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  1. Article ; Online: Blasts engulfing erythrocytes: an unusual morphological finding in adult early T-precursor acute lymphoblastic leukemia.

    Zheng, Qin / Liao, Hongyan

    International journal of hematology

    2023  Volume 117, Issue 4, Page(s) 471–472

    MeSH term(s) Humans ; Adult ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Leukocytes ; Erythrocytes
    Language English
    Publishing date 2023-03-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-023-03574-2
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  2. Article: ABA Inhibits Rice Seed Aging by Reducing H

    Zheng, Qin / Teng, Zhenning / Zhang, Jianhua / Ye, Nenghui

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 6

    Abstract: The seed, a critical organ in higher plants, serves as a primary determinant of agricultural productivity, with its quality directly influencing crop yield. Improper storage conditions can diminish seed vigor, adversely affecting seed germination and ... ...

    Abstract The seed, a critical organ in higher plants, serves as a primary determinant of agricultural productivity, with its quality directly influencing crop yield. Improper storage conditions can diminish seed vigor, adversely affecting seed germination and seedling establishment. Therefore, understanding the seed-aging process and exploring strategies to enhance seed-aging resistance are paramount. In this study, we observed that seed aging during storage leads to a decline in seed vigor and can coincide with the accumulation of hydrogen peroxide (H
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13060809
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  3. Article ; Online: CXC chemokines: Potential biomarker and immunotherapeutic target for uterine corpus endometrial carcinoma.

    Wang, Guang / Fu, Juan / Liu, Mulin / Zheng, Qin

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0277872

    Abstract: Uterine corpus endometrial carcinoma (UCEC) is one of the most common type of gynecological malignancies. Multiple lines of evidence indicated that CXC chemokines exerted an anti-tumor immunological role in the tumor microenvironment which were critical ... ...

    Abstract Uterine corpus endometrial carcinoma (UCEC) is one of the most common type of gynecological malignancies. Multiple lines of evidence indicated that CXC chemokines exerted an anti-tumor immunological role in the tumor microenvironment which were critical regulators of cancer immunity. However, the relevance of CXC chemokines in the evaluation of prognosis and immune infiltration of UCEC remains to be explored. This study utilized various online databases, including TCGA, UALCAN, Kaplan-Meier Plotter, cBioPortal, TIMER2.0, TISIDB, and MethSurv to perform the analysis. Gene expression data from the TCGA-UCEC dataset indicated decreased expression of CXCL2/12 and increased expression of CXCL14/17. CXCL2/12 expression was negatively whereas CXCL14/17 expression was positively correlated with clinicopathological features of UCEC patients, including cancer stage, patients' age, weight and menopause status. Patients with higher CXCL12/14 expression corresponded with better clinical outcomes, which were not influenced by the genetic alterations. The differential expression of CXCL2/12/14/17 was not only significantly correlated with immune infiltration levels, but also the abundance of immune checkpoint inhibitors. Heatmaps of DNA methylation of CXCL2/12/14/17 were investigated, and 4 CpGs of CXCL2, 16 CpGs of CXCL12, 3 CpGs of CXCL14/17 were identified where altered methylation affected the prognosis of UCEC patients. These findings provided novel insights into the immunologic features of UCEC and might pave the way toward the prognostic evaluation and immunotherapy selection based on CXCL2/12/14/17 expression status.
    MeSH term(s) Female ; Humans ; Biomarkers ; Carcinoma, Endometrioid ; DNA Methylation ; Databases, Factual ; Immunotherapy ; Endometrial Neoplasms/genetics ; Tumor Microenvironment
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277872
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  4. Article ; Online: A key to genera of Dikraneurini from China, with description of a new species of Cornicola Ohara & Hayashi (Hemiptera, Cicadellidae, Typhlocybinae)

    Ye Xu / Christopher H. Dietrich / Dao-Zheng Qin

    ZooKeys, Vol 1145, Iss , Pp 191-

    2023  Volume 200

    Abstract: The leafhopper genus Cornicola Ohara & Hayashi, previously recorded from Japan, is recorded from China for the first time and a new species, C. maculatus Xu, Dietrich & Qin, sp. nov., is described and illustrated, including its color polymorphism. This ... ...

    Abstract The leafhopper genus Cornicola Ohara & Hayashi, previously recorded from Japan, is recorded from China for the first time and a new species, C. maculatus Xu, Dietrich & Qin, sp. nov., is described and illustrated, including its color polymorphism. This genus has male genitalia and hind wing venation similar to those found in Empoascini but it is more appropriately placed in Dikraneurini. A key to species of Cornicola is given together with a key to the genera of Dikraneurini from China.
    Keywords Zoology ; QL1-991
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Pensoft Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Improving Confidence for the Identification of N-Linked Intact Glycopeptides Based on the Precursor Feature

    FANG Zheng;QIN Hong-qiang;YE Ming-liang

    Zhipu Xuebao, Vol 44, Iss 3, Pp 377-

    2023  Volume 386

    Abstract: As a common and heterogeneous post-translational modification (PTM), glycosylation takes part in a wide variety of biological processes. Precision analysis of glycosylation is of great value for the determination of their functional roles and the ... ...

    Abstract As a common and heterogeneous post-translational modification (PTM), glycosylation takes part in a wide variety of biological processes. Precision analysis of glycosylation is of great value for the determination of their functional roles and the discovery of novel disease biomarkers. Mass spectrometry-based identification of intact glycopeptide has become increasingly popular in glycosylation studies due to its ability for high-throughput analysis of glyco-sites and glycan modifications simultaneously. Variable modification searching strategy by setting database glycans as variable modification on glycosites is commonly used in the identification of intact glycopeptides. Due to the issues of search space and random match, the performance of variable modification strategy is affected by the size of glycan database adopted in analysis. Inappropriate using of glycan databases in intact glycopeptide identification often results in poor analysis coverage or high false positive rate. In addition, the misassignment of precursor, which causes incorrect derivation of mass value of glycopeptides, is also frequently observed in the identification process and leads to incorrect glycopeptide spectrum interpretation. As only peptide fragment ions in glycopeptide spectra are matched by setting the glycan part as variable modifications, the confidence of precursor assignment and glycopeptide identification can not be fully assessed by spectrum matching scores, which are often solely based on peptide fragment ions. The spectrum features of glycopeptide precursor, including elution profiles and intensity distributions of isotopic peak list, can be utilized to screen the incorrect glycopeptide results caused by isotopic shift, which are great helpful to elevate the reliability of identification results. In this work, the effect of glycan databases on the performance of variable modification searching was firstly investigated by using the dataset of yeast as a benchmark, since only oligo-mannose N-glycans were synthesized in ...
    Keywords proteomics ; glycosylation ; precursor ; data searching ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Editorial Board of Journal of Chinese Mass Spectrometry Society
    Document type Article ; Online
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  6. Article ; Online: Effects of pore size, water content, and oxygen-containing functional groups on oxygen adsorption in bituminous coal

    Zhongjiu Ren / Dapeng Wang / Zheng Qin / Ziwen Liu

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 9

    Abstract: Abstract To further explore the mechanism of coal spontaneous combustion and better grasp the laws of spontaneous combustion, this article studied the adsorption behavior of O2 in coal. Materials studio software was applied to study the adsorption of ... ...

    Abstract Abstract To further explore the mechanism of coal spontaneous combustion and better grasp the laws of spontaneous combustion, this article studied the adsorption behavior of O2 in coal. Materials studio software was applied to study the adsorption of oxygen under different water content, different pore sizes, and different oxygen-containing functional groups by means of grand canonical Monte Carlo and molecular dynamics simulation methods. The results show that the adsorption capacity of O2 decreases with the increase in water content. With the increase of molecular pore size of coal, the adsorption capacity of O2 increases, and the tight adsorption amounts decrease. The equivalent adsorption heat is less than 42 kJ/mol, indicating that the adsorption of O2 in coal pores is physical adsorption. The smaller the physical adsorption energy and charge transfer value of the hydroxyl group for O2, it indicates that the hydroxyl group is the active group for the physical adsorption of O2.
    Keywords Medicine ; R ; Science ; Q
    Subject code 541
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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  7. Article: Association of coagulation markers with the severity of white matter hyperintensities in cerebral small vessel disease.

    Xu, Mingyuan / Li, Jingjing / Xu, Bu / Zheng, Qin / Sun, Wenjun

    Frontiers in neurology

    2024  Volume 15, Page(s) 1331733

    Abstract: Background and purpose: This study aimed to explore the correlation and causal relationship between fibrinogen, D-dimer, and the severity of cerebral white matter hyperintensity (MMH).: Methods: A retrospective analysis of 120 patients with cerebral ... ...

    Abstract Background and purpose: This study aimed to explore the correlation and causal relationship between fibrinogen, D-dimer, and the severity of cerebral white matter hyperintensity (MMH).
    Methods: A retrospective analysis of 120 patients with cerebral small vessel disease (CSVD) confirmed by head MRI attending the Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine from August 2021 to February 2023 was performed. According to the Fazekas scale score, the patients were divided into 42 cases in the mild group, 44 cases in the moderate group, and 34 cases in the severe group. The levels of fibrinogen and D-dimer were compared among the three groups; the correlations between fibrinogen, D-dimer, and WMH severity were further analyzed; and independent risk factors for WMH severity were explored using the multivariate ordered logistic regression analysis. Furthermore, a two-sample Mendelian randomization (MR) analysis was performed to investigate the genetically predicted effect of fibrinogen and D-dimer on WMH.
    Results: As the severity of WMH increased, the levels of D-dimer and fibrinogen also gradually increased, and the results showed a positive correlational association, with significant differences within the groups (all
    Conclusion: In this retrospective-based study, the authors found possible associations between D-dimer, fibrinogen, and WMH, but there was no obvious causal evidence. Further efforts are still needed to investigate the pathophysiology between D-dimer, fibrinogen, and WMH.
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1331733
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  8. Article ; Online: Learning accurate template matching with differentiable coarse-to-fine correspondence refinement

    Zhirui Gao / Renjiao Yi / Zheng Qin / Yunfan Ye / Chenyang Zhu / Kai Xu

    Computational Visual Media, Vol 10, Iss 2, Pp 309-

    2024  Volume 330

    Abstract: Abstract Template matching is a fundamental task in computer vision and has been studied for decades. It plays an essential role in manufacturing industry for estimating the poses of different parts, facilitating downstream tasks such as robotic grasping. ...

    Abstract Abstract Template matching is a fundamental task in computer vision and has been studied for decades. It plays an essential role in manufacturing industry for estimating the poses of different parts, facilitating downstream tasks such as robotic grasping. Existing methods fail when the template and source images have different modalities, cluttered backgrounds, or weak textures. They also rarely consider geometric transformations via homographies, which commonly exist even for planar industrial parts. To tackle the challenges, we propose an accurate template matching method based on differentiable coarse-to-fine correspondence refinement. We use an edge-aware module to overcome the domain gap between the mask template and the grayscale image, allowing robust matching. An initial warp is estimated using coarse correspondences based on novel structure-aware information provided by transformers. This initial alignment is passed to a refinement network using references and aligned images to obtain sub-pixel level correspondences which are used to give the final geometric transformation. Extensive evaluation shows that our method to be significantly better than state-of-the-art methods and baselines, providing good generalization ability and visually plausible results even on unseen real data.
    Keywords template matching ; differentiable homography ; structure-awareness ; transformers ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
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  9. Article ; Online: Correction: Impact of total intravenous anesthesia and total inhalation anesthesia as the anesthesia maintenance approaches on blood glucose level and postoperative complications in patients with type 2 diabetes mellitus: a double-blind, randomized controlled trial.

    Xiong, Xinghui / He, Yong / Zhou, Cheng / Zheng, Qin / Chen, Chan / Liang, Peng

    BMC anesthesiology

    2024  Volume 24, Issue 1, Page(s) 36

    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-024-02419-7
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  10. Article ; Online: Small extracellular vesicles of organoid-derived human retinal stem cells remodel Müller cell fate via miRNA: A novel remedy for retinal degeneration.

    Huang, Shudong / Zeng, Yuxiao / Guo, Qiang / Zou, Ting / Yin, Zheng Qin

    Journal of controlled release : official journal of the Controlled Release Society

    2024  Volume 370, Page(s) 405–420

    Abstract: Remodeling retinal Müller glial fate, including gliosis inhibition and pro-reprogramming, represents a crucial avenue for treating degenerative retinal diseases. Stem cell transplantation exerts effects on modulating retinal Müller glial fate. However, ... ...

    Abstract Remodeling retinal Müller glial fate, including gliosis inhibition and pro-reprogramming, represents a crucial avenue for treating degenerative retinal diseases. Stem cell transplantation exerts effects on modulating retinal Müller glial fate. However, the optimized stem cell products and the underlying therapeutic mechanisms need to be investigated. In the present study, we found that retinal progenitor cells from human embryonic stem cell-derived retinal organoids (hERO-RPCs) transferred extracellular vesicles (EVs) into Müller cells following subretinal transplantation into RCS rats. Small EVs from hERO-RPCs (hERO-RPC-sEVs) were collected and were found to delay photoreceptor degeneration and protect retinal function in RCS rats. hERO-RPC-sEVs were taken up by Müller cells both in vivo and in vitro, and inhibited gliosis while promoting early dedifferentiation of Müller cells. We further explored the miRNA profiles of hERO-RPC-sEVs, which suggested a functional signature associated with neuroprotection and development, as well as the regulation of stem cell and glial fate. Mechanistically, hERO-RPC-sEVs might regulate the fate of Müller cells by miRNA-mediated nuclear factor I transcription factors B (NFIB) downregulation. Collectively, our findings offer novel mechanistic insights into stem cell therapy and promote the development of EV-centered therapeutic strategies.
    Language English
    Publishing date 2024-05-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2024.04.036
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