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  1. Article ; Online: Bone collision detection method for robot assisted fracture reduction based on vibration excitation.

    Cai, Chenxu / Zheng, Xuran / Shi, Mingyang / Bi, Jianping / Zhang, Qinhe

    Computer methods and programs in biomedicine

    2022  Volume 229, Page(s) 107317

    Abstract: Background and objective: In the process of robotic fracture reduction, there is a risk of unintended collision of broken bones, which is not conducive to ensuring the safety of the reduction system. In order to solve this problem, this paper proposed a ...

    Abstract Background and objective: In the process of robotic fracture reduction, there is a risk of unintended collision of broken bones, which is not conducive to ensuring the safety of the reduction system. In order to solve this problem, this paper proposed a vibration-based collision detection method for fracture reduction process.
    Methods: Based on the two degree-of-freedom vibration response model, the factors affecting the respond of the vibration, including the excitation voltage, the clamping length at the proximal and distal ends, the mass and tensile force of the soft tissue, were obtained. The effects of these factors on the vibration transfer performance of broken bones and soft tissue were investigated by single factor experiments.
    Results: The results showed that, in terms of peak value, the increase of excitation voltage would make the vibration amplitude increase linearly, and the increase of soft tissue mass and tension increased the vibration transmission capacity of soft tissue in the frequency range of 500-1000 Hz. In terms of peak frequency, the clamping length at the distal end had the greatest influence, which reached 74 Hz, followed by 45 Hz at the proximal end. While the influence of other factors was little. According to single factor experiments, the excitation frequency in the verification experiments was determined as 677 Hz. Under the vibration interference with the acceleration amplitude of 1.2 G, this method achieved correct detection.
    Conclusion: This research developed a broken bone collision detection method based on vibration excitation. The method can correctly detect the collision of broken bones with strong anti-interference ability. It is of great significance to improve the safety of fracture reduction process.
    MeSH term(s) Humans ; Vibration ; Robotics ; Bone and Bones ; Fractures, Bone ; Fracture Fixation
    Language English
    Publishing date 2022-12-17
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2022.107317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Platelet-derived microparticles and their cargos: The past, present and future.

    Guo, Jingwen / Cui, Bufeng / Zheng, Jie / Yu, Chang / Zheng, Xuran / Yi, Lixin / Zhang, Simeng / Wang, Keke

    Asian journal of pharmaceutical sciences

    2024  Volume 19, Issue 2, Page(s) 100907

    Abstract: All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Platelets form platelet-derived ... ...

    Abstract All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Platelets form platelet-derived microparticles (PMPs) in response to activation, injury, or apoptosis. This review introduces the origin, pathway, and biological functions of PMPs and their importance in physiological and pathological processes. In addition, we review the potential applications of PMPs in cancer, vascular homeostasis, thrombosis, inflammation, neural regeneration, biomarkers, and drug carriers to achieve targeted drug delivery. In addition, we comprehensively report on the origin, biological functions, and applications of PMPs. The clinical transformation, high heterogeneity, future development direction, and limitations of the current research on PMPs are also discussed in depth. Evidence has revealed that PMPs play an important role in cell-cell communication, providing clues for the development of PMPs as carriers for relevant cell-targeted drugs. The development history and prospects of PMPs and their cargos are explored in this guidebook.
    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2650931-3
    ISSN 2221-285X ; 1818-0876 ; 2221-285X
    ISSN (online) 2221-285X
    ISSN 1818-0876 ; 2221-285X
    DOI 10.1016/j.ajps.2024.100907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Upregulation of LAG3 modulates the immune imbalance of CD4+ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model.

    Li, Dewei / Ainiwaer, Abidan / Zheng, Xuran / Wang, Maolin / Shi, Yang / Rousu, Zibigu / Hou, Xinling / Kang, Xuejiao / Maimaiti, Muesier / Wang, Hui / Li, Jing / Zhang, Chuanshan

    PLoS pathogens

    2023  Volume 19, Issue 5, Page(s) e1011396

    Abstract: Infection with the cestode Echinococcus multilocularis (E. multilocularis) causes alveolar echinococcosis (AE), a tumor-like disease predominantly affecting the liver but able to spread to any organ. T cells develop functional defects during chronic E. ... ...

    Abstract Infection with the cestode Echinococcus multilocularis (E. multilocularis) causes alveolar echinococcosis (AE), a tumor-like disease predominantly affecting the liver but able to spread to any organ. T cells develop functional defects during chronic E. multilocularis infection, mostly due to upregulation of inhibitory receptors such as T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) and programmed death-1 (PD-1). However, the role of lymphocyte activation gene-3 (LAG3), an inhibitory receptor, in AE infection remains to be determined. Here, we discovered that high expression of LAG3 was mainly found in CD4+ T cells and induced regulatory T cells (iTregs) in close liver tissue (CLT) from AE patients. In a mouse model of E. multilocularis infection, LAG3 expression was predominantly found in T helper 2 (Th2) and Treg subsets, which secreted significantly more IL-4 and IL-10, resulting in host immune tolerance and disease progression at a late stage. Furthermore, LAG3 deficiency was found to drive the development of effector memory CD4+ T cells and enhance the type 1 CD4+ T-cell immune response, thus inhibiting metacestode growth in vivo. In addition, CD4+ T cells from LAG3-deficient mice produced more IFN-γ and less IL-4 when stimulated by E. multilocularis protoscoleces (EmP) antigen in vitro. Finally, adoptive transfer experiments showed that LAG3-knockout (KO) CD4+ T cells were more likely to develop into Th1 cells and less likely to develop into Tregs in recipient mice. Our work reveals that high expression of LAG3 accelerates AE disease progression by modulating the immune imbalance of CD4+ T-cell subsets. These findings may provide a novel immunotherapeutic strategy against E. multilocularis infection.
    MeSH term(s) Mice ; Animals ; CD4-Positive T-Lymphocytes ; Up-Regulation ; Interleukin-4 ; Th1 Cells ; Disease Progression
    Chemical Substances Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Echinococcus granulosus

    Hou, Xinling / Shi, Yang / Kang, Xuejiao / Rousu, Zibigu / Li, Dewei / Wang, Maolin / Ainiwaer, Abidan / Zheng, Xuran / Wang, MingKun / Jiensihan, Bahejiang / Li, Liang / Li, Jing / Wang, Hui / Zhang, Chuanshan

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 983119

    Abstract: The larval stage of the ... ...

    Abstract The larval stage of the tapeworm
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Cysts ; Disease Models, Animal ; Echinococcosis ; Echinococcus granulosus ; Humans ; Immunity, Cellular ; Liver ; Mice
    Language English
    Publishing date 2022-08-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.983119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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