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  1. AU="Zheng, Lin-Xin"
  2. AU="Lin, Sheng-Jia"
  3. AU="Oladimeji, Kelechi E"

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  1. Artikel: Interlinked Microcone Resistive Sensors Based on Self-Assembly Carbon Nanotubes Film for Monitoring of Signals.

    Luo, Chun-Li / Jiao, Jun-Yi / Su, Xing-Jie / Zheng, Lin-Xin / Yan, Wei-Guo / Zhong, Dong-Zhou

    Nanomaterials (Basel, Switzerland)

    2022  Band 12, Heft 14

    Abstract: Flexible pressure sensors still face difficulties achieving a constantly adaptable micronanostructure of substrate materials. Interlinked microcone resistive sensors were fabricated by polydimethylsiloxane (PDMS) nanocone array. PDMS nanocone array was ... ...

    Abstract Flexible pressure sensors still face difficulties achieving a constantly adaptable micronanostructure of substrate materials. Interlinked microcone resistive sensors were fabricated by polydimethylsiloxane (PDMS) nanocone array. PDMS nanocone array was achieved by the second transferring tapered polymethyl methacrylate (PMMA) structure. In addition, self-assembly 2D carbon nanotubes (CNTs) networks as a conducting layer were prepared by a low-cost, dependable, and ultrafast Langmuir−Blodgett (LB) process. In addition, the self-assembled two-dimensional carbon nanotubes (CNTs) network as a conductive layer can change the internal resistance due to pressure. The results showed that the interlinked sensor with a nanocone structure can detect the external pressure by the change of resistivity and had a sensitive resistance change in the low pressure (<200 Pa), good stability through 2800 cycles, and a detection limit of 10 kPa. Based on these properties, the electric signals were tested, including swallowing throat, finger bending, finger pressing, and paper folding. The simulation model of the sensors with different structural parameters under external pressure was established. With the advantages of high sensitivity, stability, and wide detection range, this sensor shows great potential for monitoring human motion and can be used in wearable devices.
    Sprache Englisch
    Erscheinungsdatum 2022-07-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12142325
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Oxymatrine ameliorated experimental colitis via mechanisms involving inflammatory DCs, gut microbiota and TLR/NF-κB pathway.

    Liu, Miaohua / Liu, Fuchun / Pan, Yuanle / Xiong, Yi / Zeng, Xin / Zheng, LinXin / Zhao, Haimei / Li, Yanzhen / Liu, Duanyong

    International immunopharmacology

    2022  Band 115, Seite(n) 109612

    Abstract: It is common knowledge that the crosstalk of gut microbiota (GM) and dendritic cells (DCs) are critical for the pathogenesis of inflammatory bowel disease (IBD). As a major bioactive constituent derived from the root of the Sophora flavescens, Oxymatrine ...

    Abstract It is common knowledge that the crosstalk of gut microbiota (GM) and dendritic cells (DCs) are critical for the pathogenesis of inflammatory bowel disease (IBD). As a major bioactive constituent derived from the root of the Sophora flavescens, Oxymatrine (OMT) was used to treat IBD in China. However, it is still unknown whether OMT ameliorates IBD by regulating the crosstalk between DCs and GM. In the present study, after 10 days of OMT (100 mg/kg/day) treated mice with colitis induced by dextran sulfate sodium (DSS), the change rate of body weight, colon weight, colon weight index, colon length, DAI score and colonic pathological damage scores of colitis mice were significantly ameliorate, followed with fewer ulceration and inflammatory cell infiltration, the increased expression of IL-4 and IL-13, and the decreased expression of CCL-2, IL-33 and IFN-γ. The percents of inflammatory DCs (such as TNF-α
    Mesh-Begriff(e) Animals ; Mice ; NF-kappa B/metabolism ; Gastrointestinal Microbiome ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/metabolism ; Colon/pathology ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Dextran Sulfate ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemische Substanzen NF-kappa B ; oxymatrine (85U4C366QS) ; Dextran Sulfate (9042-14-2)
    Sprache Englisch
    Erscheinungsdatum 2022-12-28
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2022.109612
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Pien Tze Huang alleviates Concanavalin A-induced autoimmune hepatitis by regulating intestinal microbiota and memory regulatory T cells.

    Zeng, Xin / Liu, Miao-Hua / Xiong, Yi / Zheng, Lin-Xin / Guo, Kai-En / Zhao, Hai-Mei / Yin, Yu-Ting / Liu, Duan-Yong / Zhou, Bu-Gao

    World journal of gastroenterology

    2023  Band 29, Heft 45, Seite(n) 5988–6016

    Abstract: Background: Traditional Chinese medicine has used the drug Pien Tze Huang (PTH), a classic prescription, to treat autoimmune hepatitis (AIH). However, the precise mode of action is still unknown.: Aim: To investigate the mechanism of PTH in an AIH ... ...

    Abstract Background: Traditional Chinese medicine has used the drug Pien Tze Huang (PTH), a classic prescription, to treat autoimmune hepatitis (AIH). However, the precise mode of action is still unknown.
    Aim: To investigate the mechanism of PTH in an AIH mouse model by determining the changes in gut microbiota structure and memory regulatory T (mTreg) cells functional levels.
    Methods: Following induction of the AIH mouse model induced by Concanavalin A (Con A), prophylactic administration of PTH was given for 10 d. The levels of mTreg cells were measured by flow cytometry, and intestinal microbiota was analyzed by 16S rRNA analysis, while western blotting was used to identify activation of the toll-like receptor (TLR)2, TLR4/nuclear factor-κB (NF-κB), and CXCL16/CXCR6 signaling pathways.
    Results: In the liver of mice with AIH, PTH relieved the pathological damage and reduced the numbers of T helper type 17 cells and interferon-γ, tumor necrosis factor-alpha, interleukin (IL)-1β, IL-2, IL-6, and IL-21 expression. Simultaneously, PTH stimulated the abundance of helpful bacteria, promoted activation of the TLR2 signal, which may enhance Treg/mTreg cells quantity to produce IL-10, and suppressed activation of the TLR4/NF-κB and CXCL16/CXCR6 signaling pathways.
    Conclusion: PTH regulates intestinal microbiota balance and restores mTreg cells to alleviate experimental AIH, which is closely related to the TLR/CXCL16/CXCR6/NF-κB signaling pathway.
    Mesh-Begriff(e) Mice ; Animals ; Hepatitis, Autoimmune/drug therapy ; Hepatitis, Autoimmune/etiology ; Hepatitis, Autoimmune/prevention & control ; NF-kappa B/metabolism ; Gastrointestinal Microbiome ; T-Lymphocytes, Regulatory/metabolism ; Concanavalin A ; Toll-Like Receptor 4/metabolism ; RNA, Ribosomal, 16S ; Hepatitis A
    Chemische Substanzen pien tze huang ; NF-kappa B ; Concanavalin A (11028-71-0) ; Toll-Like Receptor 4 ; RNA, Ribosomal, 16S
    Sprache Englisch
    Erscheinungsdatum 2023-12-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i45.5988
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance.

    Zheng, Lin-Xin / Guo, Kai-En / Huang, Jia-Qi / Liu, Miao-Hua / Deng, Bai-Ling / Liu, Duan-Yong / Zhou, Bu-Gao / Zhou, Wen / Zhong, You-Bao / Zhao, Hai-Mei

    World journal of gastroenterology

    2023  Band 29, Heft 36, Seite(n) 5226–5239

    Abstract: Background: Restoration of immune homeostasis by targeting the balance between memory T helper (mTh) cells and memory follicular T helper (mTfh) cells is a potential therapeutic strategy against ulcerative colitis (UC). Because of its anti-inflammatory ... ...

    Abstract Background: Restoration of immune homeostasis by targeting the balance between memory T helper (mTh) cells and memory follicular T helper (mTfh) cells is a potential therapeutic strategy against ulcerative colitis (UC). Because of its anti-inflammatory and immunomodulatory properties, curcumin (Cur) is a promising drug for UC treatment. However, fewer studies have demonstrated whether Cur can modulate the mTh/mTfh subset balance in mice with colitis.
    Aim: To explore the potential mechanism underlying Cur-mediated alleviation of colitis induced by dextran sulfate sodium (DSS) in mice by regulating the mTh and mTfh immune homeostasis.
    Methods: Balb/c mice were administered 3% and 2% DSS to establish the UC model and treated with Cur (200 mg/kg/d) by gavage on days 11-17. On the 18
    Results: Cur effectively mitigates DSS-induced colitis, facilitates the restoration of mouse weight and colonic length, and diminishes the colonic weight and colonic weight index. Simultaneously, it hinders ulcer development and inflammatory cell infiltration in the colonic mucous membrane. While the percentage of Th1, mTh1, Th7, mTh7, Th17, mTh17, Tfh1, mTfh1, Tfh7, mTfh7, Tfh17, and mTfh17 cells decreased after Cur treatment of the mice for 7 d, and the frequency of mTh10, Th10, mTfh10, and Tfh10 cells in the mouse spleen increased. Further studies revealed that Cur administration prominently decreased the SOCS-1, SOCS-3, STAT3, p-STAT3, JAK1, p-JAK1, and NF-κB p65 protein expression levels in the colon tissue.
    Conclusion: Cur regulated the mTh/mTfh cell homeostasis to reduce DSS-induced colonic pathological damage, potentially by suppressing the JAK1/STAT3/SOCS signaling pathway.
    Mesh-Begriff(e) Animals ; Mice ; Dextran Sulfate/toxicity ; Curcumin/pharmacology ; Curcumin/therapeutic use ; NF-kappa B/metabolism ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colon/pathology ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemische Substanzen Dextran Sulfate (9042-14-2) ; Curcumin (IT942ZTH98) ; NF-kappa B
    Sprache Englisch
    Erscheinungsdatum 2023-10-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i36.5226
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Venous thromboembolism in patients with severe lung cancer: a narrative review.

    Zheng, Lin-Xin / Li, Li / Huang, Jin-Hai / Mai, Yu-Mei / Chen, Can / Dong, Jia-Hui / Xu, Zhi-Yong / Li, Wei-Feng / Chen, Xiao-Rong

    Annals of palliative medicine

    2021  Band 10, Heft 6, Seite(n) 6957–6967

    Abstract: Objective: At present, there are several guidelines for cancer complicated with VTE, but there is no specific recommendation for the treatment of lung cancer complicated with VTE. Whether is necessary to explore treatment and prevention of VTE in lung ... ...

    Abstract Objective: At present, there are several guidelines for cancer complicated with VTE, but there is no specific recommendation for the treatment of lung cancer complicated with VTE. Whether is necessary to explore treatment and prevention of VTE in lung cancer.
    Background: Venous thromboembolism (VTE) is a common complication of severe lung cancer that can entail many adverse effects for patients. The incidence of VTE is higher in patients with lung cancer than in those with other kinds of solid tumors, and it is especially high among patients with lung adenocarcinoma, at advanced tumor-node-metastasis (TNM) stages, or with a history of central venous catheter (CVC) or chemotherapy. However, the clinical symptoms of VTE in patients with lung cancer are not typical and cannot be detected easily, and the clinical prevention rate is low. In the acute phase of VTE in lung cancer, the Eastern Cooperative Oncology Group (ECOG) performance status score of patients typically ranges from 2 to 4 points, leaving end-stage maintenance therapy as the only treatment option.
    Methods: Here, we analyze the existing literature and discuss the current status (including epidemiology, clinical manifestations, and risk factors), risk assessment tools, and the treatment and prevention of VTE in severe lung cancer. We focus particularly on the use of low-molecular-weight heparin and new oral anticoagulants (including in the management of thrombocytopenia after antitumor therapy) in lung cancer patients with VTE.
    Conclusions: Large-scale prospective multicenter studies on the treatment and prevention of VTE in lung cancer are necessary.
    Sprache Englisch
    Erscheinungsdatum 2021-06-07
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-21-1281
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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