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Article ; Online: Pyrvinium Pamoate Induces Cell Apoptosis and Autophagy in Colorectal Cancer.

Zheng, Wenqian / Chen, Kangke / Lv, Yiming / Lao, Weifeng / Zhu, Hongbo

2024 Volume 44, Issue 3, Page(s) 1193–1199

Abstract: Background/aim: In earlier research, we demonstrated that pyrvinium pamoate (PP) can effectively inhibit the proliferation and migration of colorectal cancer (CRC) cells. In the current study, we further explore the possibility of PP, as a potential ... ...

Abstract	Background/aim: In earlier research, we demonstrated that pyrvinium pamoate (PP) can effectively inhibit the proliferation and migration of colorectal cancer (CRC) cells. In the current study, we further explore the possibility of PP, as a potential therapeutic drug in the treatment of CRC. Materials and methods: Hoechst 33258 staining, immunofluorescence, and western blotting were used to further investigate the connection between PP and CRC cell apoptosis and autophagy. Results: We found that PP promoted apoptosis and autophagy of CRC cells. At the protein level, the expression of proteins related to the PI3K/mTOR signaling pathway exhibited a negative correlation with the dosage of PP. PP may therefore induce apoptosis and autophagy by inhibiting the PI3K/mTOR signaling pathway. Conclusion: Our in vitro experiments demonstrated that PP could inhibit the progression of colorectal cancer cells by inducing apoptosis and autophagy. The detailed mechanism needs further investigation.
MeSH term(s)	Humans ; TOR Serine-Threonine Kinases/metabolism ; Apoptosis ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Autophagy ; Cell Proliferation ; Proto-Oncogene Proteins c-akt/metabolism ; Cell Line, Tumor ; Pyrvinium Compounds
Chemical Substances	pyrvinium (6B9991FLU3) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Pyrvinium Compounds
Language	English
Publishing date	2024-02-29
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16914
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Article ; Online: Comparative genomics analysis and transposon mutagenesis provides new insights into high menaquinone-7 biosynthetic potential of Bacillus subtilis natto.

Jiang, Chunxu / Zhao, Genhai / Wang, Han / Zheng, Wenqian / Zhang, Rui / Wang, Li / Zheng, Zhiming

Gene

2024 Volume 907, Page(s) 148264

Abstract: This research combined Whole-Genome sequencing, intraspecific comparative genomics and transposon mutagenesis to investigate the menaquinone-7 (MK-7) synthesis potential in Bacillus subtilis natto. First, Whole-Genome sequencing showed that Bacillus ... ...

Abstract	This research combined Whole-Genome sequencing, intraspecific comparative genomics and transposon mutagenesis to investigate the menaquinone-7 (MK-7) synthesis potential in Bacillus subtilis natto. First, Whole-Genome sequencing showed that Bacillus subtilis natto BN-P15-11-1 contains one single circular chromosome in size of 3,982,436 bp with a GC content of 43.85 %, harboring 4,053 predicted coding genes. Next, the comparative genomics analysis among strain BN-P15-11-1 with model Bacillus subtilis 168 and four typical Bacillus subtilis natto strains proves that the closer evolutionary relationship Bacillus subtilis natto BN-P15-11-1 and Bacillus subtilis 168 both exhibit strong biosynthetic potential. To further dig for MK-7 biosynthesis latent capacity of BN-P15-11-1, we constructed a mutant library using transposons and a high throughput screening method using microplates. We obtained a YqgQ deficient high MK-7 yield strain F4 with a yield 3.02 times that of the parent strain. Experiments also showed that the high yield mutants had defects in different transcription and translation regulatory factor genes, indicating that regulatory factor defects may affect the biosynthesis and accumulation of MK-7 by altering the overall metabolic level. The findings of this study will provide more novel insights on the precise identification and rational utilization of the Bacillus subtilis subspecies for biosynthesis latent capacity.
MeSH term(s)	Bacillus subtilis/genetics ; Soy Foods ; Vitamin K 2/metabolism ; Genomics ; Mutagenesis
Chemical Substances	Vitamin K 2 (11032-49-8)
Language	English
Publishing date	2024-02-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2024.148264
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Zs.A 1357: Show issues

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Article ; Online: A WGCNA-based cancer-associated fibroblast risk signature in colorectal cancer for prognosis and immunotherapy response.

Lv, Yiming / Hu, Jinhui / Zheng, Wenqian / Shan, Lina / Bai, Bingjun / Zhu, Hongbo / Dai, Sheng

Translational cancer research

2023 Volume 12, Issue 9, Page(s) 2256–2275

Abstract: Background: Cancer-associated fibroblasts (CAFs) are notably involved in colorectal cancer (CRC) tumorigenesis, progression, and treatment failure. In this article, we report the : Methods: We separately downloaded CRC transcription data from The ... ...

Abstract	Background: Cancer-associated fibroblasts (CAFs) are notably involved in colorectal cancer (CRC) tumorigenesis, progression, and treatment failure. In this article, we report the Methods: We separately downloaded CRC transcription data from The Cancer Genome Atlas and the Gene Expression Omnibus database. Deconvolution algorithms, including Estimating the Proportions of Immune and Cancer Cells and the Microenvironment Cell Population-counter, were used to calculate CAF abundance, while the Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression algorithm was used to calculate the stromal score. Weighted gene co-expression network analysis (WGCNA) and the least absolute shrinkage and selection operator algorithm were used to identify CAF-related genes and prognostic signatures. Results: We identified a three-gene, prognostic, CAF-related signature and defined risk groups based on the Riskscores. Multidimensional validations were applied to evaluate the robustness of the signature and its correlation with clinical parameters. We utilized Tumor Immune Dysfunction and Exclusion (TIDE) and oncoPredict algorithms to predict therapy responses and found that patients in low-risk groups are more sensitive to immunotherapy and chemotherapy drugs such as 5-fluorouracil and oxaliplatin. Finally, we used the Cancer Cell Line Encyclopedia and Human Protein Atlas databases to evaluate the mRNA and protein levels encoded by the signature genes. Conclusions: This novel CAF-related three-gene signature is expected to become a potential prognostic biomarker in CRC and predict chemotherapy and immunotherapy responses. It may be of considerable value for studying the tumor microenvironment in CRC.
Language	English
Publishing date	2023-09-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-23-261
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Article ; Online: Study on Dynamic Modulus and Damping Characteristics of Modified Expanded Polystyrene Lightweight Soil under Cyclic Load.

Tao, Huaqiang / Zheng, Wenqian / Zhou, Xuhui / Zhou, Lin / Li, Cuihong / Yu, Yanfei / Jiang, Ping

Polymers

2023 Volume 15, Issue 8

Abstract: In recent years, expanded polystyrene (EPS) lightweight soil has been widely used as subgrade in soft soil areas because of its light weight and environmental protection. This study aimed to investigate the dynamic characteristics of sodium silicate ... ...

Abstract	In recent years, expanded polystyrene (EPS) lightweight soil has been widely used as subgrade in soft soil areas because of its light weight and environmental protection. This study aimed to investigate the dynamic characteristics of sodium silicate modified lime and fly ash treated EPS lightweight soil (SLS) under cyclic loading. The effects of EPS particles on the dynamic elastic modulus (
Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15081865
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Article: Overexpression of MdVQ37 reduces salt stress tolerance in Malus domestica

Dong, Qinglong / Duan, Dingyue / He, Jiale / Zheng, Wenqian / Huang, Dong / Wang, Qian / Yang, Jie / Ma, Fengwang / Mao, Ke

Scientia horticulturae. 2022 June 27, v. 300

2022

Abstract: Soil salinity is a major environmental threat to plant growth, development, and yield. Valine-glutamine (VQ) motif-containing proteins (VQ proteins) are involved in plant growth, development, and responses to abiotic and biotic stressors. However, the ... ...

Abstract	Soil salinity is a major environmental threat to plant growth, development, and yield. Valine-glutamine (VQ) motif-containing proteins (VQ proteins) are involved in plant growth, development, and responses to abiotic and biotic stressors. However, the relationship between salt stress and VQ proteins has not been studied in horticultural crops. In this study, overexpression of the apple VQ family gene MdVQ37 markedly reduced the salt stress tolerance of transgenic apple plants. Physiological and biochemical assays suggested that the growth limitation, reactive oxygen species production, reduced photosynthetic capacity, and imbalance of ion homeostasis caused by salt stress were aggravated in transgenic lines compared with wild-type (WT) plants. In addition, compared with WT plants, MdVQ37-overexpressing transgenic apple lines showed significantly lower transcript levels of genes associated with ion homeostasis and encoding stress-related transcription factors under salt stress. In summary, we propose that MdVQ37 plays a negative role in the salt stress response of apple, primarily by affecting reactive oxygen species elimination, ion homeostasis, and expression levels of stress-related transcription factors.
Keywords	Malus domestica ; apples ; genes ; homeostasis ; horticulture ; photosynthesis ; plant growth ; reactive oxygen species ; salt stress ; soil salinity ; stress response ; stress tolerance
Language	English
Dates of publication	2022-0627
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
DOI	10.1016/j.scienta.2022.111077
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Diverse molecular functions of aspartate β‑hydroxylase in cancer (Review).

Zheng, Wenqian / Wang, Xiaowei / Hu, Jinhui / Bai, Bingjun / Zhu, Hongbo

Oncology reports

2020 Volume 44, Issue 6, Page(s) 2364–2372

Abstract: Aspartate/asparagine β‑hydroxylase (AspH) is a type II transmembrane protein that catalyzes the post‑translational hydroxylation of definite aspartyl and asparaginyl residues in epidermal growth factor‑like domains of substrates. In the last few decades, ...

Abstract	Aspartate/asparagine β‑hydroxylase (AspH) is a type II transmembrane protein that catalyzes the post‑translational hydroxylation of definite aspartyl and asparaginyl residues in epidermal growth factor‑like domains of substrates. In the last few decades, accumulating evidence has indicated that AspH expression is upregulated in numerous types of human malignant cancer and is associated with poor survival and prognosis. The AspH protein aggregates on the surface of tumor cells, which contributes to inducing tumor cell migration, infiltration and metastasis. However, small‑molecule inhibitors targeting hydroxylase activity can markedly block these processes, both in vitro and in vivo. Immunization of tumor‑bearing mice with a phage vaccine fused with the AspH protein can substantially delay tumor growth and progression. Additionally, AspH antigen‑specific CD4+ and CD8+ T cells were identified in the spleen of tumor‑bearing mice. Therefore, these agents may be used as novel strategies for cancer treatment. The present review summarizes the current progress on the underlying mechanisms of AspH expression in cancer development.
MeSH term(s)	Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Calcium-Binding Proteins/antagonists & inhibitors ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/immunology ; Calcium-Binding Proteins/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Movement/immunology ; Furans/pharmacology ; Furans/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Membrane Proteins/metabolism ; Mixed Function Oxygenases/antagonists & inhibitors ; Mixed Function Oxygenases/genetics ; Mixed Function Oxygenases/immunology ; Mixed Function Oxygenases/metabolism ; Muscle Proteins/antagonists & inhibitors ; Muscle Proteins/genetics ; Muscle Proteins/immunology ; Muscle Proteins/metabolism ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/immunology ; Neoplasm Invasiveness/pathology ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/mortality ; Neoplasms/pathology ; Prognosis ; Sulfonic Acids/pharmacology ; Sulfonic Acids/therapeutic use ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Up-Regulation ; Xenograft Model Antitumor Assays
Chemical Substances	Antigens, Neoplasm ; Antineoplastic Agents ; Calcium-Binding Proteins ; Furans ; MO-I-1100 ; Membrane Proteins ; Muscle Proteins ; Sulfonic Acids ; Mixed Function Oxygenases (EC 1.-) ; ASPH protein, human (EC 1.14.11.16)
Language	English
Publishing date	2020-10-06
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2020.7792
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Article ; Online: Postoperative carcinoembryonic antigen (CEA) levels predict outcomes after resection of colorectal cancer in patients with normal preoperative CEA levels.

Zhang, Chiming / Zheng, Wenqian / Lv, Yiming / Shan, Lina / Xu, Dengyong / Pan, Yangtao / Zhu, Hongbo / Qi, Haiou

Translational cancer research

2022 Volume 9, Issue 1, Page(s) 111–118

Abstract: Background: Carcinoembryonic antigen (CEA) is a cancer biomarker used in colorectal cancer (CRC) for tumor screening and outcome prediction. However it is still lack of sensitivity and specificity in general population. The present study aimed to ... ...

Abstract	Background: Carcinoembryonic antigen (CEA) is a cancer biomarker used in colorectal cancer (CRC) for tumor screening and outcome prediction. However it is still lack of sensitivity and specificity in general population. The present study aimed to investigate the clinical significance of CEA in patients with normal preoperative CEA levels. Methods: Ninety-four patients were included who received surgery and developed an elevated CEA level postoperatively. They were divided into group A1 and A2 according to the peak CEA level (whether more than 10 ng/mL); group B1 and B2 according to CEA variation (whether reached a normal level at least once). The association between postoperative CEA and overall survival (OS), and disease-free survival (DFS) were analyzed using Kaplan-Meier method and Cox's proportional hazards regression model. Results: The median follow-up time was 38 months. Patients in Group A2 and Group B2 had greater opportunities for recurrence and metastasis (P<0.05) compared to Group A1 and Group B1. Cox regression analysis revealed that high CEA levels and consistently elevated CEA levels were significantly associated with worse OS and DFS. Furthermore, patients with p-stage II in group A2 had worse OS than patients with p-stage III in group A1. The same result was detected when comparing group B2 and B1. Conclusions: Among patients with an initially normal CEA level, postoperative CEA level and variation could be effective markers for tumor progression assessment. TNM stage, combined with CEA level might be more accurate in prognostic prediction.
Language	English
Publishing date	2022-01-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr.2019.11.27
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Article: Immune responses induced by a combined vaccination with a recombinant chimera of Mycoplasma hyopneumoniae antigens and capsid virus-like particles of porcine circovirus type 2

Tao, Yu / Yang, Rui / Shu, Jianhong / Zheng, Wenqian / Chen, Jian / Wu, Yuehong / He, Yulong

BMC veterinary research. 2020 Dec., v. 16, no. 1

2020

Abstract: BACKGROUND: Mycoplasma hyopneumoniae (Mhp) and porcine circovirus type 2 (PCV2) are two important pathogens causing Mycoplasma pneumonia of swine (MPS) and porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs), ... ...

Abstract	BACKGROUND: Mycoplasma hyopneumoniae (Mhp) and porcine circovirus type 2 (PCV2) are two important pathogens causing Mycoplasma pneumonia of swine (MPS) and porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs), respectively, and resulted in considerable economic loss to the swine industry worldwide. Currently, vaccination is one of the main measures to control these two diseases; however, there are few combination vaccines that can prevent these two diseases. To determine the effect of combination immunization, we developed capsid-derived (Cap) virus-like particles (VLPs) of PCV2 and a new recombinant chimera composed of the P97R1, P46, and P42 antigens of Mhp. Then we investigated the immune responses induced by the immunization with this combination vaccine in mice and piglets. RESULTS: The high level antibodies against three protein antigens (P97R1, P46, and P42 of Mhp) were produced after immunization, up to or higher than 1:400,000; the antibody levels in Pro group continuously increased throughout the 42 days for all the antigens tested. The lymphocyte proliferative response in PCV2 group was stronger than that in PBS, VP, Mhp CV in mice. The antibody levels for Cap remained stable and reached the peak at 35 DAI. The IFN-γ and IL-4 in sera were significantly enhanced in the Pro group than that in the negative control-VP group on Day 14 and 28 post-the first immunization in piglets. CONCLUSIONS: Above all, the combination immunization could induce humoral and cellular immune responses against all four antigens in mice and piglets. Therefore, our approach is a simple and effective vaccination strategy to protect pigs against MPS and PCVD/PCVAD.
Keywords	Mycoplasma hyopneumoniae ; Porcine circovirus ; Porcine circovirus-2 ; antibodies ; antigens ; capsid ; cell-mediated immunity ; financial economics ; immune response ; interleukin-4 ; mice ; pathogens ; piglets ; pneumonia ; pork industry ; vaccination ; vaccines ; veterinary medicine ; virus-like particles
Language	English
Dates of publication	2020-12
Size	p. 342.
Publishing place	BioMed Central
Document type	Article
Note	NAL-light
ISSN	1746-6148
DOI	10.1186/s12917-020-02560-8
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Article ; Online: Immune responses induced by a combined vaccination with a recombinant chimera of Mycoplasma hyopneumoniae antigens and capsid virus-like particles of porcine circovirus type 2.

Tao, Yu / Yang, Rui / Shu, Jianhong / Zheng, Wenqian / Chen, Jian / Wu, Yuehong / He, Yulong

BMC veterinary research

2020 Volume 16, Issue 1, Page(s) 342

Abstract: Background: Mycoplasma hyopneumoniae (Mhp) and porcine circovirus type 2 (PCV2) are two important pathogens causing Mycoplasma pneumonia of swine (MPS) and porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs), ... ...

Abstract	Background: Mycoplasma hyopneumoniae (Mhp) and porcine circovirus type 2 (PCV2) are two important pathogens causing Mycoplasma pneumonia of swine (MPS) and porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs), respectively, and resulted in considerable economic loss to the swine industry worldwide. Currently, vaccination is one of the main measures to control these two diseases; however, there are few combination vaccines that can prevent these two diseases. To determine the effect of combination immunization, we developed capsid-derived (Cap) virus-like particles (VLPs) of PCV2 and a new recombinant chimera composed of the P97R1, P46, and P42 antigens of Mhp. Then we investigated the immune responses induced by the immunization with this combination vaccine in mice and piglets. Results: The high level antibodies against three protein antigens (P97R1, P46, and P42 of Mhp) were produced after immunization, up to or higher than 1:400,000; the antibody levels in Pro group continuously increased throughout the 42 days for all the antigens tested. The lymphocyte proliferative response in PCV2 group was stronger than that in PBS, VP, Mhp CV in mice. The antibody levels for Cap remained stable and reached the peak at 35 DAI. The IFN-γ and IL-4 in sera were significantly enhanced in the Pro group than that in the negative control-VP group on Day 14 and 28 post-the first immunization in piglets. Conclusions: Above all, the combination immunization could induce humoral and cellular immune responses against all four antigens in mice and piglets. Therefore, our approach is a simple and effective vaccination strategy to protect pigs against MPS and PCVD/PCVAD.
MeSH term(s)	Animals ; Bacterial Vaccines/genetics ; Bacterial Vaccines/immunology ; Capsid Proteins/immunology ; Cell Line ; Circovirus/immunology ; Female ; Male ; Mice, Inbred BALB C ; Mycoplasma hyopneumoniae/genetics ; Mycoplasma hyopneumoniae/immunology ; Recombinant Fusion Proteins ; Swine ; Vaccines, Combined/immunology ; Viral Vaccines/genetics ; Viral Vaccines/immunology
Chemical Substances	Bacterial Vaccines ; Capsid Proteins ; Recombinant Fusion Proteins ; Vaccines, Combined ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-09-16
Publishing country	England
Document type	Journal Article
ISSN	1746-6148
ISSN (online)	1746-6148
DOI	10.1186/s12917-020-02560-8
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Article ; Online: The Impact of Social Value Orientation, Game Context and Trust on Cooperative Behavior After Cooperative Video Game Play.

Zheng, Wenqian / Cao, Shengli / Wang, Yangyang / Yang, Ke / Chen, Yunyun / Song, Guoping

Psychological reports

2020 Volume 124, Issue 3, Page(s) 1353–1369

Abstract: This study explores the effects of the cooperative video game context, social value orientation (SVO) and trust on cooperative behavior. The main ﬁnding is that collaborative game play signiﬁcantly increases cooperative behavior, especially in prosocial ... ...

Abstract	This study explores the effects of the cooperative video game context, social value orientation (SVO) and trust on cooperative behavior. The main ﬁnding is that collaborative game play signiﬁcantly increases cooperative behavior, especially in prosocial individuals. In addition, a mediation model is established in which trust partially mediates the association between the game mode and cooperative behavior. The results indicate that playing collaborative games increases cooperation in prosocial people partially by facilitating the trust they have in their gaming partners. The theoretical and practical implications of these findings are discussed.
MeSH term(s)	Adolescent ; Adult ; Cooperative Behavior ; Female ; Humans ; Male ; Social Values ; Trust ; Video Games ; Young Adult
Language	English
Publishing date	2020-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	205658-6
ISSN	1558-691X ; 0033-2941
ISSN (online)	1558-691X
ISSN	0033-2941
DOI	10.1177/0033294120934705
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