LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 10

Search options

  1. Article ; Online: Compound collagen peptide powder improves skin photoaging by reducing oxidative stress and activating TGF-β1/Smad pathway.

    Guo, Kaien / Zheng, Linxin / Zeng, Xin / Huang, Guangchun / Meng, Lingling / Yin, Yuting

    Photochemistry and photobiology

    2024  

    Abstract: Fish collagen peptide (FCP) has been extensively investigated as a natural product that can combat photoaging; however, its efficacy is limited by its singular composition. Compound collagen peptide powder (CCPP) is a novel functional food formulation ... ...

    Abstract Fish collagen peptide (FCP) has been extensively investigated as a natural product that can combat photoaging; however, its efficacy is limited by its singular composition. Compound collagen peptide powder (CCPP) is a novel functional food formulation that exhibits photoprotective properties and comprises FCP and a blend of natural botanical ingredients. The objective of this study was to investigate the efficacy of CCPP and its molecular mechanism. CCPP had a low molecular weight, facilitating its efficient absorption, and was abundant in amino acids, total polyphenols, and total flavonoids. The results of in vivo studies demonstrated that CCPP exhibited significant efficacy in reducing skin wrinkles, enhancing the contents of water and oil in the skin, and ameliorating histopathological alterations in mice. The results of in vitro studies demonstrated that CCPP effectively mitigated photoaging in human skin fibroblasts by attenuating oxidative stress and promoting extracellular matrix (ECM) synthesis. Moreover, we clearly demonstrated that the TGF β1/Smad pathway was involved in the promotion of ECM synthesis and cell proliferation by CCPP in human skin fibroblasts. These findings suggest that, compared with single collagen, CCPP has a more comprehensive range of antiphotoaging properties.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.13940
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: [Differential mRNA expression in C57BL/6 mice with bleomycin-induced pulmonary fibrosis and its association with LncRNA co-expression network].

    Yu, Xuefei / Li, Li / Zheng, Linxin / Li, Weifeng

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2021  Volume 41, Issue 1, Page(s) 39–46

    Abstract: Objective: To study the changes in mRNA and long non-coding RNA (lncRNA) expression profiles in a mouse model of bleomycin-induced lung fibrosis and identify lung fibrosis-related mRNA for coding-noncoding coexpression (CNC) bioinformatics analysis of ... ...

    Abstract Objective: To study the changes in mRNA and long non-coding RNA (lncRNA) expression profiles in a mouse model of bleomycin-induced lung fibrosis and identify lung fibrosis-related mRNA for coding-noncoding coexpression (CNC) bioinformatics analysis of the differential lncRNAs.
    Methods: Lung fibrosis was induced by intratracheal injection of bleomycin in 10 C57BL/6 mice and another 10 mice with intratracheal injection of saline served as the control group. Lung tissues were harvested from the mice at 14 days after the injections and lung fibrosis was assessed using Masson and HE staining. LncRNA chip technology was used to screen the differentially expressed mRNAs and lncRNAs in mice with lung fibrosis, and GO and KEGG pathway analyses of the differential mRNAs were performed using NCBI database and UCSC database to identify possible fibrosis-related mRNAs, which were validated by qRT-PCR to construct a coding and non-coding co- expression network with the differential lncRNAs.
    Results: Compared with the control mice, the mice with intratracheal injection of bleomycin showed obvious lung fibrosis. The results of gene chip analysis showed that 127 mRNAs were upregulated and 184 mRNAs were down-regulated in the model group as compared with the control group. GO and pathway analysis suggested that the differentially expressed genes participated mainly in immune response, cell differentiation, and cytoskeletons; the involved signal pathways were associated mainly with cytokine and cytokine receptor interaction and chemokine signal transduction. Bioinformatics analysis identified a significant coexpression network between the fibrosisrelated mRNA and the differentially expressed lncRNA.
    Conclusions: In mice with lung fibrosis, the differential expressions of fibrosis-related mRNAs in the lung tissues are closely correlated with the co- expressions of a large number of differential lncRNAs, which points to a new direction for investigation of the pathogenesis of pulmonary fibrosis.
    MeSH term(s) Animals ; Bleomycin/toxicity ; Gene Expression Profiling ; Gene Regulatory Networks ; Mice ; Mice, Inbred C57BL ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/genetics ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics
    Chemical Substances RNA, Long Noncoding ; RNA, Messenger ; Bleomycin (11056-06-7)
    Language Chinese
    Publishing date 2021-01-28
    Publishing country China
    Document type Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2021.01.05
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6344: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: MSA-Net: Establishing Reliable Correspondences by Multiscale Attention Network.

    Zheng, Linxin / Xiao, Guobao / Shi, Ziwei / Wang, Shiping / Ma, Jiayi

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2022  Volume 31, Page(s) 4598–4608

    Abstract: In this paper, we propose a novel multi-scale attention based network (called MSA-Net) for feature matching problems. Current deep networks based feature matching methods suffer from limited effectiveness and robustness when applied to different ... ...

    Abstract In this paper, we propose a novel multi-scale attention based network (called MSA-Net) for feature matching problems. Current deep networks based feature matching methods suffer from limited effectiveness and robustness when applied to different scenarios, due to random distributions of outliers and insufficient information learning. To address this issue, we propose a multi-scale attention block to enhance the robustness to outliers, for improving the representational ability of the feature map. In addition, we also design a novel context channel refine block and a context spatial refine block to mine the information context with less parameters along channel and spatial dimensions, respectively. The proposed MSA-Net is able to effectively infer the probability of correspondences being inliers with less parameters. Extensive experiments on outlier removal and relative pose estimation have shown the performance improvements of our network over current state-of-the-art methods with less parameters on both outdoor and indoor datasets. Notably, our proposed network achieves an 11.7% improvement at error threshold 5° without RANSAC than the state-of-the-art method on relative pose estimation task when trained on YFCC100M dataset.
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2022.3186535
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Interlinked Microcone Resistive Sensors Based on Self-Assembly Carbon Nanotubes Film for Monitoring of Signals.

    Luo, Chun-Li / Jiao, Jun-Yi / Su, Xing-Jie / Zheng, Lin-Xin / Yan, Wei-Guo / Zhong, Dong-Zhou

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 14

    Abstract: Flexible pressure sensors still face difficulties achieving a constantly adaptable micronanostructure of substrate materials. Interlinked microcone resistive sensors were fabricated by polydimethylsiloxane (PDMS) nanocone array. PDMS nanocone array was ... ...

    Abstract Flexible pressure sensors still face difficulties achieving a constantly adaptable micronanostructure of substrate materials. Interlinked microcone resistive sensors were fabricated by polydimethylsiloxane (PDMS) nanocone array. PDMS nanocone array was achieved by the second transferring tapered polymethyl methacrylate (PMMA) structure. In addition, self-assembly 2D carbon nanotubes (CNTs) networks as a conducting layer were prepared by a low-cost, dependable, and ultrafast Langmuir−Blodgett (LB) process. In addition, the self-assembled two-dimensional carbon nanotubes (CNTs) network as a conductive layer can change the internal resistance due to pressure. The results showed that the interlinked sensor with a nanocone structure can detect the external pressure by the change of resistivity and had a sensitive resistance change in the low pressure (<200 Pa), good stability through 2800 cycles, and a detection limit of 10 kPa. Based on these properties, the electric signals were tested, including swallowing throat, finger bending, finger pressing, and paper folding. The simulation model of the sensors with different structural parameters under external pressure was established. With the advantages of high sensitivity, stability, and wide detection range, this sensor shows great potential for monitoring human motion and can be used in wearable devices.
    Language English
    Publishing date 2022-07-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12142325
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Oxymatrine ameliorated experimental colitis via mechanisms involving inflammatory DCs, gut microbiota and TLR/NF-κB pathway.

    Liu, Miaohua / Liu, Fuchun / Pan, Yuanle / Xiong, Yi / Zeng, Xin / Zheng, LinXin / Zhao, Haimei / Li, Yanzhen / Liu, Duanyong

    International immunopharmacology

    2022  Volume 115, Page(s) 109612

    Abstract: It is common knowledge that the crosstalk of gut microbiota (GM) and dendritic cells (DCs) are critical for the pathogenesis of inflammatory bowel disease (IBD). As a major bioactive constituent derived from the root of the Sophora flavescens, Oxymatrine ...

    Abstract It is common knowledge that the crosstalk of gut microbiota (GM) and dendritic cells (DCs) are critical for the pathogenesis of inflammatory bowel disease (IBD). As a major bioactive constituent derived from the root of the Sophora flavescens, Oxymatrine (OMT) was used to treat IBD in China. However, it is still unknown whether OMT ameliorates IBD by regulating the crosstalk between DCs and GM. In the present study, after 10 days of OMT (100 mg/kg/day) treated mice with colitis induced by dextran sulfate sodium (DSS), the change rate of body weight, colon weight, colon weight index, colon length, DAI score and colonic pathological damage scores of colitis mice were significantly ameliorate, followed with fewer ulceration and inflammatory cell infiltration, the increased expression of IL-4 and IL-13, and the decreased expression of CCL-2, IL-33 and IFN-γ. The percents of inflammatory DCs (such as TNF-α
    MeSH term(s) Animals ; Mice ; NF-kappa B/metabolism ; Gastrointestinal Microbiome ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/metabolism ; Colon/pathology ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Dextran Sulfate ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemical Substances NF-kappa B ; oxymatrine (85U4C366QS) ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2022-12-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2022.109612
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Pien Tze Huang alleviates Concanavalin A-induced autoimmune hepatitis by regulating intestinal microbiota and memory regulatory T cells.

    Zeng, Xin / Liu, Miao-Hua / Xiong, Yi / Zheng, Lin-Xin / Guo, Kai-En / Zhao, Hai-Mei / Yin, Yu-Ting / Liu, Duan-Yong / Zhou, Bu-Gao

    World journal of gastroenterology

    2023  Volume 29, Issue 45, Page(s) 5988–6016

    Abstract: Background: Traditional Chinese medicine has used the drug Pien Tze Huang (PTH), a classic prescription, to treat autoimmune hepatitis (AIH). However, the precise mode of action is still unknown.: Aim: To investigate the mechanism of PTH in an AIH ... ...

    Abstract Background: Traditional Chinese medicine has used the drug Pien Tze Huang (PTH), a classic prescription, to treat autoimmune hepatitis (AIH). However, the precise mode of action is still unknown.
    Aim: To investigate the mechanism of PTH in an AIH mouse model by determining the changes in gut microbiota structure and memory regulatory T (mTreg) cells functional levels.
    Methods: Following induction of the AIH mouse model induced by Concanavalin A (Con A), prophylactic administration of PTH was given for 10 d. The levels of mTreg cells were measured by flow cytometry, and intestinal microbiota was analyzed by 16S rRNA analysis, while western blotting was used to identify activation of the toll-like receptor (TLR)2, TLR4/nuclear factor-κB (NF-κB), and CXCL16/CXCR6 signaling pathways.
    Results: In the liver of mice with AIH, PTH relieved the pathological damage and reduced the numbers of T helper type 17 cells and interferon-γ, tumor necrosis factor-alpha, interleukin (IL)-1β, IL-2, IL-6, and IL-21 expression. Simultaneously, PTH stimulated the abundance of helpful bacteria, promoted activation of the TLR2 signal, which may enhance Treg/mTreg cells quantity to produce IL-10, and suppressed activation of the TLR4/NF-κB and CXCL16/CXCR6 signaling pathways.
    Conclusion: PTH regulates intestinal microbiota balance and restores mTreg cells to alleviate experimental AIH, which is closely related to the TLR/CXCL16/CXCR6/NF-κB signaling pathway.
    MeSH term(s) Mice ; Animals ; Hepatitis, Autoimmune/drug therapy ; Hepatitis, Autoimmune/etiology ; Hepatitis, Autoimmune/prevention & control ; NF-kappa B/metabolism ; Gastrointestinal Microbiome ; T-Lymphocytes, Regulatory/metabolism ; Concanavalin A ; Toll-Like Receptor 4/metabolism ; RNA, Ribosomal, 16S ; Hepatitis A
    Chemical Substances pien tze huang ; NF-kappa B ; Concanavalin A (11028-71-0) ; Toll-Like Receptor 4 ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i45.5988
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance.

    Zheng, Lin-Xin / Guo, Kai-En / Huang, Jia-Qi / Liu, Miao-Hua / Deng, Bai-Ling / Liu, Duan-Yong / Zhou, Bu-Gao / Zhou, Wen / Zhong, You-Bao / Zhao, Hai-Mei

    World journal of gastroenterology

    2023  Volume 29, Issue 36, Page(s) 5226–5239

    Abstract: Background: Restoration of immune homeostasis by targeting the balance between memory T helper (mTh) cells and memory follicular T helper (mTfh) cells is a potential therapeutic strategy against ulcerative colitis (UC). Because of its anti-inflammatory ... ...

    Abstract Background: Restoration of immune homeostasis by targeting the balance between memory T helper (mTh) cells and memory follicular T helper (mTfh) cells is a potential therapeutic strategy against ulcerative colitis (UC). Because of its anti-inflammatory and immunomodulatory properties, curcumin (Cur) is a promising drug for UC treatment. However, fewer studies have demonstrated whether Cur can modulate the mTh/mTfh subset balance in mice with colitis.
    Aim: To explore the potential mechanism underlying Cur-mediated alleviation of colitis induced by dextran sulfate sodium (DSS) in mice by regulating the mTh and mTfh immune homeostasis.
    Methods: Balb/c mice were administered 3% and 2% DSS to establish the UC model and treated with Cur (200 mg/kg/d) by gavage on days 11-17. On the 18
    Results: Cur effectively mitigates DSS-induced colitis, facilitates the restoration of mouse weight and colonic length, and diminishes the colonic weight and colonic weight index. Simultaneously, it hinders ulcer development and inflammatory cell infiltration in the colonic mucous membrane. While the percentage of Th1, mTh1, Th7, mTh7, Th17, mTh17, Tfh1, mTfh1, Tfh7, mTfh7, Tfh17, and mTfh17 cells decreased after Cur treatment of the mice for 7 d, and the frequency of mTh10, Th10, mTfh10, and Tfh10 cells in the mouse spleen increased. Further studies revealed that Cur administration prominently decreased the SOCS-1, SOCS-3, STAT3, p-STAT3, JAK1, p-JAK1, and NF-κB p65 protein expression levels in the colon tissue.
    Conclusion: Cur regulated the mTh/mTfh cell homeostasis to reduce DSS-induced colonic pathological damage, potentially by suppressing the JAK1/STAT3/SOCS signaling pathway.
    MeSH term(s) Animals ; Mice ; Dextran Sulfate/toxicity ; Curcumin/pharmacology ; Curcumin/therapeutic use ; NF-kappa B/metabolism ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colon/pathology ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemical Substances Dextran Sulfate (9042-14-2) ; Curcumin (IT942ZTH98) ; NF-kappa B
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i36.5226
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Gefitinib Inhibits Bleomycin-Induced Pulmonary Fibrosis via Alleviating the Oxidative Damage in Mice.

    Li, Li / Cai, Lin / Zheng, Linxin / Hu, Yujie / Yuan, Weifeng / Guo, Zhenhui / Li, Weifeng

    Oxidative medicine and cellular longevity

    2018  Volume 2018, Page(s) 8249693

    Abstract: Pulmonary fibrosis (PF) is a life-threatening interstitial lung disease. In this study, we tried to reveal the model of action between high-mobility group box 1 (HMGB1) ... ...

    Abstract Pulmonary fibrosis (PF) is a life-threatening interstitial lung disease. In this study, we tried to reveal the model of action between high-mobility group box 1 (HMGB1) and
    MeSH term(s) Actins/metabolism ; Animals ; Bleomycin/toxicity ; Down-Regulation/drug effects ; Female ; HMGB1 Protein/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Lung/drug effects ; Lung/pathology ; Malondialdehyde/blood ; Mice ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/pathology ; Quinazolines/pharmacology ; Signal Transduction/drug effects ; Transcription Factor AP-1/metabolism
    Chemical Substances Actins ; HMGB1 Protein ; NF-kappa B ; Quinazolines ; Transcription Factor AP-1 ; alpha-smooth muscle actin, mouse ; Bleomycin (11056-06-7) ; Malondialdehyde (4Y8F71G49Q) ; NADPH Oxidases (EC 1.6.3.-) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; gefitinib (S65743JHBS)
    Language English
    Publishing date 2018-04-12
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2018/8249693
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Venous thromboembolism in patients with severe lung cancer: a narrative review.

    Zheng, Lin-Xin / Li, Li / Huang, Jin-Hai / Mai, Yu-Mei / Chen, Can / Dong, Jia-Hui / Xu, Zhi-Yong / Li, Wei-Feng / Chen, Xiao-Rong

    Annals of palliative medicine

    2021  Volume 10, Issue 6, Page(s) 6957–6967

    Abstract: Objective: At present, there are several guidelines for cancer complicated with VTE, but there is no specific recommendation for the treatment of lung cancer complicated with VTE. Whether is necessary to explore treatment and prevention of VTE in lung ... ...

    Abstract Objective: At present, there are several guidelines for cancer complicated with VTE, but there is no specific recommendation for the treatment of lung cancer complicated with VTE. Whether is necessary to explore treatment and prevention of VTE in lung cancer.
    Background: Venous thromboembolism (VTE) is a common complication of severe lung cancer that can entail many adverse effects for patients. The incidence of VTE is higher in patients with lung cancer than in those with other kinds of solid tumors, and it is especially high among patients with lung adenocarcinoma, at advanced tumor-node-metastasis (TNM) stages, or with a history of central venous catheter (CVC) or chemotherapy. However, the clinical symptoms of VTE in patients with lung cancer are not typical and cannot be detected easily, and the clinical prevention rate is low. In the acute phase of VTE in lung cancer, the Eastern Cooperative Oncology Group (ECOG) performance status score of patients typically ranges from 2 to 4 points, leaving end-stage maintenance therapy as the only treatment option.
    Methods: Here, we analyze the existing literature and discuss the current status (including epidemiology, clinical manifestations, and risk factors), risk assessment tools, and the treatment and prevention of VTE in severe lung cancer. We focus particularly on the use of low-molecular-weight heparin and new oral anticoagulants (including in the management of thrombocytopenia after antitumor therapy) in lung cancer patients with VTE.
    Conclusions: Large-scale prospective multicenter studies on the treatment and prevention of VTE in lung cancer are necessary.
    Language English
    Publishing date 2021-06-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-21-1281
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-

    Huang, Jianhua / Li, Li / Yuan, Weifeng / Zheng, Linxin / Guo, Zhenhui / Huang, Wenjie

    Mediators of inflammation

    2016  Volume 2016, Page(s) 7349603

    Abstract: The aim of the present study is to investigate the protective effects and relevant mechanisms exerted by NEMO-binding domain peptide (NBD) against lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice. The ALI model was induced by ... ...

    Abstract The aim of the present study is to investigate the protective effects and relevant mechanisms exerted by NEMO-binding domain peptide (NBD) against lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice. The ALI model was induced by intratracheally administered atomized LPS (5 mg/kg) to BABL/c mice. Half an hour before LPS administration, we treated the mice with increasing concentrations of intratracheally administered NBD or saline aerosol. Two hours after LPS administration, each group of mice was sacrificed. We observed that NBD pretreatment significantly attenuated LPS-induced lung histopathological injury in a dose-dependent manner. Western blotting established that NBD pretreatment obviously attenuated LPS-induced I
    MeSH term(s) Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/immunology ; Acute Lung Injury/metabolism ; Animals ; Interleukin-1beta/metabolism ; Lipopolysaccharides/toxicity ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Male ; Mice ; Mice, Inbred BALB C ; NF-kappa B/metabolism ; Peptides/therapeutic use ; Signal Transduction/drug effects ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Interleukin-1beta ; Lipopolysaccharides ; NBD peptide, mouse ; NF-kappa B ; Peptides ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2016/7349603
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3575: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top