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  1. Article ; Online: Synthesis of a

    Song, Jian / Zheng, Wen-Hua

    Journal of the American Chemical Society

    2023  

    Abstract: Notwithstanding the common use of boronic acids in catalysis, the design and synthesis of efficient chiral boronic acids remains a formidable challenge. Herein we disclose a rational design and a concise synthesis of a series of ... ...

    Abstract Notwithstanding the common use of boronic acids in catalysis, the design and synthesis of efficient chiral boronic acids remains a formidable challenge. Herein we disclose a rational design and a concise synthesis of a series of novel
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c02331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  2. Article ; Online: Synthesis of Chiral Biphenyl Monophosphines as Ligands in Enantioselective Suzuki-Miyaura Coupling.

    Qu, Hong-Yu / Zheng, Wen-Hua

    Organic letters

    2023  Volume 25, Issue 51, Page(s) 9119–9123

    Abstract: Herein, we describe our design and synthesis of novel chiral monophosphine ligands by the short-step addition of chiral lactates as side chains to the well-known ligand SPhos/RuPhos. The new chiral ligands were shown to be highly efficient in palladium- ... ...

    Abstract Herein, we describe our design and synthesis of novel chiral monophosphine ligands by the short-step addition of chiral lactates as side chains to the well-known ligand SPhos/RuPhos. The new chiral ligands were shown to be highly efficient in palladium-catalyzed Suzuki-Miyaura coupling, providing a series of axially chiral biphenyl products in high yield and high enantioselectivity. Furthermore, the gram-scale reaction and the diverse conversions of the products demonstrated the potential utility of the approach.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c03487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A highly enantioselective approach towards optically active γ-amino alcohols by tin-catalyzed kinetic resolution of 1,3-amino alcohols.

    Song, Jian / Zheng, Wen-Hua

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 53, Page(s) 7392–7395

    Abstract: A highly enantioselective kinetic resolution of racemic 1,3-amino ... ...

    Abstract A highly enantioselective kinetic resolution of racemic 1,3-amino alcohols
    MeSH term(s) Amino Alcohols ; Catalysis ; Molecular Structure ; Stereoisomerism ; Tin
    Chemical Substances Amino Alcohols ; Tin (7440-31-5)
    Language English
    Publishing date 2022-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01963a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Kinetic Resolution of Tertiary Alcohols by Chiral Organotin-Catalyzed O-Acylation.

    Song, Jian / Zheng, Wen-Hua

    Organic letters

    2022  Volume 24, Issue 12, Page(s) 2349–2353

    Abstract: A novel highly enantioselective method for the kinetic resolution of racemic tertiary alcohols has been achieved through chiral organotin-catalyzed intermolecular acylation of the hydroxyl group. This process has demonstrated a broad substrate scope ( ... ...

    Abstract A novel highly enantioselective method for the kinetic resolution of racemic tertiary alcohols has been achieved through chiral organotin-catalyzed intermolecular acylation of the hydroxyl group. This process has demonstrated a broad substrate scope (both alkyl- and aryl-substituted tertiary alcohols) with high enantioselectivity under mild reaction conditions, affording the corresponding products and the recovered tertiary alcohols with high enantioselectivities, with
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c00537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Kinetic Resolution of Tertiary Alcohols by Chiral Organotin-Catalyzed O-Acylation

    Song, Jian / Zheng, Wen-Hua

    Organic letters. 2022 Mar. 22, v. 24, no. 12

    2022  

    Abstract: A novel highly enantioselective method for the kinetic resolution of racemic tertiary alcohols has been achieved through chiral organotin-catalyzed intermolecular acylation of the hydroxyl group. This process has demonstrated a broad substrate scope ( ... ...

    Abstract A novel highly enantioselective method for the kinetic resolution of racemic tertiary alcohols has been achieved through chiral organotin-catalyzed intermolecular acylation of the hydroxyl group. This process has demonstrated a broad substrate scope (both alkyl- and aryl-substituted tertiary alcohols) with high enantioselectivity under mild reaction conditions, affording the corresponding products and the recovered tertiary alcohols with high enantioselectivities, with s factors up to >200.
    Keywords acylation ; alcohols ; enantioselectivity ; methodology
    Language English
    Dates of publication 2022-0322
    Size p. 2349-2353.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c00537
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: A highly enantioselective approach towards optically active γ-amino alcohols by tin-catalyzed kinetic resolution of 1,3-amino alcohols

    Song, Jian / Zheng, Wen-Hua

    Chemical communications. 2022 June 30, v. 58, no. 53

    2022  

    Abstract: A highly enantioselective kinetic resolution of racemic 1,3-amino alcohols via O-Acylation was achieved using a chiral organotin as the catalyst. Alkyl- and aryl-substituted 1,3-amino alcohols were resolved with excellent efficiencies to afford the ... ...

    Abstract A highly enantioselective kinetic resolution of racemic 1,3-amino alcohols via O-Acylation was achieved using a chiral organotin as the catalyst. Alkyl- and aryl-substituted 1,3-amino alcohols were resolved with excellent efficiencies to afford the recovered 1,3-amino alcohols and acylative products with high enantioselectivities, with s factors up to >600. Notably, the chiral organotin catalyst was more selective for anti-1,3-amino alcohols than for syn-isomers. A Gram-scale reaction with loading using 2 mol% catalysts demonstrated the utility of this protocol.
    Keywords acylation ; catalysts ; enantioselectivity
    Language English
    Dates of publication 2022-0630
    Size p. 7392-7395.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01963a
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8.

    Yang, Chao / Ge, Lijun / Yu, Xiyong / Lazarovici, Philip / Zheng, Wenhua

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 8

    Abstract: Increased oxidative stress is one of the critical pathologies inducing age-related macular degeneration (AMD), characterized by retinal pigment epithelial (RPE) cell damage and death. The unbalanced acetylation and deacetylation of histones have been ... ...

    Abstract Increased oxidative stress is one of the critical pathologies inducing age-related macular degeneration (AMD), characterized by retinal pigment epithelial (RPE) cell damage and death. The unbalanced acetylation and deacetylation of histones have been implicated in AMD pathogenesis or hydrogen peroxide (H
    MeSH term(s) Humans ; Histones/metabolism ; Apoptosis/drug effects ; Acetylation/drug effects ; Hydrogen Peroxide/pharmacology ; Artemisinins/pharmacology ; Retinal Pigment Epithelium/drug effects ; Retinal Pigment Epithelium/metabolism ; Retinal Pigment Epithelium/cytology ; Lysine/metabolism ; Cell Survival/drug effects ; Oxidative Stress/drug effects ; Cell Line ; Cytoprotection/drug effects ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism
    Chemical Substances Histones ; Hydrogen Peroxide (BBX060AN9V) ; Artemisinins ; Lysine (K3Z4F929H6) ; artemisinin (9RMU91N5K2)
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29081789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article ; Online: Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases.

    Yang, Chao / Rubin, Limor / Yu, Xiyong / Lazarovici, Philip / Zheng, Wenhua

    Medicinal research reviews

    2024  Volume 44, Issue 3, Page(s) 1326–1369

    Abstract: Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is a highly conserved eukaryotic enzyme discovered as a key regulator of cellular energy homeostasis, with anti-inflammation, antioxidative stress, anticancer, and antifibrosis beneficial ... ...

    Abstract Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is a highly conserved eukaryotic enzyme discovered as a key regulator of cellular energy homeostasis, with anti-inflammation, antioxidative stress, anticancer, and antifibrosis beneficial effects. AMPK is dysregulated in human pulmonary diseases such as acute lung injury, nonsmall cell lung cancer, pulmonary fibrosis, chronic obstructive pulmonary disease, and asthma. This review provides an overview of the beneficial role of natural, synthetic, and Chinese traditional medicines AMPK modulators in pulmonary diseases, and highlights the role of the AMPK signaling pathway in the lung, emphasizing the importance of finding lead compounds and drugs that can target and modulate AMPK to treat the lung diseases.
    MeSH term(s) Humans ; AMP-Activated Protein Kinases/metabolism ; Carcinoma, Non-Small-Cell Lung ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Lung Neoplasms ; Lung Diseases/drug therapy
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Biological Products
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603210-2
    ISSN 1098-1128 ; 0198-6325
    ISSN (online) 1098-1128
    ISSN 0198-6325
    DOI 10.1002/med.22014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1764: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Synthesis and Chiroptical Properties of Planar Chiral Azahelicenes Based on [2.2]Paracyclophane.

    Xu, Dan / Zheng, Wen-Hua

    Organic letters

    2021  Volume 23, Issue 21, Page(s) 8612–8616

    Abstract: Three pairs of planar chiral heteroarenes were synthesized using palladium-catalyzed Buchwald-Hartwig coupling and hypervalent iodine-mediated oxidative cyclization from optically pure 4-amino[2.2]paracyclophane. Among them, an enantiomer of planar ... ...

    Abstract Three pairs of planar chiral heteroarenes were synthesized using palladium-catalyzed Buchwald-Hartwig coupling and hypervalent iodine-mediated oxidative cyclization from optically pure 4-amino[2.2]paracyclophane. Among them, an enantiomer of planar chiral azahelicene was found to have circularly polarized luminescence activity that was remarkably stronger than that of planar chiral heteroarenes.
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c03325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Enantioselective Construction of Tertiary α-Alkyl Fluoride via BTM-Catalyzed Fluorination of α-Alkynyl-Substituted Acetic Acids.

    Yuan, Shiru / Zheng, Wen-Hua

    The Journal of organic chemistry

    2021  Volume 87, Issue 1, Page(s) 713–720

    Abstract: The isothiourea-catalyzed enantioselective construction of tertiary α-fluoro stereogenic centers has been demonstrated by using branched alkynyl-substituted acetic acids as starting materials, providing a broad range of optically active tertiary α-alkyl ... ...

    Abstract The isothiourea-catalyzed enantioselective construction of tertiary α-fluoro stereogenic centers has been demonstrated by using branched alkynyl-substituted acetic acids as starting materials, providing a broad range of optically active tertiary α-alkyl fluorides in high enantioselectivity (up to 97%
    MeSH term(s) Acetates ; Catalysis ; Fluorides ; Halogenation ; Stereoisomerism
    Chemical Substances Acetates ; Fluorides (Q80VPU408O)
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c02710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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