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  1. Article ; Online: Innate Lymphoid Cells and Intestinal Inflammatory Disorders.

    Zheng, Mingzhu / Zhu, Jinfang

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Innate lymphoid cells (ILCs) are a population of lymphoid cells that do not express T cell or B cell antigen-specific receptors. They are largely tissue-resident and enriched at mucosal sites to play a protective role against pathogens. ILCs mimic the ... ...

    Abstract Innate lymphoid cells (ILCs) are a population of lymphoid cells that do not express T cell or B cell antigen-specific receptors. They are largely tissue-resident and enriched at mucosal sites to play a protective role against pathogens. ILCs mimic the functions of CD4 T helper (Th) subsets. Type 1 innate lymphoid cells (ILC1s) are defined by the expression of signature cytokine IFN-γ and the master transcription factor T-bet, involving in the type 1 immune response; ILC2s are characterized by the expression of signature cytokine IL-5/IL-13 and the master transcription factor GATA3, participating in the type 2 immune response; ILC3s are RORγt-expressing cells and are capable of producing IL-22 and IL-17 to maintain intestinal homeostasis. The discovery and investigation of ILCs over the past decades extends our knowledge beyond classical adaptive and innate immunology. In this review, we will focus on the roles of ILCs in intestinal inflammation and related disorders.
    MeSH term(s) Animals ; Gastroenteritis/immunology ; Gene Expression Regulation ; Humans ; Immunity, Innate ; Interferon-gamma/metabolism ; Interleukin-17/metabolism ; Interleukins/metabolism ; Lymphocytes/immunology ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; T-Box Domain Proteins/metabolism ; Interleukin-22
    Chemical Substances IFNG protein, human ; Interleukin-17 ; Interleukins ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; RORC protein, human ; T-Box Domain Proteins ; T-box transcription factor TBX21 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2022-02-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CD8

    Qin, Yingyu / Bao, Xueyang / Zheng, Mingzhu

    Frontiers in immunology

    2023  Volume 13, Page(s) 1109347

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Humans ; Natural Killer T-Cells ; CD8-Positive T-Lymphocytes ; Lymphocyte Activation ; Cytokines ; Neoplasms
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1109347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Postharvest ripening of newly harvested corn: Weakened interactions between starch and protein.

    Hu, Nannan / Qi, Weihua / Zhu, Jinying / Li, Sheng / Zheng, Mingzhu / Zhao, Chengbin / Liu, Jingsheng

    Food chemistry

    2024  Volume 451, Page(s) 139450

    Abstract: The effects of postharvest ripening of corn on the mechanisms of starch and protein interactions were investigated using molecular dynamics and several chemical substances. Sodium dodecyl sulfate (SDS) treatment all significantly affected the starch ... ...

    Abstract The effects of postharvest ripening of corn on the mechanisms of starch and protein interactions were investigated using molecular dynamics and several chemical substances. Sodium dodecyl sulfate (SDS) treatment all significantly affected the starch content, molecular weight of proteins, relative crystallinity, pasting characteristics and dynamic viscoelasticity in samples before and after postharvest ripening. In the corn that had not undergone postharvest ripening, there were also significant electrostatic interactions and hydrogen bonds between starch and protein. In addition, molecular dynamics had demonstrated that the forces between starch and protein in corn were mainly hydrophobic interactions, electrostatic interaction, and hydrogen bonds. Compared with zein, corn glutelin was more tightly bound to starch. The binding energy of starch to both proteins was reduced in after postharvest-ripened corn. This study laid a rationale for investigating the change mechanism of corn postharvest ripening quality and improving processing property and edible quality of corn.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.139450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  4. Article ; Online: A novel autophagy-related subtypes to distinguish immune phenotypes and predict immunotherapy response in head and neck squamous cell carcinoma.

    Ma, Bo / Li, Hui / Zheng, Mingzhu / Cao, Rui / Yu, Riyue

    Biomolecules & biomedicine

    2023  Volume 23, Issue 6, Page(s) 997–1013

    Abstract: Both the absence of autophagy and excessive autophagy is double-edged sword in tumorigenesis. Due to the specificity of autophagy, its role in head and neck squamous cell carcinoma (HNSCC) is still unclear. In this study, we established five autophagy- ... ...

    Abstract Both the absence of autophagy and excessive autophagy is double-edged sword in tumorigenesis. Due to the specificity of autophagy, its role in head and neck squamous cell carcinoma (HNSCC) is still unclear. In this study, we established five autophagy-related patterns in 1165 HNSCC patients with distinct cellular and molecular characteristics. Additionally, we developed a new scoring system (ATPscore) based on the differentially expressed genes (DEGs) among these five patterns, to represent the individual autophagy regulation pattern. ATPscore was shown to be significantly correlated with tumor immune microenvironment (TIME) infiltration, immune phenotypes, molecular subtypes, and genetic variations. We further found that ATPscore was both an independent prognostic factor and a potent predictor of clinical response to immune-checkpoint inhibitors (ICIs) based immunotherapy. We further verified the value of key gene SRPX in ATPscore in HNSCC cell lines with the in-depth research of ATPscore and found that it is closely related to immune subtypes, molecular subtypes, and immune activation-related markers. Our research could help us to understand the underlying mechanisms of tumor immunity and provide a solid foundation for combination of autophagy-targeted therapies with immunotherapies for clinical application in HNSCC.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck ; Autophagy ; Immunotherapy ; Phenotype ; Head and Neck Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2023-11-03
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ISSN 2831-090X
    ISSN (online) 2831-090X
    DOI 10.17305/bb.2023.9094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transcriptional Regulation of Early T-Lymphocyte Development in Thymus.

    Bao, Xueyang / Qin, Yingyu / Lu, Linrong / Zheng, Mingzhu

    Frontiers in immunology

    2022  Volume 13, Page(s) 884569

    Abstract: T-lymphocytes play crucial roles for maintaining immune homeostasis by fighting against various pathogenic microorganisms and establishing self-antigen tolerance. They will go through several stages and checkpoints in the thymus from progenitors to ... ...

    Abstract T-lymphocytes play crucial roles for maintaining immune homeostasis by fighting against various pathogenic microorganisms and establishing self-antigen tolerance. They will go through several stages and checkpoints in the thymus from progenitors to mature T cells, from CD4
    MeSH term(s) Animals ; CD4 Antigens ; CD8 Antigens ; Mice ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocytes
    Chemical Substances CD4 Antigens ; CD8 Antigens ; Receptors, Antigen, T-Cell ; Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.884569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Thermodynamics and Physicochemical Properties of Immobilized Maleic Anhydride-Modified Xylanase and Its Application in the Extraction of Oligosaccharides from Wheat Bran

    Zhao, Yang / Li, Xinrui / Guo, Shuo / Xu, Jingwen / Cui, Yan / Zheng, Mingzhu / Liu, Jingsheng

    Foods. 2023 June 20, v. 12, no. 12

    2023  

    Abstract: Xylanases are the preferred enzymes for the extracting of oligosaccharides from wheat bran. However, free xylanases have poor stability and are difficult to reuse, which limit their industrial application. In the present study, we covalently immobilized ... ...

    Abstract Xylanases are the preferred enzymes for the extracting of oligosaccharides from wheat bran. However, free xylanases have poor stability and are difficult to reuse, which limit their industrial application. In the present study, we covalently immobilized free maleic anhydride-modified xylanase (FMA-XY) to improve its reusability and stability. The immobilized maleic anhydride-modified xylanase (IMA-XY) exhibited better stability compared with the free enzyme. After six repeated uses, 52.24% of the activity of the immobilized enzyme remained. The wheat bran oligosaccharides extracted using IMA-XY were mainly xylopentoses, xylohexoses, and xyloheptoses, which were the β-configurational units and α-configurational units of xylose. The oligosaccharides also exhibited good antioxidant properties. The results indicated that FMA-XY can easily be recycled and can remain stable after immobilization; therefore, it has good prospects for future industrial applications.
    Keywords antioxidants ; chemical bonding ; immobilized enzymes ; industrial applications ; oligosaccharides ; thermodynamics ; wheat bran ; xylanases ; xylose
    Language English
    Dates of publication 2023-0620
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12122424
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Maleic anhydride-modified xylanase and its application to the clarification of fruits juices.

    Zhao, Yang / Zhang, Luyue / Zhang, Shiyu / Zheng, Xing / Zheng, Mingzhu / Liu, Jingsheng

    Food chemistry: X

    2023  Volume 19, Page(s) 100830

    Abstract: At presently, the catalytic activity of xylanase is sub-optimal, and the required reaction conditions are harsh. To improve its catalytic activity and stability, xylanase (XY) was chemically modified with maleic anhydride (MA). The enzymatic properties ... ...

    Abstract At presently, the catalytic activity of xylanase is sub-optimal, and the required reaction conditions are harsh. To improve its catalytic activity and stability, xylanase (XY) was chemically modified with maleic anhydride (MA). The enzymatic properties of this maleic anhydride-modified xylanase (MA-XY) were then evaluated and analyzed spectroscopically. The results showed that the thermal stability, use of organic solvents, storage stability and the pH range of 3.0 to 9.0 for MA-XY were better than that for XY alone. The kinetic parameters of the enzyme (K
    Language English
    Publishing date 2023-08-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1575
    ISSN (online) 2590-1575
    DOI 10.1016/j.fochx.2023.100830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Study on physicochemical, structural, and functional properties of Zhengdan958 and Xianyu335 cornstarch from newly harvested corn under postharvest ripening conditions at ambient temperature.

    Cao, Yong / Wang, Xiujuan / Zhao, Chengbin / Zhang, Hao / Zheng, Mingzhu / Xu, Xiuying / Liu, Jingsheng

    Heliyon

    2023  Volume 9, Issue 5, Page(s) e15650

    Abstract: The importance of starch in nutrition and industry is unquestionable. This study investigated the changes in physicochemical, structural, and functional properties of cornstarch from newly harvested Zhengdan958 (Zd958) and Xianyu335 (Xy335) corn during ... ...

    Abstract The importance of starch in nutrition and industry is unquestionable. This study investigated the changes in physicochemical, structural, and functional properties of cornstarch from newly harvested Zhengdan958 (Zd958) and Xianyu335 (Xy335) corn during for 0, 20, 40, and 60 d at ambient temperature. The results showed no significant changes in the proximate components and apparent structure of Zd958 and Xy335 cornstarch under postharvest ripening conditions. Compared with 0 d, the molecular weight distribution and mass fraction of Zd958 and Xy335 cornstarch have changed significantly, the relative crystallinity (RC) has significantly increased from 26.4% to 26.5%-28.8% and 28.4%, and R1045/1022 has significantly increased from 0.828 to 0.826 to 0.843 and 0.883, respectively. The changes in structure indicated that the synthesis and rearrangement of cornstarch molecules formed highly ordered crystalline structures, and the ordered structures of long-range and short-range molecules increased. Moreover, the changes in structure affected the pasting characteristics and texture profiles of cornstarch, therefore, affecting the final food quality.
    Language English
    Publishing date 2023-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e15650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Thermodynamics and Physicochemical Properties of Immobilized Maleic Anhydride-Modified Xylanase and Its Application in the Extraction of Oligosaccharides from Wheat Bran.

    Zhao, Yang / Li, Xinrui / Guo, Shuo / Xu, Jingwen / Cui, Yan / Zheng, Mingzhu / Liu, Jingsheng

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: Xylanases are the preferred enzymes for the extracting of oligosaccharides from wheat bran. However, free xylanases have poor stability and are difficult to reuse, which limit their industrial application. In the present study, we covalently immobilized ... ...

    Abstract Xylanases are the preferred enzymes for the extracting of oligosaccharides from wheat bran. However, free xylanases have poor stability and are difficult to reuse, which limit their industrial application. In the present study, we covalently immobilized free maleic anhydride-modified xylanase (FMA-XY) to improve its reusability and stability. The immobilized maleic anhydride-modified xylanase (IMA-XY) exhibited better stability compared with the free enzyme. After six repeated uses, 52.24% of the activity of the immobilized enzyme remained. The wheat bran oligosaccharides extracted using IMA-XY were mainly xylopentoses, xylohexoses, and xyloheptoses, which were the β-configurational units and α-configurational units of xylose. The oligosaccharides also exhibited good antioxidant properties. The results indicated that FMA-XY can easily be recycled and can remain stable after immobilization; therefore, it has good prospects for future industrial applications.
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12122424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Tespa1 deficiency reduces the antitumour immune response by decreasing CD8

    Yang, Ruhui / Yang, Mingyue / Wu, Zehua / Liu, Bingjin / Zheng, Mingzhu / Lu, Linrong / Wu, Songquan

    International immunopharmacology

    2023  Volume 124, Issue Pt A, Page(s) 110865

    Abstract: Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a key molecule in T-cell development and has been linked to immune diseases. However, its role in antitumour ... ...

    Abstract Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a key molecule in T-cell development and has been linked to immune diseases. However, its role in antitumour CD8
    Language English
    Publishing date 2023-09-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.110865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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