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  1. Article ; Online: Omicron breakthrough infected individuals show enhanced nasal antibody responses and preserved T cell responses against the EG.5.1 and BA.2.86.

    Zhu, Zheng / Li, Shixiong / Fan, Junhao / Shang, Shihao / Zhang, Yao / Zi, Qiong / Zheng, Jihao / Wang, Dongfang / Mou, Xiaoli / Liu, Kepu / Lv, Maoxin / Yuan, Jianlin / Wang, Zhongfang / Yu, Jingyou

    Journal of medical virology

    2024  Volume 96, Issue 3, Page(s) e29537

    MeSH term(s) Humans ; Antibody Formation ; T-Lymphocytes
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses.

    Fan, Junhao / Li, Shixiong / Zhang, Yao / Zheng, Jihao / Wang, Dongfang / Liao, Yunxi / Cui, Zhibo / Zhao, Dongyu / Barouch, Dan H / Yu, Jingyou

    Viruses

    2023  Volume 15, Issue 12

    Abstract: Despite the effective antivirals and vaccines, COVID-19 remains a public health concern. The mutations that occurred during the early stage of the pandemic can be valuable in assessing the viral fitness and evolutionary trajectory. In this study, we ... ...

    Abstract Despite the effective antivirals and vaccines, COVID-19 remains a public health concern. The mutations that occurred during the early stage of the pandemic can be valuable in assessing the viral fitness and evolutionary trajectory. In this study, we analyzed a panel of 2969 spike sequences deposited in GISAID before April 2020 and characterized nine representative spike single-point mutants in detail. Compared with the WA01/2020, most (8 out of 9) mutants demonstrated an equivalent or diminished protein expression or processing, pseudovirus infectivity, and cell-cell fusion. Interestingly, most of the mutants in native form elicited minimum antibody responses in mice despite unaltered CD4+ and CD8+ T cell responses. The mutants remained sensitive to the antisera and the type I interferon. Taken together, these data suggest that the early emerging mutants are virologically divergent, and some of which showed transmission fitness. Our findings have important implications for the retrospective tracing of the early SARS-CoV-2 transmission and future pandemic preparedness.
    MeSH term(s) Animals ; Mice ; Antibody Formation ; Biological Evolution ; COVID-19 ; Retrospective Studies ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2023-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15122401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Emergence of porcine circovirus‐like viruses associated with porcine diarrheal disease in China

    Liu, Xianhui / Zhang, Xinming / Xu, Ge / Wang, Zhe / Shen, Hanqin / Lian, Kaiqi / Lin, Yihan / Zheng, Jihao / Liang, Pengshuai / Zhang, Leyi / Liu, Yanling / Song, Changxu

    Transboundary and emerging diseases. 2021 Nov., v. 68, no. 6

    2021  

    Abstract: BACKGROUND: The circular replication‐associated protein (Rep)‐encoding single‐stranded (CRESS) DNA virus emergence in diverse host has been associated with severe disease. Porcine circovirus‐like virus (Po‐Circo‐like [PCL] virus) is a CRESS DNA virus, ... ...

    Abstract BACKGROUND: The circular replication‐associated protein (Rep)‐encoding single‐stranded (CRESS) DNA virus emergence in diverse host has been associated with severe disease. Porcine circovirus‐like virus (Po‐Circo‐like [PCL] virus) is a CRESS DNA virus, the prevalence and pathogenicity of which are rarely studied. METHODS: We obtained two blood samples, four faecal samples, and two intestinal samples from a pig farm suffered from diarrheal disease in the delivery room in September 2020 and attempted to isolate and identify a causative pathogen. Subsequently, only PCL virus was positive, and qRT‐PCR was designed to detect the loading titre of PCL virus. We then initiated a heightened surveillance program on the pathogenicity and epidemiology of PCL virus. RESULTS: Six PCL virus strains, with severe diarrhoea and haemorrhagic enteritis, have been found in six different pig farms in Guangdong province, China. A multiple sequence alignment of these PCL viruses and bovine circovirus‐like virus/CH showed a similarity of 92.5‐94.8% for the Rep protein, indicating these PCL viruses are highly homologous to Bo‐Circo‐like virus associated with calf diarrhoea. There were striking similarities between the PCL virus and bovine circovirus‐like virus outbreaks in aetiological settings and Genomic sequence. We found that 11.2% (20/178) of diarrhoea samples and 13.3% (6/45) of pig farms were positive for PCL virus, suggesting that PCL virus may have spread widely in Pig farms. Moreover, this article underscores the risk of PCL virus spilling over and adapting to new species. CONCLUSIONS: Porcine circovirus‐like virus was found to be associated with porcine diarrheal disease in China.
    Keywords DNA viruses ; blood ; calves ; diarrhea ; disease severity ; farms ; hemorrhagic enteritis ; intestines ; monitoring ; new species ; nucleotide sequences ; pathogenicity ; pathogens ; risk ; sequence alignment ; swine ; viruses ; China
    Language English
    Dates of publication 2021-11
    Size p. 3167-3173.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.14223
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Emergence of porcine circovirus-like viruses associated with porcine diarrheal disease in China.

    Liu, Xianhui / Zhang, Xinming / Xu, Ge / Wang, Zhe / Shen, Hanqin / Lian, Kaiqi / Lin, Yihan / Zheng, Jihao / Liang, Pengshuai / Zhang, Leyi / Liu, Yanling / Song, Changxu

    Transboundary and emerging diseases

    2021  Volume 68, Issue 6, Page(s) 3167–3173

    Abstract: Background: The circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA virus emergence in diverse host has been associated with severe disease. Porcine circovirus-like virus (Po-Circo-like [PCL] virus) is a CRESS DNA virus, ... ...

    Abstract Background: The circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA virus emergence in diverse host has been associated with severe disease. Porcine circovirus-like virus (Po-Circo-like [PCL] virus) is a CRESS DNA virus, the prevalence and pathogenicity of which are rarely studied.
    Methods: We obtained two blood samples, four faecal samples, and two intestinal samples from a pig farm suffered from diarrheal disease in the delivery room in September 2020 and attempted to isolate and identify a causative pathogen. Subsequently, only PCL virus was positive, and qRT-PCR was designed to detect the loading titre of PCL virus. We then initiated a heightened surveillance program on the pathogenicity and epidemiology of PCL virus.
    Results: Six PCL virus strains, with severe diarrhoea and haemorrhagic enteritis, have been found in six different pig farms in Guangdong province, China. A multiple sequence alignment of these PCL viruses and bovine circovirus-like virus/CH showed a similarity of 92.5-94.8% for the Rep protein, indicating these PCL viruses are highly homologous to Bo-Circo-like virus associated with calf diarrhoea. There were striking similarities between the PCL virus and bovine circovirus-like virus outbreaks in aetiological settings and Genomic sequence. We found that 11.2% (20/178) of diarrhoea samples and 13.3% (6/45) of pig farms were positive for PCL virus, suggesting that PCL virus may have spread widely in Pig farms. Moreover, this article underscores the risk of PCL virus spilling over and adapting to new species.
    Conclusions: Porcine circovirus-like virus was found to be associated with porcine diarrheal disease in China.
    MeSH term(s) Animals ; Cattle ; Cattle Diseases ; China/epidemiology ; Circovirus/genetics ; Diarrhea/epidemiology ; Diarrhea/veterinary ; Phylogeny ; Swine ; Swine Diseases/epidemiology ; Viruses
    Language English
    Publishing date 2021-07-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.14223
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Kategorien

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