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  1. AU="Zhenqiang Bi"
  2. AU=Wang Jun
  3. AU=Zhang Fuping
  4. AU="Shatilov, D N"

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  1. Artikel ; Online: Intestinal colonization with ESBL-producing Klebsiella pneumoniae in healthy rural villager

    Shuang Wang / Hengjie Xie / Yuzhen Chen / Lu Liu / Ming Fang / Dapeng Sun / Liuchen Xu / Zhenqiang Bi / Gaoxiang Sun / Yan Li / Xiaolin Yu / Huaning Zhang / Zengqiang Kou / Beiwen Zheng

    Frontiers in Public Health, Vol

    A genomic surveillance study in China, 2015-2017

    2022  Band 10

    Abstract: BackgroundThe worldwide emergence and diffusion of extended-spectrum β-lactamase-K. pneumoniae (ESBL-KP) is of particular concern. Although ESBL-KP can inhabit the human gut asymptomatically, colonization with ESBL-KP is associated with an increased risk ...

    Abstract BackgroundThe worldwide emergence and diffusion of extended-spectrum β-lactamase-K. pneumoniae (ESBL-KP) is of particular concern. Although ESBL-KP can inhabit the human gut asymptomatically, colonization with ESBL-KP is associated with an increased risk of ESBL-KP infection and mortality. In this study, we investigated the prevalence and characteristics of ESBL-KP in fecal samples from healthy persons in 12 villages in Shandong Province, China.MethodsScreening for ESBL-KP in fecal samples was performed by selective cultivation. The bacterial species were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rDNA sequence analysis. Minimum inhibitory concentrations (MICs) of 16 antibiotics were determined by the agar dilution method. Plasmid replicons, antimicrobial resistance genes and Sequence types (STs) of the isolates were determined by whole-genome sequencing (WGS). Genetic relatedness of ESBL-KP isolates was determined by the single nucleotide polymorphisms (SNP). The S1 nuclease-pulsed-field gel electrophoresis (S1-PFGE) was used to characterize the plasmids carried by ESBL-KP isolates. Conjugation assays was used to verify the transferability of blaCTX − M.ResultsESBL-KP prevalence rates increased from 12.0% in 2015 to 27.5% in 2017. The experimental results showed that 97% of isolates had multi-drug resistance. Multiple ESBL resistance genotypes were commonly detected in the isolates. STs among the ESBL-KP isolates were diverse. All 69 blaCTX−M−3-positive isolates were located on plasmids, and these genes could be transferred with plasmids between different strains. Phylogenetic analysis showed the possibility of transmission among some isolates.ConclusionThis study obtained the drug resistance patterns, the drug resistance phenotype and molecular characteristics of fecal-derived ESBL-KP in rural communities in Shandong Province, China. We report a rapid increase in occurrence of ESBL-KP among fecal samples collected from healthy rural ...
    Schlagwörter intestinal colonization ; ST101 ; CTX-M-3 ; core-genome single nucleotide polymorphisms ; ESBL-producing K. pneumoniae ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-12-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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  2. Artikel: Characterization of Vibrio cholerae isolates from 1976 to 2013 in Shandong Province, China

    Lü, Hui / Bing Guan / Kun Shao / Na Sun / Tongzhan Wang / Yuqi Yuan / Zhenqiang Bi / Zhenwang Bi

    Sociedade Brasileira de Microbiologia Brazilian journal of microbiology. 2017 Jan., Mar., v. 48, no. 1

    2017  

    Abstract: Cholera continues to be a serious public health issue in developing countries. We analyzed the epidemiological data of cholera from 1976 to 2013 in Shandong Province, an eastern coastal area of China. A total of 250 Vibrio cholerae isolates were selected ...

    Abstract Cholera continues to be a serious public health issue in developing countries. We analyzed the epidemiological data of cholera from 1976 to 2013 in Shandong Province, an eastern coastal area of China. A total of 250 Vibrio cholerae isolates were selected for PCR analysis of virulence genes and pulsed-field gel electrophoresis (PFGE). The analysis of the virulence genes showed that the positive rates for tcpA and tcpI were the highest among strains from the southwest region, which had the highest incidence rate of cholera. Low positive rates for tcpA, tcpI and ctxAB among isolates from after 2000 may be an influencing factor contributing to the contemporary decline in cholera incidence rates. Spatiotemporal serotype shifts (Ogawa, Inaba, Ogawa, Inaba and O139) generally correlated with the variations in the PFGE patterns (PIV, PIIIc, PIa, PIIIb, PIIIa, PIb, and PII). O1 strains from different years or regions also had similar PFGE patterns, while O139 strains exclusively formed one cluster and differed from all other O1 strains. These data indicate that V. cholerae isolates in Shandong Province have continually undergone spatiotemporal changes. The serotype switching between Ogawa and Inaba originated from indigenous strains, while the emergence of serogroup O139 appeared to be unrelated to endemic V. cholerae O1 strains.
    Schlagwörter cholera ; coasts ; developing countries ; genes ; microbiology ; polymerase chain reaction ; public health ; pulsed-field gel electrophoresis ; serotypes ; Vibrio cholerae ; virulence ; China
    Sprache Englisch
    Erscheinungsverlauf 2017-01
    Umfang p. 173-179.
    Erscheinungsort Elsevier Editora Ltda.
    Dokumenttyp Artikel
    ZDB-ID 2042078-X
    ISSN 1517-8382
    ISSN 1517-8382
    DOI 10.1016/j.bjm.2016.09.013
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  3. Artikel ; Online: Hantavirus Infection

    Zhenqiang Bi, Pierre B.H. Formenty, Cathy E. Roth

    Journal of Infection in Developing Countries, Vol 2, Iss 1, Pp 3-

    a review and global update

    2008  Band 23

    Abstract: Hantaviruses have the potential to cause two different types of diseases in human: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS, initially described clinically at the turn of the 20th century, occurs ... ...

    Abstract Hantaviruses have the potential to cause two different types of diseases in human: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS, initially described clinically at the turn of the 20th century, occurs endemically in the Asian and European continents, while HPS, recognized as a clinical entity since 1993, represents the prototype of emerging diseases occurring in the Western hemisphere. Approximately 150,000 to 200,000 cases of HFRS are hospitalized each year world wide, with most of the cases occurring in the developing countries. The case fatality rate of HFRS varies from <1% to 12% depending on the viruses. Although HPS is much smaller in number than HFRS, with approximately 200 HPS cases per year in the Americas, the average case fatality rate is 40%. The reported cases of hantaviral infection is increasing in many countries and new hantavirus strains have been increasingly identified worldwide, which constitutes a public health problem of increasing global concern. Hantaviral infection might be underestimated due to its asymptomatic and nonspecific mild infection, and the lack of simple standardized laboratory diagnostics in hospitals, especially in the developing countries. This review summarizes the current knowledge on virology, epidemiology, clinical manifestation, laboratory diagnostics, treatment and prevention of hantaviruses and hantaviral infections.
    Schlagwörter hantavirus ; hemorrhagic fever with renal syndrome ; HFRS ; hantavirus pulmonary syndrome ; HPS ; rodent control ; vaccine ; Internal medicine ; RC31-1245 ; Microbiology ; QR1-502
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2008-02-01T00:00:00Z
    Verlag The Journal of Infection in Developing Countries
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  4. Artikel: Two novel ail-positive biotype 1A strains of Yersinia enterocolitica isolated in China with unequal adhesion and invasion properties

    Liang, Junrong / Zhenqiang Bi / Guoxiang Shi / Yuchun Xiao / Haiyan Qiu / Zengqiang Kou / Bin Hu / Huaiqi Jing / Xin Wang

    Infection, Genetics and Evolution. 2014 Oct., v. 27

    2014  

    Abstract: Yersinia enterocolitica is an enteric pathogen having six biotypes: 1A, 1B, 2, 3, 4, and 5. Different bioserotypes have been associated with varying pathogenicity, and the strains of biotype 1A lack the virulence-associated pYV-bearing genes and were ... ...

    Abstract Yersinia enterocolitica is an enteric pathogen having six biotypes: 1A, 1B, 2, 3, 4, and 5. Different bioserotypes have been associated with varying pathogenicity, and the strains of biotype 1A lack the virulence-associated pYV-bearing genes and were once considered to be avirulent. However, there is growing epidemiological, clinical, and experimental evidence to suggest some biotype 1A isolates are virulent and can cause gastrointestinal disease. Here, we describe two biotype 1A strains discovered from 3807 isolates that carry the ail (attachment and invasion locus) gene. The two strains showed unique PFGE patterns compared to all other isolates in the Chinese Y. enterocolitica isolate PFGE database. Strain SDWL-003 isolated from a sheep shared ail sequence identical to A1 pattern, and the foxA (ferrioxamine receptor) sequence was identical to the pathogenic F5 pattern, besides, the PFGE patterns of SDWL-003 was also cluster to pathogenic branch; however it does not attach to or invade Hep-2 cells. The ail sequence of strain 2006RAT isolated from a Microtus fortis showed several mutations compared to other published genomes, and therefore formed an entirely new pathogenic pattern. Though it clustered to non-pathogenic block with foxA sequence polymorphism analysis or PFGE assay, the strain 2006RAT showed adhesion properties. The data here bring new insights into the molecular genetics of Y. enterocolitica biotype 1A, show some isolates of 1A biotype gaining potential pathogenicity using the function of the virulence gene – ail, and indicate the lateral gene transfer of ail virulence genes proceeded between pathogenic and nonpathogenic Y. enterocolitica.
    Schlagwörter Microtus ; Yersinia enterocolitica ; adhesion ; biotypes ; databases ; digestive system diseases ; enteropathogens ; genes ; horizontal gene transfer ; human cell lines ; loci ; mutation ; pulsed-field gel electrophoresis ; sheep ; virulence ; China
    Sprache Englisch
    Erscheinungsverlauf 2014-10
    Umfang p. 83-88.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2014.07.009
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  5. Artikel: Dynamic patterns of circulating influenza virus from 2005 to 2012 in Shandong Province, China

    Liu, Ti / Aiqiang Xu / Lin Sun / Shaoxia Song / Shengyang Zhang / Xianjun Wang / Yi Lin / Yulu Wang / Zhenqiang Bi / Zhong Li

    Archives of virology. 2016 Nov., v. 161, no. 11

    2016  

    Abstract: To identify circulating emerging/reemerging viral strains and epidemiological trends, an influenza sentinel surveillance network was established in Shandong Province, China, in 2005. Nasal and/or throat swabs from patients with influenza-like-illness ... ...

    Abstract To identify circulating emerging/reemerging viral strains and epidemiological trends, an influenza sentinel surveillance network was established in Shandong Province, China, in 2005. Nasal and/or throat swabs from patients with influenza-like-illness were collected at sentinel hospitals. Influenza viruses were detected by reverse transcription polymerase chain reaction (RT-PCR) or virus isolation. From October 2005 to March 2012, 7763 (21.44 %) of 36,209 swab samples were positive for influenza viruses, including 5221 (67.25 %) influenza A and 2542 (32.75 %) influenza B. While the influenza viruses were detected year-round, their type/subtype distribution varied significantly. Peak influenza activity was observed from November to February. The proportion of laboratory-confirmed influenza cases was highest among participants aged 0-4 years (14.97 %) in the 2005-2009 and 2010-2012 influenza seasons and the positivity rate of influenza A(H1N1)pdm09 was highest in the 15 to 24 year age group during the 2009-2010 influenza season. Genetic analysis of hemagglutinin (HA) and neuraminidase (NA) genes revealed that the viruses matched seasonal influenza vaccine strains in general, with some amino acid mutations. Influenza A(H1N1)pdm09 strains isolated in Shandong Province were characterized by an S203T mutation that is specific to clade 7 isolates. This report illustrates that the Shandong Provincial influenza surveillance system was sensitive in detecting influenza virus variability by season and by genetic composition. This system will help official public health target interventions such as education programs and vaccines.
    Schlagwörter amino acids ; genes ; hemagglutinins ; hospitals ; influenza ; Influenza A virus ; Influenza B virus ; monitoring ; mutation ; nose ; patients ; reverse transcriptase polymerase chain reaction ; sialidase ; throat ; transcription (genetics) ; vaccines ; viruses ; China
    Sprache Englisch
    Erscheinungsverlauf 2016-11
    Umfang p. 3047-3059.
    Erscheinungsort Springer Vienna
    Dokumenttyp Artikel
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-016-2997-2
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  6. Artikel: Prevalence of the mcr-1 colistin resistance gene in extended-spectrum β-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China

    Bi, Zhenwang / Baoli Chen / Björn Berglund / Cecilia Stålsby Lundborg / Göran Tomson / Jingjing Yao / Lennart E. Nilsson / Lilu Ding / Maria Tärnberg / Maud Nilsson / Qiang Sun / Xiao Yin / Zengqiang Kou / Zhanying Gu / Zhenqiang Bi

    International journal of antimicrobial agents. 2017 Apr., v. 49, no. 4

    2017  

    Abstract: Since its initial discovery in China in 2015, the plasmid-mediated colistin resistance gene mcr-1 has been reported in Escherichia coli isolated from clinical samples, animals and meat worldwide. In this study, 706 extended-spectrum β-lactamase (ESBL)- ... ...

    Abstract Since its initial discovery in China in 2015, the plasmid-mediated colistin resistance gene mcr-1 has been reported in Escherichia coli isolated from clinical samples, animals and meat worldwide. In this study, 706 extended-spectrum β-lactamase (ESBL)-producing E. coli from 411 persons were detected in a collection of faecal samples from 1000 rural residents in three counties in Shandong Province, China. These isolates were screened for mcr-1 and phenotypic colistin resistance. The gene was found in 3.5% of the isolates (from 4.9% of persons) from all three counties. All isolates with phenotypic colistin resistance carried mcr-1. These data indicate that commensal carriage of ESBL-producing E. coli with mcr-1 among persons in rural China was already present in 2012 and that mcr-1 was the most important colistin resistance mechanism. Interventions are necessary to minimise further dissemination of mcr-1, which would limit the future usefulness of colistin as a last-resort antibiotic.
    Schlagwörter antibiotic resistance ; beta-lactamase ; colistin ; Escherichia coli ; feces ; genes ; humans ; meat ; people ; phenotype ; villages ; China
    Sprache Englisch
    Erscheinungsverlauf 2017-04
    Umfang p. 493-497.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2016.12.018
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  7. Artikel ; Online: Multiple antibiotic resistance of Vibrio cholerae serogroup O139 in China from 1993 to 2009.

    Li Yu / Yanyan Zhou / Ruibai Wang / Jing Lou / Lijuan Zhang / Jie Li / Zhenqiang Bi / Biao Kan

    PLoS ONE, Vol 7, Iss 6, p e

    2012  Band 38633

    Abstract: Regarded as an emerging diarrheal micropathogen, Vibrio cholerae serogroup O139 was first identified in 1992 and has become an important cause of cholera epidemics over the last two decades. O139 strains have been continually isolated since O139 cholera ... ...

    Abstract Regarded as an emerging diarrheal micropathogen, Vibrio cholerae serogroup O139 was first identified in 1992 and has become an important cause of cholera epidemics over the last two decades. O139 strains have been continually isolated since O139 cholera appeared in China in 1993, from sporadic cases and dispersed foodborne outbreaks, which are the common epidemic types of O139 cholera in China. Antibiotic resistance profiles of these epidemic strains are required for development of clinical treatments, epidemiological studies and disease control. In this study, a comprehensive investigation of the antibiotic resistance of V. cholerae O139 strains isolated in China from 1993 to 2009 was conducted. The initial O139 isolates were resistant to streptomycin, trimethoprim-sulfamethoxazole and polymyxin B only, while multidrug resistance increased suddenly and became common in strains isolated after 1998. Different resistance profiles were observed in the isolates from different years. In contrast, most V. cholerae O1 strains isolated in the same period were much less resistant to these antibiotics and no obvious multidrug resistance patterns were detected. Most of the non-toxigenic strains isolated from the environment and seafood were resistant to four antibiotics or fewer, although a few multidrug resistant strains were also identified. These toxigenic O139 strains exhibited a high prevalence of the class I integron and the SXT element, which were rare in the non-toxigenic strains. Molecular subtyping of O139 strains showed highly diverse pulsed-field gel electrophoresis patterns, which may correspond to the epidemic state of sporadic cases and small-scale outbreaks and complex resistance patterns. Severe multidrug resistance, even resistance transfers based on mobile antibiotic resistance elements, increases the probability of O139 cholera as a threat to public health. Therefore, continual epidemiological and antibiotic sensitivity surveillance should focus on the occurrence of multidrug resistance and frequent ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2012-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: The public health emergency management system in China

    Mei Sun / Ningze Xu / Chengyue Li / Dan Wu / Jiatong Zou / Ying Wang / Li Luo / Mingzhu Yu / Yu Zhang / Hua Wang / Peiwu Shi / Zheng Chen / Jian Wang / Yueliang Lu / Qi Li / Xinhua Wang / Zhenqiang Bi / Ming Fan / Liping Fu /
    Jingjin Yu / Mo Hao

    BMC Public Health, Vol 18, Iss 1, Pp 1-

    trends from 2002 to 2012

    2018  Band 9

    Abstract: Abstract Background Public health emergencies have challenged the public health emergency management systems (PHEMSs) of many countries critically and frequently since this century. As the world’s most populated country and the second biggest economy in ... ...

    Abstract Abstract Background Public health emergencies have challenged the public health emergency management systems (PHEMSs) of many countries critically and frequently since this century. As the world’s most populated country and the second biggest economy in the world, China used to have a fragile PHEMS; however, the government took forceful actions to build PHEMS after the 2003 SARS outbreak. After more than one decade’s efforts, we tried to assess the improvements and problems of China’s PHEMS between 2002 and 2012. Methods We conducted two rounds of national surveys and collected the data of the year 2002 and 2012, including all 32 provincial, 139 municipal, and 489 county CDCs. The municipal and county CDCs were selected by systematic random sampling. Twenty-one indicators of four stages (preparation, readiness, response and recovery) from the National Assessment Criteria for CDC Performance were chosen to assess the ten-year trends. Results At the preparation stage, organization, mechanisms, workforce, and stockpile across all levels and regions were significantly improved after one decade’s efforts. At the readiness stage, the capability for formulating an emergency plan was also significantly improved during the same period. At the response stage, internet-based direct reporting was 98.8%, and coping scores were nearly full points of ten in 2012. At the recovery stage, the capabilities were generally lower than expected. Conclusions Due to forceful leadership, sounder regulations, and intensive resources, China’s PHEMS has been improved at the preparation, readiness, and response stages; however, the recovery stage was still weak and could not meet the requirements of crisis management and preventive governance. In addition, CDCs in the Western region and counties lagged behind in performance on most indicators. Future priorities should include developing the recovery stage, establishing a closed feedback loop, and strengthening the capabilities of CDCs in Western region and counties.
    Schlagwörter Public health emergency management system ; China ; Trend ; Preparation ; Readiness ; Response ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 950
    Sprache Englisch
    Erscheinungsdatum 2018-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
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  9. Artikel ; Online: Alcohol Use, Stigmatizing/Discriminatory Attitudes, and HIV High-Risk Sexual Behaviors among Men Who Have Sex with Men in China

    Meizhen Liao / Dianmin Kang / Xiaorun Tao / Jennifer Huang Bouey / Muktar H. Aliyu / Yuesheng Qian / Guoyong Wang / Xiaoguang Sun / Bin Lin / Zhenqiang Bi / Yujiang Jia

    BioMed Research International, Vol

    2014  Band 2014

    Abstract: Objective. This research was conducted to assess the correlates of alcohol consumption and HIV/AIDS-related stigmatizing and discriminatory attitudes among men who have sex with men (MSM) in Shandong province, China. Methods. A cross-sectional survey ... ...

    Abstract Objective. This research was conducted to assess the correlates of alcohol consumption and HIV/AIDS-related stigmatizing and discriminatory attitudes among men who have sex with men (MSM) in Shandong province, China. Methods. A cross-sectional survey provided demographics, sexual behaviors, illicit drug use, alcohol consumptions, and service utilization. Results. Of 1,230 participants, 82.8% were single, 85.7% aged <35 years, 47.2% had college or higher education, and 11.7% drank alcohol >3 times per week in the past six months. The average total score of stigmatizing and discriminatory attitude was 37.4 ± 4.4. More frequent episodes of alcohol use were independently associated with higher levels of HIV/AIDS-related stigma and discrimination, unprotected anal sex, bisexual identity, multiple male sex partners, drug use, and lower levels of education. Expressing higher levels of HIV/AIDS-related stigmatizing and discriminatory attitudes was independently associated with alcohol use, unprotected male anal sex, bisexuals, more male sex partners, commercial sex with men, and non-receipt of peer education in the past year. Conclusion. HIV/AIDS-related stigmatizing and discriminatory attitudes are common and associated with alcohol use and unprotected sex among MSM. The finding highlights the needs to develop programs that would reduce HIV/AIDS-related stigmatizing and discriminatory attitudes and strengthen alcohol use prevention and risk reduction initiatives among MSM.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Hindawi Limited
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  10. Artikel: Molecular typing of Chinese Streptococcus pyogenes isolates

    You, Yuanhai / Bin Hu / Fanliang Meng / Fengji Luo / Haibin Wang / Haijian Zhou / Jianzhong Zhang / Mark Walker / Menghan Zhang / Xianhui Peng / Xiaoxia Tao / Yanyan Song / Zengqiang Kou / Zhenqiang Bi / Zhenwang Bi

    Molecular and cellular probes. 2015 June, v. 29

    2015  

    Abstract: Streptococcus pyogenes causes human infections ranging from mild pharyngitis and impetigo to serious diseases including necrotizing fasciitis and streptococcal toxic shock syndrome. The objective of this study was to compare molecular emm typing and ... ...

    Abstract Streptococcus pyogenes causes human infections ranging from mild pharyngitis and impetigo to serious diseases including necrotizing fasciitis and streptococcal toxic shock syndrome. The objective of this study was to compare molecular emm typing and pulsed field gel electrophoresis (PFGE) with multiple-locus variable-number tandem-repeat analysis (MLVA) for genotyping of Chinese S. pyogenes isolates. Molecular emm typing and PFGE were performed using standard protocols. Seven variable number tandem repeat (VNTR) loci reported in a previous study were used to genotype 169 S. pyogenes geographically-diverse isolates from China isolated from a variety of disease syndromes. Multiple-locus variable-number tandem-repeat analysis provided greater discrimination between isolates when compared to emm typing and PFGE. Removal of a single VNTR locus (Spy2) reduced the sensitivity by only 0.7%, which suggests that Spy2 was not informative for the isolates screened. The results presented support the use of MLVA as a powerful epidemiological tool for genotyping S. pyogenes clinical isolates.
    Schlagwörter genotype ; human diseases ; loci ; minisatellite repeats ; multiple-locus variable number tandem-repeat analysis ; pharyngitis ; pulsed-field gel electrophoresis ; septic shock ; Streptococcus pyogenes ; tandem repeat sequences ; China
    Sprache Englisch
    Erscheinungsverlauf 2015-06
    Umfang p. 172-176.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 639082-1
    ISSN 1096-1194 ; 0890-8508
    ISSN (online) 1096-1194
    ISSN 0890-8508
    DOI 10.1016/j.mcp.2015.03.009
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