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  1. Article ; Online: Copper-Catalyzed Synthesis of Quinoline-4-thiols from Diaryliodonium Salts, Alkynyl Sulfides, and Nitriles.

    Chang, Shunqin / Xing, Donghui / Zheng, Yuzhen / Huang, Liangbin

    Organic letters

    2023  Volume 25, Issue 28, Page(s) 5350–5355

    Abstract: A three-component cascade cyclization catalyzed by copper was employed to synthesize quinoline-4-thiols using easily available diaryliodonium salts, alkynyl sulfides, and nitriles as starting materials. Sulfur atoms play an important role in controlling ... ...

    Abstract A three-component cascade cyclization catalyzed by copper was employed to synthesize quinoline-4-thiols using easily available diaryliodonium salts, alkynyl sulfides, and nitriles as starting materials. Sulfur atoms play an important role in controlling the regioselectivity, by stabilizing the high-valent vinyl copper intermediate. Meanwhile, the sulfide group at position 4 of quinoline could be further utilized as a transformable group for
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c01929
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  2. Article ; Online: Analysis of cancer-associated fibroblasts related genes identifies COL11A1 associated with lung adenocarcinoma prognosis.

    Zheng, Haosheng / Tan, Jian / Qin, Fei / Zheng, Yuzhen / Yang, Xingping / Qin, Xianyu / Liao, Hongying

    BMC medical genomics

    2024  Volume 17, Issue 1, Page(s) 97

    Abstract: Background: The treatment of lung adenocarcinoma is difficult due to the limited therapeutic options. Cancer-associated fibroblasts play an important role in the development of cancers. This study aimed to identify a promising molecular target ... ...

    Abstract Background: The treatment of lung adenocarcinoma is difficult due to the limited therapeutic options. Cancer-associated fibroblasts play an important role in the development of cancers. This study aimed to identify a promising molecular target associated with cancer-associated fibroblasts for the treatment of lung adenocarcinoma.
    Methods: The Cancer Genome Atlas lung adenocarcinoma dataset was used to screen hub genes associated with cancer-associated fibroblasts via the EPIC algorithm and Weighted Gene Co-expression Network Analysis. Multiple databases were used together with our data to verify the differential expression and survival of COL11A1. Functional enrichment analysis and the single-cell TISCH database were used to elucidate the mechanisms underlying COL11A1 expression. The correlation between COL11A1 and immune checkpoint genes in human cancers was also evaluated.
    Results: Using the EPIC algorithm and Weighted Gene Co-expression Network Analysis, 13 hub genes associated with cancer-associated fibroblasts in lung adenocarcinoma were screened. Using the GEPIA database, Kaplan-Meier Plotter database, GSE72094, GSE75037, GSE32863, and our immunohistochemistry experiment data, we confirmed that COL11A1 overexpresses in lung adenocarcinoma and that high expression of COL11A1 is associated with a poor prognosis. COL11A1 has a genetic alteration frequency of 22% in patients with lung adenocarcinoma. COL11A1 is involved in the extracellular matrix activities of lung adenocarcinoma. Using the TISCH database, we found that COL11A1 is mainly expressed by cancer-associated fibroblasts in the tumor microenvironment rather than by lung adenocarcinoma cells. Finally, we found that COL11A1 is positively correlated with HAVCR2(TIM3), CD274 (PD-L1), CTLA4, and LAG3 in lung adenocarcinoma.
    Conclusion: COL11A1 may be expressed and secreted by cancer-associated fibroblasts, and a high expression of COL11A1 may result in T cell exhaustion in the tumor microenvironment of lung adenocarcinoma. COL11A1 may serve as an attractive biomarker to provide new insights into cancer therapeutics.
    MeSH term(s) Humans ; Collagen Type XI/genetics ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Prognosis ; Gene Expression Regulation, Neoplastic ; Biomarkers, Tumor/genetics ; Databases, Genetic ; Gene Regulatory Networks ; Tumor Microenvironment/genetics ; Gene Expression Profiling
    Chemical Substances COL11A1 protein, human ; Collagen Type XI ; Biomarkers, Tumor
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411865-5
    ISSN 1755-8794 ; 1755-8794
    ISSN (online) 1755-8794
    ISSN 1755-8794
    DOI 10.1186/s12920-024-01863-1
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  3. Article: Concentration-dependent chloride effect on radical distribution and micropollutant degradation in the sulfate radical-based AOPs

    Sun, Bo / Zheng, Yuzhen / Shang, Chii / Yin, Ran

    Journal of hazardous materials. 2022 May 15, v. 430

    2022  

    Abstract: This study quantitatively evaluated the effect of chloride (Cl⁻) on the radical distribution and micropollutant degradation in the UV/peroxydisulfate AOP using both experimental and modeling approaches. Results showed that SO₄•⁻ was significantly ... ...

    Abstract This study quantitatively evaluated the effect of chloride (Cl⁻) on the radical distribution and micropollutant degradation in the UV/peroxydisulfate AOP using both experimental and modeling approaches. Results showed that SO₄•⁻ was significantly scavenged by Cl⁻ at environmentally relevant concentrations (1–5000 mg/L). With increasing Cl⁻ concentrations from 1 to 5000 mg/L, Cl⁻ transformed SO₄•⁻ to HO• and then to Cl₂•⁻. The critical role of Cl₂•⁻ as a precursor of HO• in the radical transformation was highlighted. The inhibitory effects of bicarbonate and dissolved organic matter (DOM) on micropollutant degradation was more significant in the presence of Cl⁻ than that in the absence of Cl⁻, mainly due to the consumption of Cl₂•⁻ by bicarbonate and DOM. Using the model-predicted radical concentrations in the UV/peroxydisulfate process in the presence of different concentrations of Cl⁻, the degradation rate constants of 34 micropollutants and the contributions of each radical to the degradation were predicted and compared. The findings improved the fundamental understanding of the Cl⁻ effect on radical transformation and micropollutant degradation in the SO₄•⁻-based AOPs. The model enables to foresee whether a SO₄•⁻-based AOP is effective for the degradation of a certain micropollutant in the water with known concentrations of Cl⁻.
    Keywords bicarbonates ; chlorides ; models ; pollutants ; sulfates
    Language English
    Dates of publication 2022-0515
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.128450
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  4. Article ; Online: Concentration-dependent chloride effect on radical distribution and micropollutant degradation in the sulfate radical-based AOPs.

    Sun, Bo / Zheng, Yuzhen / Shang, Chii / Yin, Ran

    Journal of hazardous materials

    2022  Volume 430, Page(s) 128450

    Abstract: This study quantitatively evaluated the effect of chloride ( ... ...

    Abstract This study quantitatively evaluated the effect of chloride (Cl
    MeSH term(s) Chlorides ; Chlorine ; Hydrogen Peroxide ; Kinetics ; Oxidation-Reduction ; Sulfates ; Ultraviolet Rays ; Water Pollutants, Chemical/analysis ; Water Purification/methods
    Chemical Substances Chlorides ; Sulfates ; Water Pollutants, Chemical ; sulfate radical ; Chlorine (4R7X1O2820) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2022-02-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.128450
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  5. Article: Addition of bevacizumab to EGFR tyrosine kinase inhibitors in advanced NSCLC: an updated systematic review and meta-analysis.

    Zheng, Haosheng / Qin, Xianyu / Zheng, Yuzhen / Yang, Xingping / Tan, Jian / Cai, Weijie / He, Shiyun / Liao, Hongying

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1238579

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1238579
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  6. Article ; Online: Fabrication of Al/AlO

    Zheng, Yuzhen / Li, Shuming / Ding, Zengqian / Xiong, Kanglin / Feng, Jiagui / Yang, Hui

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11874

    Abstract: Tantalum and aluminum on sapphire are widely used platforms for qubits of long coherent time. As quantum chips scale up, the number of Josephson junctions on sapphire increases. Thus, both the uniformity and stability of the junctions are crucial to ... ...

    Abstract Tantalum and aluminum on sapphire are widely used platforms for qubits of long coherent time. As quantum chips scale up, the number of Josephson junctions on sapphire increases. Thus, both the uniformity and stability of the junctions are crucial to quantum devices, such as scalable superconducting quantum computer circuit, and quantum-limited amplifiers. By optimizing the fabrication process, especially, the conductive layer during the electron beam lithography process, Al/AlO
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-39052-2
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  7. Article: Correction: Zheng et al. Glycolysis-Related SLC2A1 Is a Potential Pan-Cancer Biomarker for Prognosis and Immunotherapy.

    Zheng, Haosheng / Long, Guojie / Zheng, Yuzhen / Yang, Xingping / Cai, Weijie / He, Shiyun / Qin, Xianyu / Liao, Hongying

    Cancers

    2023  Volume 15, Issue 3

    Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

    Abstract The authors wish to make the following corrections to this paper [...].
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030586
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  8. Article: SH3BGRL Suppresses Liver Tumor Progression through Enhanced ATG5-Dependent Autophagy.

    Saleh, Abdulmomen Ali Mohammed / Haider, Farhan / Lv, Haimei / Liu, Bin / Xiao, Jing / Zhang, Mingming / Zheng, Yuzhen / Yang, Shulan / Wang, Haihe

    Journal of oncology

    2023  Volume 2023, Page(s) 1105042

    Abstract: SH3BGRL, an adaptor protein, is upregulated in breast cancers and indicates its tumorigenic role. But the function of SH3BGRL in other types of cancers is largely unknown. Here, we modulate SH3BGRL expression level in two liver cancer cells and conduct ... ...

    Abstract SH3BGRL, an adaptor protein, is upregulated in breast cancers and indicates its tumorigenic role. But the function of SH3BGRL in other types of cancers is largely unknown. Here, we modulate SH3BGRL expression level in two liver cancer cells and conduct both in vitro and in vivo analyses of SH3BGRL in cell proliferation and tumorigenesis. Results demonstrate that SH3BGRL notably inhibits cell proliferation and arrests the cell cycle in both LO2 and HepG2 cells. Molecularly, SH3BGRL upregulates the expression of ATG5 from proteasome degradation as well as the inhibitions of Src activation and its downstream ERK and AKT signaling pathways, which eventually enhance autophagic cell death. The xenograft mouse model reveals that SH3BGRL overexpression can efficiently suppress tumorigenesis in vivo, while the additional silencing ATG5 in SH3BGRL-overexpressing cells attenuates the inhibitory effect of SH3BGRL on both hepatic tumor cell proliferation and tumorigenicity in vivo. The relevance of SH3BGRL downregulation in liver cancers and their progression is validated based on the large-scale tumor data. Taken together, our results clarify the suppressive role of SH3BGRL in tumorigenesis of liver cancer, which would be of help to the diagnosis of liver cancer, while either promoting the autophagy of liver cancer cells or inhibiting the downstream signaling induced from SH3BGRL downregulation would be a promising therapy.
    Language English
    Publishing date 2023-04-24
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2461349-6
    ISSN 1687-8469 ; 1687-8450
    ISSN (online) 1687-8469
    ISSN 1687-8450
    DOI 10.1155/2023/1105042
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  9. Article: Curcumin suppresses the stemness of non‐small cell lung cancer cells via promoting the nuclear‐cytoplasm translocation of TAZ

    Zheng, Yuzhen / Yang, Xingping / Tan, Jian / Tian, Renjiang / Shen, Piao / Cai, Weijie / Liao, Hongying

    Environmental toxicology. 2021 June, v. 36, no. 6

    2021  

    Abstract: Curcumin has been shown to suppress the progression of lung cancer, however, the underlying mechanisms are largely unknown. Here, we aimed to investigate the effects of curcumin on the stemness of non‐small cell lung cancer (NSCLC) cells. We found that ... ...

    Abstract Curcumin has been shown to suppress the progression of lung cancer, however, the underlying mechanisms are largely unknown. Here, we aimed to investigate the effects of curcumin on the stemness of non‐small cell lung cancer (NSCLC) cells. We found that curcumin reduced the sphere formation ability at the concentrations without affecting the cell viability of NSCLC cells and normal pulmonary epithelial cells, which is evident by the decrease of sphere size and number. In addition, curcumin decreased ALDH activity and the expression of stemness markers (CD133, EpCAM, Oct4). RNA sequencing analysis revealed that the Hippo pathway was mostly enriched in cells with curcumin treatment. Indeed, the expression of cancer stem cell markers was significantly decreased by curcumin treatment by analyzing the RNA sequencing data. Gene set enrichment analysis (GSEA) showed that curcumin negatively regulated the cancer stem cell function and positively modulated cancer stem cell differentiation ability. Furthermore, curcumin enhanced the cisplatin sensitivity of NSCLC cells. Mechanistically, it was found that curcumin promoted the nuclear‐cytoplasm translocation of TAZ, but not YAP, the critical effectors of Hippo pathway. In addition, curcumin destabilzed TAZ protein stability and promoted TAZ protein degradation in lung cancer cells, which is dependent on the proteasome degradation system, not by autophagy lysosome degradation system. Overexpression of TAZ rescued the inhibition of curcumin on the stemness of lung cancer cells. Thus, our results suggest that curcumin can attenuate the stemness of lung cancer cells through promoting TAZ protein degradation and thus activating Hippo pathway.
    Keywords RNA ; autophagy ; cell differentiation ; cell viability ; cisplatin ; curcumin ; ecotoxicology ; epithelium ; genes ; lung neoplasms ; lysosomes ; proteasome endopeptidase complex ; protein degradation ; stem cells
    Language English
    Dates of publication 2021-06
    Size p. 1135-1142.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note NAL-AP-2-clean ; JOURNAL ARTICLE
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23112
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  10. Article: Micropollutant abatement by the UV/chloramine process in potable water reuse: A review

    Cao, Zhenfeng / Yu, Ximing / Zheng, Yuzhen / Aghdam, Ehsan / Sun, Bo / Song, Mingming / Wang, Aijie / Han, Jinglong / Zhang, Jian

    Journal of hazardous materials. 2022 Feb. 15, v. 424

    2022  

    Abstract: The need in using reclaimed water increased significantly to address the water shortage and its continuing quality deterioration in sustaining societal development. Degrading micropollutants in wastewater treatment plant effluents is one of the most ... ...

    Abstract The need in using reclaimed water increased significantly to address the water shortage and its continuing quality deterioration in sustaining societal development. Degrading micropollutants in wastewater treatment plant effluents is one of the most important tasks in supplying safe drinking water, which is often achieved by full advanced treatment technologies (FATs), including reverse osmosis (RO) and the UV-based advanced oxidation process (AOP). As an emerging AOP, UV/chloramine process shows many noteworthy advantages in the scenario of potable water reuse, including membrane biological fouling control by chloramine, producing highly reactive radicals (e.g., Cl•, HO•, Cl₂•–, and reactive nitrogen-containing species) to degrade the RO permeated pollutants, and acting as long-lasting disinfectant in the potable water distribution system. In addition, chloramine is often designedly produced by taking advantage of the ammonia in source. Thus, UV/chloramine processes gather much attention from researcher and published papers on UV/chloramine process have drastically increased since 2016, which were thoroughly reviewed in this paper. The fundamentals of chloramine photolysis, including the photolysis kinetics, the quantum yield, the generation and transformation of radicals and the final products, were scrutinized. Further, the impacts of reaction conditions such as pH, chloramine dosage and water matrix on the degradation of micropollutants by the UV/chloramine process are discussed. Moreover, the formation potential of disinfection by-products is debated. The opportunity of application of the UV/chloramine process in real-world practice is also presented, emphasizing the need for extensive efforts to remove currently prevalent knowledge roadblocks.
    Keywords ammonia ; disinfectants ; disinfection ; drinking water ; oxidation ; pH ; photolysis ; researchers ; reverse osmosis ; wastewater treatment ; water distribution ; water reuse ; water shortages
    Language English
    Dates of publication 2022-0215
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2021.127341
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