LIVIVO - Search results -

Search results

Result 1 - 10 of total 33

Search options

Article ; Online: Assessing radiation-induced carotid artery injury using ultrasound in patients with head and neck cancer.

Zheng, Zhuangzhuang / Shen, Yingying / Su, Jing / Ji, Xiaorui / Zhang, Qiang / Zhao, Qin / Jiang, Xin

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2024 Volume 196, Page(s) 110285

Abstract: Background and purpose: Radiotherapy (RT) can damage neck vessels in patients with head and neck cancer (HNC). This study investigated the early effects of RT on carotid artery, including the internal media thickness (IMT) and carotid plaques of the ... ...

Abstract	Background and purpose: Radiotherapy (RT) can damage neck vessels in patients with head and neck cancer (HNC). This study investigated the early effects of RT on carotid artery, including the internal media thickness (IMT) and carotid plaques of the common carotid artery (CCA). Materials and methods: This study included 69 patients with HNC who underwent RT at the First Hospital of Jilin University from March 2017 to September 2022, and 69 healthy participants as controls. Color Doppler ultrasound (CDUS) of the carotid artery was used to measure the CCA IMT and plaques. Results: Left CCA IMT increased from 0.60 mm (0.60, 0.70) before RT to 0.70 mm (0.60, 1.20) after RT (P < 0.0001). Right CCA IMT changed from 0.60 mm (0.60, 0.71) before RT to 0.60 mm (0.60, 1.10) after RT (P = 0.0002). CCA IMT was 0.60 mm (0.60, 0.70) and 0.80 mm (0.60, 1.20) in the ≤40 Gy and >40 Gy groups (P = 0.0004). The CCA plaques number increased significantly after RT on both the left and right sides (P Conclusion: RT significantly increased CCA IMT, and the growth was related to the radiation dose. The number and volume of the CCA plaques also increased after RT.
Language	English
Publishing date	2024-04-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2024.110285
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1926: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: An open, multicenter, exploratory study of apatinib mesylate maintenance therapy for recurrent/metastatic head and neck squamous cell carcinoma (ChiCTR1800019375).

Wei, Jinlong / Su, Jing / Wang, Jianfeng / Jia, Xiaojing / Zhao, Qin / Shi, Weiyan / Wang, Huanhuan / Zheng, Zhuangzhuang / Jiang, Xin

Head & neck

2024 Volume 46, Issue 4, Page(s) 915–925

Abstract: Background: This study evaluated the efficacy of apatinib in maintenance therapy in patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC).: Methods: Twenty-six patients from three centers were enrolled from November ... ...

Abstract	Background: This study evaluated the efficacy of apatinib in maintenance therapy in patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). Methods: Twenty-six patients from three centers were enrolled from November 2018 to September 2021. These patients received 2 weeks apatinib, administered at 250 mg qd. Then apatinib dose may be administered to 500 mg qd continuous in 4 weeks cycle if no patients experienced adverse reaction. Enrolled patients can receive a combination of radiotherapy or chemotherapy. The primary endpoints were progression-free survival (PFS), and secondary endpoints included overall survival (OS), disease control rate (DCR), objective response rate (ORR), quality of life (QOL) score, and adverse drug reactions. Results: Median PFS of all patients was 3.2 months (95% CI: 2.06-4.33). Median OS of all patients was 7.3 months (95% CI: 2.14-12.46). The DCR was 92.3%. The ORR was 30.8%. In univariate analysis, the results showed that ECOG score 0-1 (HR = 0.31, p = 0.006) and treated with apatinib for more than 60 days (HR = 0.31, p = 0.003) were independent prognostic indicators affecting PFS, and ECOG score 0-1 (HR = 0.40, p = 0.027) and moderately differentiated or highly differentiated (HR = 0.38, p = 0.048) were independent prognostic indicators of OS. The most common adverse events among treated subjects included hypertension (46.1%), fatigue (42.3%), and hand-foot syndrome (23.1%). There were only two cases (7.7%) of Grade III or above adverse reactions. Conclusions: Maintenance therapy with apatinib is an effective and well-tolerated regimen in patients with R/M HNSCC.
MeSH term(s)	Humans ; Antineoplastic Agents/adverse effects ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Quality of Life ; Carcinoma/drug therapy ; Head and Neck Neoplasms/drug therapy ; Pyridines
Chemical Substances	apatinib (5S371K6132) ; Antineoplastic Agents ; Pyridines
Language	English
Publishing date	2024-01-14
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27636
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1493: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced

Bao, Xueying / Zheng, Zhuangzhuang / Lv, Jincai / Bao, Jindian / Chang, Sitong / Jiang, Xin / Xin, Ying

Frontiers in pharmacology

2023 Volume 14, Page(s) 1265571

Abstract: Numerous studies have shown that neuroinflammation is involved in the process of neuronal damage in neurodegenerative diseases such as Parkinson's disease (PD), for example, and that inhibiting neuroinflammation help improve PD. Shikimic acid (SA) has ... ...

Abstract	Numerous studies have shown that neuroinflammation is involved in the process of neuronal damage in neurodegenerative diseases such as Parkinson's disease (PD), for example, and that inhibiting neuroinflammation help improve PD. Shikimic acid (SA) has anti-inflammatory, analgesic and antioxidant activities in numerous diseases. However, its effect and mechanism in PD remain unclear. In this experiment, we found that SA inhibits production of pro-inflammatory mediators and ROS in LPS-induced BV2 cells. Mechanistic studies demonstrated that SA suppresses neuro-inflammation by activating the AKT/Nrf2 pathway and inhibiting the NF-κB pathway. Further
Language	English
Publishing date	2023-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1265571
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mechanisms and applications of radiation-induced oxidative stress in regulating cancer immunotherapy.

Zheng, Zhuangzhuang / Su, Jing / Bao, Xueying / Wang, Huanhuan / Bian, Chenbin / Zhao, Qin / Jiang, Xin

Frontiers in immunology

2023 Volume 14, Page(s) 1247268

Abstract: Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to the death of tumor cells. OS not only causes apoptosis, autophagy and ... ...

Abstract	Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to the death of tumor cells. OS not only causes apoptosis, autophagy and ferroptosis, but also affects tumor immune response. The combination of RT and immunotherapy has revolutionized the management of various cancers. In this process, OS caused by ROS plays a critical role. Specifically, RT-induced ROS can promote the release of tumor-associated antigens (TAAs), regulate the infiltration and differentiation of immune cells, manipulate the expression of immune checkpoints, and change the tumor immune microenvironment (TME). In this review, we briefly summarize several ways in which IR induces tumor cell death and discuss the interrelationship between RT-induced OS and antitumor immunity, with a focus on the interaction of ferroptosis with immunogenic death. We also summarize the potential mechanisms by which ROS regulates immune checkpoint expression, immune cells activity, and differentiation. In addition, we conclude the therapeutic opportunity improving radiotherapy in combination with immunotherapy by regulating OS, which may be beneficial for clinical treatment.
MeSH term(s)	Humans ; Reactive Oxygen Species ; Immunotherapy ; Oxidative Stress ; Apoptosis ; Autophagy ; Neoplasms/radiotherapy
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2023-08-04
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1247268
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Locally advanced head and neck squamous cell carcinoma treatment efficacy and safety: a systematic review and network meta-analysis.

Wang, Huanhuan / Zheng, Zhuangzhuang / Zhang, Yangyu / Bian, Chenbin / Bao, Jindian / Xin, Ying / Jiang, Xin

Frontiers in pharmacology

2023 Volume 14, Page(s) 1269863

Abstract: Head and neck squamous cell carcinoma (HNSCC) accounts for approximately 3% of new cancer cases and 3% of all deaths worldwide. Most HNSCC patients are locally advanced (LA) at diagnosis. The combination of radiotherapy (RT), chemotherapy, targeted ... ...

Abstract	Head and neck squamous cell carcinoma (HNSCC) accounts for approximately 3% of new cancer cases and 3% of all deaths worldwide. Most HNSCC patients are locally advanced (LA) at diagnosis. The combination of radiotherapy (RT), chemotherapy, targeted therapy, and immunotherapy are the primary LA-HNSCC treatment options. Nevertheless, the choice of optimal LA-HNSCC treatment remains controversial. We systematically searched public databases for LA-HNSCC-related studies and assess treatment effectiveness and safety by assessing the objective response rate (ORR), ≥3 adverse events (AEs), overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), local-region control (LRC), and disease-specific survival (DSS). 126 randomized controlled clinical trials (RCTs) were included in this study. We show that concurrent RT with nimotuzumab or conventional concurrent chemo-radiotherapy (CCRT) had significantly better efficacy and long-term survival without increasing AEs than RT alone. Accelerated fractionated radiotherapy (AFRT) showed better efficiency than conventional fractionated RT, although it had higher AEs. In addition, concurrent cetuximab combined with RT failed to show a significant advantage over RT alone.
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1269863
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: New methods of coalbed methane production analysis based on the generalized gamma distribution and field applications

Zhang, Xian-min / Chen, Bai-yan-yue / Zheng, Zhuang-zhuang / Feng, Qi-hong / Fan, Bin

Applied Energy. 2023, p.121729-

2023 , Page(s) 121729–

Abstract: Decline curve analysis is a simple and fast regression method of estimating recoverable reserves and future performance, but it is challenged when applied to unconventional reservoirs. Based on a generalized Gamma distribution in the real number field, a ...

Abstract	Decline curve analysis is a simple and fast regression method of estimating recoverable reserves and future performance, but it is challenged when applied to unconventional reservoirs. Based on a generalized Gamma distribution in the real number field, a theoretical forecasting model describing the whole-process change of coalbed methane well production was constructed, that is, the gas production can be estimated by the early rising section data and a few declining section data, or even just the early rising section data. Furthermore, a generalized production decline analysis model was proposed, which can match all flow regimes in coalbed methane reservoirs as well as in shale gas and tight gas reservoirs. Particularly, the Arps exponential decline model, Duong model, and SEPD model are some of its special forms. By analyzing the production of typical wells in the Zhengzhuang-Fanzhuang block of China, it has demonstrated that the generalized production forecasting model performs significantly better than the Duong model in terms of data fitting accuracy and prediction accuracy, and in comparison to the Arps model, PLE model, SEPD model and Duong model, the generalized production decline model has also demonstrated greater scientific validity and field applicability for predicting coalbed methane production. The MAPE value between the predicted and actual gas production ranges from 4.46% to 8.82%, with an average of 5.75%, and the RRMSE between them ranges from 6.24% to 9.74%, with an average of 7.53%, which are both significantly lower than those provided by the Arps model, PLE model, SEPD model, and Duong model.
Keywords	coalbed methane ; decline ; energy ; methane production ; models ; prediction ; regression analysis ; shale gas ; China ; Production forecasting ; Recoverable reserves ; Generalized gamma distribution ; Generalized production decline model
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2000772-3
ISSN	0306-2619
ISSN	0306-2619
DOI	10.1016/j.apenergy.2023.121729
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism.

Bian, Chenbin / Zheng, Zhuangzhuang / Su, Jing / Wang, Huanhuan / Chang, Sitong / Xin, Ying / Jiang, Xin

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: Radiotherapy failure and poor tumor prognosis are primarily attributed to radioresistance. Improving the curative effect of radiotherapy and delaying cancer progression have become difficult problems for clinicians. Glucose metabolism has long been ... ...

Abstract	Radiotherapy failure and poor tumor prognosis are primarily attributed to radioresistance. Improving the curative effect of radiotherapy and delaying cancer progression have become difficult problems for clinicians. Glucose metabolism has long been regarded as the main metabolic process by which tumor cells meet their bioenergetic and anabolic needs, with the complex interactions between the mitochondria and tumors being ignored. This misconception was not dispelled until the early 2000s; however, the cellular molecules and signaling pathways involved in radioresistance remain incompletely defined. In addition to being a key metabolic site that regulates tumorigenesis, mitochondria can influence the radiation effects of malignancies by controlling redox reactions, participating in oxidative phosphorylation, producing oncometabolites, and triggering apoptosis. Therefore, the mitochondria are promising targets for the development of novel anticancer drugs. In this review, we summarize the internal relationship and related mechanisms between mitochondrial metabolism and cancer radioresistance, thus exploring the possibility of targeting mitochondrial signaling pathways to reverse radiation insensitivity. We suggest that attention should be paid to the potential value of mitochondria in prolonging the survival of cancer patients.
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11112202
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury.

Su, Jing / Bian, Chenbin / Zheng, Zhuangzhuang / Wang, Huanhuan / Meng, Lingbin / Xin, Ying / Jiang, Xin

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 951116

Abstract: Ferroptosis is a kind of oxidative stress-dependent cell death characterized by iron accumulation and lipid peroxidation. It can work in conjunction with radiation to increase reactive oxygen species (ROS) generation and disrupt the antioxidant system, ... ...

Abstract	Ferroptosis is a kind of oxidative stress-dependent cell death characterized by iron accumulation and lipid peroxidation. It can work in conjunction with radiation to increase reactive oxygen species (ROS) generation and disrupt the antioxidant system, suppressing tumor progression. Radiation can induce ferroptosis by creating ROS, depleting glutathione, activating genes linked to DNA damage and increasing the expression of acyl-CoA synthetase long-chain family member 4 (ACSL4) in tumor cells. Furthermore, ferroptosis can enhance radiosensitivity by causing an iron overload, destruction of the antioxidant system, and lipid peroxidation. Radiation can also cause ferroptosis in normal cells, resulting in radiation injury. The role of ferroptosis in radiation-induced lung, intestinal, skin, and hematological injuries have been studied. In this review, we summarize the potential mechanisms linking ferroptosis, oxidative stress and radiation; analyze the function of ferroptosis in tumor suppression and radiation injury; and discuss the potential of ferroptosis regulation to improve radiotherapy efficacy and reduce adverse effects.
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.951116
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Prediction of immunotherapy efficacy and immunomodulatory role of hypoxia in colorectal cancer.

Zheng, Zhuangzhuang / Bian, Chenbin / Wang, Huanhuan / Su, Jing / Meng, Lingbin / Xin, Ying / Jiang, Xin

Therapeutic advances in medical oncology

2022 Volume 14, Page(s) 17588359221138383

Abstract: Immunotherapy has been used in the clinical treatment of colorectal cancer (CRC); however, most patients fail to achieve satisfactory survival benefits. Biomarkers with high specificity and sensitivity are being increasingly developed to predict the ... ...

Abstract	Immunotherapy has been used in the clinical treatment of colorectal cancer (CRC); however, most patients fail to achieve satisfactory survival benefits. Biomarkers with high specificity and sensitivity are being increasingly developed to predict the efficacy of CRC immunotherapy. In addition to DNA alteration markers, such as microsatellite instability/mismatch repair and tumor mutational burden, immune cell infiltration and immune checkpoints (ICs), epigenetic changes and no-coding RNA, and gut microbiomes all show potential predictive ability. Recently, the hypoxic tumor microenvironment (TME) has been identified as a key factor mediating CRC immune evasion and resistance to treatment. Hypoxia-inducible factor-1α is the central transcription factor in the hypoxia response that drives the expression of a vast number of survival genes by binding to the hypoxia response element in cancer and immune cells in the TME. Hypoxia regulates angiogenesis, immune cell infiltration and activation, expression of ICs, and secretion of various immune molecules in the TME and is closely associated with the immunotherapeutic efficacy of CRC. Currently, various agents targeting hypoxia have been found to improve the TME and enhance the efficacy of immunotherapy. We reviewed current markers commonly used in CRC to predict therapeutic efficacy and the mechanisms underlying hypoxia-induced angiogenesis and tumor immune evasion. Exploring the mechanisms by which hypoxia affects the TME will assist the discovery of new immunotherapeutic predictive biomarkers and development of more effective combinations of agents targeting hypoxia and immunotherapy.
Language	English
Publishing date	2022-11-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359221138383
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Copper homeostasis and cuproptosis in tumor pathogenesis and therapeutic strategies.

Bian, Chenbin / Zheng, Zhuangzhuang / Su, Jing / Chang, Sitong / Yu, Huiyuan / Bao, Jindian / Xin, Ying / Jiang, Xin

Frontiers in pharmacology

2023 Volume 14, Page(s) 1271613

Abstract: Copper is an indispensable micronutrient for the development and replication of all eukaryotes, and its redox properties are both harmful and beneficial to cells. An imbalance in copper homeostasis is thought to be involved in carcinogenesis. Importantly, ...

Abstract	Copper is an indispensable micronutrient for the development and replication of all eukaryotes, and its redox properties are both harmful and beneficial to cells. An imbalance in copper homeostasis is thought to be involved in carcinogenesis. Importantly, cancer cell proliferation, angiogenesis, and metastasis cannot be separated from the effects of copper. Cuproposis is a copper-dependent form of cell death that differs from other existing modalities of regulatory cell death. The role of cuproptosis in the pathogenesis of the nervous and cardiovascular systems has been widely studied; however, its impact on malignant tumors is yet to be fully understood from a clinical perspective. Exploring signaling pathways related to cuproptosis will undoubtedly provide a new perspective for the development of anti-tumor drugs in the future. Here, we systematically review the systemic and cellular metabolic processes of copper and the regulatory mechanisms of cuproptosis in cancer. In addition, we discuss the possibility of targeting copper ion drugs to prolong the survival of cancer patients, with an emphasis on the most representative copper ionophores and chelators. We suggest that attention should be paid to the potential value of copper in the treatment of specific cancers.
Language	English
Publishing date	2023-09-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1271613
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito