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  1. Article ; Online: Battling pancreatic cancer: the role of Chinese surgeons.

    Zheng, Lei

    Annals of pancreatic cancer

    2023  Volume 5

    Language English
    Publishing date 2023-04-25
    Publishing country China
    Document type Journal Article
    ISSN 2616-2741
    ISSN (online) 2616-2741
    DOI 10.21037/apc-2022-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Advancing rainwater treatment technologies for irrigation of urban agriculture: A pathway toward innovation.

    Zheng, Lei / Deng, Yang

    The Science of the total environment

    2024  Volume 916, Page(s) 170087

    Abstract: Urban agriculture (UA) has emerged for local food security since the 1960s. However, the access to sufficient and safe irrigation water remains a significant constraint. Municipal water supply, though commonly used in UA practices, proves unsustainable ... ...

    Abstract Urban agriculture (UA) has emerged for local food security since the 1960s. However, the access to sufficient and safe irrigation water remains a significant constraint. Municipal water supply, though commonly used in UA practices, proves unsustainable due to high costs, intensive energy consumption, and limited availability in many vacant urban spaces. In contrast, rainwater harvesting (RWH) exhibits a potential as a non-traditional water supply for urban farming. This article aims to provide insights into the advantages and challenges associated with RWH for UA irrigation, analyze existing low-cost RWH treatment technologies, and identify a visionary way toward innovative, new-generation RWH treatment processes in UA practices. Despite a promising water source, harvested rainwater is challenged for crop irrigation owing to the presence of various contaminants (e.g., waterborne pathogens, potentially toxic metals and metalloids, and synthetic organic chemicals). While established RWH treatment processes (e.g., first flush diversion, sedimentation, solar disinfection, chlorination, UV irradiation, granular filtration, and bio-sand filtration) can remove certain pollutants, they cannot offer viable treatment solutions for UA irrigation due to different technical, economic, and social restrictions. Particularly, their capacity to reliably remove contaminants of emerging concern in runoff remains limited or uncertain. Consequently, it is essential to develop next-generation RWH treatment technologies tailored specifically for UA irrigation. To this end, three fundamental principles are recommended. First, the focus should be on technically viable, low-cost, simple-operation, and easy-maintenance treatment technologies capable of simultaneously addressing traditional and emerging runoff contaminants, while minimizing the production of undesirable treatment byproducts. Second, advancing the understanding of the water, soil, and crop interactions enables the development of "right" RWH treatment processes for irrigation of "right" crops at a "right" place. Last, crop nutrients, if possible, are retained in rainwater to reduce the nutrient demand for crop production. The insights and perspectives have far-reaching implications for water conservation, stormwater management, and the integration of water, food, and energy systems within the urban environment.
    Language English
    Publishing date 2024-01-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recent advances in cancer-associated fibroblast: Biomarkers, signaling pathways, and therapeutic opportunities.

    Zhou, Donger / Zheng, Lei

    Chinese medical journal

    2024  Volume 137, Issue 6, Page(s) 638–650

    Abstract: Abstract: Anti-cancer therapies usually focus on tumor cells, but non-tumor stromal components in the tumor microenvironment also play vital roles in tumor initiation and progression, which may be the prognostic factors and potential therapeutic targets. ...

    Abstract Abstract: Anti-cancer therapies usually focus on tumor cells, but non-tumor stromal components in the tumor microenvironment also play vital roles in tumor initiation and progression, which may be the prognostic factors and potential therapeutic targets. Cancer-associated fibroblasts (CAFs) are the essential component in the tumor environment, exhibiting high heterogeneity in their cell origin and phenotype with diverse functions that influence tumor angiogenesis, immune systems, and metabolism. Single-cell RNA sequencing and genetically engineered mouse models have increased our understanding of CAF diversity, and many subtypes have been defined. However, the precise functions of these subtypes need to be studied and validated. Studies of signaling pathways and epigenetic changes in CAFs facilitate understanding of the phenotypes of CAFs and the crosstalk between tumor cells and CAFs to provide potential therapeutic targets. Some clinical trials, including phase III trials targeting CAFs, have been performed recently. However, few of these trials have generated promising results, which indicates that the complexity of CAFs in the tumor microenvironment remains largely unknown, and in-depth investigations of CAFs should be performed. This review summarizes the research on CAFs, focusing on the heterogeneity of their phenotypes and functions, specific signaling pathways, and the therapeutic strategies involving CAFs. Additionally, we briefly discuss the current technologies commonly used in CAF studies and describe the challenges and future perspectives of CAF research.
    MeSH term(s) Animals ; Mice ; Cancer-Associated Fibroblasts ; Biomarkers ; Phenotype ; Cell Transformation, Neoplastic ; Epigenesis, Genetic ; Tumor Microenvironment
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-29
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000003031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An overview of phosphodiesterase 9 inhibitors: Insights from skeletal structure, pharmacophores, and therapeutic potential.

    Zheng, Lei / Zhou, Zhong-Zhen

    European journal of medicinal chemistry

    2023  Volume 259, Page(s) 115682

    Abstract: Cyclic nucleotide phosphodiesterase 9 (PDE9), a specifically hydrolytic enzyme with the highest affinity for cyclic guanosine monophosphate (cGMP) among the phosphodiesterases family, plays a critical role in many biological processes. Consequently, the ... ...

    Abstract Cyclic nucleotide phosphodiesterase 9 (PDE9), a specifically hydrolytic enzyme with the highest affinity for cyclic guanosine monophosphate (cGMP) among the phosphodiesterases family, plays a critical role in many biological processes. Consequently, the development of PDE9 inhibitors has received increasing attention in recent years, with several compounds undergoing clinical trials for the treatment of central nervous system (CNS) diseases such as Alzheimer's disease, schizophrenia, and psychotic disorders, as well as heart failure and sickle cell disease. This review analyzes the recent primary literatures and patents published from 2004 to 2023, focusing on the structure, pharmacophores, selectivity, and therapeutic potential of PDE9 inhibitors. It hoped to provide a comprehensive overview of the field's current state to inform the development of novel PDE9 inhibitors.
    MeSH term(s) 3',5'-Cyclic-AMP Phosphodiesterases ; Cyclic GMP ; Pharmacophore ; Phosphodiesterase Inhibitors/pharmacology ; Phosphodiesterase Inhibitors/therapeutic use ; Phosphoric Diester Hydrolases
    Chemical Substances 3',5'-Cyclic-AMP Phosphodiesterases (EC 3.1.4.17) ; Cyclic GMP (H2D2X058MU) ; Phosphodiesterase Inhibitors ; Phosphoric Diester Hydrolases (EC 3.1.4.-) ; PDE9A protein, human (EC 3.1.4.17)
    Language English
    Publishing date 2023-07-28
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: On the Adaptive Buffer-Aided TDMA Uplink System with AoI-Aware Status-Update Services and Timely Throughput Traffics.

    Wang, Tianheng / Chen, Qingchun / Wang, Shuo / Zheng, Lei

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 2

    Abstract: In this paper, we study a buffer-aided TDMA uplink network, where multiple status-update devices and throughput-demand devices are supposed to upload their data to one information access point (AP), and all devices are assumed to be provisioned with a ... ...

    Abstract In this paper, we study a buffer-aided TDMA uplink network, where multiple status-update devices and throughput-demand devices are supposed to upload their data to one information access point (AP), and all devices are assumed to be provisioned with a data buffer to temporarily store the randomly generated data from either the installed sensor or upper-layer applications. To fulfill the communication requirements using two types of devices, the average Age of Information (AoI) is utilized to characterize the data freshness of the status-update devices, while the average sum rate is employed to capture the average transmission performance of the throughput-demand devices. On this basis, a joint-optimization problem was formulated to minimize the average AoI for status-update devices and to maximize the average sum rate for the throughput-demand devices. Lyapunov optimization framework was used to solve the problem of obtaining an AoI-aware adaptive TDMA uplink scheme. Numerical results are presented to show that an AoI-aware adaptive TDMA uplink scheme can effectively fulfill the heterogeneous service requirements using status-update devices and throughput-demand devices.
    Language English
    Publishing date 2024-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24020506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risk factors analysis of endoscopy and TIPS in the treatment of secondary esophagogastric varicose bleeding with cirrhosis.

    Liu, Xiaoyan / Wang, Yanli / Zheng, Lei / Zhu, Jinzhao

    African health sciences

    2024  Volume 23, Issue 3, Page(s) 655–663

    Abstract: Objective: To analyse the risk factors of secondary hemorrhage and survival rate in cirrhotic patients with esophagogastric variceal rupture and to compare the efficacy and safety of endoscopic hemostasis and TIPS (transjugular intrahepatic ... ...

    Abstract Objective: To analyse the risk factors of secondary hemorrhage and survival rate in cirrhotic patients with esophagogastric variceal rupture and to compare the efficacy and safety of endoscopic hemostasis and TIPS (transjugular intrahepatic portosystemic shunt).
    Methods: A total of 120 patients with secondary bleeding after endoscopic treatment of esophagogastric varicose bleeding with cirrhosis in our hospital during the past 3 years were retrospectively analysed. There were 65 males and 55 females, ranging in age from 49 to 74 years old, with an average of (59.5 ± 8.4) years old. The etiology, degree of varicose veins, bleeding location, hemostasis method, Infection, ascites, portal vein thrombosis or cancer thrombus, albumin, platelets, prothrombin activity, Child Pugh (Child-Pugh classification is a diagnostic criterion for liver reserve function) grade were compared in each group. The risk factors of treatment failure and analyse the survival time was analysed.
    Results: There were statistically significant differences in varicosis degree, infection, ascites, portal vein thrombosis or cancer thrombus, child Pugh grade, albumin and prothrombin activity between the failed Endoscopy group and the successful hemostasis group (P< 0.05). There were statistically significant differences in child Pugh grade, albumin and prothrombin activity between the failed TIPS treatment group and successful hemostasis group (P< 0.05). There was no significant difference in 1-year survival between the endoscopy group and the TIPS group.
    Conclusion: Severe varicose veins, infection, ascites, portal vein thrombosis or cancer thrombus, child pugh classification, albumin, and prothrombin activity were the major risk factors for failed secondary endoscopic therapy, child Pugh classification, albumin and prothrombin activity were the main risk factors for failure TIPS treatment. There is no significant difference in long-term survival between the two methods.
    MeSH term(s) Male ; Female ; Humans ; Middle Aged ; Aged ; Ascites/complications ; Retrospective Studies ; Prothrombin ; Esophageal and Gastric Varices/surgery ; Esophageal and Gastric Varices/complications ; Gastrointestinal Hemorrhage/etiology ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Neoplasm Recurrence, Local ; Liver Cirrhosis/complications ; Risk Factors ; Varicose Veins/surgery ; Varicose Veins/complications ; Endoscopy, Gastrointestinal/adverse effects ; Albumins ; Thrombosis ; Treatment Outcome
    Chemical Substances Prothrombin (9001-26-7) ; Albumins
    Language English
    Publishing date 2024-02-03
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2240308-5
    ISSN 1729-0503 ; 1680-6905
    ISSN (online) 1729-0503
    ISSN 1680-6905
    DOI 10.4314/ahs.v23i3.76
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer.

    Zheng, Lei / Lu, Jia / Kong, Da-Lu

    World journal of gastrointestinal oncology

    2024  Volume 16, Issue 2, Page(s) 314–330

    Abstract: Background: Cyclin-dependent kinase 9 (CDK9) expression and autophagy in colorectal cancer (CRC) tissues has not been widely studied. CDK9, a key regulator of transcription, may influence the occurrence and progression of CRC. The expression of ... ...

    Abstract Background: Cyclin-dependent kinase 9 (CDK9) expression and autophagy in colorectal cancer (CRC) tissues has not been widely studied. CDK9, a key regulator of transcription, may influence the occurrence and progression of CRC. The expression of autophagy-related genes
    Aim: To investigate the relationship between CDK9 expression and autophagy in CRC, assess differences in autophagy between left and right colon cancer, and analyze the associations of autophagy-related genes with clinical features and prognosis.
    Methods: We collected tumor tissues and paracarcinoma tissues from colon cancer patients with liver metastasis to observe the level of autophagy in tissues with high levels of CDK9 and low levels of CDK9. We also collected primary tissue from left and right colon cancer patients with liver metastasis to compare the autophagy levels and the expression of
    Results: The incidence of autophagy and the expression of
    Conclusion: This study laid the foundation for further research on the combination of CDK9 inhibitors and autophagy inhibitors in the treatment of patients with CRC.
    Language English
    Publishing date 2024-02-29
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v16.i2.314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Bibliometric analysis of systematic review and meta-analysis on diabetic foot ulcer.

    Wang, Yanyan / Wang, Cong / Zheng, Lei

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27534

    Abstract: Many clinical management strategies have been proposed to deal with diabetic foot ulcers. However, the occurrence and recurrence of foot ulcers remain the major problems for diabetics. This study aims to identify, visualize, and characterize the meta- ... ...

    Abstract Many clinical management strategies have been proposed to deal with diabetic foot ulcers. However, the occurrence and recurrence of foot ulcers remain the major problems for diabetics. This study aims to identify, visualize, and characterize the meta-analyses on diabetic foot ulcer research. Articles published online were retrieved from the Web of Science core collection database using a search query incorporating MeSH terms and topics related to diabetic foot ulcers and meta-analysis. The publications were then analyzed for basic characteristics, including publication year, countries, topics covered, references, and keywords discussed in the articles. Data visualization was performed using CiteSpace. 334 meta-analyses and systematic reviews on diabetic foot ulcers were identified. The number of publications has experienced rapid growth in recent years (nearly 6-fold since 2016). The United States, China, Netherlands, England, and Australia had a strong collaboration in the contribution of publication. 7 primary topics were summarized from the top 100 highly cited publications: #1 Interventions (proportion: 59%), #2 Risk factors and Prevention (22%), #3 Epidemiology analysis (6%), #4 Cost-effectiveness of interventions (5%), #5 Long-term prognosis (3%), #6 Quality of life analysis (3%), and #7 Economic burden analysis (2%). Footwear and offloading interventions, multidisciplinary care, hyperbaric oxygen, platelet-rich plasma, and negative pressure wound therapies are highly regarded in terms of intervention. Diabetic foot osteomyelitis, peripheral diabetic neuropathy, chronic limb-threatening ischemia, and infections are the main comorbidities. In recent years, offloading interventions, debridement, telemedicine, long-term prognosis, and economic burden analyses have gradually received attention. Individualized treatment, multidisciplinary collaboration, quality of life considerations, and economic burden analyses are the long-term concerns.
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Differences between the glans and shaft of the penis: a review.

    Wei, Letian / Zheng, Lei / Jiang, Hui / Jiang, Tao

    Sexual medicine reviews

    2024  

    Abstract: Introduction: The penis serves as a vital receptor in men, playing a significant role in sexual intercourse. While there are discernible disparities between the glans penis and the penile shaft, a comprehensive and detailed analysis of these ... ...

    Abstract Introduction: The penis serves as a vital receptor in men, playing a significant role in sexual intercourse. While there are discernible disparities between the glans penis and the penile shaft, a comprehensive and detailed analysis of these distinctions is currently lacking.
    Objectives: This study aimed to review the existing literature on the variances between the glans penis and the penile shaft, providing a systematic examination of their anatomical and histological dissimilarities.
    Methods: Our investigation encompassed a thorough search of the published literature, including original articles, reviews, letters to the editor, and case reports focused on the penis. We conducted a comprehensive review of the anatomical and histological dissimilarities between the glans penis and the penile shaft.
    Results: The following key differences were identified. First, regarding innervation, the glans penis and the penile shaft possess distinct neural pathways. The glans penis exhibits a 3-dimensional structure, while the penile shaft exhibits a 2-dimensional distribution. Notably, the nerves of the penile shaft extend penetrating branches into the corpus cavernosum. Furthermore, there are variations in nerve-specific antibodies between the 2 regions. Second, regarding composition, the glans penis and the penile shaft consist of dissimilar cavernous bodies. The glans penis contains unique epithelial structures and receptors, setting it apart from the penile shaft. Third, regarding the veins, there are disparities in the venous systems of the glans penis and the penile shaft. Fourth, regarding biothesiometry, variances in biothesiometry research have been observed between the 2 regions.
    Conclusion: There are differences between the glans and the shaft. To further advance our understanding, future research should delve deeper into the discrepancies between the glans penis and the penile shaft. Additionally, a more specialized subdivision of the glans penis and the penile shaft would facilitate more precise and tailored treatments.
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2722257-3
    ISSN 2050-0521 ; 2050-0513
    ISSN (online) 2050-0521
    ISSN 2050-0513
    DOI 10.1093/sxmrev/qeae019
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  10. Article ; Online: Immune defects in pancreatic cancer.

    Zheng, Lei

    Annals of pancreatic cancer

    2018  Volume 1

    Abstract: Pancreatic cancer is resistant to the immunotherapy. This resistance is caused by any of the four immune "defects" that occur in pancreatic cancer, including lack of "high quality" T cells, stromal barriers to T cells getting access to tumor cells, ... ...

    Abstract Pancreatic cancer is resistant to the immunotherapy. This resistance is caused by any of the four immune "defects" that occur in pancreatic cancer, including lack of "high quality" T cells, stromal barriers to T cells getting access to tumor cells, immunosuppressive cells such as M2 macrophages, myeloid derivative suppressor cells, and T regulatory cells, in the tumor microenvironment of pancreatic cancer. One or more defects may occur in an individual pancreatic cancer. To overcome the resistance to the immunotherapy such as immune checkpoint inhibitors, a rational combination of agents that target multiple immune defects is highly demanded.
    Language English
    Publishing date 2018-12-06
    Publishing country China
    Document type Journal Article
    ISSN 2616-2741
    ISSN (online) 2616-2741
    DOI 10.21037/apc.2018.11.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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