Artikel ; Online: Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis.
Chinese journal of natural medicines
2022 Band 20, Heft 6, Seite(n) 432–442
Abstract: Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction (MI), by far, there are few preventive and therapeutic options for ischemic heart failure (IHF) after MI. Qi-Tai-Suan (QTS) is an oleanolic ... ...
| Abstract | Although anti-thrombotic therapy has been successful for prevention of deaths from acute myocardial infarction (MI), by far, there are few preventive and therapeutic options for ischemic heart failure (IHF) after MI. Qi-Tai-Suan (QTS) is an oleanolic acid (OA) derivative which once underwent a clinical trial for treating hepatitis. In this study, we investigated the potential cardioprotective effect of QTS on IHF. IHF mouse model was constructed by coronary artery ligation in male C57BL/6J mice, and the protective effects of QTS on IHF were examined by echocardiography measurement, histological and TUNEL analysis, etc. We found that QTS exhibited promising cardioprotective effect on IHF. QTS treatment significantly improved cardiac function of IHF mice and the symptoms of heart failure. Notably, QTS had much better oral bioavailability (F = 41.91%) in mice than its parent drug OA, and took effects mainly as its original form. Mechanistically, QTS ameliorated ischemic heart failure likely through suppression of cardiac apoptosis, inflammation and fibrosis. Taken together, QTS holds great promise as a preventive and therapeutic agent for ischemic heart failure and related diseases. |
|---|---|
| Mesh-Begriff(e) | Animals ; Apoptosis ; Fibrosis ; Heart Failure/drug therapy ; Inflammation/drug therapy ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/pathology ; Oleanolic Acid/pharmacology |
| Chemische Substanzen | Oleanolic Acid (6SMK8R7TGJ) |
| Sprache | Englisch |
| Erscheinungsdatum | 2022-06-24 |
| Erscheinungsland | China |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2192577-X |
| ISSN | 1875-5364 ; 2095-6975 ; 1672-3651 |
| ISSN (online) | 1875-5364 |
| ISSN | 2095-6975 ; 1672-3651 |
| DOI | 10.1016/S1875-5364(22)60156-0 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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