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Article ; Online: Cell division cycle 42 attenuates high glucose-treated renal tubular epithelial cell apoptosis, fibrosis, and inflammation, but activates the PAK1/AKT pathway.

Zheng, Shanshan / Zhao, Na / Feng, Chuwen / Ma, Jian

2024

Abstract: Background: Cell division cycle 42 (CDC42) modulates metabolism, inflammation, and fibrosis to engage in the pathology of diabetic complications. This study intended to further investigate the influence of CDC42 on viability, apoptosis, inflammation, ... ...

Abstract	Background: Cell division cycle 42 (CDC42) modulates metabolism, inflammation, and fibrosis to engage in the pathology of diabetic complications. This study intended to further investigate the influence of CDC42 on viability, apoptosis, inflammation, epithelial-mesenchymal transition, and fibrosis in high glucose (HG)-treated renal tubular epithelial cells. Methods: HK-2 cells were exposed to HG medium (30 mM) to establish the diabetic nephropathy (DN) cellular model, then the cells were transfected with scramble overexpression control (oeNC) or CDC42 overexpression (oeCDC42) vectors. Results: Both the level of CDC42 mRNA and protein were decreased in HG-treated HK-2 cells in a dose- and time-dependent manner. Then HG-treated HK-2 cells were proposed for the following experiments. It was found that CDC42 increased CCK-8 detected viability and EdU positive cells. On the contrary, CDC42 reduced cell apoptosis, which was reflected by decreased TUNEL positive rate, increased BCL2, and reduced BAX. Interestingly, CDC42 inhibited fibrosis, which was reflected by increased E-Cadherin, as well as decreased Vimentin, TGF-β1, Collagen1, and α-SMA. Apart from these, CDC42 also attenuated proinflammatory cytokine production, including TNF-α, IL-1β, and IL-6. Moreover, CDC42 activated the PAK1/AKT pathway, which was reflected by increased p-PAK1 and p-AKT. However, CDC42 did not affect p-ERK. Conclusion: CDC42 may retard DN progression via its regulation of renal tubular epithelial cell functions, which may be due to its stimulation of the PAK1/AKT pathway.
Language	English
Publishing date	2024-02-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-024-02468-9
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Article ; Online: Health belief model and social media engagement: A cross-national study of health promotion strategies against COVID-19 in 2020.

Mao, Zhifei / Wang, Di / Zheng, Shanshan

Frontiers in public health

2023 Volume 11, Page(s) 1093648

Abstract: Background: Using the Health Belief Model (HBM), this study analyzed tweets related to COVID-19 published by national health departments of the United States, the South Korea, the United Kingdom, Japan, Germany, and India to explore their differences in ...

Abstract	Background: Using the Health Belief Model (HBM), this study analyzed tweets related to COVID-19 published by national health departments of the United States, the South Korea, the United Kingdom, Japan, Germany, and India to explore their differences in (1) the health measures against COVID-19, (2) the health promotion strategies, (3) the social media engagements that those measures and strategies have triggered. Method: We conducted a content analysis with 1,200 randomly selected COVID-19-related tweets from six national health departments' Twitter accounts from 1 January 2020 to 31 December 2020. We coded the six HBM constructs and 21 sub-themes of the HBM constructs for each tweet. Results: Results showed that all six HBM constructs were used in the full sample. The most commonly used HBM construct was cues to action, followed by susceptibility, benefits, self-efficacy, severity, and barriers. All the HBM constructs were positively related to Twitter engagement variables except barriers. Further analysis illustrated that people from the six countries responded differently to the HBM constructs and the HBM sub-themes. Twitter users in Germany, India, the U.S., and Japan positively reacted to the clear directions of "what to do against COVID-19" (cues to action), while Twitter users in the U.S. and Japan were also eager to know the justifications for such directions (benefits); people in South Korea and the U.K. were mainly seeking a diagnosis of the severity and susceptibility of COVID-19, instead of health measures, of COVID-19 in the year 2020. Conclusions: This study showed the use of HBM constructs is generally effective in inducing Twitter engagement. The further comparison illustrated a homogenization in the promotion strategies that the health departments implemented and the health measures they promoted, yet responses to such promotions varied across nations. This study broadened the scope of HBM applications from predicting health behaviors in surveys to guiding the design of health promotion messages online.
MeSH term(s)	Humans ; United States ; COVID-19/epidemiology ; COVID-19/prevention & control ; Social Media ; Health Promotion ; Health Belief Model ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1093648
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Article ; Online: Construction of an immune-related risk score signature for gastric cancer based on multi-omics data.

Wang, Ying / Huang, Wenting / Zheng, Shanshan / Wang, Liming / Zhang, Lili / Pei, Xiaojuan

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1422

Abstract: Early identification of gastric cancer (GC) is associated with a superior survival rate compared to advanced GC. However, the poor specificity and sensitivity of traditional biomarkers suggest the importance of identifying more effective biomarkers. This ...

Abstract	Early identification of gastric cancer (GC) is associated with a superior survival rate compared to advanced GC. However, the poor specificity and sensitivity of traditional biomarkers suggest the importance of identifying more effective biomarkers. This study aimed to identify novel biomarkers for the prognosis of GC and construct a risk score (RS) signature based on these biomarkers, with to validation of its predictive performance. We used multi-omics data from The Cancer Genome Atlas to analyze the significance of differences in each omics data and combined the data using Fisher's method. Hub genes were subsequently subjected to univariate Cox and LASSO regression analyses and used to construct the RS signature. The RS of each patient was calculated, and the patients were divided into two subgroups according to the RS. The RS signature was validated in two independent datasets from the Gene Expression Omnibus and subsequent analyses were subsequently conducted. Five immune-related genes strongly linked to the prognosis of GC patients were obtained, namely CGB5, SLC10A2, THPO, PDGFRB, and APOD. The results revealed significant differences in overall survival between the two subgroups (p < 0.001) and indicated the high accuracy of the RS signature. When validated in two independent datasets, the results were consistent with those in the training dataset (p = 0.003 and p = 0.001). Subsequent analyses revealed that the RS signature is independent and has broad applicability among various GC subtypes. In conclusion, we used multi-omics data to obtain five immune-related genes comprising the RS signature, which can independently and effectively predict the prognosis of GC patients with high accuracy.
MeSH term(s)	Humans ; Stomach Neoplasms/genetics ; Multiomics ; Risk Factors ; Receptor, Platelet-Derived Growth Factor beta ; Biomarkers ; Prognosis
Chemical Substances	Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1) ; Biomarkers
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52087-3
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Article: Collectivism, face concern and Chinese-style lurking among university students: the moderating role of trait mindfulness.

Hu, Bing / Zhu, Yi / Liu, Chao / Zheng, Shanshan / Zhao, Ziying / Bao, Ruxiang

Frontiers in psychology

2024 Volume 15, Page(s) 1298357

Abstract: Introduction: This study focuses on understanding the unique causes and mechanisms of "Chinese-style lurking" on WeChat among university students, within a cultural context that emphasizes collectivism and face concern. The research also looks into the ... ...

Abstract	Introduction: This study focuses on understanding the unique causes and mechanisms of "Chinese-style lurking" on WeChat among university students, within a cultural context that emphasizes collectivism and face concern. The research also looks into the moderating role of trait mindfulness. Methods: For the confirmation of these phenomena and to validate the theories, a structural equation model was constructed using the Stress-Strain-Outcome (SSO) theory and mindfulness buffering theory. The model was then tested and validated with data from 1,453 valid online surveys. These data were analyzed using the SmartPLS 4.0 software. Results: The results indicate that collectivism increases face concern, which in turn escalates online social anxiety. Face concern completely mediates between collectivism and online social anxiety, creating a serial mediation effect between face concern, online social anxiety, and lurking behavior. Additionally, trait mindfulness was found to negatively modulate the pathways from collectivism to face concern and from online social anxiety to lurking. Discussion: The findings underscore the influence of traditional Chinese culture on contemporary students' online behavior and provide a new perspective for understanding social media lurking in an Eastern context. The results suggest that a mindfulness-based approach could be used to mitigate the associated silence and anxiety.
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2024.1298357
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Article: Surgical and Conservative Treatment of Post-infarction Left Ventricular Pseudoaneurysm.

Zhong, Zhaoji / Song, Wu / Zheng, Shanshan / Liu, Sheng

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 801511

Abstract: Background: Post-infarction left ventricular (LV) pseudoaneurysm is a rare mechanical complication of myocardial infarction that carries a substantial risk of sudden rupture. The purpose of this study was to compare the surgical results of post- ... ...

Abstract	Background: Post-infarction left ventricular (LV) pseudoaneurysm is a rare mechanical complication of myocardial infarction that carries a substantial risk of sudden rupture. The purpose of this study was to compare the surgical results of post-infarction LV pseudoaneurysm with those of conservative treatment. Methods: From 2016 to 2021, 22 patients were hospitalized for LV pseudoaneurysm, including 17 cases (77.3%) caused by myocardial infarction. Of the 17 patients, 10 (58.8%) underwent surgical repair, while seven (41.2%) were treated medically. The clinical course, echocardiograph data, and surgical outcomes were analyzed. Survival rates of the surgical and conservative groups were compared. Results: There were no perioperative deaths. Intra-aortic balloon pumping support was required in two (20%) patients. No follow-up mortality was observed in the surgical group and at the last follow-up, all the patients were classified as New York Heart Association class I-II. In the conservative group, there was one (14.3%) hospital death and two (28.6%) additional deaths during follow-up. A significant difference was found in survival between the two groups ( Conclusions: Surgical repair of post-infarction LV pseudoaneurysm can be performed with good results, while conservative treatment carries a significant risk of sudden death. Surgical repair is indicated for every patient diagnosed, even those with a small pseudoaneurysm without symptoms.
Language	English
Publishing date	2022-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.801511
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Article ; Online: CircUBE3B High Expression Participates in Sevoflurane-Induced Human Hippocampal Neuron Injury via Targeting miR-326 and Regulating MYD88 Expression.

Qian, Xinye / Zheng, Shanshan / Yu, Yingfang

Neurotoxicity research

2022 Volume 41, Issue 1, Page(s) 16–28

Abstract: The clinical application of Sevoflurane (Sevo) brings about non-negligible neuron injury, leading to postoperative cognitive dysfunction (POCD). However, related pathogenesis is complex and not fully established. We aimed to disclose the role of circRNA ... ...

Abstract	The clinical application of Sevoflurane (Sevo) brings about non-negligible neuron injury, leading to postoperative cognitive dysfunction (POCD). However, related pathogenesis is complex and not fully established. We aimed to disclose the role of circRNA UBE3B (circUBE3B) in neuron injury induced by Sevo. Cell viability and apoptosis were determined by CCK-8 and flow cytometry experiments. Inflammation production was monitored by ELISA. The expression of circUBE3B, miR-326, and myeloid differentiation factor 88 (MYD88) mRNA was assessed by quantitative real-time PCR (qPCR). Apoptosis-associated markers and MYD88 protein were quantified by western blot. The putative binding site between miR-326 and circUBE3B or MYD88 was verified by a dual-luciferase reporter experiment, and their binding was validated by a pull-down assay. Sevo treatment weakened cell viability and promoted cell apoptosis and inflammatory response. CircUBE3B expression was elevated in Sevo-treated neurons. Sevo-induced neuron injury was alleviated by circUBE3B downregulation but aggravated by circUBE3B overexpression. MiR-326 was targeted by circUBE3B, and miR-326 inhibition recovered neuron injury that was repressed by circUBE3B absence in Sevo-treated neurons. MiR-326 interacted with MYD88. MiR-326 enrichment attenuated Sevo-induced neuron injury, while these effects were reversed by MYD88 overexpression. CircUBE3B dysregulation was involved in Sevo-induced human hippocampal neuron injury via targeting the miR-326/MYD88 network.
MeSH term(s)	Humans ; Sevoflurane/toxicity ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Myeloid Differentiation Factor 88/pharmacology ; MicroRNAs/metabolism ; Hippocampus ; Neurons ; Apoptosis ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Sevoflurane (38LVP0K73A) ; Myeloid Differentiation Factor 88 ; MicroRNAs ; UBE3B protein, human (EC 2.3.2.26) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; MIRN326 microRNA, human
Language	English
Publishing date	2022-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-022-00617-0
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Zs.A 5749: Show issues

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Article ; Online: Development of China Feed Nutrition Big Data Analysis Platform

XIONG Benhai / ZHAO Yiguang / LUO Qingyao / ZHENG Shanshan / GAO Huajie

智慧农业, Vol 4, Iss 2, Pp 110-

2022 Volume 120

Abstract: The shortage of feed grain is continually worsening in China, which leads to the transformation of feed grain security into national food security. Therefore, comprehensively integrating the basic data resources of feed nutrition and improving the ... ...

Abstract	The shortage of feed grain is continually worsening in China, which leads to the transformation of feed grain security into national food security. Therefore, comprehensively integrating the basic data resources of feed nutrition and improving the nutritional value of all available feed resources will be one of the key technical strategies to ensure national food security in China. In this study, based on the description specification and attribute data standard of 16 categories of Chinese feed raw materials, more than 500,000 pieces of data on the types, spatial distribution, chemical composition and nutritional value characteristics of existing feed resources, which were accumulated through previous projects from the sixth Five-Year Plan to the thirteenth Five-Year Plan period, were digitally collected, recorded, categorized and comprehensively analyzed. By using MySQL relational database technology and PHP program, a new generation of feed nutrition big data online platform (http://www.chinafeeddata.org.cn/) was developed and web data sharing service was provided as well. First of all, the online platform provided visual analysis of all warehousing data, which could realize the visual comparison of a single or multiple feed nutrients in various graphic forms such as scatter diagram, histogram, curve line and column chart. By using two-dimensional code technology, all feed nutrition attribute data and feed entity sample traceability data could be shared and downloaded remotely in real-time on mobile phones. Secondly, the online platform also incorporated various regression models for prediction of feed effective nutrient values using readily available feed chemical composition in the datasets, providing dynamic analysis for feed raw material nutrient variation. Finally, based on Geographic Information System technology, the online platform integrated the data of feed chemical composition and major mineral element concentrations with their geographical location information, which was able to provide the ...
Keywords	feed grain ; feed nutrition data ; big data ; data mining ; gis ; feed security ; Agriculture (General) ; S1-972 ; Technology (General) ; T1-995
Subject code	670
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Editorial Office of Smart Agriculture
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Optimal Diffusion Auctions

Zhang, Yao / Zheng, Shanshan / Zhao, Dengji

2023

Abstract: Diffusion auction design is a new trend in mechanism design for which the main goal is to incentivize existing buyers to invite new buyers, who are their neighbors on a social network, to join an auction even though they are competitors. With more buyers, ...

Abstract	Diffusion auction design is a new trend in mechanism design for which the main goal is to incentivize existing buyers to invite new buyers, who are their neighbors on a social network, to join an auction even though they are competitors. With more buyers, a diffusion auction will be able to give a more efficient allocation and receive higher revenue. Existing studies have proposed many interesting diffusion auctions to attract more buyers, but the seller's revenue is not optimized. Hence, in this study, we investigate what optimal revenue the seller can achieve by attracting more buyers. In traditional single-item auctions, Myerson has proposed a mechanism to achieve optimal revenue. However, in the network setting, we prove that a globally optimal mechanism for all structures does not exist. Instead, we show that given a structure, we have a mechanism to get the optimal revenue under this structure only. Since a globally optimal mechanism does not exist, our next goal is to design a mechanism that has a bounded approximation of the optimal revenue in all structures. The approximation of all the early diffusion auctions is zero, and we propose the first mechanism with a non-zero approximation.
Keywords	Computer Science - Computer Science and Game Theory
Subject code	303
Publishing date	2023-02-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advances in the research and application of neurokinin-1 receptor antagonists.

Hong, Xiangyu / Ma, Junjie / Zheng, Shanshan / Zhao, Guangyu / Fu, Caiyun

Journal of Zhejiang University. Science. B

2022 Volume 25, Issue 2, Page(s) 91–105

Abstract: Recently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have ... ...

Title translation	神经激肽1受体拮抗剂的研究与应用进展.
Abstract	Recently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK-1R system with the progression of multiple carcinoma types and poor clinical prognosis. These findings indicate that the modulation of SP/NK-1R system with NK-1R antagonists can be a potential broad-spectrum antitumor strategy. This review updates the latest potential and applications of NK-1R antagonists in the treatment of human diseases and cancers, as well as the underlying mechanisms. Furthermore, the strategies to improve the bioavailability and efficacy of NK-1R antagonist drugs are summarized, such as solid dispersion systems, nanonization, and nanoencapsulation. As a radiopharmaceutical therapeutic, the NK-1R antagonist aprepitant was originally developed as radioligand receptor to target NK-1R-overexpressing tumors. However, combining NK-1R antagonists with other drugs can produce a synergistic effect, thereby enhancing the therapeutic effect, alleviating the symptoms, and improving patients quality of life in several diseases and cancers.
MeSH term(s)	Humans ; Neurokinin-1 Receptor Antagonists/pharmacology ; Neurokinin-1 Receptor Antagonists/therapeutic use ; Quality of Life ; Substance P ; Receptors, Neurokinin-1 ; Neoplasms/drug therapy
Chemical Substances	Neurokinin-1 Receptor Antagonists ; Substance P (33507-63-0) ; Receptors, Neurokinin-1
Language	Chinese
Publishing date	2022-12-29
Publishing country	China
Document type	Review ; Journal Article
ZDB-ID	2247290-3
ISSN	1862-1783 ; 1673-1581
ISSN (online)	1862-1783
ISSN	1673-1581
DOI	10.1631/jzus.B2300455
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Article ; Online: PLA2G4A and ACHE modulate lipid profiles via glycerophospholipid metabolism in platinum-resistant gastric cancer.

Chen, Menglin / Zhang, Cancan / Li, Huaizhi / Zheng, Shanshan / Li, Yaqi / Yuan, Mengyun / Chen, Yuxuan / Wu, Jian / Sun, Qingmin

Journal of translational medicine

2024 Volume 22, Issue 1, Page(s) 249

Abstract: Background: Bioactive lipids involved in the progression of various diseases. Nevertheless, there is still a lack of biomarkers and relative regulatory targets. The lipidomic analysis of the samples from platinum-resistant in gastric cancer patients is ... ...

Abstract	Background: Bioactive lipids involved in the progression of various diseases. Nevertheless, there is still a lack of biomarkers and relative regulatory targets. The lipidomic analysis of the samples from platinum-resistant in gastric cancer patients is expected to help us further improve our understanding of it. Methods: We employed LC-MS based untargeted lipidomic analysis to search for potential candidate biomarkers for platinum resistance in GC patients. Partial least squares discriminant analysis (PLS-DA) and variable importance in projection (VIP) analysis were used to identify differential lipids. The possible molecular mechanisms and targets were obtained by metabolite set enrichment analysis and potential gene network screened. Finally, verified them by immunohistochemical of a tissue microarray. Results: There were 71 differential lipid metabolites identified in GC samples between the chemotherapy-sensitivity group and the chemotherapy resistance group. According to Foldchange (FC) value, VIP value, P values (FC > 2, VIP > 1.5, p < 0.05), a total of 15 potential biomarkers were obtained, including MGDG(43:11)-H, Cer(d18:1/24:0) + HCOO, PI(18:0/18:1)-H, PE(16:1/18:1)-H, PE(36:2) + H, PE(34:2p)-H, Cer(d18:1 + hO/24:0) + HCOO, Cer(d18:1/23:0) + HCOO, PC(34:2e) + H, SM(d34:0) + H, LPC(18:2) + HCOO, PI(18:1/22:5)-H, PG(18:1/18:1)-H, Cer(d18:1/24:0) + H and PC(35:2) + H. Furthermore, we obtained five potential key targets (PLA2G4A, PLA2G3, DGKA, ACHE, and CHKA), and a metabolite-reaction-enzyme-gene interaction network was built to reveal the biological process of how they could disorder the endogenous lipid profile of platinum resistance in GC patients through the glycerophospholipid metabolism pathway. Finally, we further identified PLA2G4A and ACHE as core targets of the process by correlation analysis and tissue microarray immunohistochemical verification. Conclusion: PLA2G4A and ACHE regulated endogenous lipid profile in the platinum resistance in GC patients through the glycerophospholipid metabolism pathway. The screening of lipid biomarkers will facilitate earlier precision medicine interventions for chemotherapy-resistant gastric cancer. The development of therapies targeting PLA2G4A and ACHE could enhance platinum chemotherapy effectiveness.
MeSH term(s)	Humans ; Biomarkers ; Discriminant Analysis ; Glycerophospholipids ; Group III Phospholipases A2 ; Group IV Phospholipases A2 ; Lipid Metabolism/genetics ; Lipids ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics
Chemical Substances	Biomarkers ; Glycerophospholipids ; Group III Phospholipases A2 (EC 3.1.1.4) ; Group IV Phospholipases A2 (EC 3.1.1.4) ; Lipids ; PLA2G3 protein, human (EC 3.1.1.4) ; PLA2G4A protein, human (EC 3.1.1.4) ; ACHE protein, human (EC 3.1.1.7)
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-05055-4
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