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  1. AU="Zheng, Si Yao"
  2. AU="Silva, Ana Filipa"
  3. AU="Takayoshi Koike"
  4. AU="Alireza Choobineh"
  5. AU="Michael J. Sadowsky"
  6. AU=Jatt Lauren P
  7. AU=Couser W G
  8. AU="Yingjie Xiao"
  9. AU="Hyunghee Lee"
  10. AU=Seif Sherif AU=Seif Sherif
  11. AU=Rajput Dinesh Vijay
  12. AU="Nilsson, Lovisa"
  13. AU="Wijns, Julie"
  14. AU="Gutiérrez Tolentino, Rey"
  15. AU="Reuss, Annette"
  16. AU=Cook Rebecca
  17. AU="Zhu, Tianhui"
  18. AU=Li Liwu
  19. AU="Akamine, Yuko"
  20. AU=Pereira Carlos
  21. AU=Roosa Kimberlyn
  22. AU=Rodrguez-Garca-de-Cortzar Ainhoa AU=Rodrguez-Garca-de-Cortzar Ainhoa
  23. AU="Eltan, Sevgi Bilgic"
  24. AU=Shibley I A Jr
  25. AU="Shin Ohta"
  26. AU="Herrera, José M."
  27. AU="Bolanle, Ogunyemi Folasade"
  28. AU="Spezialetti, Matteo"
  29. AU=Rosas Lucia E
  30. AU="Spadotto, Valeria"
  31. AU="Jimenez-Macias, Jorge L"

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  1. Artikel ; Online: Tripartite motif 2b (

    Fang, Hong / Wu, Xiao Man / Zheng, Si Yao / Chang, Ming Xian

    Journal of virology

    2024  , Seite(n) e0015824

    Abstract: Tripartite motif (TRIM) proteins are involved in different cellular functions, including regulating virus infection. In teleosts, two orthologous genes of mammalian TRIM2 are identified. However, the functions and molecular mechanisms of piscine TRIM2 ... ...

    Abstract Tripartite motif (TRIM) proteins are involved in different cellular functions, including regulating virus infection. In teleosts, two orthologous genes of mammalian TRIM2 are identified. However, the functions and molecular mechanisms of piscine TRIM2 remain unclear. Here, we show that
    Sprache Englisch
    Erscheinungsdatum 2024-05-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00158-24
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  2. Artikel ; Online: Immunoprotective Effects of Two Histone H2A Variants in the Grass Carp Against

    Yang, Yuan Yuan / Zheng, Si Yao / Fang, Hong / Wu, Xiao Man / Zhang, Jie / Chang, Ming Xian

    Frontiers in immunology

    2022  Band 13, Seite(n) 939464

    Abstract: In teleost fish, the nucleotide polymorphisms of histone H2A significantly affect the resistance or susceptibility of zebrafish ... ...

    Abstract In teleost fish, the nucleotide polymorphisms of histone H2A significantly affect the resistance or susceptibility of zebrafish to
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents ; Carps/genetics ; Disease Resistance/genetics ; Fish Diseases/genetics ; Fish Diseases/prevention & control ; Flavobacteriaceae Infections ; Flavobacterium ; Histones ; NLR Proteins ; Saccharomyces cerevisiae ; Toll-Like Receptors ; Zebrafish
    Chemische Substanzen Anti-Bacterial Agents ; Histones ; NLR Proteins ; Toll-Like Receptors
    Sprache Englisch
    Erscheinungsdatum 2022-07-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.939464
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Nucleus-Targeting Nanoplatform Based on Dendritic Peptide for Precise Photothermal Therapy.

    Wang, Wen-Song / Ma, Xiao-Yu / Zheng, Si-Yao / Chen, Si / Fan, Jin-Xuan / Liu, Fan / Yan, Guo-Ping

    Polymers

    2023  Band 15, Heft 7

    Abstract: Photothermal therapy directly acting on the nucleus is a potential anti-tumor treatment with higher killing efficiency. However, in practical applications, it is often difficult to achieve precise nuclear photothermal therapy because agents are difficult ...

    Abstract Photothermal therapy directly acting on the nucleus is a potential anti-tumor treatment with higher killing efficiency. However, in practical applications, it is often difficult to achieve precise nuclear photothermal therapy because agents are difficult to accurately anchor to the nucleus. Therefore, it is urgent to develop a nanoheater that can accurately locate the nucleus. Here, we designed an amphiphilic arginine-rich dendritic peptide (RDP) with the sequence CRRK(RRCG(Fmoc))
    Sprache Englisch
    Erscheinungsdatum 2023-03-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15071753
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Effects and Molecular Regulation Mechanisms of Salinity Stress on the Health and Disease Resistance of Grass Carp.

    Fang, Hong / Yang, Yuan Yuan / Wu, Xiao Man / Zheng, Si Yao / Song, Yun Jie / Zhang, Jie / Chang, Ming Xian

    Frontiers in immunology

    2022  Band 13, Seite(n) 917497

    Abstract: Though some freshwater fish have been successfully cultivated in saline-alkali water, the survival rates of freshwater fish are greatly affected by different saline-alkali conditions. The mechanisms of immune adaptation or immunosuppression of freshwater ...

    Abstract Though some freshwater fish have been successfully cultivated in saline-alkali water, the survival rates of freshwater fish are greatly affected by different saline-alkali conditions. The mechanisms of immune adaptation or immunosuppression of freshwater fish under different saline-alkali stress remain unclear. Here, grass carp were exposed to 3‰ and 6‰ salinity for 30 days. It was observed that salinity treatments had no obvious effects on survival rates, but significantly increased the percent of unhealthy fish. Salinity treatments also increased the susceptibility of grass carp against
    Mesh-Begriff(e) Alkalies ; Animals ; Carps ; Disease Resistance ; Fish Diseases ; Flavobacteriaceae Infections ; NLR Proteins ; Salt Stress
    Chemische Substanzen Alkalies ; NLR Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-06-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.917497
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Dual-modal polypeptide-containing contrast agents for magnetic resonance/fluorescence imaging.

    Zheng, Si-Yao / Tang, Wan-Qi / Zhang, Miao / Yan, Jia-Rui / Liu, Fan / Yan, Guo-Ping / Liang, Shu-Cai / Wang, Yu-Fang

    Bioorganic chemistry

    2022  Band 129, Seite(n) 106161

    Abstract: Dual-modal magnetic resonance/fluorescent imaging (MRI/FI) attracts moreandmoreattentions in diagnosis of tumors. A corresponding dual-modal imaging agent with sufficient tumor sensitivity and specificity should be matched to improve imaging quality. ... ...

    Abstract Dual-modal magnetic resonance/fluorescent imaging (MRI/FI) attracts moreandmoreattentions in diagnosis of tumors. A corresponding dual-modal imaging agent with sufficient tumor sensitivity and specificity should be matched to improve imaging quality. Tripeptide (RGD) and pentapeptide (YIGSR) were selected as the tumor-targeting groups and attached to gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) and rhodamine B (RhB), and then make two novel polypeptide-based derivatives (RGD-Gd-DTPA-RhB and YIGSR-Gd-DTPA-RhB), respectively. These derivatives were further characterized and their properties, such as cell uptake, cell cytotoxicity, MRI and FI assay, were measured. YIGSR-Gd-DTPA-RhB and RGD-Gd-DTPA-RhB had high relaxivity, good tumor-targeting property, low cell cytotoxicity and good red FI in B16F10 melanoma cells. Moreover, YIGSR-Gd-DTPA-RhB and RGD-Gd-DTPA-RhB possessed high uptake to B16F10 melanoma, and then achieve highly enhanced FI and MRI of tumors in mice for a prolonged time. Therefore, YIGSR-Gd-DTPA-RhB and RGD-Gd-DTPA-RhB can be applied as the potential agents for tumor targeted MRI/FI in vivo.
    Mesh-Begriff(e) Mice ; Animals ; Contrast Media/chemistry ; Gadolinium DTPA/pharmacology ; Gadolinium DTPA/chemistry ; Gadolinium/chemistry ; Magnetic Resonance Imaging/methods ; Oligopeptides/pharmacology ; Optical Imaging/methods ; Melanoma ; Magnetic Resonance Spectroscopy
    Chemische Substanzen Contrast Media ; Gadolinium DTPA (K2I13DR72L) ; Gadolinium (AU0V1LM3JT) ; Oligopeptides
    Sprache Englisch
    Erscheinungsdatum 2022-09-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2022.106161
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4207: Hefte anzeigen Standort:
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  6. Artikel: The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis

    Zhou, Jin‐Xing / Su, Xiao‐Min / Zheng, Si‐Yao / Wu, Chan‐Juan / Su, Yin‐Na / Jiang, Zhaodi / Li, Lin / Chen, She / He, Xin‐Jian

    Journal of integrative plant biology. 2022 Apr., v. 64, no. 4

    2022  

    Abstract: Although two Enhancer of Polycomb‐like proteins, EPL1A and EPL1B (EPL1A/B), are known to be conserved and characteristic subunits of the NuA4‐type histone acetyltransferase complex in Arabidopsis thaliana, the biological function of EPL1A/B and the ... ...

    Abstract Although two Enhancer of Polycomb‐like proteins, EPL1A and EPL1B (EPL1A/B), are known to be conserved and characteristic subunits of the NuA4‐type histone acetyltransferase complex in Arabidopsis thaliana, the biological function of EPL1A/B and the mechanism by which EPL1A/B function in the complex remain unknown. Here, we report that EPL1A/B are required for the histone acetyltransferase activity of the NuA4 complex on the nucleosomal histone H4 in vitro and for the enrichment of histone H4K5 acetylation at thousands of protein‐coding genes in vivo. Our results suggest that EPL1A/B are required for linking the NuA4 catalytic subunits HISTONE ACETYLTRANSFERASE OF THE MYST FAMILY 1（HAM1) and HAM2 with accessory subunits in the NuA4 complex. EPL1A/B function redundantly in regulating plant development especially in chlorophyll biosynthesis and de‐etiolation. The EPL1A/B‐dependent transcription and H4K5Ac are enriched at genes involved in chlorophyll biosynthesis and photosynthesis. We also find that EAF6, another characteristic subunit of the NuA4 complex, contributes to de‐etiolation. These results suggest that the Arabidopsis NuA4 complex components function as a whole to mediate histone acetylation and transcriptional activation specifically at light‐responsive genes and are critical for photomorphogenesis.
    Schlagwörter Arabidopsis thaliana ; acetylation ; biosynthesis ; chlorophyll ; etiolation ; histone acetyltransferase ; histones ; photomorphogenesis ; photosynthesis ; transcriptional activation
    Sprache Englisch
    Erscheinungsverlauf 2022-04
    Umfang p. 901-914.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13227
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Zebrafish nos2a benefits bacterial proliferation via suppressing ROS and inducing NO production to impair the expressions of inflammatory cytokines and antibacterial genes.

    Zheng, Si Yao / Shao, Xinbin / Qi, Zhitao / Yan, Maocang / Tao, Min Hui / Wu, Xiao Man / Zhang, Lining / Ma, Jianzhong / Li, An / Chang, Ming Xian

    Fish & shellfish immunology

    2023  Band 142, Seite(n) 109178

    Abstract: The enzyme nitric oxide synthase 2 or inducible NOS (NOS2), reactive oxygen species (ROS) and nitric oxide (NO) are important participants in various inflammatory and immune responses. However, the functional significances of the correlations among ... ...

    Abstract The enzyme nitric oxide synthase 2 or inducible NOS (NOS2), reactive oxygen species (ROS) and nitric oxide (NO) are important participants in various inflammatory and immune responses. However, the functional significances of the correlations among piscine NOS2, ROS and NO during pathogen infection remain unclear. In teleost, there are two nos2 genes (nos2a and nos2b). It has been previously reported that zebrafish nos2a behaves as a classical inducible NOS, and nos2b exerts some functions similar to mammalian NOS3. In the present study, we reported the functional characterization of zebrafish nos2a during bacterial infection. We found that zebrafish nos2a promoted bacterial proliferation, accompanied by an increased susceptibility to Edwardsiella piscicida infection. The nagative regulation of zebrafish nos2a during E. piscicida infection was characterized by the impaired ROS levels, the induced NO production and the decreased expressions of proinflammatory cytokines, antibacterial genes and oxidant factors. Furthermore, although both inducing ROS and inhibiting NO production significantly inhibited bacterial proliferation, only inhibiting NO production but not inducing ROS significantly increased resistance to E. piscicida infection. More importantly, ROS supplementation and inhibition of NO completely abolished this detrimental consequence mediated by zebrafish nos2a during E. piscicida infection. All together, these results firstly demonstrate that the innate response mediated by zebrafish nos2a in promoting bacterial proliferation is dependent on the lower ROS level and higher NO production. The present study also reveals that inhibition of NO can be effective in the protection against E. piscicida infection.
    Mesh-Begriff(e) Animals ; Cytokines ; Zebrafish ; Nitric Oxide/metabolism ; Reactive Oxygen Species/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Cell Proliferation ; Edwardsiella/physiology ; Enterobacteriaceae Infections ; Mammals/metabolism
    Chemische Substanzen Cytokines ; Nitric Oxide (31C4KY9ESH) ; Reactive Oxygen Species ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Sprache Englisch
    Erscheinungsdatum 2023-10-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2023.109178
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Dual roles of the Arabidopsis PEAT complex in histone H2A deubiquitination and H4K5 acetylation.

    Zheng, Si-Yao / Guan, Bin-Bin / Yuan, Dan-Yang / Zhao, Qiang-Qiang / Ge, Weiran / Tan, Lian-Mei / Chen, Shan-Shan / Li, Lin / Chen, She / Xu, Rui-Ming / He, Xin-Jian

    Molecular plant

    2023  Band 16, Heft 11, Seite(n) 1847–1865

    Abstract: Histone H2A monoubiquitination is associated with transcriptional repression and needs to be removed by deubiquitinases to facilitate gene transcription in eukaryotes. However, the deubiquitinase responsible for genome-wide H2A deubiquitination in plants ...

    Abstract Histone H2A monoubiquitination is associated with transcriptional repression and needs to be removed by deubiquitinases to facilitate gene transcription in eukaryotes. However, the deubiquitinase responsible for genome-wide H2A deubiquitination in plants has yet to be identified. In this study, we found that the previously identified PWWP-EPCR-ARID-TRB (PEAT) complex components interact with both the ubiquitin-specific protease UBP5 and the redundant histone acetyltransferases HAM1 and HAM2 (HAM1/2) to form a larger version of PEAT complex in Arabidopsis thaliana. UBP5 functions as an H2A deubiquitinase in a nucleosome substrate-dependent manner in vitro and mediates H2A deubiquitination at the whole-genome level in vivo. HAM1/2 are shared subunits of the PEAT complex and the conserved NuA4 histone acetyltransferase complex, and are responsible for histone H4K5 acetylation. Within the PEAT complex, the PWWP components (PWWP1, PWWP2, and PWWP3) directly interact with UBP5 and are necessary for UBP5-mediated H2A deubiquitination, while the EPCR components (EPCR1 and EPCR2) directly interact with HAM1/2 and are required for HAM1/2-mediated H4K5 acetylation. Collectively, our study not only identifies dual roles of the PEAT complex in H2A deubiquitination and H4K5 acetylation but also illustrates how these processes collaborate at the whole-genome level to regulate the transcription and development in plants.
    Mesh-Begriff(e) Histones/metabolism ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Endothelial Protein C Receptor ; Acetylation ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Deubiquitinating Enzymes ; Soil
    Chemische Substanzen Histones ; Endothelial Protein C Receptor ; Histone Acetyltransferases (EC 2.3.1.48) ; Deubiquitinating Enzymes (EC 3.4.19.12) ; Soil
    Sprache Englisch
    Erscheinungsdatum 2023-10-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2023.10.006
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  9. Artikel ; Online: The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis.

    Zhou, Jin-Xing / Su, Xiao-Min / Zheng, Si-Yao / Wu, Chan-Juan / Su, Yin-Na / Jiang, Zhaodi / Li, Lin / Chen, She / He, Xin-Jian

    Journal of integrative plant biology

    2022  Band 64, Heft 4, Seite(n) 901–914

    Abstract: Although two Enhancer of Polycomb-like proteins, EPL1A and EPL1B (EPL1A/B), are known to be conserved and characteristic subunits of the NuA4-type histone acetyltransferase complex in Arabidopsis thaliana, the biological function of EPL1A/B and the ... ...

    Abstract Although two Enhancer of Polycomb-like proteins, EPL1A and EPL1B (EPL1A/B), are known to be conserved and characteristic subunits of the NuA4-type histone acetyltransferase complex in Arabidopsis thaliana, the biological function of EPL1A/B and the mechanism by which EPL1A/B function in the complex remain unknown. Here, we report that EPL1A/B are required for the histone acetyltransferase activity of the NuA4 complex on the nucleosomal histone H4 in vitro and for the enrichment of histone H4K5 acetylation at thousands of protein-coding genes in vivo. Our results suggest that EPL1A/B are required for linking the NuA4 catalytic subunits HISTONE ACETYLTRANSFERASE OF THE MYST FAMILY 1（HAM1) and HAM2 with accessory subunits in the NuA4 complex. EPL1A/B function redundantly in regulating plant development especially in chlorophyll biosynthesis and de-etiolation. The EPL1A/B-dependent transcription and H4K5Ac are enriched at genes involved in chlorophyll biosynthesis and photosynthesis. We also find that EAF6, another characteristic subunit of the NuA4 complex, contributes to de-etiolation. These results suggest that the Arabidopsis NuA4 complex components function as a whole to mediate histone acetylation and transcriptional activation specifically at light-responsive genes and are critical for photomorphogenesis.
    Mesh-Begriff(e) Acetylation ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Chlorophyll ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Histones/metabolism ; Photosynthesis/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemische Substanzen Histones ; Saccharomyces cerevisiae Proteins ; Chlorophyll (1406-65-1) ; Histone Acetyltransferases (EC 2.3.1.48)
    Sprache Englisch
    Erscheinungsdatum 2022-02-28
    Erscheinungsland China (Republic : 1949- )
    Dokumenttyp Journal Article
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13227
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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