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  1. Article ; Online: Temozolomide for aggressive pituitary tumors:-A literature review.

    Hui-Zheng, Hu / Lei, Lei

    Asian journal of surgery

    2023  Volume 47, Issue 2, Page(s) 1300–1301

    MeSH term(s) Humans ; Temozolomide/therapeutic use ; Pituitary Neoplasms ; Antineoplastic Agents, Alkylating/therapeutic use
    Chemical Substances Temozolomide (YF1K15M17Y) ; Antineoplastic Agents, Alkylating
    Language English
    Publishing date 2023-11-29
    Publishing country Netherlands
    Document type Review ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.11.106
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  2. Article ; Online: Possible association of the prognosis with the postoperative hyperglycemia during intensive care for patients with cerebral hemorrhage: A case series.

    Hui-Zheng, Hu / Lei, Lei

    Asian journal of surgery

    2023  Volume 47, Issue 3, Page(s) 1612–1613

    MeSH term(s) Humans ; Hyperglycemia/etiology ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/surgery ; Prognosis ; Critical Care ; Retrospective Studies
    Language English
    Publishing date 2023-12-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.034
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  3. Article ; Online: miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy

    Zheng Hu / Wu Liuyang / Yuan Huisheng

    Open Medicine, Vol 18, Iss 1, Pp 1811-

    2023  Volume 24

    Abstract: GRIN2A is associated with epilepsy (EP); however, its regulatory mechanism involving upstream miRNA (miR-30b-5p) has been overlooked. In this study, we aimed to identify the regulatory mechanism of the miR-30b-5p/GRIN2A axis in EP. Hippocampal neurons ... ...

    Abstract GRIN2A is associated with epilepsy (EP); however, its regulatory mechanism involving upstream miRNA (miR-30b-5p) has been overlooked. In this study, we aimed to identify the regulatory mechanism of the miR-30b-5p/GRIN2A axis in EP. Hippocampal neurons isolated from mice were incubated in magnesium-free medium for 48 h to establish an in vitro EP model. An in vivo model of EP was constructed by the intraperitoneal injection of atropine into mice. Nissl staining and hematoxylin and eosin staining were used to evaluate pathological injuries in the hippocampal CA1 regions of mice. The CCK8 assay confirmed that miR-30b-5p overexpression restored the suppressed proliferative capacity of hippocampal neurons exposed to magnesium-free conditions. Caspase-3 activity assay revealed that miR-30b-5p overexpression abrogated the increased apoptosis of hippocampal neurons under magnesium-free conditions. In an in vivo model of EP, miR-30b-5p overexpression reversed pathological injuries in the hippocampal CA1 regions of mice and abrogated the increased apoptosis in the EP mouse model. Luciferase assays and western blotting confirmed that miR-30b-5p targeted GRIN2A, thereby inhibiting GRIN2A expression. Overall, miR-30b-5p can protect against cell proliferation and attenuate apoptosis in hippocampal neurons under magnesium-free conditions by targeting GRIN2A.
    Keywords epilepsy ; mirna ; targeting ; proliferation ; Medicine ; R
    Subject code 500
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Analysis of cases with co-infection of COVID-19 and pulmonary aspergillosis.

    Zheng Hu, Hui / Wu, Li Bo / Liu, Qian / Wu, Bin Yan / Wang, Yu / Wang, Rui Ying

    The new microbiologica

    2024  Volume 47, Issue 1, Page(s) 98–102

    Abstract: The objective of this study was to investigate the risk factors and diagnosis measure of COVID-19-associated pulmonary aspergillosis (CAPA). This study included 201 COVID-19 patients from December 1, 2022, to January 31, 2023; 7 (3.5%) were diagnosed ... ...

    Abstract The objective of this study was to investigate the risk factors and diagnosis measure of COVID-19-associated pulmonary aspergillosis (CAPA). This study included 201 COVID-19 patients from December 1, 2022, to January 31, 2023; 7 (3.5%) were diagnosed with CAPA. The main risk factors were age, MV, ICU admission and COPD, and the presence of comorbidities such as ARDS and hypoproteinemia in COVID-19 patients, more susceptible to Aspergillus infection. In addition to specimen culture in the lower respiratory tract, the 1,3-β-D-glucan antigen test can serve as an important screening indicator for early CAPA diagnosis in non-granulocytopenia patients.
    MeSH term(s) Humans ; COVID-19/complications ; Coinfection/microbiology ; Male ; Middle Aged ; Female ; Pulmonary Aspergillosis/complications ; Pulmonary Aspergillosis/epidemiology ; Aged ; SARS-CoV-2 ; Risk Factors ; Adult ; Retrospective Studies ; Comorbidity ; Aged, 80 and over
    Language English
    Publishing date 2024-05-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 756168-4
    ISSN 1121-7138 ; 0391-5352
    ISSN 1121-7138 ; 0391-5352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2267: Show issues Location:
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  5. Article: miR-30b-5p targeting GRIN2A inhibits hippocampal damage in epilepsy.

    Zheng, Hu / Wu, Liuyang / Yuan, Huisheng

    Open medicine (Warsaw, Poland)

    2023  Volume 18, Issue 1, Page(s) 20230675

    Abstract: GRIN2A is associated with epilepsy (EP); however, its regulatory mechanism involving upstream miRNA (miR-30b-5p) has been overlooked. In this study, we aimed to identify the regulatory mechanism of the miR-30b-5p/GRIN2A axis in EP. Hippocampal neurons ... ...

    Abstract GRIN2A is associated with epilepsy (EP); however, its regulatory mechanism involving upstream miRNA (miR-30b-5p) has been overlooked. In this study, we aimed to identify the regulatory mechanism of the miR-30b-5p/GRIN2A axis in EP. Hippocampal neurons isolated from mice were incubated in magnesium-free medium for 48 h to establish an
    Language English
    Publishing date 2023-03-30
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2829380-0
    ISSN 2391-5463
    ISSN 2391-5463
    DOI 10.1515/med-2023-0675
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  6. Article: Current Treatment for Central Nervous System Involvement in Children with Hemophagocytic Lymphohistiocytosis.

    Zheng, Hu-Yong

    Chinese medical journal

    2018  Volume 131, Issue 15, Page(s) 1765–1766

    MeSH term(s) Brain ; Central Nervous System Diseases/etiology ; Central Nervous System Diseases/therapy ; Child ; China ; Humans ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/therapy
    Language English
    Publishing date 2018-07-30
    Publishing country China
    Document type Editorial
    ZDB-ID 127089-8
    ISSN 0366-6999 ; 1002-0187
    ISSN 0366-6999 ; 1002-0187
    DOI 10.4103/0366-6999.237413
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    Zs.B 1207: Show issues Location:
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  7. Article ; Online: Comparative Study of AC Signal Analysis Methods for Impedance Spectroscopy Implementation in Embedded Systems

    Ahmed Yahia Kallel / Zheng Hu / Olfa Kanoun

    Applied Sciences, Vol 12, Iss 591, p

    2022  Volume 591

    Abstract: For embedded impedance spectroscopy, a suitable method for analyzing AC signals needs to be carefully chosen to overcome limited processing capability and memory availability. This paper compares various methods, including the fast Fourier transform (FFT) ...

    Abstract For embedded impedance spectroscopy, a suitable method for analyzing AC signals needs to be carefully chosen to overcome limited processing capability and memory availability. This paper compares various methods, including the fast Fourier transform (FFT), the FFT with barycenter correction, the FFT with windowing, the Goertzel filter, the discrete-time Fourier transform (DTFT), and sine fitting using linear or nonlinear least squares, and cross-correlation, for analyzing AC signals in terms of speed, memory requirements, amplitude measurement accuracy, and phase measurement accuracy. These methods are implemented in reference systems with and without hardware acceleration for validation. The investigation results show that the Goertzel algorithm has the best overall performance when hardware acceleration is excluded or in the case of memory constraints. In implementations with hardware acceleration, the FFT with barycentre correction stands out. The linear sine fitting method provides the most accurate amplitude and phase determinations at the expense of speed and memory requirements.
    Keywords AC signal processing ; embedded impedance spectroscopy ; impedance spectroscopy ; multisine ; Fast-Fourier Transform ; Goertzel algorithm ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 518
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Optimal Configurations of Mueller Polarimeter for Gaussian–Poisson Mixed Noise

    Zheng Hu / Qianhao Zhao / Hui Ma

    Applied Sciences, Vol 12, Iss 6521, p

    2022  Volume 6521

    Abstract: The accuracy of the Mueller polarimeter is usually affected by Gaussian–Poisson mixed noise, and by optimizing the instrument matrices of polarization state generator and polarization state analyzer in the measurement system, the estimation variance ... ...

    Abstract The accuracy of the Mueller polarimeter is usually affected by Gaussian–Poisson mixed noise, and by optimizing the instrument matrices of polarization state generator and polarization state analyzer in the measurement system, the estimation variance caused by Gaussian noise can be suppressed, and the estimation variance caused by Poisson noise can be made independent of the sample. However, the optimization procedure usually targets only the numerical value of the instrument matrix without considering how to configure the measurement system to achieve the optimal instrument matrix. In this paper, we investigate how to make the measurement system optimal for different measurement systems by combining geometric optimization on the Poincaré sphere and finally propose a series of measurement configurations for different applications.
    Keywords optimization ; Mueller polarimetry ; Gaussian–Poisson mixed noise ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 620
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Looking backward in time to define the chronology of metastasis

    Zheng Hu / Christina Curtis

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 4

    Abstract: The timing of cancer metastasis has implications for treatment and prevention. Traditional forward-time views of metastasis assume it occurs late during evolution. However, looking backward in time reveals metastasis often occurs prior to clinical ... ...

    Abstract The timing of cancer metastasis has implications for treatment and prevention. Traditional forward-time views of metastasis assume it occurs late during evolution. However, looking backward in time reveals metastasis often occurs prior to clinical detection of primary tumors.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
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  10. Article ; Online: Looking backward in time to define the chronology of metastasis

    Zheng Hu / Christina Curtis

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 4

    Abstract: The timing of cancer metastasis has implications for treatment and prevention. Traditional forward-time views of metastasis assume it occurs late during evolution. However, looking backward in time reveals metastasis often occurs prior to clinical ... ...

    Abstract The timing of cancer metastasis has implications for treatment and prevention. Traditional forward-time views of metastasis assume it occurs late during evolution. However, looking backward in time reveals metastasis often occurs prior to clinical detection of primary tumors.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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