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  1. Article ; Online: Photoelectrochemical properties of self-powered corundum-structured Ga

    Zheng, Zhi-Yuan / Fan, Ming-Ming

    Nanotechnology

    2024  

    Abstract: Herein, corundum-structured ... ...

    Abstract Herein, corundum-structured Ga
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad470e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Design and Implementation of a SiC-Based Multifunctional Back-to-Back Three-Phase Inverter for Advanced Microgrid Operation.

    Ma, Chao-Tsung / Zheng, Zhi-Yuan

    Micromachines

    2023  Volume 14, Issue 1

    Abstract: Because of the worldwide trend of microgrid (MG) and renewable energy (RE)-based distributed power generation (DG), advanced power flow control schemes with wide bandgap (WBG) semiconductor technologies to ensure high-level performance of grid-connected ... ...

    Abstract Because of the worldwide trend of microgrid (MG) and renewable energy (RE)-based distributed power generation (DG), advanced power flow control schemes with wide bandgap (WBG) semiconductor technologies to ensure high-level performance of grid-connected MGs is one of the crucial research topics. In grid-connected MGs, a static switch (SS) is commonly used at the point of common coupling (PCC) of two systems. In this paper, the role of SS is replaced by a SiC-based three-phase back-to-back (BTB) inverter system for seamless switching between grid-connected and standalone modes through advanced power flow control schemes. According to scenarios of different grid/load conditions and available DG capacities in an MG, various advanced control functions can be developed for both MG operating modes: bidirectional control of active and reactive power flows, seamless switching between operating modes, improvement of grid power quality (PQ), and voltage stabilization. In this paper, mathematical models of the BTB inverter in a synchronous reference frame (SRF) is first derived, and the required controllers are then designed. For functional testing, two typical cases are simulated and analyzed in a MATLAB/Simulink environment and then verified through 1kVA small-scale hardware implementation with Texas Instruments (TI) digital signal processor (DSP) TMS320LF2812 as the control core. Results show satisfactory performances of power flow control and PQ improvement of MG.
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14010134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protection of neutrophils by bone marrow mesenchymal stromal cells is enhanced by tumor-associated inflammatory cytokines.

    Liang, Yingqi / Lou, Xiulan / Xu, Yazhang / Zheng, Zhiyuan

    Frontiers in immunology

    2024  Volume 15, Page(s) 1361596

    Abstract: Mesenchymal stromal/stem cells (MSCs), which are distributed in many tissues including bone marrow, have been reported to play a critical role in tumor development. While bone marrow, the primary site for hematopoiesis, is important for establishing the ... ...

    Abstract Mesenchymal stromal/stem cells (MSCs), which are distributed in many tissues including bone marrow, have been reported to play a critical role in tumor development. While bone marrow, the primary site for hematopoiesis, is important for establishing the immune system, whether MSCs in the bone marrow can promote tumor growth via influencing hematopoiesis remains unclear. We observed that the numbers of MSCs and neutrophils were increased in bone marrow in tumor-bearing mice. Moreover, co-culture assay showed that MSCs strongly protected neutrophils from apoptosis and induced their maturation. G-CSF and GM-CSF have been well-documented to be associated with neutrophil formation. We found a remarkably increased level of G-CSF, but not GM-CSF, in the supernatant of MSCs and the serum of tumor-bearing mice. The G-CSF expression can be enhanced with inflammatory cytokines (IFNγ and TNFα) stimulation. Furthermore, we found that IFNγ and TNFα-treated MSCs enhanced their capability of promoting neutrophil survival and maturation. Our results indicate that MSCs display robustly protective effects on neutrophils to contribute to tumor growth in bone niches.
    MeSH term(s) Animals ; Mesenchymal Stem Cells/immunology ; Mesenchymal Stem Cells/metabolism ; Neutrophils/immunology ; Neutrophils/metabolism ; Mice ; Cytokines/metabolism ; Mice, Inbred C57BL ; Coculture Techniques ; Granulocyte Colony-Stimulating Factor/metabolism ; Apoptosis ; Tumor Necrosis Factor-alpha/metabolism ; Cell Line, Tumor ; Neoplasms/immunology ; Neoplasms/pathology
    Chemical Substances Cytokines ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1361596
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  4. Article ; Online: Overexpression of IL22 by adeno-associated virus effectively ameliorates dextran sulfate sodium-induced colitis in mice

    WU Tianyu / SONG Yalan / WU Jingfeng / ZHENG Zhiyuan

    陆军军医大学学报, Vol 45, Iss 19, Pp 1995-

    2023  Volume 2006

    Abstract: Objective To investigate the effects of interleukin22 (IL22) in acute colitis induced by dextran sulfate sodium salt (DSS) in mice and its underlying mechanism. Methods Three IL22 knockout mice (IL22-/-) and 3 control mice (IL22+/+) of 8-week-old males ... ...

    Abstract Objective To investigate the effects of interleukin22 (IL22) in acute colitis induced by dextran sulfate sodium salt (DSS) in mice and its underlying mechanism. Methods Three IL22 knockout mice (IL22-/-) and 3 control mice (IL22+/+) of 8-week-old males were subjected from the same litter, and then had free-choice drinking of 2.5% DSS water for 6 d followed by normal water for 2 d to construct a mouse model of acute colitis. The changes in body mass weight and disease activity index (DAI) were measured and calculated. After the intervention of 8 d, mouse enteroscopy was performed, and the length of colon and the organ index of major immune organs were measured in both groups. Protein levels of pro-inflammatory cytokines, such as IL1α, IL1β, IL6 and TNFα were detected by Western blotting. Adeno-associated virus (AAV) transfection model was established in 8-week-old male C57BL/6 mice, which were then treated by 2.5%DSS drinking. The mice were randomly divided into PBS group (n=5), AAV-mock+DSS group (n=5) and AAV-IL22+DSS group (n=5). The expression levels of colonic closed small loop protein 1 (ZO-1) and calcium adhesion protein (E-claudin) in different groups were detected by immunofluorescence assay. The protein levels of IL22, Occludin, Stat3 and p-Stat3 were detected by Western blotting. Results Compared with the IL22+/+ group, the mice in the IL22-/- group had significantly decreased body weight on day 8 (P<0.05), obviously increased DAI score (P<0.01), endoscopy score (P<0.05) and pathological score (P<0.01) after DSS induction, and notable up-regulation of pro-inflammatory cytokines including IL1α, IL1β, cleaved-IL1β, IL6, and TNFα in the colon tissues (P<0.05). While AAV-IL22 transfection reversed DSS-induced colitis. Significantly reduced inflammation in colonic tissues (P<0.05), enhanced E-claudin expression (P<0.05) and up-regulation of p-Stat3 and Occludin (P<0.01) were observed in the AAV-IL22+DSS group than the AAV-mock+DSS group. Conclusion IL22 deficiency aggravates ...
    Keywords il22 ; adeno-associated virus ; inflammatory bowel disease ; dextran sulfate sodium ; jak/stat3 pathway ; Medicine (General) ; R5-920
    Subject code 570
    Language Chinese
    Publishing date 2023-10-01T00:00:00Z
    Publisher Editorial Office of Journal of Army Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Effects of Acupuncture Combined with Yi Qi Yang Yin and Blood Activating Formula on Blood Glucose and Renal Function in Early Diabetic Nephropathy: A Randomized Controlled Trial.

    Tang, Yange / Yang, Jiaxiang / Wang, Jing / Wu, Jie / Zheng, Zhiyuan / Gu, Mengjin

    Alternative therapies in health and medicine

    2024  

    Abstract: Objective: To study the effects of acupuncture combined with the formula of Yi Qi Yang Yin and blood activating (A-YBF) on blood glucose levels and renal function in patients with early diabetic nephropathy.: Methods: 96 patients with early diabetic ... ...

    Abstract Objective: To study the effects of acupuncture combined with the formula of Yi Qi Yang Yin and blood activating (A-YBF) on blood glucose levels and renal function in patients with early diabetic nephropathy.
    Methods: 96 patients with early diabetic nephropathy treated in our hospital from April 2021 to April 2022 were included in the study and divided into the control group (conventional medical treatment) and the study group (A-YBF), with 48 cases in each group. The efficacy and adverse effects were recorded by comparing the Chinese medicine symptom points, blood glucose level, renal function, and inflammatory factor level between the two groups before and after the treatment.
    Results: The clinical efficacy of the study group was significantly higher than that of the control group (P < .05). Before treatment, no difference was found between the primary and secondary symptom scores of the two groups (P > .05); after treatment, the primary and secondary symptom scores of the study group were lower than those of the control group (P < .05). Before treatment, there was no difference in fasting blood glucose (FPG) and 2h postprandial glucose (2hPG) levels; 24h urine protein quantification, cystatin C (Cys-C), urinary albumin excretion rate (UAER), and estimated glomerular filtration rate (eGFR) levels; and growth differentiation factor-15 (GDF-15), interleukin-1β (IL-1β), interleukin-17 (IL-17), and serum amyloid A (SAA) levels between the two groups (P > .05). After treatment, FPG and 2hPG levels; 24h urine protein quantification, Cys-C and UAER levels; and GDF-15, IL-1β, IL-17, and SAA levels were lower in the study group than in the control group, while eGFR levels were higher than those in the control group (P < .05).
    Conclusion: A-YBF can effectively reduce blood glucose levels and improve renal function in patients with early diabetic nephropathy and can be promoted in clinical application.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 vaccination, infection, and symptoms among cancer survivors in the United States.

    Yang, Nuo Nova / Zhao, Jingxuan / Zheng, Zhiyuan / Yabroff, K Robin / Han, Xuesong

    Journal of the National Cancer Institute

    2024  

    Abstract: The experiences of cancer survivors with the COVID-19 pandemic in the United States during 2021 and 2022, when vaccinations became widely available, are largely undocumented. Using nationally representative survey data in 2021 and 2022, we found that ... ...

    Abstract The experiences of cancer survivors with the COVID-19 pandemic in the United States during 2021 and 2022, when vaccinations became widely available, are largely undocumented. Using nationally representative survey data in 2021 and 2022, we found that compared with adults without a cancer history, cancer survivors were more likely to have at least 2 COVID-19 vaccines (2021: 66.6% vs 62.3%, P = .003; 2022: 77.0% vs 72.4%, P < .001) and as likely to have a COVID-19 infection history (2021: 14.1% vs 14.2%, P = .93; 2022: 39.9% vs 39.3%, P = .55) but, once infected, were more likely to develop moderate to severe symptoms (2021: 62.5% vs 54.2%, P = .02; 54.5% vs 61.3%; P = .13). Among cancer survivors, younger age, lower educational attainment, lack of health insurance, and more comorbidities were statistically significantly associated with lower vaccination rates (P < .001). Among infected cancer survivors, being female and younger were associated with higher likelihood of developing moderate to severe symptoms (P < .001). Our findings suggest tailored efforts to prevent and control COVID-19 infections for cancer survivors.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djae029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Associations of Medical Debt With Health Status, Premature Death, and Mortality in the US.

    Han, Xuesong / Hu, Xin / Zheng, Zhiyuan / Shi, Kewei Sylvia / Yabroff, K Robin

    JAMA network open

    2024  Volume 7, Issue 3, Page(s) e2354766

    Abstract: Importance: Medical debt is increasingly common in the US. Little is known regarding its association with population health.: Objective: To examine the associations of medical debt with health status, premature death, and mortality at the county ... ...

    Abstract Importance: Medical debt is increasingly common in the US. Little is known regarding its association with population health.
    Objective: To examine the associations of medical debt with health status, premature death, and mortality at the county level in the US.
    Design, setting, and participants: This cross-sectional study was conducted at the US county level using 2018 medical debt data from the Urban Institute Debt in America project linked with 2018 data on self-reported health status and premature death from the County Health Rankings & Roadmaps and with 2015 to 2019 mortality data from the National Center for Health Statistics. Data analysis was performed from August 2022 to May 2023.
    Exposure: Share of population with any medical debt in collections and median amount of medical debt.
    Main outcomes and measures: Health status was measured as (1) the mean number of physically and mentally unhealthy days in the past 30 days per 1000 people, (2) the mean number of premature deaths measured as years of life lost before age 75 years per 1000 people, and (3) age-adjusted all-cause and 18 cause-specific mortality rates (eg, malignant cancers, heart disease, and suicide) per 100 000 person-years. Multivariable linear models were fitted to estimate the associations between medical debt and health outcomes.
    Results: A total of 2943 counties were included in this analysis. The median percentage of the county population aged 65 years or older was 18.3% (IQR, 15.8%-20.9%). Across counties, a median 3.0% (IQR, 1.2%-11.9%) of the population were Black residents, 4.3% (IQR, 2.3%-9.7%) were Hispanic residents, and 84.5% (IQR, 65.7%-93.3%) were White residents. On average, 19.8% (range, 0%-53.6%) of the population had medical debt. After adjusting for county-level sociodemographic characteristics, a 1-percentage point increase in the population with medical debt was associated with 18.3 (95% CI, 16.3-20.2) more physically unhealthy days and 17.9 (95% CI, 16.1-19.8) more mentally unhealthy days per 1000 people during the past month, 1.12 (95% CI, 1.03-1.21) years of life lost per 1000 people, and an increase of 7.51 (95% CI, 6.99-8.04) per 100 000 person-years in age-adjusted all-cause mortality rate. Associations of medical debt and elevated mortality rates were consistent for all leading causes of death, including cancer (1.12 [95% CI, 1.02-1.22]), heart disease (1.39 [95% CI, 1.21-1.57]), and suicide (0.09 [95% CI, 0.06-0.11]) per 100 000 person-years. Similar patterns were observed for associations between the median amount of medical debt and the aforementioned health outcomes.
    Conclusions and relevance: These findings suggest that medical debt is associated with worse health status, more premature deaths, and higher mortality rates at the county level in the US. Therefore, policies increasing access to affordable health care, such as expanding health insurance coverage, may improve population health.
    MeSH term(s) Humans ; Academies and Institutes ; Black People ; Cross-Sectional Studies ; Health Status ; Heart Diseases ; Mortality, Premature ; United States/epidemiology ; Aged
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.54766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sub-nanopores enabling optimized ion storage performance of carbon cathodes for Zn-ion hybrid supercapacitors.

    Kang, Fulian / Li, Yang / Zheng, Zhiyuan / Peng, Xinya / Rong, Jianhua / Dong, Liubing

    Journal of colloid and interface science

    2024  Volume 669, Page(s) 766–774

    Abstract: Aqueous Zn-ion hybrid supercapacitors (ZHSs) are attracting significant attention as a promising electrochemical energy storage system. However, carbon cathodes of ZHSs exhibit unsatisfactory ion storage performance due to the large size of hydrated Zn- ... ...

    Abstract Aqueous Zn-ion hybrid supercapacitors (ZHSs) are attracting significant attention as a promising electrochemical energy storage system. However, carbon cathodes of ZHSs exhibit unsatisfactory ion storage performance due to the large size of hydrated Zn-ions (e.g., [Zn(H
    Language English
    Publishing date 2024-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.05.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neutrophils in the tumor microenvironment and their functional modulation by mesenchymal stromal cells.

    Zheng, Zhiyuan / Xu, Yazhang / Shi, Yufang / Shao, Changshun

    Cellular immunology

    2022  Volume 379, Page(s) 104576

    Abstract: Neutrophils are the most predominant cell population in the innate immune system. The role of neutrophils in the initiation, development and metastasis of tumor has been actively studied in recent years. In cancer, neutrophils exert both pro- and anti- ... ...

    Abstract Neutrophils are the most predominant cell population in the innate immune system. The role of neutrophils in the initiation, development and metastasis of tumor has been actively studied in recent years. In cancer, neutrophils exert both pro- and anti-cancer effects, and their phenotype and function are affected by the tumor microenvironment (TME). This review aims to summarize the role of neutrophils in tumorigenesis with emphasis on their interaction with mesenchymal stromal cells (MSCs).
    MeSH term(s) Carcinogenesis ; Humans ; Mesenchymal Stem Cells ; Neoplasms ; Neutrophils/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2022-07-01
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2022.104576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sigma-1 Receptor Alleviates Airway Inflammation and Airway Remodeling Through AMPK/CXCR4 Signal Pathway.

    Jiang, Te / Zhao, Di / Zheng, Zhiyuan / Li, Zhankui

    Inflammation

    2022  Volume 45, Issue 3, Page(s) 1298–1312

    Abstract: Sigma non-opioid intracellular receptor 1 (Sigma-1R) has been proven to play a major role in inflammation and structural remodeling. However, its role in airway inflammation and airway remodeling remains unclear. The purpose of this study aimed to ... ...

    Abstract Sigma non-opioid intracellular receptor 1 (Sigma-1R) has been proven to play a major role in inflammation and structural remodeling. However, its role in airway inflammation and airway remodeling remains unclear. The purpose of this study aimed to explore the role and mechanism of Sigma-1R in airway remodeling and epithelial-mesenchymal transition (EMT) process in vivo and in vitro. We observed the decrease of Sigma-1R in lung tissue of asthma model. In the mouse model of allergic airway inflammation (AAI), Sigma-1R agonist RPE-084 significantly relieved airway inflammation and airway remodeling, while Sigma-1R antagonist BD1047 (B8562) had opposite effects. Further research showed that RPE-084 treatment increased the expression of pAMPK and inhibited the expression of CXCR4. Furthermore, RPE-084 treatment suppressed the levels of IL-4, IL-5, and IL-13 in BALF. We found that RPE-084 or Sigma-1R overexpression vector treatment regulated cell cycle and inhibited cell proliferation, migration, and EMT process in TGF-β1-induced 16HBE cells. Finally, we confirmed that AMP-activated protein kinase (AMPK) inhibitor compound C or CXCR4 agonist ATI-2341 both reversed the effects of Sigma-1R on TGF-β1-induced 16 HBE cells. In a word, our research shows that Sigma-1R is helpful to improve airway remodeling of asthma, and emphasizes a new candidate molecular for asthma treatment.
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Airway Remodeling ; Animals ; Asthma/drug therapy ; Asthma/metabolism ; Disease Models, Animal ; Inflammation/drug therapy ; Mice ; Ovalbumin ; Receptors, CXCR4 ; Receptors, sigma/metabolism ; Signal Transduction ; Transforming Growth Factor beta1/metabolism ; Sigma-1 Receptor
    Chemical Substances CXCR4 protein, mouse ; Receptors, CXCR4 ; Receptors, sigma ; Transforming Growth Factor beta1 ; Ovalbumin (9006-59-1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-022-01621-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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