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  1. Book ; Online ; E-Book: Treatment-Resistant Depression

    Li, Cheng-Ta / Zheng, Zhiming

    (Issn Series)

    2023  

    Author's details Cheng-Ta Li and Chih-Ming Cheng
    Series title Issn Series
    Keywords Depression, Mental/Treatment
    Subject code 616.852706
    Language English
    Size 1 online resource (190 pages)
    Edition First edition.
    Publisher Zoe Kruze
    Publishing place Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-95778-1 ; 0-323-95779-X ; 978-0-323-95778-6 ; 978-0-323-95779-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online ; E-Book: Treatment-Resistant Depression Part B

    Zheng, Zhiming / Li, Cheng-Ta

    2023  

    Author's details Chih-Ming Cheng and Cheng-Ta Li
    Keywords Depression/Mental Treatment
    Subject code 733
    Language English
    Size 1 online resource (190 pages)
    Edition First edition.
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-22395-5 ; 0-443-22394-7 ; 978-0-443-22395-2 ; 978-0-443-22394-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: RNA therapy is shining for genetic diseases.

    Zheng, Zhi-Ming

    Molecular therapy. Nucleic acids

    2023  Volume 34, Page(s) 102042

    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type News
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.102042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Oncogenic SRSF3 in health and diseases.

    Jia, Rong / Zheng, Zhi-Ming

    International journal of biological sciences

    2023  Volume 19, Issue 10, Page(s) 3057–3076

    Abstract: Serine/arginine rich splicing factor 3 (SRSF3) is an important multi-functional splicing factor, and has attracted increasing attentions in the past thirty years. The importance of SRSF3 is evidenced by its impressively conserved protein sequences in all ...

    Abstract Serine/arginine rich splicing factor 3 (SRSF3) is an important multi-functional splicing factor, and has attracted increasing attentions in the past thirty years. The importance of SRSF3 is evidenced by its impressively conserved protein sequences in all animals and alternative exon 4 which represents an autoregulatory mechanism to maintain its proper cellular expression level. New functions of SRSF3 have been continuously discovered recently, especially its oncogenic function. SRSF3 plays essential roles in many cellular processes by regulating almost all aspects of RNA biogenesis and processing of many target genes, and thus, contributes to tumorigenesis when overexpressed or disregulated. This review updates and highlights the gene, mRNA, and protein structure of SRSF3, the regulatory mechanisms of SRSF3 expression, and the characteristics of SRSF3 targets and binding sequences that contribute to SRSF3's diverse molecular and cellular functions in tumorigenesis and human diseases.
    MeSH term(s) Animals ; Humans ; Cell Line, Tumor ; Exons ; RNA Splicing Factors/metabolism ; Carcinogenesis/genetics ; Serine-Arginine Splicing Factors/genetics ; Serine-Arginine Splicing Factors/metabolism ; Alternative Splicing/genetics
    Chemical Substances RNA Splicing Factors ; Serine-Arginine Splicing Factors (170974-22-8) ; SRSF3 protein, human
    Language English
    Publishing date 2023-06-12
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.83368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: RNA Granules in Antiviral Innate Immunity: A Kaposi's Sarcoma-Associated Herpesvirus Journey.

    Sharma, Nishi R / Zheng, Zhi-Ming

    Frontiers in microbiology

    2022  Volume 12, Page(s) 794431

    Abstract: RNA granules are cytoplasmic, non-membranous ribonucleoprotein compartments that form ubiquitously and are often referred to as foci for post-transcriptional gene regulation. Recent research on RNA processing bodies (PB) and stress granules (SG) has ... ...

    Abstract RNA granules are cytoplasmic, non-membranous ribonucleoprotein compartments that form ubiquitously and are often referred to as foci for post-transcriptional gene regulation. Recent research on RNA processing bodies (PB) and stress granules (SG) has shown wide implications of these cytoplasmic RNA granules and their components in suppression of RNA translation as host intracellular innate immunity against infecting viruses. Many RNA viruses either counteract or co-opt these RNA granules; however, many fundamental questions about DNA viruses with respect to their interaction with these two RNA granules remain elusive. Kaposi's sarcoma-associated herpesvirus (KSHV), a tumor-causing DNA virus, exhibits two distinct phases of infection and encodes ∼90 viral gene products during the lytic phase of infection compared to only a few (∼5) during the latent phase. Thus, productive KSHV infection relies heavily on the host cell translational machinery, which often links to the formation of PB and SG. One major question is how KSHV counteracts the hostile environment of RNA granules for its productive infection. Recent studies demonstrated that KSHV copes with the translational suppression by cellular RNA granules, PB and SG, by expressing ORF57, a viral RNA-binding protein, during KSHV lytic infection. ORF57 interacts with Ago2 and GW182, two major components of PB, and prevents the scaffolding activity of GW182 at the initial stage of PB formation in the infected cells. ORF57 also interacts with protein kinase R (PKR) and PKR-activating protein (PACT) to block PKR dimerization and kinase activation, and thus inhibits eIF2α phosphorylation and SG formation. The homologous immediate-early regulatory protein ICP27 of herpes simplex virus type 1 (HSV-1), but not the EB2 protein of Epstein-Barr virus (EBV), shares this conserved inhibitory function with KSHV ORF57 on PB and SG. Through KSHV ORF57 studies, we have learned much about how a DNA virus in the infected cells is equipped to evade host antiviral immunity for its replication and productive infection. KSHV ORF57 would be an excellent viral target for development of anti-KSHV-specific therapy.
    Language English
    Publishing date 2022-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.794431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Linking a nuclear lncRNA to cytoplasmic lysosome integrity and cell death.

    Liu, Haibin / Zheng, Zhi-Ming

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 8

    MeSH term(s) Cell Death ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Lysosomes/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-02-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2123082119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Human Papillomavirus Type 16 Circular RNA Is Barely Detectable for the Claimed Biological Activity.

    Yu, Lulu / Zheng, Zhi-Ming

    mBio

    2022  Volume 13, Issue 1, Page(s) e0359421

    Abstract: Human papillomavirus type 16 (HPV16) E7 oncoprotein plays an essential role in cervical carcinogenesis and is encoded predominantly by an E6*I mRNA through alternative RNA splicing of a P97 promoter-transcribed bicistronic E6E7 pre-mRNA. Recently, an ... ...

    Abstract Human papillomavirus type 16 (HPV16) E7 oncoprotein plays an essential role in cervical carcinogenesis and is encoded predominantly by an E6*I mRNA through alternative RNA splicing of a P97 promoter-transcribed bicistronic E6E7 pre-mRNA. Recently, an HPV16 circular RNA, circE7, was detected in two HPV16-positive cervical cancer cell lines, CaSki and SiHa. It was generated through back-splicing of the E6E7 pre-mRNA. The reported findings showed that, because viral E6*I RNA was nuclear, E7 was mainly translated from the cytoplasmic circE7, and knockdown of circE7 in CaSki cells led to reduction of E7 oncoprotein, cell proliferation, and xenograft tumor formation. We have reanalyzed the published data, conducted detailed experiments, and found that the circE7 in CaSki cells is only 0.4 copies per cell, which is ∼1,640-fold lower than E6*I RNA and also barely detectable from two W12 subclone cell lines, 20861 (integrated HPV16) and 20863 (extrachromosomal HPV16) cells derived from a low-grade cervical lesion. We also determined HPV16 E6*I and E6*II RNAs in CaSki cells are mainly cytoplasmic in cell fractionation analyses, as reported in other studies. We further demonstrated that the claimed circE7 functions in the published report have resulted from off-target effects on E6*I RNA by the circE7 small interfering RNAs used in the reported study.
    MeSH term(s) Female ; Humans ; RNA, Circular/metabolism ; Oncogene Proteins, Viral/genetics ; Human papillomavirus 16/genetics ; Human Papillomavirus Viruses ; Uterine Cervical Neoplasms/genetics ; RNA Precursors/metabolism ; Repressor Proteins/genetics ; Papillomavirus E7 Proteins/genetics ; RNA, Small Interfering/genetics ; Cell Line, Tumor
    Chemical Substances RNA, Circular ; Oncogene Proteins, Viral ; RNA Precursors ; Repressor Proteins ; Papillomavirus E7 Proteins ; RNA, Small Interfering
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03594-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Correction to: Circular RNAs and RNase L in PKR activation and virus infection.

    Zheng, Zhi-Ming

    Cell & bioscience

    2019  Volume 9, Page(s) 58

    Abstract: This corrects the article DOI: 10.1186/s13578-019-0307-x.]. ...

    Abstract [This corrects the article DOI: 10.1186/s13578-019-0307-x.].
    Language English
    Publishing date 2019-07-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-019-0320-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Circular RNAs and RNase L in PKR activation and virus infection.

    Zheng, Zhi-Ming

    Cell & bioscience

    2019  Volume 9, Page(s) 43

    Abstract: Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and ... ...

    Abstract Circular RNAs (circRNAs) from back-splicing have been found in every cell and tissue. By binding to miRNAs and proteins or even by encoding small proteins, circRNAs are now emerging as important regulators in modulating transcription, RNA splicing and interference. The highlighted discovery reports an important role of circRNAs in antiviral innate immunity by binding PKR as PKR inhibitors. Rapid degradation of circRNAs by activated RNase L from virus infection or poly I:C stimulation is required to free PKR for its activation. Systemic lupus erythematosus patients remark with circRNA reduction and aberrant PKR activation.
    Language English
    Publishing date 2019-05-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-019-0307-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The nonlinear energy model and stress-strain model of sandstone.

    Zheng, Zhiming / Yang, Yu / Pan, Cheng

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 8456

    Abstract: The relationship between strain and elastic energy is simplified by introducing a stress state parameter based on the generalised Hooke's law. It is assumed that the micro-element strengths satisfy the Weibull distribution and a new model for the non- ... ...

    Abstract The relationship between strain and elastic energy is simplified by introducing a stress state parameter based on the generalised Hooke's law. It is assumed that the micro-element strengths satisfy the Weibull distribution and a new model for the non-linear evolution of energy is developed by introducing the concept of rock micro-element strengths. A sensitivity analysis of the model parameters is carried out on this basis. The results show that the model agrees well with the experimental data. The model is close to the deformation and damage laws of the rock and is able to reflect the relationship between the elastic energy and strain of the rock. By comparing with other model curves, the model of this paper is more suitable for the experimental curve. They show that the improved model could better describe the stress-strain relationship of rock. Finally, according to the analysis of the influence of the distribution parameter on the variation pattern of the elastic energy of the rock, the magnitude of the distribution parameter can directly reflect the peak energy of the rock.
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35145-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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