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Article ; Online: Integrating both common and rare variants to predict bone mineral density and fracture.

Gai, Sirui / Qian, Yu / Zhang, Zhenlin / Zheng, Hou-Feng

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2024 Volume 39, Issue 3, Page(s) 193–194

MeSH term(s)	Humans ; Bone Density ; Fractures, Bone ; Osteoporosis ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1093/jbmr/zjad022
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Article ; Online: Phage Display-Derived Peptides and Antibodies for Bacterial Infectious Diseases Therapy and Diagnosis

Hui Zhao / Dan Nie / Yue Hu / Zhou Chen / Zheng Hou / Mingkai Li / Xiaoyan Xue

Molecules, Vol 28, Iss 2621, p

2023 Volume 2621

Abstract: The emergence of antibiotic-resistant-bacteria is a serious public health threat, which prompts us to speed up the discovery of novel antibacterial agents. Phage display technology has great potential to screen peptides or antibodies with high binding ... ...

Abstract	The emergence of antibiotic-resistant-bacteria is a serious public health threat, which prompts us to speed up the discovery of novel antibacterial agents. Phage display technology has great potential to screen peptides or antibodies with high binding capacities for a wide range of targets. This property is significant in the rapid search for new antibacterial agents for the control of bacterial resistance. In this paper, we not only summarized the recent progress of phage display for the discovery of novel therapeutic agents, identification of action sites of bacterial target proteins, and rapid detection of different pathogens, but also discussed several problems of this technology that must be solved. Breakthrough in these problems may further promote the development and application of phage display technology in the biomedical field in the future.
Keywords	phage display ; antibacterial peptide ; multidrug-resistant ; antibodies ; virulence factor ; library construction ; Organic chemistry ; QD241-441
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on Video Captioning Based on Multifeature Fusion.

Zhao, Hong / Guo, Lan / Chen, ZhiWen / Zheng, HouZe

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 1204909

Abstract: Aiming at the problems that the existing video captioning models pay attention to incomplete information and the generation of expression text is not accurate enough, a video captioning model that integrates image, audio, and motion optical flow is ... ...

Abstract	Aiming at the problems that the existing video captioning models pay attention to incomplete information and the generation of expression text is not accurate enough, a video captioning model that integrates image, audio, and motion optical flow is proposed. A variety of large-scale dataset pretraining models are used to extract video frame features, motion information, audio features, and video sequence features. An embedded layer structure based on self-attention mechanism is designed to embed single-mode features and learn single-mode feature parameters. Then, two schemes of joint representation and cooperative representation are used to fuse the multimodal features of the feature vectors output by the embedded layer, so that the model can pay attention to different targets in the video and their interactive relationships, which effectively improves the performance of the video captioning model. The experiment is carried out on large datasets MSR-VTT and LSMDC. Under the metrics BLEU4, METEOR, ROUGEL, and CIDEr, the MSR-VTT benchmark dataset obtained scores of 0.443, 0.327, 0.619, and 0.521, respectively. The result shows that the proposed method can effectively improve the performance of the video captioning model, and the evaluation indexes are improved compared with comparison models.
MeSH term(s)	Motion
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/1204909
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Article ; Online: Human genetics of face recognition: discovery of MCTP2 mutations in humans with face blindness (Congenital Prosopagnosia).

Sun, Yun / Men, Weiwei / Kennerknecht, Ingo / Fang, Wan / Zheng, Hou-Feng / Zhang, Wenxia / Rao, Yi

Genetics

2024

Abstract: Face recognition is important for both visual and social cognition. While prosopagnosia or face blindness has been known for seven decades and face specific neurons for half a century, the molecular genetic mechanism is not clear. Here we report results ... ...

Abstract	Face recognition is important for both visual and social cognition. While prosopagnosia or face blindness has been known for seven decades and face specific neurons for half a century, the molecular genetic mechanism is not clear. Here we report results after 17 years of research with classic genetics and modern genomics. From a large family with 18 congenital prosopagnosia (CP) members with obvious difficulties in face recognition in daily life, we uncovered a fully cosegregating private mutation in the MCTP2 gene which encodes a calcium binding transmembrane protein expressed in the brain. After screening through cohorts of 6589, we found more CPs and their families, allowing detection of more CP associated mutations in MCTP2. Face recognition differences were detected between 14 carriers with the frameshift mutation S80fs in MCTP2 and 19 non-carrying volunteers. 6 families including one with 10 members showed the S80fs-CP correlation. Functional magnetic resonance imaging found association of impaired recognition of individual faces by MCTP2 mutant CPs with reduced repetition suppression to repeated facial identities in the right fusiform face area. Our results have revealed genetic predisposition of MCTP2 mutations in CP, 76 years after the initial report of prosopagnosia and 47 years after the report of the first CP. This is the first time a gene required for a higher form of visual social cognition was found in humans.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyae047
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Article ; Online: Swietephragmin D, a limonoid from Swietenia mahagoni, reverses multidrug resistance by inhibiting P-glycoprotein dependent efflux

Han Guo / Sheng Gao / Yifan Zhu / Yuanqiang Guo / Zheng Hou / Yonggang Ma

Phytomedicine Plus, Vol 2, Iss 2, Pp 100266- (2022)

2022

Abstract: Background: : P-glycoprotein mediated efflux leads to multidrug resistance of tumor cells, which is an important reason for chemotherapy failure. Thus inhibiting P-gp is an effective approach to reverse multidrug resistance. Purpose: : Swietephragmin D ... ...

Abstract	Background: : P-glycoprotein mediated efflux leads to multidrug resistance of tumor cells, which is an important reason for chemotherapy failure. Thus inhibiting P-gp is an effective approach to reverse multidrug resistance. Purpose: : Swietephragmin D is a limonoid compound isolated from the fruits and leaves of Swietenia mahagoni (L.) Jacq. The reversal efficiency of swietephragmin D was examined in this study. Methods: : Rhodamine 123 efflux assays were used to measure inhibition efficiency of swietephragmin D. Cytotoxicity assays were used to measure the reversal effect of swietephragmin D. Real-time PCR and ATPase assays were performed to explore the mechanisms of reversion. Results: : Swietephragmin D inhibited P-glycoprotein-induced efflux in a dose and time dependent manner. This compound inhibited P-glycoprotein more effectively than verapamil. The IC50 values of the multidrug resistant cells were reduces by swietephragmin D significantly. The transcription levels of ABCB1 (encoded P-glycoprotein) were not affected by swietephragmin D. However, the ATPase activity of P-glycoprotein was stimulated by swietephragmin D. Conclusion: : Swietephragmin D was a substrate of P-glycoprotein and inhibited P-gp mediated efflux. It did not interfere with expression of ABCB1. Thus swietephragmin D reversed multidrug resistance as a competitive inhibitor of P-glycoprotein.
Keywords	Multidrug resistance ; ABC transporters ; P-glycoprotein ; Swietenia mahagoni (L.) Jacq ; Swietephragmin D ; Other systems of medicine ; RZ201-999
Subject code	500
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The negative association between serum albumin levels and coronary heart disease risk in adults over 45 years old

Xin-zheng Hou / En-qi Liu / Si-qi Liu / Hao Lv / Hua-feng Cui / Jing Han

Scientific Reports, Vol 13, Iss 1, Pp 1-

a cross-sectional survey

2023 Volume 9

Abstract: Abstract This study aimed to assess the correlation between serum albumin levels and coronary heart disease (CHD) risk in adults aged over 45 years. This cross-sectional study used the non-institutionalized US population from the National Health and ... ...

Abstract	Abstract This study aimed to assess the correlation between serum albumin levels and coronary heart disease (CHD) risk in adults aged over 45 years. This cross-sectional study used the non-institutionalized US population from the National Health and Nutrition Examination Survey (NHANES 2011–2018) as the sample source. Multiple logistic regression was performed to evaluate the association between serum albumin levels and CHD risk. Smooth curve fitting was performed to explore potential nonlinear relationships. When nonlinear relationships were found, a recursive algorithm was used to calculate inflection points. Additionally, a piecewise logistic regression model was constructed. After adjusting for confounders, multiple logistic regression and smooth curve fitting indicated an inverse association between serum albumin levels and CHD risk [OR = 0.970, 95% CI = (0.948, 0.992)]. Subgroup analysis revealed that the negative correlation was statistically significant in the population of female patients, over 60 years, with hypertension, without diabetes. There was a correlation between serum albumin levels and CHD risk. Lower serum albumin levels were associated with a higher CHD risk.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phylotranscriptomic insights into a Mesoproterozoic–Neoproterozoic origin and early radiation of green seaweeds (Ulvophyceae)

Zheng Hou / Xiaoya Ma / Xuan Shi / Xi Li / Lingxiao Yang / Shuhai Xiao / Olivier De Clerck / Frederik Leliaert / Bojian Zhong

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 11

Abstract: Ulvophyceae is a remarkably morphologically and ecologically diverse clade of green algae. Here, the authors reconstruct the Ulvophyceae phylogeny, showing that these algae originated earlier than expected and may have influenced biogeochemical cycles ... ...

Abstract	“Ulvophyceae is a remarkably morphologically and ecologically diverse clade of green algae. Here, the authors reconstruct the Ulvophyceae phylogeny, showing that these algae originated earlier than expected and may have influenced biogeochemical cycles at the Mesoproterozoic-Neoproterozoic transition.”
Keywords	Science ; Q
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of endophyte diversity of Gentiana officinalis among different tissue types and ages and their association with four medicinal secondary metabolites

QinZheng Hou / DaWei Chen / Yu-pei Wang / Nurbiye Ehmet / Jing Ma / Kun Sun

PeerJ, Vol 10, p e

2022 Volume 13949

Abstract: Background The difference of metabolites in medicinal plants has always been concerned to be influenced by external environmental factors. However, the relationship between endophytes and host metabolites remains unclear. Methods In this study, we used ... ...

Abstract	Background The difference of metabolites in medicinal plants has always been concerned to be influenced by external environmental factors. However, the relationship between endophytes and host metabolites remains unclear. Methods In this study, we used 16S and ITS amplicon sequencing to compare endophyte diversity among different tissue types and ages of Gentiana officinalis. Endophyte diversity and abundance was also analyzed in relation to the abundance of four secondary metabolites (Gentiopicroside, Loganic acid, Swertiamarine and Sweroside). Results The diversity and richness of G. officinalis endophyte differed as a function of tissue types and ages. Four metabolites of G. officinalis were significantly correlated with the abundance of dominant endophyte genera. The predictive function analysis showed that metabolism was main function of endophytic bacteria in different tissue and year root samples, while saprotroph was dominant trophic modes of endophytic fungi in the different year root samples. The dominant trophic modes of endophytic fungi was saprotroph and pathotroph, and relative abundances differed in the different tissue samples. The results of this study will help to elucidate the plant-microbial interactions and provide key information on the role of endophytes in the production of G.officinalis and its important metabolites.
Keywords	G. officinalis ; Endophytes ; Diversity ; Secondary metabolite ; Correlation analysis ; Ecological function ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence.

Zhao, Pianpian / Sheng, Zhifeng / Xu, Lin / Li, Peng / Xiao, Wenjin / Yuan, Chengda / Xu, Zhanwei / Yang, Mengyuan / Qian, Yu / Zhong, Jiadong / Gu, Jiaxuan / Karasik, David / Zheng, Hou-Feng

eLife

2024 Volume 12

Abstract: The 'diabetic bone paradox' suggested that type 2 diabetes (T2D) patients would have higher areal bone mineral density (BMD) but higher fracture risk than individuals without T2D. In this study, we found that the genetically predicted T2D was associated ... ...

Abstract	The 'diabetic bone paradox' suggested that type 2 diabetes (T2D) patients would have higher areal bone mineral density (BMD) but higher fracture risk than individuals without T2D. In this study, we found that the genetically predicted T2D was associated with higher BMD and lower risk of fracture in both weighted genetic risk score (wGRS) and two-sample Mendelian randomization (MR) analyses. We also identified ten genomic loci shared between T2D and fracture, with the top signal at SNP rs4580892 in the intron of gene
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Prospective Studies ; Fractures, Bone/epidemiology ; Fractures, Bone/genetics ; Risk Factors ; Bone and Bones/metabolism ; Genome-Wide Association Study
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.89281
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Article ; Online: Long-term sustainability of biogas bubbles in sand

Xiaoying Hu / Dandan Li / Erxing Peng / Zheng Hou / Yu Sheng / Yaling Chou

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 12

Abstract: Abstract Desaturation is a new method to mitigate liquefaction of sand. It aims to prevent liquefaction by generating gas/air in the pores of fully saturated sands, and biogas is one of the most suitable gas. In order to evaluate the long-term ... ...

Abstract	Abstract Desaturation is a new method to mitigate liquefaction of sand. It aims to prevent liquefaction by generating gas/air in the pores of fully saturated sands, and biogas is one of the most suitable gas. In order to evaluate the long-term sustainability of biogas bubbles, a series sustainability test on biogas bubbles in pores of sand was conducted with a one-dimensional device under hydrostatic condition, hydraulic gradient flow condition and horizontal excitation condition. The variation trend of the retention of biogas bubbles in the pores of soil under the aforementioned conditions was analyzed. Test results indicated that after 72 weeks of monitoring sand samples, biogas bubbles existed stably in the pores of soil under hydrostatic conditions. In hydraulic gradient flow, the stability under upward seepage flow showed a similar trend to that of downward seepage flow. When the hydraulic gradient was constant, the degree of saturation increased in a certain period and finally remained constant. When the hydraulic gradient increased by 0.1, 0.2, 0.3, 0.4, and 0.5, the degrees of saturation increase were 0.8%, 11.5%, 0.5%, 0.1%, and 0%, respectively. After 41,200 cycles with different accelerations, the degree of saturation of the sample increased slightly, and the biogas bubbles basically remained stable.
Keywords	Medicine ; R ; Science ; Q
Subject code	551
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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