried out and analysis of the time-frequency characteristics of the acoustic signals was conducted based on Variational Mode Decomposition and Hilbert–Huang Transform (VMD-HHT). We propose a relative center frequency difference method to determine the decomposition numbers K which has to be given before the application of VMD and the result is satisfying. The HHT spectrum and marginal spectrum are obtained, then, some valuable conclusions are drawn. The high-frequency components of the acoustic signal are mainly attributed to the shock wave, and the low-frequency components mostly result from the bubble pulse. The frequency range of the acoustic signal is basically from 0 to 90kHz, and the ratio of energy in the low-frequency band(0–4kHz) to that of the total acoustic signal is up to 55.56%. Furthermore, this ratio versus gaps is also explored and it has the minimum at the gap of 1.5 mm which is the optimal gap for the peak pressure and radiated energy of the acoustic signal. Therefore, we can not obtain the maximum energy of the acoustic signal and the maximum ratio in the low-frequency band simultaneously.
Keywords	Medicine ; R ; Science ; Q
Subject code	621
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of Erosion Characteristics in Purple and Yellow Soils Using Simulated Rainfall Experiments

Banglin Luo / Zhen Han / Jing Yang / Qing Wang

International Journal of Environmental Research and Public Health, Vol 19, Iss 357, p

2022 Volume 357

Abstract: Soil erosion of sloped lands is one of the important sources of substantive sediments in watersheds. In order to investigate erosion characteristics of sloped lands during rainfall events in the Three Gorges Reservoir Area, erosion processes of purple ... ...

Abstract	Soil erosion of sloped lands is one of the important sources of substantive sediments in watersheds. In order to investigate erosion characteristics of sloped lands during rainfall events in the Three Gorges Reservoir Area, erosion processes of purple and yellow soils under different slope gradients and rainfall intensities were studied by using a rainfall simulator. The results showed that the sediment concentration in runoff was closely correlated with rainfall intensity. The sediment concentration in runoff gradually rose to a peak with time, and then gradually declined and approach a steady rate during simulation rainfall events. The particle size distribution of surface soils before the rainfall was different from that after the rainfall. Soil erosion mainly resulted in the loss of fine particles of surface soil through runoff, and the fine particles of soil were enriched in sediments. Soil erosion rates were gradually increased with the slope gradient when the slope gradient was less than 10°, and significantly increased when the slope gradient was more than 10°. The slope factor of yellow soil could be fitted well to that calculated by the formula of Universal Soil Loss Equation (USLE). The trend of the slope factor of purple soil was similar to that of the slope factor that was derived from USLE. Therefore, the effect of slope gradients on soil erosion need to be further researched when USLE was applied to predict erosion in purple soil area.
Keywords	erosion ; particle size distribution ; sediment concentration ; slope factor ; Medicine ; R
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Joint Denoising Learning Model for Weight Update Space–Time Diversity Method

Yu Zhang / Dan Zhang / Zhen Han / Peng Jiang

Remote Sensing, Vol 14, Iss 2430, p

2022 Volume 2430

Abstract: Space–time diversity (STD) has been widely applied in underwater acoustic (UWA) communication due to its exceptional anti-multipath performance. However, underwater noise can seriously affect the processing results of STD. The conventional filtering ... ...

Abstract	Space–time diversity (STD) has been widely applied in underwater acoustic (UWA) communication due to its exceptional anti-multipath performance. However, underwater noise can seriously affect the processing results of STD. The conventional filtering algorithms cannot deal with the nonlinear components of underwater noise and may not work well for complex-type signals. This study proposes an improved STD method with a joint noise-reduction learning model for the above issues. We construct a noise-reduction learning model dedicated to complex-type UWA signals in the first stage. Complex-type features based on UWA data are extracted for pre-processing data, and a conditional generative adversarial network (CGAN) is used as the backbone network for noise-reduction. Residual learning is used to accomplish noise cancellation and yield noise-reduction estimates. In the second stage, an STD structure based on a weight update strategy is constructed. The STD structure can further constrain the weights of the signals from the main path, enhance the reception of the main path, and suppress the multi-access interference (MAI) caused by the spread spectrum communication. Finally, combining the signals on each path can improve the communication quality of the system based on the principle of the maximum signal-to-interference plus noise ratio (SINR). The simulation and experiments on a lake showed that the proposed method is more robust over the changing signal-to-noise ratio (SNR) and has a lower bit error rate (BER) than conventional methods.
Keywords	underwater acoustic communication ; space–time diversity ; noise-reduction ; deep neural network ; weight update strategy ; Science ; Q
Subject code	620
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Human Resource Practice Management for Knowledge Intensive Team

Zhen Han / Hao Ren / Shiyu Yang / Yuhang Han

Sustainability, Vol 13, Iss 4801, p

IMPACT on Team Innovation Performance and Substitution Effect of Empowerment Leadership

2021 Volume 4801

Abstract: As an important factor in society development, human resource management is crucial to enhance the effectiveness of an organization. In this paper, the research focuses on the human resource management practice in knowledge-intensive teams, and studies ... ...

Abstract	As an important factor in society development, human resource management is crucial to enhance the effectiveness of an organization. In this paper, the research focuses on the human resource management practice in knowledge-intensive teams, and studies the relationship between knowledge sharing and team innovation performance in combination with the practice of ability improvement, opportunity improvement and motivation improvement, aiming at verifying the various research hypotheses, practical policy suggestions are proposed to improve the enterprises management. A leadership substitution model is used to introduce empowerment leadership as the boundary condition to the analysis framework, and the regulatory effect of the empowerment leadership on human resource management practice and team knowledge sharing are discussed through the method of empirical analysis. The analysis results showed the substitution effect between cross-level empowerment leadership and human resource management practice and proved an alternative role between human resource management practice and empowerment leadership in a knowledge-intensive team, which provides a preliminary research basis for later research. The results fully demonstrate that for knowledge-intensive teams, more targeted human resource management practice is needed as the theoretical support. Based on leadership substitution theory, this study explored the relationship between human resource practice and innovation, trying to extend the reverse effect of leadership substitution theory. A cross-layer model is discussed as the paper distinguished implementation of human resource management practices and perceived human resource management practice.
Keywords	knowledge-intensive team ; human resource management ; innovation performance ; empowerment leadership ; substitution effect ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ship Instance Segmentation Based on Rotated Bounding Boxes for SAR Images

Xinpeng Yang / Qiang Zhang / Qiulei Dong / Zhen Han / Xiliang Luo / Dongdong Wei

Remote Sensing, Vol 15, Iss 1324, p

2023 Volume 1324

Abstract: Ship instance segmentation in synthetic aperture radar (SAR) images is a hard and challenging task, which not only locates ships but also obtains their shapes with pixel-level masks. However, in ocean SAR images, because of the consistent reflective ... ...

Abstract	Ship instance segmentation in synthetic aperture radar (SAR) images is a hard and challenging task, which not only locates ships but also obtains their shapes with pixel-level masks. However, in ocean SAR images, because of the consistent reflective intensities of ships, the appearances of different ships are similar, thus making it far too difficult to distinguish ships when they are in densely packed groups. Especially when ships have incline directions and large aspect ratios, the horizontal bounding boxes (HB-Boxes) used by all the instance-segmentation networks that we know so far inevitably contain redundant backgrounds, docks, and even other ships, which mislead the following segmentation. To solve this problem, a novel ship instance-segmentation network, called SRNet, is proposed with rotated bounding boxes (RB-Boxes), which are taken as the foundation of segmentation. Along the directions of ships, the RB-Boxes can surround the ships tightly, but a minor deviation will corrupt the integrity of the ships’ masks. To improve the performance of the RB-Boxes, a dual feature alignment module (DAM) was designed to obtain the representative features with the direction and shape information of ships. On account of the difference between the classification task and regression task, two different sampling location calculation strategies were used in two convolutional kernels of the DAM, making these locations distributed dynamically on the ships’ bodies and along the ships’ boundaries. Moreover, to improve the effectiveness of training, a new adaptive Intersection-over-Union threshold (AIoU) was proposed based on the aspect-ratio information of ships to raise positive samples. To obtain the masks in the RB-Boxes, a new Mask-segmentation Head (MaskHead) with the twice sampling processes was explored. In experiments to evaluate the RB-Boxes, the accuracy of the RB-Boxes output from the Detection Head (DetHead) of SRNet outperformed eight rotated object-detection networks. In experiments to evaluate the final ...
Keywords	synthetic aperture radar (SAR) image ; ship instance segmentation ; rotated bounding box ; dual feature alignment ; adaptive IoU threshold (AIoU) ; Science ; Q
Subject code	600
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Progress and expectation of stem cell therapy for diabetic wound healing.

Xu, Zhen-Han / Ma, Meng-Hui / Li, Yan-Qing / Li, Li-Lin / Liu, Gui-Hua

World journal of clinical cases

2023 Volume 11, Issue 3, Page(s) 506–513

Abstract: Impaired wound healing presents great health risks to diabetics. Encouragingly, the current clinical successfully found out meaningful method to repair wound tissue, and stem cell therapy could be an effective method for diabetic wound healing with its ... ...

Abstract	Impaired wound healing presents great health risks to diabetics. Encouragingly, the current clinical successfully found out meaningful method to repair wound tissue, and stem cell therapy could be an effective method for diabetic wound healing with its ability to accelerate wound closure and avoid amputation. This minireview aims at introducing stem cell therapy for facilitating tissue repair in diabetic wounds, discussing the possible therapeutic mechanism and clinical application status and problems.
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i3.506
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate

Nian-Da Yu / Bing Wang / Xin-Zhu Li / Hao-Zhen Han / Dongxiang Liu

Molecules, Vol 27, Iss 2714, p

2022 Volume 2714

Abstract: SIRT1, an NAD + -dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD + into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr). Selective SIRT1 activators have potential clinical applications in atherosclerosis, ...

Abstract	SIRT1, an NAD + -dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD + into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr). Selective SIRT1 activators have potential clinical applications in atherosclerosis, acute renal injury, and Alzheimer’s disease. Here, we found that the activity of the potent SIRT1 activator CWR is independent of the acetylated substrate. It adopts a novel mechanism to promote SIRT1 activity by covalently bonding to the anomeric C1′ carbon of the ribose ring in OAADPr. In addition, CWR is highly selective for SIRT1, with no effect on SIRT2, SIRT3, SIRT5, or SIRT6. The longer distance between the anomeric C1′ carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1′ carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1. This was confirmed by site-directed mutagenesis of SIRT3. Consistent with the in vitro assays, the activator also reduced the acetylation levels of p53 in a concentration-dependent manner via SIRT1 in cells. Our study provides a new perspective for designing SIRT1 activators that does not rely on the chemical moiety immediately C-terminal to the acetyl-lysine of the substrate.
Keywords	SIRT1 ; activator ; covalent bond ; 2′-O-acetyl-ADP-ribose ; deacetylase ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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